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The map label for this gene is ispD [H]

Identifier: 238896227

GI number: 238896227

Start: 4199803

End: 4200513

Strand: Reverse

Name: ispD [H]

Synonym: KP1_4379

Alternate gene names: 238896227

Gene position: 4200513-4199803 (Counterclockwise)

Preceding gene: 238896228

Following gene: 238896226

Centisome position: 80.03

GC content: 64.84

Gene sequence:

>711_bases
ATGGCAGCCACTTTTCCGGGCGTTTGCGCCGTGGTGCCGGCAGCCGGTTTCGGCCGCCGCATGCAAACGGAATGCCCGAA
ACAATATCTCTCAATCGGTAACAAAACGATTCTCGAACACGCGGTCGCCGCGCTGCTGGCGGATGCGCGCGTCCAGCGGG
TGGTGATTGCCGTCAGCCCCGGCGATCGCCGCTTCAGCCAGCTGCCGCTGGCGCAGCATCCGCAAATTACCGTGGTGGAT
GGCGGCGCTGAGCGTGCCGATTCGGTGCTCGCCGGCCTGCAGGCGTTGCCGGAGGCGCAGTGGGTGCTGGTGCATGACGC
CGCGCGCCCCTGCCTGCATCAGGACGACCTCAGCCGCCTGCTGTCGCTCTGCGAAACCAGCCGCGTCGGCGGGATCCTTG
CGGCGCCAGTGCGCGACACCATGAAGCGCGCCGAGCCGGGCAAAACCGCTATCGCCCATACCGTCGACCGCAATGACCTG
TGGCATGCGCTCACCCCGCAATTTTTCCCTCGCGAGCTGCTGGTGGATTGCCTCACTCGCGCGCTAAACGAGGGAGCCAC
TATCACCGATGAAGCCTCGGCGCTGGAGTACTGCGGCTTCCATCCGCAGCTGGTCGCCGGACGCGCGGATAATATTAAAG
TGACGCGCCCGGAAGACCTGGCGCTGGCTGAATTTTACCTCACCCGTTCCCGACACCAGGAGAAAGCTTAA

Upstream 100 bases:

>100_bases
CCGGGCGAAACCTTCTATCGTCTGGTACCGGATGCGTCTAAACGCAATCAGGCATCGGGGCAACAGCAGAACAATCGATA
ACCAGGCCCAGGATTACAAC

Downstream 100 bases:

>100_bases
TGCGAATTGGACATGGTTTTGACGTACACGCTTTTGGCGGTGAAGGCCCAATCATCATTGGCGGGGTACGCATTCCTTAT
GAAAAAGGGCTGCTGGCCCA

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MAATFPGVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHAVAALLADARVQRVVIAVSPGDRRFSQLPLAQHPQITVVD
GGAERADSVLAGLQALPEAQWVLVHDAARPCLHQDDLSRLLSLCETSRVGGILAAPVRDTMKRAEPGKTAIAHTVDRNDL
WHALTPQFFPRELLVDCLTRALNEGATITDEASALEYCGFHPQLVAGRADNIKVTRPEDLALAEFYLTRSRHQEKA

Sequences:

>Translated_236_residues
MAATFPGVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHAVAALLADARVQRVVIAVSPGDRRFSQLPLAQHPQITVVD
GGAERADSVLAGLQALPEAQWVLVHDAARPCLHQDDLSRLLSLCETSRVGGILAAPVRDTMKRAEPGKTAIAHTVDRNDL
WHALTPQFFPRELLVDCLTRALNEGATITDEASALEYCGFHPQLVAGRADNIKVTRPEDLALAEFYLTRSRHQEKA
>Mature_235_residues
AATFPGVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHAVAALLADARVQRVVIAVSPGDRRFSQLPLAQHPQITVVDG
GAERADSVLAGLQALPEAQWVLVHDAARPCLHQDDLSRLLSLCETSRVGGILAAPVRDTMKRAEPGKTAIAHTVDRNDLW
HALTPQFFPRELLVDCLTRALNEGATITDEASALEYCGFHPQLVAGRADNIKVTRPEDLALAEFYLTRSRHQEKA

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=252, Percent_Identity=26.984126984127, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1789104, Length=235, Percent_Identity=87.2340425531915, Blast_Score=419, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25659; Mature: 25527

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATFPGVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHAVAALLADARVQRVVIAVSP
CCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEECC
GDRRFSQLPLAQHPQITVVDGGAERADSVLAGLQALPEAQWVLVHDAARPCLHQDDLSRL
CCHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
LSLCETSRVGGILAAPVRDTMKRAEPGKTAIAHTVDRNDLWHALTPQFFPRELLVDCLTR
HHHHHHHHCCCEEEHHHHHHHHHCCCCCHHHHEECCCCCHHHHCCCCCCCHHHHHHHHHH
ALNEGATITDEASALEYCGFHPQLVAGRADNIKVTRPEDLALAEFYLTRSRHQEKA
HHHCCCCCCCHHHHHHHCCCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AATFPGVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHAVAALLADARVQRVVIAVSP
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEECC
GDRRFSQLPLAQHPQITVVDGGAERADSVLAGLQALPEAQWVLVHDAARPCLHQDDLSRL
CCHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
LSLCETSRVGGILAAPVRDTMKRAEPGKTAIAHTVDRNDLWHALTPQFFPRELLVDCLTR
HHHHHHHHCCCEEEHHHHHHHHHCCCCCHHHHEECCCCCHHHHCCCCCCCHHHHHHHHHH
ALNEGATITDEASALEYCGFHPQLVAGRADNIKVTRPEDLALAEFYLTRSRHQEKA
HHHCCCCCCCHHHHHHHCCCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA