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The map label for this gene is iap [H]

Identifier: 238896234

GI number: 238896234

Start: 4205982

End: 4207028

Strand: Direct

Name: iap [H]

Synonym: KP1_4386

Alternate gene names: 238896234

Gene position: 4205982-4207028 (Clockwise)

Preceding gene: 238896220

Following gene: 238896238

Centisome position: 80.14

GC content: 59.69

Gene sequence:

>1047_bases
ATGTTTTCCGCGTTGTGCCGCCGTCTGCTTCCGCTGGCGCTCGGCACCGGTTTTGTTTTTGCCGCCGCCCCCGCATTCAG
CGCGCTGGGCGACACCGCCAGTAGCCAGGCCCGCCATATCGCCACCGTCTTCCCGGGACGAATGACCGGAACGCCGCCGG
AAATGCTCTCAGCTGACTATCTGCGCCAGCAGTTCGCCCTGATGGGGTATCAGAGCGACGTGCGAAGCTTCAATACCCGC
TATATCTATACCGACAGCAATCAGCGCAAGAACTGGCATAACGCCACCGGCAGTACGGTGATCGCCGCCCATGAAGGTAA
AGTGCGCCAGCAGATTATTATCATGGCACACCTCGACACCTATGCGCCGCAGAGCGATAAAGACGTGGAGAACAACCTCG
GCGGCCTGACGCTGCAGGGCATCGACGACAACGCGATGGGACTTGGCGTATTGCTGGAGCTGGCGGAGCATTTAAAGAAC
GTCCCTACCCGCTATGGCATCCGCTTTATCGCCACCAGCGGTGAAGAGGAAGGCCGTCTCGGTGCGCAAAACCTGCTGCA
GCGGATGAGCGAAGCGGAAAAGAAAAATACCCTGCTGGTGATCAATCTCGATAATCTGGTGGTGGGCGATAAGCTTTACT
TCAACAGCGGCCGCAGCACGCCGGCCTCGGTGCGCAAGCTGACCCGCGACCGTGCGCTGGCTATCGCTCGCAGCAAGGGC
ATCGCCGCCTACACCAACCCGGGACTCAACCCGGCTTATCCGAAAGGCACCAGCTGCTGCAATGACGCCAGCGTCTTCGA
CAACGCCGGGATCCCGGTGCTGTCGGTCGAGGCGACTAACTGGTCACTCGGCAAAAAAGATGGCTATCAGCAGCGGAGCA
AATCGGCCAGTTTCCCGCAGGGAACCAGTTGGCATGACGTCCAGCTGGATAATCAGCAGTATATCGACCACGCGCTGCCG
GGGCGCATCGAACACCGCGGACGCGAGGTAGTGAAAGTCATGCTGCCGCTGGTGAAAGAGCTGGCGAAGGTGGAGAAGAA
AAGCTAA

Upstream 100 bases:

>100_bases
GCTATTTTTCCGCTATTTAAGAGCAATTGAAATTGTTTAACAGCGGTCACAGTTTCATACTGTACGCGTCAAATTGTCTT
GTTCGTGTAAGGACCCCCTT

Downstream 100 bases:

>100_bases
TACGCACAAAAGAACGCGCGGTATCGCCCGCGTGTTCTTTTTAAATTATCACTCAGAGGAAGAGCTAACAGCTTAACCCT
CGTGCAATCCGCACTCGCGT

Product: alkaline phosphatase isozyme conversion aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MFSALCRRLLPLALGTGFVFAAAPAFSALGDTASSQARHIATVFPGRMTGTPPEMLSADYLRQQFALMGYQSDVRSFNTR
YIYTDSNQRKNWHNATGSTVIAAHEGKVRQQIIIMAHLDTYAPQSDKDVENNLGGLTLQGIDDNAMGLGVLLELAEHLKN
VPTRYGIRFIATSGEEEGRLGAQNLLQRMSEAEKKNTLLVINLDNLVVGDKLYFNSGRSTPASVRKLTRDRALAIARSKG
IAAYTNPGLNPAYPKGTSCCNDASVFDNAGIPVLSVEATNWSLGKKDGYQQRSKSASFPQGTSWHDVQLDNQQYIDHALP
GRIEHRGREVVKVMLPLVKELAKVEKKS

Sequences:

>Translated_348_residues
MFSALCRRLLPLALGTGFVFAAAPAFSALGDTASSQARHIATVFPGRMTGTPPEMLSADYLRQQFALMGYQSDVRSFNTR
YIYTDSNQRKNWHNATGSTVIAAHEGKVRQQIIIMAHLDTYAPQSDKDVENNLGGLTLQGIDDNAMGLGVLLELAEHLKN
VPTRYGIRFIATSGEEEGRLGAQNLLQRMSEAEKKNTLLVINLDNLVVGDKLYFNSGRSTPASVRKLTRDRALAIARSKG
IAAYTNPGLNPAYPKGTSCCNDASVFDNAGIPVLSVEATNWSLGKKDGYQQRSKSASFPQGTSWHDVQLDNQQYIDHALP
GRIEHRGREVVKVMLPLVKELAKVEKKS
>Mature_348_residues
MFSALCRRLLPLALGTGFVFAAAPAFSALGDTASSQARHIATVFPGRMTGTPPEMLSADYLRQQFALMGYQSDVRSFNTR
YIYTDSNQRKNWHNATGSTVIAAHEGKVRQQIIIMAHLDTYAPQSDKDVENNLGGLTLQGIDDNAMGLGVLLELAEHLKN
VPTRYGIRFIATSGEEEGRLGAQNLLQRMSEAEKKNTLLVINLDNLVVGDKLYFNSGRSTPASVRKLTRDRALAIARSKG
IAAYTNPGLNPAYPKGTSCCNDASVFDNAGIPVLSVEATNWSLGKKDGYQQRSKSASFPQGTSWHDVQLDNQQYIDHALP
GRIEHRGREVVKVMLPLVKELAKVEKKS

Specific function: This protein, presumably an aminopeptidase, mediates the conversion of E.coli alkaline phosphatase isozyme 1, to isozymes 2 and 3 by removing, one by one, the two amino-terminal arginine residues [H]

COG id: COG2234

COG function: function code R; Predicted aminopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M28 family. M28C subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789111, Length=343, Percent_Identity=74.6355685131195, Blast_Score=540, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007484 [H]

Pfam domain/function: PF04389 Peptidase_M28 [H]

EC number: 3.4.11.- [C]

Molecular weight: Translated: 38139; Mature: 38139

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSALCRRLLPLALGTGFVFAAAPAFSALGDTASSQARHIATVFPGRMTGTPPEMLSADY
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHCEEEEECCCCCCCCCHHHHHHHH
LRQQFALMGYQSDVRSFNTRYIYTDSNQRKNWHNATGSTVIAAHEGKVRQQIIIMAHLDT
HHHHHHHHCHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCC
YAPQSDKDVENNLGGLTLQGIDDNAMGLGVLLELAEHLKNVPTRYGIRFIATSGEEEGRL
CCCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHCEEEEEECCCCCCCC
GAQNLLQRMSEAEKKNTLLVINLDNLVVGDKLYFNSGRSTPASVRKLTRDRALAIARSKG
CHHHHHHHHHHHHHCCCEEEEEECCEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IAAYTNPGLNPAYPKGTSCCNDASVFDNAGIPVLSVEATNWSLGKKDGYQQRSKSASFPQ
CEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCC
GTSWHDVQLDNQQYIDHALPGRIEHRGREVVKVMLPLVKELAKVEKKS
CCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFSALCRRLLPLALGTGFVFAAAPAFSALGDTASSQARHIATVFPGRMTGTPPEMLSADY
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHCEEEEECCCCCCCCCHHHHHHHH
LRQQFALMGYQSDVRSFNTRYIYTDSNQRKNWHNATGSTVIAAHEGKVRQQIIIMAHLDT
HHHHHHHHCHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCC
YAPQSDKDVENNLGGLTLQGIDDNAMGLGVLLELAEHLKNVPTRYGIRFIATSGEEEGRL
CCCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHCEEEEEECCCCCCCC
GAQNLLQRMSEAEKKNTLLVINLDNLVVGDKLYFNSGRSTPASVRKLTRDRALAIARSKG
CHHHHHHHHHHHHHCCCEEEEEECCEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IAAYTNPGLNPAYPKGTSCCNDASVFDNAGIPVLSVEATNWSLGKKDGYQQRSKSASFPQ
CEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCC
GTSWHDVQLDNQQYIDHALPGRIEHRGREVVKVMLPLVKELAKVEKKS
CCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Aminopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3316184; 9278503; 1316900 [H]