Click here to switch to the map view.

The map label for this gene is galR [H]

Identifier: 238896197

GI number: 238896197

Start: 4170304

End: 4171266

Strand: Direct

Name: galR [H]

Synonym: KP1_4346

Alternate gene names: 238896197

Gene position: 4170304-4171266 (Clockwise)

Preceding gene: 238896196

Following gene: 238896198

Centisome position: 79.46

GC content: 61.37

Gene sequence:

>963_bases
ATGCCAACGATTGATGATGTTTCAAGATTAGCGAATGTCTCAAGAGCGACGGTATCCCGCGTGCTGACCGGCACCCGGGG
CGTGCGCGAAGAGAGCCGGGAAGCTGTGCTGCGGGCCGTTGAAGAACTCAACTATCGCCCGAGCTTTGCCGCGCAAAACC
TCGCCAGTCAGACATCCAGCCACGTTGGTCTGGTGATTTCCGCGCAGGACGAAAGCCACGGCGCACGTCTGCTGCCGCTG
CTCTCTCAGGCGCTGAAAGGGCTGAATAAAAGCCTGCTGGTCCAGTACGTCAGCGACCCGGTAGAGCAGGCGGCGGTAAT
CGACGATCTGCAGCGCCAGTGCGTGGCGGTGGTGGTGCTGGGCGCCGTTGCCGCCGACGCGCCGCGCAACGTTATCGCCT
TTGACCGCTTCGGCGTCGCCGGGAGCAACAGCCAGGGCTATGACTTCGCCTTTGCCACCGAAAGCGCCTGCCGCTATGTG
ATTGGCAAGGGACACCGCAACATCGCCCTGCTGGTGGACAGCGATAGCGACGATGCCAGCCGTCAGATGCTGGAAGGCTA
CCGCAACGTCCTGCAGAACTACTCCATTCCTTTTAACCGTCAGCTGGTGCTGACGGCCAACGATGACGTCGAGCAGGCGC
TGCTGACCTTAATTAACAGCTTCAGTAAATACTCAGTCATTATCGTTAAACGCGACCGCTACGCGGCTGAGGCGATGCGT
CTGCTGCGCGAATTCACCATCGCCGTCCCGCAGGAGGTCTCCCTGCTGAGCCTTGAGGATTCCCCGCTCGCCTCGCTGCT
CTACCCGCCGCTGACCTGCATCTCCTGGCCACTGGAGGCGCTGCTGGATAACTGTATTCAGCGTATTCGCAGCCTGATTG
ACGACCGGCCAACCTTCGCCACCGAGGGCCGCTCGCTGGCTGGCCGCCTGATCCCGCGCCAGTCGGTCGCCGATATTTCT
TGA

Upstream 100 bases:

>100_bases
CCTGGCTGCCCCGGCTTCCCGGCGTCGCGCAAGGGCAGCGGTAGACACTTTTTTCAGCAGGTATGTTAAGCTAGGCGAAA
ATGTTCAGACAGAAAAAGCC

Downstream 100 bases:

>100_bases
TCTTCGCCCGGTTGGCGCCGGGCCAGACTTACCTCCCCTTTTCGCGCTTTCGTTTCCCGGCTCATTATTACCCACGCATG
CAAATAAGAATTATTTTCAT

Product: repressor of galETK operon

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MPTIDDVSRLANVSRATVSRVLTGTRGVREESREAVLRAVEELNYRPSFAAQNLASQTSSHVGLVISAQDESHGARLLPL
LSQALKGLNKSLLVQYVSDPVEQAAVIDDLQRQCVAVVVLGAVAADAPRNVIAFDRFGVAGSNSQGYDFAFATESACRYV
IGKGHRNIALLVDSDSDDASRQMLEGYRNVLQNYSIPFNRQLVLTANDDVEQALLTLINSFSKYSVIIVKRDRYAAEAMR
LLREFTIAVPQEVSLLSLEDSPLASLLYPPLTCISWPLEALLDNCIQRIRSLIDDRPTFATEGRSLAGRLIPRQSVADIS

Sequences:

>Translated_320_residues
MPTIDDVSRLANVSRATVSRVLTGTRGVREESREAVLRAVEELNYRPSFAAQNLASQTSSHVGLVISAQDESHGARLLPL
LSQALKGLNKSLLVQYVSDPVEQAAVIDDLQRQCVAVVVLGAVAADAPRNVIAFDRFGVAGSNSQGYDFAFATESACRYV
IGKGHRNIALLVDSDSDDASRQMLEGYRNVLQNYSIPFNRQLVLTANDDVEQALLTLINSFSKYSVIIVKRDRYAAEAMR
LLREFTIAVPQEVSLLSLEDSPLASLLYPPLTCISWPLEALLDNCIQRIRSLIDDRPTFATEGRSLAGRLIPRQSVADIS
>Mature_319_residues
PTIDDVSRLANVSRATVSRVLTGTRGVREESREAVLRAVEELNYRPSFAAQNLASQTSSHVGLVISAQDESHGARLLPLL
SQALKGLNKSLLVQYVSDPVEQAAVIDDLQRQCVAVVVLGAVAADAPRNVIAFDRFGVAGSNSQGYDFAFATESACRYVI
GKGHRNIALLVDSDSDDASRQMLEGYRNVLQNYSIPFNRQLVLTANDDVEQALLTLINSFSKYSVIIVKRDRYAAEAMRL
LREFTIAVPQEVSLLSLEDSPLASLLYPPLTCISWPLEALLDNCIQRIRSLIDDRPTFATEGRSLAGRLIPRQSVADIS

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789202, Length=311, Percent_Identity=29.903536977492, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789068, Length=334, Percent_Identity=27.5449101796407, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=28.6195286195286, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787948, Length=350, Percent_Identity=25.4285714285714, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=24.9240121580547, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786540, Length=325, Percent_Identity=26.7692307692308, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35062; Mature: 34931

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50932 HTH_LACI_2 ; PS00205 TRANSFERRIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIDDVSRLANVSRATVSRVLTGTRGVREESREAVLRAVEELNYRPSFAAQNLASQTSS
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
HVGLVISAQDESHGARLLPLLSQALKGLNKSLLVQYVSDPVEQAAVIDDLQRQCVAVVVL
CEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVAADAPRNVIAFDRFGVAGSNSQGYDFAFATESACRYVIGKGHRNIALLVDSDSDDAS
HHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCHHH
RQMLEGYRNVLQNYSIPFNRQLVLTANDDVEQALLTLINSFSKYSVIIVKRDRYAAEAMR
HHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHH
LLREFTIAVPQEVSLLSLEDSPLASLLYPPLTCISWPLEALLDNCIQRIRSLIDDRPTFA
HHHHHHHCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TEGRSLAGRLIPRQSVADIS
HCCHHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
PTIDDVSRLANVSRATVSRVLTGTRGVREESREAVLRAVEELNYRPSFAAQNLASQTSS
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
HVGLVISAQDESHGARLLPLLSQALKGLNKSLLVQYVSDPVEQAAVIDDLQRQCVAVVVL
CEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVAADAPRNVIAFDRFGVAGSNSQGYDFAFATESACRYVIGKGHRNIALLVDSDSDDAS
HHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCHHH
RQMLEGYRNVLQNYSIPFNRQLVLTANDDVEQALLTLINSFSKYSVIIVKRDRYAAEAMR
HHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHH
LLREFTIAVPQEVSLLSLEDSPLASLLYPPLTCISWPLEALLDNCIQRIRSLIDDRPTFA
HHHHHHHCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TEGRSLAGRLIPRQSVADIS
HCCHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1282642; 7542800 [H]