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The map label for this gene is hycC [H]

Identifier: 238896180

GI number: 238896180

Start: 4151446

End: 4153272

Strand: Reverse

Name: hycC [H]

Synonym: KP1_4327

Alternate gene names: 238896180

Gene position: 4153272-4151446 (Counterclockwise)

Preceding gene: 238896181

Following gene: 238896179

Centisome position: 79.13

GC content: 65.35

Gene sequence:

>1827_bases
ATGAGTGTAATTGGATTAGTGAATCAGGCGGTGGCGTGGTATGCCGCCAGCGCCGTACTGGCCTTTCTGTTTGCCATGCG
CAAACCGCTCAGCGGCGCCATTGCCGGGATCGGCGGCGCGGTGGCCAGCGCCATGCTGGTGGTCACCGGCGGCGCCGCGC
TGCTGATGCCGGAGCGGATCCACGGCGGCATGCTGCAGTTTCTCCACCTGACGATACGGGTGGGGGGCGTCAACGCGCTG
TGGCTGCTGGCCATCGGCCTGTCGGCGCTGCCGGTGTCGCTGTTCAATATTAGCTGGCATCGCCACCCGCAGGTGAAGGC
CAACGGCCCGCTGGTCAACCTGCTGCTGGCCGCCGCGACCTGCGCGGTGGTGGTGACCAATATCGGTTCACTGGTGGTGA
TGGCGGAGATCATGGCGCTCTGCGCGGCGTTTCTCACCGGCTGCGCCGCCTCCGGTAAGCTGTGGTTTGCCCTGGGGCGT
CTCGGTACTCTGCTGATGGCCTGGACCTGCTGGCTGGTGTGGTCAACCTACGGCACCCTCGAGCTGGCGCAGATCAACCT
TCAGGCGGTGGATATGATGCAGAACCCGCTGCTCTGGCTGCCGGGTCTGGTGGGGTTCGCCCTGCTGGCCGGGGCGATCC
CGCTGCACGGCTGGGCGCCGCAGGCTCACGCCGGGGCCAGCGCGCCGGCCGCCGCGCTGTTTTCCACGGTGGTAATGAAG
GTTGGTCTGTACGGCATGCTGACCGTTTCGCTGGCCGGCGGCGTGCCGCCGCTGTGGTGGGGCGTGATGCTGCTGGCGCT
GGGGATGATCACCGCCTTTATCGGCGGACTGTATGCGCTGATGGAGCATAACATTCAGCGCCTGCTGGCCTATCACACCC
TGGAGAATATCGGCATTATCCTGCTGGGGCTGGGCGCCTTCGTCACCGGCGTGGCGACCCGCAACAGCACGCTGATGGTG
CTGGGCTTTATCGGCGGCATGTATCACCTGATTAACCACAGCCTGTTCAAAACCACGCTGTTCCTCGGTGCCGGAGCGGT
GTGGTTCCGCACCGGTCATCGCGATATCGAGAAGCTGGGCGGCATCGGTAAAAAAATGCCGCTGATCTCCCTCGCCATGC
TGGTGGGGCTGATGGCAATGGCGGCCCTGCCGCCGCTGAACGGCTTCGCCGGCGAGTGGGTTATCTATCAATCCTTCTTC
AAAATGAGCACTGGCGACCTGTTTATCGGCCGTTTGCTGGGGCCGCTACTGGCCGTTGGCCTGGCGATCACTGGCGCACT
GGCGGTGATGTGTATGGCGAAAGTCTATGGCGTGACCTTCCTCGGCGCGCCGCGGACGAAAGAGGCGGAAAACGCTACCT
GCGCCCCCTGGCTGATGACCCTGAGCGTGGTGCTGGCGGCGGTTTTCTGCCTCGTTGGCGGCATCGCCGCGCCGTGGCTG
CTGCCGCTGGTGAGCGGCGCCTTCCCGGTGCAGGCTCAGGTATCGAGCGTGGTGTCGCAGCCGATGATCGCGCTGCTGCT
TATCGCCTGCCCGCTGCTGCCGTTCCTGCTGATGATCTTCTTTAAAGGCGATCGCCTGGCGGCGCGCTCGCGCGGCGCGG
CGTGGGTCTGCGGTTACGACCACGAGCAGTCGATGGTGGTAACGGCCCACGGCTTTGCCATGCCGGTGAAAGAGGCCTTT
GCGCCGTTGCTGAAGCTGCGTCACTGGCTGAACCCGGTGCGTCTGGTGCCGGGCTGGCAATCGGCCTCGGCGCCGGCGCT
GCTGCGCGGGATCGCGCTGGTTGAGCTGGCGGTGCTGGTGGTGATTGTCATTTCGCGAGGAGCCTGA

Upstream 100 bases:

>100_bases
GCCGTGATATCGCCCAGGCCAGCAAGCGTAAACGCCAGCTGACCTTTAATACCGACCTTGGCGACTTGTCGCTGTTCCAG
GCGCAACAGGGGGAGAGGGA

Downstream 100 bases:

>100_bases
GAATGAGTCTGTTAATTGCATTGCTACAGGCGCTGGTGCTGTTTGCCGTCGCGCCGCTGTTGTCCGGGATCGTTCGCGTC
GCCCGCGCGCGGCTGCATAA

Product: formate hydrogenlyase subunit 3

Products: NA

Alternate protein names: FHL subunit 3; Hydrogenase-3 component C [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSVIGLVNQAVAWYAASAVLAFLFAMRKPLSGAIAGIGGAVASAMLVVTGGAALLMPERIHGGMLQFLHLTIRVGGVNAL
WLLAIGLSALPVSLFNISWHRHPQVKANGPLVNLLLAAATCAVVVTNIGSLVVMAEIMALCAAFLTGCAASGKLWFALGR
LGTLLMAWTCWLVWSTYGTLELAQINLQAVDMMQNPLLWLPGLVGFALLAGAIPLHGWAPQAHAGASAPAAALFSTVVMK
VGLYGMLTVSLAGGVPPLWWGVMLLALGMITAFIGGLYALMEHNIQRLLAYHTLENIGIILLGLGAFVTGVATRNSTLMV
LGFIGGMYHLINHSLFKTTLFLGAGAVWFRTGHRDIEKLGGIGKKMPLISLAMLVGLMAMAALPPLNGFAGEWVIYQSFF
KMSTGDLFIGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPWLMTLSVVLAAVFCLVGGIAAPWL
LPLVSGAFPVQAQVSSVVSQPMIALLLIACPLLPFLLMIFFKGDRLAARSRGAAWVCGYDHEQSMVVTAHGFAMPVKEAF
APLLKLRHWLNPVRLVPGWQSASAPALLRGIALVELAVLVVIVISRGA

Sequences:

>Translated_608_residues
MSVIGLVNQAVAWYAASAVLAFLFAMRKPLSGAIAGIGGAVASAMLVVTGGAALLMPERIHGGMLQFLHLTIRVGGVNAL
WLLAIGLSALPVSLFNISWHRHPQVKANGPLVNLLLAAATCAVVVTNIGSLVVMAEIMALCAAFLTGCAASGKLWFALGR
LGTLLMAWTCWLVWSTYGTLELAQINLQAVDMMQNPLLWLPGLVGFALLAGAIPLHGWAPQAHAGASAPAAALFSTVVMK
VGLYGMLTVSLAGGVPPLWWGVMLLALGMITAFIGGLYALMEHNIQRLLAYHTLENIGIILLGLGAFVTGVATRNSTLMV
LGFIGGMYHLINHSLFKTTLFLGAGAVWFRTGHRDIEKLGGIGKKMPLISLAMLVGLMAMAALPPLNGFAGEWVIYQSFF
KMSTGDLFIGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPWLMTLSVVLAAVFCLVGGIAAPWL
LPLVSGAFPVQAQVSSVVSQPMIALLLIACPLLPFLLMIFFKGDRLAARSRGAAWVCGYDHEQSMVVTAHGFAMPVKEAF
APLLKLRHWLNPVRLVPGWQSASAPALLRGIALVELAVLVVIVISRGA
>Mature_607_residues
SVIGLVNQAVAWYAASAVLAFLFAMRKPLSGAIAGIGGAVASAMLVVTGGAALLMPERIHGGMLQFLHLTIRVGGVNALW
LLAIGLSALPVSLFNISWHRHPQVKANGPLVNLLLAAATCAVVVTNIGSLVVMAEIMALCAAFLTGCAASGKLWFALGRL
GTLLMAWTCWLVWSTYGTLELAQINLQAVDMMQNPLLWLPGLVGFALLAGAIPLHGWAPQAHAGASAPAAALFSTVVMKV
GLYGMLTVSLAGGVPPLWWGVMLLALGMITAFIGGLYALMEHNIQRLLAYHTLENIGIILLGLGAFVTGVATRNSTLMVL
GFIGGMYHLINHSLFKTTLFLGAGAVWFRTGHRDIEKLGGIGKKMPLISLAMLVGLMAMAALPPLNGFAGEWVIYQSFFK
MSTGDLFIGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPWLMTLSVVLAAVFCLVGGIAAPWLL
PLVSGAFPVQAQVSSVVSQPMIALLLIACPLLPFLLMIFFKGDRLAARSRGAAWVCGYDHEQSMVVTAHGFAMPVKEAFA
PLLKLRHWLNPVRLVPGWQSASAPALLRGIALVELAVLVVIVISRGA

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=185, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI2367154, Length=612, Percent_Identity=69.4444444444444, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=551, Percent_Identity=36.6606170598911, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI1788831, Length=197, Percent_Identity=33.502538071066, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788614, Length=290, Percent_Identity=27.9310344827586, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788829, Length=194, Percent_Identity=27.319587628866, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788613, Length=206, Percent_Identity=29.6116504854369, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: NA

Molecular weight: Translated: 64003; Mature: 63872

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIGLVNQAVAWYAASAVLAFLFAMRKPLSGAIAGIGGAVASAMLVVTGGAALLMPERI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEECHHHH
HGGMLQFLHLTIRVGGVNALWLLAIGLSALPVSLFNISWHRHPQVKANGPLVNLLLAAAT
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
CAVVVTNIGSLVVMAEIMALCAAFLTGCAASGKLWFALGRLGTLLMAWTCWLVWSTYGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ELAQINLQAVDMMQNPLLWLPGLVGFALLAGAIPLHGWAPQAHAGASAPAAALFSTVVMK
EEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VGLYGMLTVSLAGGVPPLWWGVMLLALGMITAFIGGLYALMEHNIQRLLAYHTLENIGII
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLGLGAFVTGVATRNSTLMVLGFIGGMYHLINHSLFKTTLFLGAGAVWFRTGHRDIEKLG
EEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHC
GIGKKMPLISLAMLVGLMAMAALPPLNGFAGEWVIYQSFFKMSTGDLFIGRLLGPLLAVG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPWLMTLSVVLAAVFCLVGGIAAPWL
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLVSGAFPVQAQVSSVVSQPMIALLLIACPLLPFLLMIFFKGDRLAARSRGAAWVCGYD
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCC
HEQSMVVTAHGFAMPVKEAFAPLLKLRHWLNPVRLVPGWQSASAPALLRGIALVELAVLV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHH
VIVISRGA
HHHHCCCC
>Mature Secondary Structure 
SVIGLVNQAVAWYAASAVLAFLFAMRKPLSGAIAGIGGAVASAMLVVTGGAALLMPERI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEECHHHH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HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]