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The map label for this gene is mexE [H]

Identifier: 238896070

GI number: 238896070

Start: 4036312

End: 4037487

Strand: Direct

Name: mexE [H]

Synonym: KP1_4204

Alternate gene names: 238896070

Gene position: 4036312-4037487 (Clockwise)

Preceding gene: 238896068

Following gene: 238896071

Centisome position: 76.9

GC content: 59.69

Gene sequence:

>1176_bases
ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTG
CGACGACAGCGTCGCGCAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTC
AGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAA
GTGAATTACACCGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCT
GGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTGGCGCAAAGCGAGGCGAACCGCACCGATAAAT
TAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCACAGGCCGACATTCGC
GCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGTGCCAG
CCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAGAAGA
CGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCC
AGCGATAATCAGGCGCTTCCGGTGGAGATTGGCCTGGTTGGCGAGGAGGGTTACCCCCACCAGGGCAAAGTGGATTTTCT
CGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACGCCAG
GGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTTATCGACGACAAAGCGGTACTGACCGAT
CAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCAGA
CGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGG
GTATGCCGGTTAACGCCAAAACCGTTGCCATGACCTCCAGCGCCACCCTTAACTGA

Upstream 100 bases:

>100_bases
TGATCGACACAAATGGCCTTAAGCCAGCCCGGACAAAGGAAGTGGCGCGGCTTCTCACGCTGCGTCTTGCCCGGCGGCTA
CATTTACCGGAATAAAAATA

Downstream 100 bases:

>100_bases
TCCCTAATCAGAGAATCCAAGACATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATT
TTAATTTTTATCACCGGGTT

Product: putative multidrug efflux system membrane fusion component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDK
VNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIR
AAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGAS
SDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTD
QDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN

Sequences:

>Translated_391_residues
MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDK
VNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIR
AAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGAS
SDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTD
QDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN
>Mature_390_residues
SLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKV
NYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRA
AQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASS
DNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQ
DRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=383, Percent_Identity=30.8093994778068, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789665, Length=373, Percent_Identity=32.7077747989276, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1786668, Length=382, Percent_Identity=33.5078534031414, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082036, Length=338, Percent_Identity=28.4023668639053, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1789637, Length=157, Percent_Identity=38.8535031847134, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081951, Length=246, Percent_Identity=31.3008130081301, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081796, Length=350, Percent_Identity=25.1428571428571, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790519, Length=279, Percent_Identity=26.1648745519713, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42395; Mature: 42264

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNG
CCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
RIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQ
EEEEEEEEEECCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
ASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTA
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEEEEC
PIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGAS
CCCCCCCEEEEECCCEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCCC
SDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVR
CCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCEEECCCCEEEEE
LPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGD
CCCCCCEEEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCH
SVIVDGLQKVFMPGMPVNAKTVAMTSSATLN
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNG
CCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
RIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQ
EEEEEEEEEECCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
ASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTA
HHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEEEEC
PIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGAS
CCCCCCCEEEEECCCEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCCC
SDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVR
CCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCEEECCCCEEEEE
LPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGD
CCCCCCEEEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCH
SVIVDGLQKVFMPGMPVNAKTVAMTSSATLN
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]