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The map label for this gene is guaB [H]

Identifier: 238895962

GI number: 238895962

Start: 3915131

End: 3916663

Strand: Reverse

Name: guaB [H]

Synonym: KP1_4087

Alternate gene names: 238895962

Gene position: 3916663-3915131 (Counterclockwise)

Preceding gene: 238895964

Following gene: 238895961

Centisome position: 74.62

GC content: 58.9

Gene sequence:

>1533_bases
ATGCAATCGGTTACGCTCTGTATAATGCCACGGCAATATTTATCCACCCTGGTCGAGATATTGCCCATGCTACGTATCGC
TAAAGAAGCCCTGACGTTTGACGACGTCCTCCTCGTTCCCGCTCATTCTACCGTTCTGCCGAATACTGCCGATCTCAGCA
CTCAGCTGACGAAAACCATTCGTCTGAATATTCCTATGCTCTCCGCAGCCATGGATACCGTAACGGAAGCGCGTCTGGCT
ATTGCCCTGGCACAGGAAGGCGGCATCGGCTTTATTCACAAAAACATGTCCATCGAGCGCCAGGCTGAAGAAGTTCGTCG
CGTGAAGAAACATGAGTCCGGCGTGGTCACCGACCCGCAGACCGTTCTGCCAACCACCACCCTGCGTGAAGTGAAAGAGC
TGACCGAGCGCAACGGTTTCGCCGGCTACCCGGTGGTTACCGAAGAAAACGAGCTGGTCGGCATCATCACCGGCCGCGAC
GTGCGTTTCGTCACCGATTTGAACCAGCCGGTCAGCGTCTACATGACGCCGAAAGAGCGTCTGGTCACCGTTCGTGAAGG
CGAAAGCCGTGAAGTGGTCTTCGCTAAGATGCACGAAAAACGCGTCGAGAAAGCGCTGGTCGTGGATGAGAGCTTCCACC
TGCGCGGCATGATCACCGTCAAAGACTTCCAGAAAGCAGAACGTAAACCGAACGCCTGTAAAGATGAGCAGGGCCGTCTG
CGCGTAGGCGCGGCGGTCGGCGCCGGTGCCGGCAACGAAGAGCGCGTAGACGCGTTGGTAGCGGCAGGCGTTGACGTTCT
GCTGATCGACTCCTCGCACGGTCACTCAGAAGGCGTTCTGCAGCGTATCCGTGAAACGCGCGCGAAATATCCTGACCTGC
AGATCATCGGCGGCAACGTCGCCACTGGCGCAGGCGCGCGCGCGCTGGCGGAAGCCGGCTGCAGCGCGGTGAAAGTGGGC
ATCGGCCCGGGCTCCATCTGTACTACCCGTATCGTCACCGGCGTGGGTGTGCCGCAGATCACCGCTGTTTCCGACGCGGT
GGAAGCGCTGGAAGGGACCGGTATTCCGGTTATCGCTGACGGCGGTATCCGTTTCTCCGGCGATATCGCCAAAGCGATCG
CCGCCGGTGCGGCGGCGGTGATGGTTGGCTCCATGCTGGCGGGTACCGAAGAGTCCCCGGGTGAAATCGAACTCTATCAG
GGTCGCTCTTACAAATCCTACCGCGGGATGGGCTCCCTTGGCGCGATGTCCAAAGGCTCCTCTGATCGCTATTTCCAGAG
CGATAACGCCGCTGACAAACTGGTGCCGGAAGGTATCGAAGGCCGCGTGGCCTATAAAGGCCGCCTGAAAGAGATCATTC
ACCAGCAGATGGGCGGTCTGCGTTCCTGTATGGGTCTGACCGGCTGTGGTACCATTGATCTGCTGCGTACCAAAGCTGAA
TTCGTACGCATCAGCGGTGCGGGCATTCAGGAAAGCCACGTTCACGACGTGACCATCACCAAAGAGTCCCCGAACTACCG
TCTGGGCTCCTGA

Upstream 100 bases:

>100_bases
GGTAACATGTGAGCAAGATCAAACTTTAAATCAGCAGGTTATTCAGTCGATAGTAACGCGCTCAGAGGGGATGGCAAGTA
TTATTTGCAAAAAAGGGTAG

Downstream 100 bases:

>100_bases
TTTCTTCGCCCGACCTTGCGTCGGGCGATTTATTTACTCTGTTTCACTTGCCTCGGAATTAGCGTCAATGACGGAAAACA
TTCATAAACATCGCATCCTC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQSVTLCIMPRQYLSTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLA
IALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRD
VRFVTDLNQPVSVYMTPKERLVTVREGESREVVFAKMHEKRVEKALVVDESFHLRGMITVKDFQKAERKPNACKDEQGRL
RVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVG
IGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAAAVMVGSMLAGTEESPGEIELYQ
GRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDLLRTKAE
FVRISGAGIQESHVHDVTITKESPNYRLGS

Sequences:

>Translated_510_residues
MQSVTLCIMPRQYLSTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLA
IALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRD
VRFVTDLNQPVSVYMTPKERLVTVREGESREVVFAKMHEKRVEKALVVDESFHLRGMITVKDFQKAERKPNACKDEQGRL
RVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVG
IGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAAAVMVGSMLAGTEESPGEIELYQ
GRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDLLRTKAE
FVRISGAGIQESHVHDVTITKESPNYRLGS
>Mature_510_residues
MQSVTLCIMPRQYLSTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLA
IALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRD
VRFVTDLNQPVSVYMTPKERLVTVREGESREVVFAKMHEKRVEKALVVDESFHLRGMITVKDFQKAERKPNACKDEQGRL
RVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVG
IGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAAAVMVGSMLAGTEESPGEIELYQ
GRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDLLRTKAE
FVRISGAGIQESHVHDVTITKESPNYRLGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=444, Percent_Identity=42.5675675675676, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI217035146, Length=462, Percent_Identity=40.4761904761905, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=40.2597402597403, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=40.2597402597403, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=40.2597402597403, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035152, Length=480, Percent_Identity=39.5833333333333, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI217035148, Length=462, Percent_Identity=39.6103896103896, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI217035150, Length=462, Percent_Identity=37.012987012987, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI156104880, Length=267, Percent_Identity=34.4569288389513, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.0323886639676, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.0323886639676, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.0323886639676, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.0323886639676, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=98.155737704918, Blast_Score=968, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.6515837104072, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=35.7740585774059, Blast_Score=261, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=38.0614657210402, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=36.986301369863, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=39.8706896551724, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=39.2241379310345, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=39.8706896551724, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.766081871345, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=40.6779661016949, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=41.0677618069815, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=41.0677618069815, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI28571163, Length=445, Percent_Identity=41.5730337078652, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54576; Mature: 54576

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSVTLCIMPRQYLSTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHEEEEE
RLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQ
EECCCHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
TVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKER
HHCCCHHHHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHH
LVTVREGESREVVFAKMHEKRVEKALVVDESFHLRGMITVKDFQKAERKPNACKDEQGRL
EEEEECCCCCCEEHHHHHHHHHHHHEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCE
RVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNV
EEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCC
ATGAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIAD
CCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEC
GGIRFSGDIAKAIAAGAAAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGS
CCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCC
SDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDLLRTKAE
CCCCCCCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHH
FVRISGAGIQESHVHDVTITKESPNYRLGS
EEEEECCCCCCCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MQSVTLCIMPRQYLSTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHEEEEE
RLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQ
EECCCHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
TVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKER
HHCCCHHHHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHH
LVTVREGESREVVFAKMHEKRVEKALVVDESFHLRGMITVKDFQKAERKPNACKDEQGRL
EEEEECCCCCCEEHHHHHHHHHHHHEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCE
RVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNV
EEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCC
ATGAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIAD
CCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEC
GGIRFSGDIAKAIAAGAAAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGS
CCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCC
SDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDLLRTKAE
CCCCCCCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHH
FVRISGAGIQESHVHDVTITKESPNYRLGS
EEEEECCCCCCCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]