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The map label for this gene is prpR [H]

Identifier: 238896114

GI number: 238896114

Start: 4088103

End: 4090001

Strand: Direct

Name: prpR [H]

Synonym: KP1_4253

Alternate gene names: 238896114

Gene position: 4088103-4090001 (Clockwise)

Preceding gene: 238896108

Following gene: 238896116

Centisome position: 77.89

GC content: 64.51

Gene sequence:

>1899_bases
ATGGTCAGCCACTGTCGCACGGGTTTCCACTTATGTGTTGCAAATCGCAACACCAAATACACCAAATGGCTACAATATTG
CAACACAGCAACATCGACCCAGAGGTGCCCTGTGGCAGGCAATCCCTTTCTTCTCGCACCAGAGGTTAATGCGAATCCCC
TGCTGAGCGATTCGTGGTCTCGCTGCCAGCGCTACGGGCTGGATCCCGCCACCGAGGATTTTCCCCGCCTCGGCGCCGGC
GAGCTGGCGGACCGGCTCGCCAGCCACCGCGGCCTGCAGCAGCTGGCGCAGCCGGTGGTGGAAGCCCTGTCGCGCCAGGT
CGCAGACCTGCAGTCGGTGGTGATCCTTTCCGACCCCGACGGCCTGGTGCTGCATACTCTCGGCGATACCCAGGCGCTGC
AAAAGGCCCAGCGCGTGGCGCTGGCTCCCGGCAATCTGTGGAGTGAAAGCGGGCGCGGGACCAACGCCATCGGCACCGCG
CTGGCGATTGACGATGGCTGCGAGATCGATGGCCGTCAGCACTTTCTTACCCGCAACCAGAATCTGTACTGCGCGGCGAT
GCCGCTCCAGCGACCGGACGGAAGCATCGCCGGGGTGCTGGATATCTCCGGCCCGGCGAATTTTCCCCACCAGCACACCT
TTGGCTGGGTAAAAGCGGCGGCAAAGCAAATTGAATATCTGTGGGTGAAACAGAGTCTGCATCCTGAGCAGTGGCTGATG
AGCCTGCACCGGCAGGTGGACAAACTCGACAGCGTCGAGGAGCTGCTGCTGGTCTTTTCCGACAACGTCCTCACCGCCGG
CAACCGGCTGGCGATGCGCGAGTTCGGCCTGAGCGCGGCGCAGTTTGGCCAGCTCACCTTTGCCTCGCTTTTTCCGACGC
TGACGCAAACGGCGGTCAGCGTCCCGCTGCCGCTGACCACGCCGCAGAGCCGCTACCACTATCGCCTGCGGGAGCCCACC
CGCCGCCGGGTGGCGGTAAGCGCCCCGCCGGCCATGCATCTCCCCTTTACCAGTCCGCGCGAAGGCGAAAAGCTGCTGCG
GCTGCTCAACGCCGGCATCGCCCTGTGCATTGAAGGAGAAACCGGCAGCGGCAAAGAGTATGTCAGCCGCACGTTGCACC
GGCACAGCCGCTGGCGCAGCGGTAAATTTGTCGCCATTAACTGCGCCGCCATTCCGGAATCGCTGATCGAATCCGAGCTC
TTCGGCTACCAGCCGGGGGCGTTTACCGGCGCCAGCAAAAATGGCTATATCGGTAAAATCCGCGAGGCTGACGGCGGGGT
GCTGTTTCTTGATGAGATCGGCGATATGCCGCTGGCGCTGCAGACCCGCCTCCTGCGCGTCCTGCAGGAGAAAGAGGTCG
CTCCGCTGGGCGCCAGTCGCAGCGTGCCGGTGAATTTCGCCTTGATCTGCGCCACCCACCGCAACCTGACCCAGCGGGTC
AGCGCCGGAGAATTCCGTGAAGATCTGCTGTGGCGCCTGCGGGAATACGCCCTGGCGCTGCCTCCGCTGCGCGAGTGGCC
GGCGCTGGAAACCTTTATCGCCACCCTGTGGCACGACCTGGGCGGTGCTTCACGCCGGGTGACGCTTTCAAACGCGCTGC
TGGTTCACCTCAGCCAGCTGCCGTGGCCGGGAAACGTACGCCAGTTGCAGAGCGTCCTGAAGGTAATGCTGGCTCTCGCC
GATGAGGGCGACACGCTGACGCCCGACGCGCTGCCGGAGGCGTATCGCGCCGCGCCTGCGCCGTTGCCGCGCGGGGGATT
GCAGGCCCATGATGAGCAGTTGATTGTCGATACCCTGGCCAGGGTCAACGGCAACGTCAGCCGGGCGGCGCAGATACTGG
GTATCGCCCGCAGCACATTGTATCGCCGTGCCGCCCGTGCCGGACGGCCTCGTCGCTGA

Upstream 100 bases:

>100_bases
TTGCCGCCGAACGCTTCTCACTTTGCAGGGGTTATGCCAGTTTTTTATTTTCTTTAAATATTTTTTATTTATTAATACGT
TGCCTTCACTAACCGAGCAG

Downstream 100 bases:

>100_bases
GGCTACGGCGTAAAGCGCGCCGGTAGCTTGCACGCTGTCGGAAAACCTCCGCCGCCATAGATGGCGGTTATTTCTCTCTG
CGCTAACCAGGTGTTGCGGT

Product: putative Fis-type transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MVSHCRTGFHLCVANRNTKYTKWLQYCNTATSTQRCPVAGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAG
ELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILSDPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTA
LAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSLHPEQWLM
SLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGLSAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQSRYHYRLREPT
RRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCIEGETGSGKEYVSRTLHRHSRWRSGKFVAINCAAIPESLIESEL
FGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRV
SAGEFREDLLWRLREYALALPPLREWPALETFIATLWHDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALA
DEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVDTLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR

Sequences:

>Translated_632_residues
MVSHCRTGFHLCVANRNTKYTKWLQYCNTATSTQRCPVAGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAG
ELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILSDPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTA
LAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSLHPEQWLM
SLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGLSAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQSRYHYRLREPT
RRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCIEGETGSGKEYVSRTLHRHSRWRSGKFVAINCAAIPESLIESEL
FGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRV
SAGEFREDLLWRLREYALALPPLREWPALETFIATLWHDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALA
DEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVDTLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR
>Mature_632_residues
MVSHCRTGFHLCVANRNTKYTKWLQYCNTATSTQRCPVAGNPFLLAPEVNANPLLSDSWSRCQRYGLDPATEDFPRLGAG
ELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILSDPDGLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTA
LAIDDGCEIDGRQHFLTRNQNLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSLHPEQWLM
SLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGLSAAQFGQLTFASLFPTLTQTAVSVPLPLTTPQSRYHYRLREPT
RRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCIEGETGSGKEYVSRTLHRHSRWRSGKFVAINCAAIPESLIESEL
FGYQPGAFTGASKNGYIGKIREADGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRV
SAGEFREDLLWRLREYALALPPLREWPALETFIATLWHDLGGASRRVTLSNALLVHLSQLPWPGNVRQLQSVLKVMLALA
DEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVDTLARVNGNVSRAAQILGIARSTLYRRAARAGRPRR

Specific function: Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex [H]

COG id: COG3284

COG function: function code QK; Transcriptional activator of acetoin/glycerol metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789233, Length=296, Percent_Identity=39.1891891891892, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1786524, Length=291, Percent_Identity=43.298969072165, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI87082117, Length=304, Percent_Identity=42.1052631578947, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1789087, Length=288, Percent_Identity=42.0138888888889, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1790299, Length=315, Percent_Identity=39.3650793650794, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788905, Length=297, Percent_Identity=39.3939393939394, Blast_Score=185, Evalue=9e-48,
Organism=Escherichia coli, GI1790437, Length=282, Percent_Identity=39.7163120567376, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1788550, Length=290, Percent_Identity=36.2068965517241, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082152, Length=292, Percent_Identity=37.6712328767123, Blast_Score=162, Evalue=9e-41,
Organism=Escherichia coli, GI87081872, Length=290, Percent_Identity=35.5172413793103, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787583, Length=287, Percent_Identity=33.4494773519164, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI87081858, Length=640, Percent_Identity=23.28125, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789828, Length=223, Percent_Identity=36.7713004484305, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 69511; Mature: 69511

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSHCRTGFHLCVANRNTKYTKWLQYCNTATSTQRCPVAGNPFLLAPEVNANPLLSDSWS
CCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHH
RCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILSDPD
HHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
GLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTALAIDDGCEIDGRQHFLTRNQ
CEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHCEEEEECCCCCCCCCHHHEECCC
NLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSLHPEQWLM
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGLSAAQFGQLTFASLFPTLTQTAVS
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHC
VPLPLTTPQSRYHYRLREPTRRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCIEGE
CCCCCCCCCHHHEEECCCCCCCEEEEECCCCEECCCCCCCCHHHHHHHHHCCEEEEEECC
TGSGKEYVSRTLHRHSRWRSGKFVAINCAAIPESLIESELFGYQPGAFTGASKNGYIGKI
CCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEE
READGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRV
EECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHH
SAGEFREDLLWRLREYALALPPLREWPALETFIATLWHDLGGASRRVTLSNALLVHLSQL
HHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCC
PWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVDTLA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
RVNGNVSRAAQILGIARSTLYRRAARAGRPRR
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVSHCRTGFHLCVANRNTKYTKWLQYCNTATSTQRCPVAGNPFLLAPEVNANPLLSDSWS
CCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHH
RCQRYGLDPATEDFPRLGAGELADRLASHRGLQQLAQPVVEALSRQVADLQSVVILSDPD
HHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
GLVLHTLGDTQALQKAQRVALAPGNLWSESGRGTNAIGTALAIDDGCEIDGRQHFLTRNQ
CEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHCEEEEECCCCCCCCCHHHEECCC
NLYCAAMPLQRPDGSIAGVLDISGPANFPHQHTFGWVKAAAKQIEYLWVKQSLHPEQWLM
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLHRQVDKLDSVEELLLVFSDNVLTAGNRLAMREFGLSAAQFGQLTFASLFPTLTQTAVS
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHC
VPLPLTTPQSRYHYRLREPTRRRVAVSAPPAMHLPFTSPREGEKLLRLLNAGIALCIEGE
CCCCCCCCCHHHEEECCCCCCCEEEEECCCCEECCCCCCCCHHHHHHHHHCCEEEEEECC
TGSGKEYVSRTLHRHSRWRSGKFVAINCAAIPESLIESELFGYQPGAFTGASKNGYIGKI
CCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEE
READGGVLFLDEIGDMPLALQTRLLRVLQEKEVAPLGASRSVPVNFALICATHRNLTQRV
EECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHH
SAGEFREDLLWRLREYALALPPLREWPALETFIATLWHDLGGASRRVTLSNALLVHLSQL
HHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCC
PWPGNVRQLQSVLKVMLALADEGDTLTPDALPEAYRAAPAPLPRGGLQAHDEQLIVDTLA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
RVNGNVSRAAQILGIARSTLYRRAARAGRPRR
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377; 10368162 [H]