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The map label for this gene is tadA [H]

Identifier: 238896010

GI number: 238896010

Start: 3973954

End: 3974496

Strand: Reverse

Name: tadA [H]

Synonym: KP1_4138

Alternate gene names: 238896010

Gene position: 3974496-3973954 (Counterclockwise)

Preceding gene: 238896011

Following gene: 238896008

Centisome position: 75.73

GC content: 62.98

Gene sequence:

>543_bases
ATGCGCCCCGCTTTTTCTGCTGGAGTGGCCGCTGTGTCTGACCTCGAACTCAATGATGAATACTGGATGCGTCATGCCCT
GACGCTGGCGAAACGCGCCTGGGAAGAGGGCGAGGTGCCGGTGGGCGCGGTGCTGGTGCATAACAATCAGGTCATTGGCG
AGGGCTGGAACCGGCCGATAGGCCGTCACGACCCCACCGCCCATGCGGAGATCATGGCCTTACGCCAGGGCGGACTAGTG
CTGCAAAACTACCGCCTGATCGACGCCACGCTGTACGTGACCCTCGAGCCCTGCGTCATGTGCGCGGGCGCGATGGTGCA
CAGCCGTATCGCCCGCCTGGTGTTTGGCGCCAGGGATGCCAAGACCGGCGCCGCCGGCTCGCTGATGGATGTTCTGCACC
ACCCGGGAATGAACCATCGGGTTGAGATTAGCGAAGGCGTGCTGGCAGAGTCCTGCTCTGCCATGCTGAGCGACTTCTTC
CGCTGGCGGCGGGAAGAGAAAAAAGCGCTGAAGAAAGCCCGGGCGCAGACCGGGGAAAGTTAA

Upstream 100 bases:

>100_bases
ATCCATTGCTCGGCTTTTGCCAGCATCGCTGGCGGGTAACCCCTCAGGGAGAGCTTCAGCAGCTGGAGTAATAGTGTGTA
ATTGATAGCGCCCATGTATA

Downstream 100 bases:

>100_bases
TACAGGTGGCCGGGGAGTTTCATCCGGGCATTATCCATCTGCTTATCGGCGCGAAACTTGAAAAAGGGCAGGGTGGTCTC
CTGCGGCTGTTCGAGCTCAT

Product: tRNA-specific adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MRPAFSAGVAAVSDLELNDEYWMRHALTLAKRAWEEGEVPVGAVLVHNNQVIGEGWNRPIGRHDPTAHAEIMALRQGGLV
LQNYRLIDATLYVTLEPCVMCAGAMVHSRIARLVFGARDAKTGAAGSLMDVLHHPGMNHRVEISEGVLAESCSAMLSDFF
RWRREEKKALKKARAQTGES

Sequences:

>Translated_180_residues
MRPAFSAGVAAVSDLELNDEYWMRHALTLAKRAWEEGEVPVGAVLVHNNQVIGEGWNRPIGRHDPTAHAEIMALRQGGLV
LQNYRLIDATLYVTLEPCVMCAGAMVHSRIARLVFGARDAKTGAAGSLMDVLHHPGMNHRVEISEGVLAESCSAMLSDFF
RWRREEKKALKKARAQTGES
>Mature_180_residues
MRPAFSAGVAAVSDLELNDEYWMRHALTLAKRAWEEGEVPVGAVLVHNNQVIGEGWNRPIGRHDPTAHAEIMALRQGGLV
LQNYRLIDATLYVTLEPCVMCAGAMVHSRIARLVFGARDAKTGAAGSLMDVLHHPGMNHRVEISEGVLAESCSAMLSDFF
RWRREEKKALKKARAQTGES

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=164, Percent_Identity=34.1463414634146, Blast_Score=94, Evalue=6e-20,
Organism=Escherichia coli, GI145693172, Length=166, Percent_Identity=84.3373493975904, Blast_Score=301, Evalue=1e-83,
Organism=Escherichia coli, GI1786616, Length=156, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17541138, Length=170, Percent_Identity=35.2941176470588, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554608, Length=150, Percent_Identity=31.3333333333333, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322425, Length=167, Percent_Identity=31.7365269461078, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355527, Length=146, Percent_Identity=33.5616438356164, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 19844; Mature: 19844

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAFSAGVAAVSDLELNDEYWMRHALTLAKRAWEEGEVPVGAVLVHNNQVIGEGWNRPI
CCCCHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCCCC
GRHDPTAHAEIMALRQGGLVLQNYRLIDATLYVTLEPCVMCAGAMVHSRIARLVFGARDA
CCCCCCHHHHHHHHHCCCEEEECEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
KTGAAGSLMDVLHHPGMNHRVEISEGVLAESCSAMLSDFFRWRREEKKALKKARAQTGES
CCCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPAFSAGVAAVSDLELNDEYWMRHALTLAKRAWEEGEVPVGAVLVHNNQVIGEGWNRPI
CCCCHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCCCC
GRHDPTAHAEIMALRQGGLVLQNYRLIDATLYVTLEPCVMCAGAMVHSRIARLVFGARDA
CCCCCCHHHHHHHHHCCCEEEECEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
KTGAAGSLMDVLHHPGMNHRVEISEGVLAESCSAMLSDFFRWRREEKKALKKARAQTGES
CCCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]