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The map label for this gene is hmuU [H]

Identifier: 238896210

GI number: 238896210

Start: 4183936

End: 4184931

Strand: Direct

Name: hmuU [H]

Synonym: KP1_4361

Alternate gene names: 238896210

Gene position: 4183936-4184931 (Clockwise)

Preceding gene: 238896209

Following gene: 238896211

Centisome position: 79.72

GC content: 68.07

Gene sequence:

>996_bases
ATGCGCCCTGCCCTCGCTCGCCGTTTGCTGCTGATGACGCTGCTGCTGGTCTCCCTGACGTTGTTTGCCACCACCCTCGG
CGCCATGCGCTTGCCGCTGGTCAACCTGCTGCCTTCCGGGGATGACATGCTGCGCCATATCTGGCTGACCATCCGTCTGC
CGCGGGTGCTGCTGGCCCTGCTGGTGGGCGCGGCGCTGGCCCTCTCCGGCTGCGTGATGCAGGGGCTGTTTCGCAACCCG
CTTGCCGACCCGGGCCTGCTGGGCATCAGCAGCGGCGCCGCGCTGGCGGTGGCCAGCTGGCTGGTGCTCCCGTTCTCCGC
TGCGGGGCTGATCGCTCTGTATATGCCGATGCTGGCGGCGTTTATTGGCAGCCTGGCGGTGATGGTGGTGATTTTCATCC
TCAGTCGGGCGGAGGAGGGTTCGCTGTCGCGCCTGCTGCTGGTGGGGATCGCCATCAACGCGCTGTGCGGCGCGCTGGTC
GGCGTCCTGTCCTGGCTGAGCAATGACGCCCAGCTGCGCCAGCTGTCGCTGTGGGGAATGGGCAGTCTGGGCCAGGCCGA
ATGGCCGACGCTGCTGGTGGCCGCGACCTTGATTATCCCGGCGGCGCTGGCGGTGTGGTGGATGGCGTCCCGCCTCAATC
TGCTGCAGCTTGGCGATGAAGAGGCGCACTATCTTGGGGTCAACGTGCAGGCGCTGCAGCGCTGGCTGCTGCTGTGCAGC
GCGGTGCTGGTGGCCGTCGCGGTGGCCATCAGCGGAGTCATCGGCTTTATCGGCCTGGTGGTGCCGCACCTGATGCGCCT
GTGGCTGGGACCGGACCATCGCGGACTGATCCCCGGCTCGCTGCTGGCCGGCGCGATCCTGCTTCTGCTGGCCGACACCC
TGGCCCGCACCGTGGCGGCGCCGGCGGAGATACCGGTCGGTCTGCTCACCAGCCTGCTGGGCGCCCCCTGGTTTCTGTGG
CTGGTCTTTCGTCGGGAGAACTCCAGACATGGTTAA

Upstream 100 bases:

>100_bases
AACAGCTGCTGACGATCGACGATATGGCCCTGCTGGGCTTCGGGCCGCGCACACCGCAGGCGATAATCGCGCTGCGAAAC
AAAGCGGAGCAGTTGCCCTG

Downstream 100 bases:

>100_bases
TGAATACTGCGCCCAGGGGCTGTCACTTCACCTTGGTAAACGACAGATTATCGACAACGTCTCCGTCGCGCTGCGCGGCG
GCGAGATGACGGTGCTTATC

Product: hemin transport system permease component

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MRPALARRLLLMTLLLVSLTLFATTLGAMRLPLVNLLPSGDDMLRHIWLTIRLPRVLLALLVGAALALSGCVMQGLFRNP
LADPGLLGISSGAALAVASWLVLPFSAAGLIALYMPMLAAFIGSLAVMVVIFILSRAEEGSLSRLLLVGIAINALCGALV
GVLSWLSNDAQLRQLSLWGMGSLGQAEWPTLLVAATLIIPAALAVWWMASRLNLLQLGDEEAHYLGVNVQALQRWLLLCS
AVLVAVAVAISGVIGFIGLVVPHLMRLWLGPDHRGLIPGSLLAGAILLLLADTLARTVAAPAEIPVGLLTSLLGAPWFLW
LVFRRENSRHG

Sequences:

>Translated_331_residues
MRPALARRLLLMTLLLVSLTLFATTLGAMRLPLVNLLPSGDDMLRHIWLTIRLPRVLLALLVGAALALSGCVMQGLFRNP
LADPGLLGISSGAALAVASWLVLPFSAAGLIALYMPMLAAFIGSLAVMVVIFILSRAEEGSLSRLLLVGIAINALCGALV
GVLSWLSNDAQLRQLSLWGMGSLGQAEWPTLLVAATLIIPAALAVWWMASRLNLLQLGDEEAHYLGVNVQALQRWLLLCS
AVLVAVAVAISGVIGFIGLVVPHLMRLWLGPDHRGLIPGSLLAGAILLLLADTLARTVAAPAEIPVGLLTSLLGAPWFLW
LVFRRENSRHG
>Mature_331_residues
MRPALARRLLLMTLLLVSLTLFATTLGAMRLPLVNLLPSGDDMLRHIWLTIRLPRVLLALLVGAALALSGCVMQGLFRNP
LADPGLLGISSGAALAVASWLVLPFSAAGLIALYMPMLAAFIGSLAVMVVIFILSRAEEGSLSRLLLVGIAINALCGALV
GVLSWLSNDAQLRQLSLWGMGSLGQAEWPTLLVAATLIIPAALAVWWMASRLNLLQLGDEEAHYLGVNVQALQRWLLLCS
AVLVAVAVAISGVIGFIGLVVPHLMRLWLGPDHRGLIPGSLLAGAILLLLADTLARTVAAPAEIPVGLLTSLLGAPWFLW
LVFRRENSRHG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=322, Percent_Identity=39.4409937888199, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788004, Length=275, Percent_Identity=43.2727272727273, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790741, Length=277, Percent_Identity=39.3501805054152, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786805, Length=308, Percent_Identity=37.012987012987, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786804, Length=337, Percent_Identity=34.7181008902077, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786347, Length=286, Percent_Identity=34.965034965035, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35168; Mature: 35168

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPALARRLLLMTLLLVSLTLFATTLGAMRLPLVNLLPSGDDMLRHIWLTIRLPRVLLAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LVGAALALSGCVMQGLFRNPLADPGLLGISSGAALAVASWLVLPFSAAGLIALYMPMLAA
HHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLAVMVVIFILSRAEEGSLSRLLLVGIAINALCGALVGVLSWLSNDAQLRQLSLWGM
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GSLGQAEWPTLLVAATLIIPAALAVWWMASRLNLLQLGDEEAHYLGVNVQALQRWLLLCS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHHHHH
AVLVAVAVAISGVIGFIGLVVPHLMRLWLGPDHRGLIPGSLLAGAILLLLADTLARTVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PAEIPVGLLTSLLGAPWFLWLVFRRENSRHG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRPALARRLLLMTLLLVSLTLFATTLGAMRLPLVNLLPSGDDMLRHIWLTIRLPRVLLAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LVGAALALSGCVMQGLFRNPLADPGLLGISSGAALAVASWLVLPFSAAGLIALYMPMLAA
HHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLAVMVVIFILSRAEEGSLSRLLLVGIAINALCGALVGVLSWLSNDAQLRQLSLWGM
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GSLGQAEWPTLLVAATLIIPAALAVWWMASRLNLLQLGDEEAHYLGVNVQALQRWLLLCS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHHHHH
AVLVAVAVAISGVIGFIGLVVPHLMRLWLGPDHRGLIPGSLLAGAILLLLADTLARTVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PAEIPVGLLTSLLGAPWFLWLVFRRENSRHG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]