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The map label for this gene is srlD [H]

Identifier: 238896159

GI number: 238896159

Start: 4130557

End: 4131336

Strand: Direct

Name: srlD [H]

Synonym: KP1_4304

Alternate gene names: 238896159

Gene position: 4130557-4131336 (Clockwise)

Preceding gene: 238896158

Following gene: 238896160

Centisome position: 78.7

GC content: 59.62

Gene sequence:

>780_bases
ATGAATCAGGTTGCTGTTGTCATTGGCGGTGGACAAACCTTAGGAGAGTTTCTGTGCCGCGGGCTGGCCGCCGAGGGCTA
CCGCGTGGCGGTGGTCGATATTCAGAGCGAAAAAGCCAGCCGCGTCGCCCAGGAGATTAACGCTGAGTATGGCGAAGGTA
TGGCGTACGGCTTCGGCGCCGACGCCACCAGCGAGGCCAGCGTCACCGCCCTGGCCCACGGGGTGGATGAGATTTTTTCG
CGCGTCGACCTGCTGGTGTACAGCGCCGGGATCGCCAAGGCGGCGTTTATTAGCGACTTCGCGCTGGGGGATTTCGACCG
CTCGCTGCAGGTCAATCTGGTGGGCTATTTTCTCTGCGCCCGCGAGTTCTCGCGGTTGATGATCCGCGACGGCATTAAGG
GGCGGATCATTCAGATCAACTCGAAATCCGGTAAAGTCGGCAGTAAGCACAACTCCGGCTACAGCGCGGCGAAGTTCGGC
GGCGTCGGGCTGACCCAGTCGCTGGCGCTGGATCTGGCGGAATATGGCATTACCGTGCATTCGCTGATGCTCGGCAATCT
GCTGAAGTCGCCGATGTTCCAGTCGCTGCTGCCGCAGTATGCCACCAAGCTCGGTATCGATGAGAGCGAAGTCGAGCAGT
ACTACATCGACAAGGTGCCGCTGAAGCGCGGCTGCGAATATCAGGATGTGCTGAACGTATTGATGTTTTACGCTAGCCCA
CAGGCGTCGTACTGCACCGGGCAGTCGATCAACGTCACCGGCGGCCAGGTGATGTTTTAA

Upstream 100 bases:

>100_bases
TGAAGCGGAGTTCCCAGGTACCGTCCATGTGGCGGGCCCGGTGCCGGACGCCATCGCGCCCGGCTGCGTACTGAAGTTTG
TTGCTTAAAAGGAGAGAGAG

Downstream 100 bases:

>100_bases
CAGGTTCCCGGATGGCGCTGCGCTTATCCGGGGTACAAAACTGTAGGTCGGGTAAGGCGTTAGCCGCCACCCGACAAAAA
AACGGCACCGCGGGTCGCTC

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNQVAVVIGGGQTLGEFLCRGLAAEGYRVAVVDIQSEKASRVAQEINAEYGEGMAYGFGADATSEASVTALAHGVDEIFS
RVDLLVYSAGIAKAAFISDFALGDFDRSLQVNLVGYFLCAREFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIDESEVEQYYIDKVPLKRGCEYQDVLNVLMFYASP
QASYCTGQSINVTGGQVMF

Sequences:

>Translated_259_residues
MNQVAVVIGGGQTLGEFLCRGLAAEGYRVAVVDIQSEKASRVAQEINAEYGEGMAYGFGADATSEASVTALAHGVDEIFS
RVDLLVYSAGIAKAAFISDFALGDFDRSLQVNLVGYFLCAREFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIDESEVEQYYIDKVPLKRGCEYQDVLNVLMFYASP
QASYCTGQSINVTGGQVMF
>Mature_259_residues
MNQVAVVIGGGQTLGEFLCRGLAAEGYRVAVVDIQSEKASRVAQEINAEYGEGMAYGFGADATSEASVTALAHGVDEIFS
RVDLLVYSAGIAKAAFISDFALGDFDRSLQVNLVGYFLCAREFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIDESEVEQYYIDKVPLKRGCEYQDVLNVLMFYASP
QASYCTGQSINVTGGQVMF

Specific function: Sorbitol metabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=32.0754716981132, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=27.4436090225564, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758504, Length=205, Percent_Identity=34.1463414634146, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI59889578, Length=240, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=26.7175572519084, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=91.8918918918919, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=28.6274509803922, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=28.90625, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=27.6264591439689, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788459, Length=263, Percent_Identity=27.7566539923954, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=28.2945736434109, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.1828793774319, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=22.1343873517787, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=25.4901960784314, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=28.740157480315, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=28.3464566929134, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=30.1775147928994, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=25.6505576208178, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=204, Percent_Identity=32.843137254902, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=218, Percent_Identity=28.8990825688073, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=243, Percent_Identity=26.3374485596708, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=243, Percent_Identity=26.3374485596708, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=25.390625, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=30.8056872037915, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=29.0196078431373, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737361, Length=214, Percent_Identity=32.7102803738318, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=30, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=25.1937984496124, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 27838; Mature: 27838

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVAVVIGGGQTLGEFLCRGLAAEGYRVAVVDIQSEKASRVAQEINAEYGEGMAYGFGA
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
DATSEASVTALAHGVDEIFSRVDLLVYSAGIAKAAFISDFALGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLGIDESEVEQYYIDKVPLKRGCEYQDVLNVLMFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCC
QASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC
>Mature Secondary Structure
MNQVAVVIGGGQTLGEFLCRGLAAEGYRVAVVDIQSEKASRVAQEINAEYGEGMAYGFGA
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
DATSEASVTALAHGVDEIFSRVDLLVYSAGIAKAAFISDFALGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLGIDESEVEQYYIDKVPLKRGCEYQDVLNVLMFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCC
QASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]