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The map label for this gene is yqcB [H]

Identifier: 238896253

GI number: 238896253

Start: 4231560

End: 4232354

Strand: Reverse

Name: yqcB [H]

Synonym: KP1_4406

Alternate gene names: 238896253

Gene position: 4232354-4231560 (Counterclockwise)

Preceding gene: 238896254

Following gene: 238896252

Centisome position: 80.64

GC content: 62.26

Gene sequence:

>795_bases
ATGCTGGAGATTATCTACCAGGACGACTGGCTGGTGGCGGTCAACAAACCCTCGGGCTGGCTGGTGCATCGCAGCTGGCT
CGATCGCGACGAGAAAGTGGTGGTGATGCAGACCGTGCGCGACCAGATTGGTCAGCACGTTTTTACCGCTCATCGTCTCG
ACCGGCCCACCTCCGGCGTGCTGCTGATGGGATTGTCGAGCGAGGCGGGCCGGCTGCTGGCGCAACAGTTCGAGCAGCAC
CAGATCCGGAAGCGCTACCATGCGATCGTCCGCGGCTGGCTGATGGAAGAGGCGCTGCTGGATTACCCGCTGGTAGAGGA
GCTGGATAGAATCGCCGATAAGTTCGCCCGCGAAGATAAAGGGCCGCAGCCAGCGGTAACCCACTACCGCGGTCTGGCGA
CAGTGGAGATGCCAGTGGCGACTGGGCGCTATCCCACCTCGCGCTATGGGCTGGTGGAACTGGAGCCGAAAACCGGCCGC
AAGCACCAGCTGCGCCGTCATCTGGCCCACCTCCGTCATCCGATCCTCGGCGACAGCAAGCACGGCGATCTGCGGCAAAA
CCGCAGCGCCGCGGAACATTTCGGCTGTCACCGCCTGATGCTGCACGCCAGCGAGCTGTCGTTAACCCATCCTTTTACCG
GCGAGCCGCTGACCCTGCGCGCCGGTTTTGACGACGTCTGGATGCGCGCGCTGTCGCAGTTTGGCTGGCGCGGGCTTCTC
CCGCTAAATGAAAGGGTTGAGTTTGCCGACGACAGCGGTCAGGATGAAGAGAATAAGGTCAATCCAGGGAGATAA

Upstream 100 bases:

>100_bases
CTTATTACGAAATGGCTCTGGATCAGGCCCACCCGGTCCGCGAATCCATGCTGGCGGAACTTCTGCTGTTAGACGCGCTG
TTTGCCGGTGAGCAGGCCTG

Downstream 100 bases:

>100_bases
TAGCATGGCGGAAGTCGGAATTTTTGTCGGCACCATGTACGGCAACTCGCTGCTGGTCGCGGAAGAAGCGGAAGCGATCC
TCAGCGGACTGGGACACAAG

Product: tRNA pseudouridine synthase C

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MLEIIYQDDWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQH
QIRKRYHAIVRGWLMEEALLDYPLVEELDRIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTSRYGLVELEPKTGR
KHQLRRHLAHLRHPILGDSKHGDLRQNRSAAEHFGCHRLMLHASELSLTHPFTGEPLTLRAGFDDVWMRALSQFGWRGLL
PLNERVEFADDSGQDEENKVNPGR

Sequences:

>Translated_264_residues
MLEIIYQDDWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQH
QIRKRYHAIVRGWLMEEALLDYPLVEELDRIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTSRYGLVELEPKTGR
KHQLRRHLAHLRHPILGDSKHGDLRQNRSAAEHFGCHRLMLHASELSLTHPFTGEPLTLRAGFDDVWMRALSQFGWRGLL
PLNERVEFADDSGQDEENKVNPGR
>Mature_264_residues
MLEIIYQDDWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQH
QIRKRYHAIVRGWLMEEALLDYPLVEELDRIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTSRYGLVELEPKTGR
KHQLRRHLAHLRHPILGDSKHGDLRQNRSAAEHFGCHRLMLHASELSLTHPFTGEPLTLRAGFDDVWMRALSQFGWRGLL
PLNERVEFADDSGQDEENKVNPGR

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudouridine synthase rluA family [H]

Homologues:

Organism=Homo sapiens, GI221316667, Length=186, Percent_Identity=32.7956989247312, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI221316663, Length=204, Percent_Identity=30.3921568627451, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1789155, Length=257, Percent_Identity=91.8287937743191, Blast_Score=489, Evalue=1e-140,
Organism=Escherichia coli, GI1787327, Length=233, Percent_Identity=32.618025751073, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786244, Length=225, Percent_Identity=36, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788946, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320168, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324506, Length=192, Percent_Identity=24.4791666666667, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583449, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583447, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583445, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 30382; Mature: 30382

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEIIYQDDWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV
CEEEEEECCEEEEEECCCCEEEEHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCE
LLMGLSSEAGRLLAQQFEQHQIRKRYHAIVRGWLMEEALLDYPLVEELDRIADKFAREDK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
GPQPAVTHYRGLATVEMPVATGRYPTSRYGLVELEPKTGRKHQLRRHLAHLRHPILGDSK
CCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
HGDLRQNRSAAEHFGCHRLMLHASELSLTHPFTGEPLTLRAGFDDVWMRALSQFGWRGLL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCC
PLNERVEFADDSGQDEENKVNPGR
CCCCCCEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLEIIYQDDWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV
CEEEEEECCEEEEEECCCCEEEEHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCE
LLMGLSSEAGRLLAQQFEQHQIRKRYHAIVRGWLMEEALLDYPLVEELDRIADKFAREDK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
GPQPAVTHYRGLATVEMPVATGRYPTSRYGLVELEPKTGRKHQLRRHLAHLRHPILGDSK
CCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
HGDLRQNRSAAEHFGCHRLMLHASELSLTHPFTGEPLTLRAGFDDVWMRALSQFGWRGLL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCC
PLNERVEFADDSGQDEENKVNPGR
CCCCCCEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]