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The map label for this gene is ppx [H]

Identifier: 238895954

GI number: 238895954

Start: 3903412

End: 3904944

Strand: Direct

Name: ppx [H]

Synonym: KP1_4079

Alternate gene names: 238895954

Gene position: 3903412-3904944 (Clockwise)

Preceding gene: 238895953

Following gene: 238895956

Centisome position: 74.37

GC content: 58.38

Gene sequence:

>1533_bases
ATGCCAATAAACGATAACACCCCTCGGCCGCAGGAGTTCGCTGCGGTTGACCTTGGTTCGAACAGTTTTCATATGGTGAT
CGCCCGTGTCGTCGACGGCGCCATGCAGATCATCGGACGCCTGAAACAGCGCGTACATCTGGCCGATGGCCTCGATGAAA
ACTCGGTGTTGAGCGAAGAAGCCATGACCCGTGGGCTGAACTGCCTGTCGCTGTTTGCCGAACGCCTGCAGGGGTTCTCC
CCCTCCAGCGTCTGTATCGTCGGGACGCATACGCTGCGTCAGGCGACCAACGCGGCGGAGTTTCTTAAACGCGCGGAAAA
AGTGATCCCCTACCCGATCGAGATCATCTCCGGTAATGAAGAAGCGCGCCTGATTTTTATGGGCGTTGAGCACACGCAGC
CGGAGCGCGGCCGCAAGCTGGTGATTGATATCGGCGGCGGTTCAACCGAGCTGGTCATTGGCGAAGATTTTGAGCCCCGC
CTGGTGGAAAGCCGCCGCATGGGCTGCGTGAGCTTCTCGCAGGCCTATTTCCCTGGCGGCGTTATCAATAAAGAAAACTT
CCAGCGCGCGCGCCTGGCGGCGGTGCAGAAGCTGGAGACGCTGGCCTGGCAGTTCCGTATTCAGGGATGGACCGTGGCGC
TGGGCGCCTCCGGCACCATTAAAGCCGCCCAGGAAGTGCTGGTGGCGATGGGCGAGAAGGACGGATTTATTACGCCGGAA
CGCCTCGAAATGCTGGTCAGTGAGCTGCTGAAGCATAAAAACTTCGACGCGCTCAGTCTGCCTGGTCTTTCTGAAGATCG
TAAAGCGGTCTTTGCCCCGGGGCTGGCGATTCTGTGCGGCGTGTTTGACGCGCTGGCCATCAAAGAACTTCGTCTGTCCG
ATGGCGCCCTGCGTGAAGGCGTGCTGTACGAAATGGAAGGCCGCTTCCGCCACCAGGATATTCGTAGCCGCACGGCACAG
AGTCTGGCAAATCAGTACAACATCGATCGCGAACAGGCGCGCCGGGTACTGGAAACTACCACCCAGATGCTGGAGCAGTG
GCAGGAGCAGAATCCCAAGCTGGCCAATCCGCACCTCGCGGCGCTGTTGAAATGGGCGGTGATGCTCCATGAGGTAGGGC
TGAATATCAACCACAGCGGCATGCATCGTCACTCGGCCTACATTCTCCAAAATAGCGACCTGCCGGGCTTCAATCAGGAG
CAGCAGATGCTGATGGCCACCCTCGTACGCTATCATCGCAAAGCGATCAAGCTCGACGATCTGCCGCGCTTTACGCTATT
CAGGAAAAAGCAGTTTCTCCCGCTAATTCAGCTACTGCGCCTGGGCGTACTGCTGAATAACCAGCGTCAGGCTACCACTA
CGCCGCCGACGCTGCGCCTGCAGACGGAAGCTCACCACTGGACGCTGACGTTTCCGCACAACTGGTTTAGCCAGAATGCG
CTGGTGCTGCTGGATCTGGAAAAAGAGCAACAGTACTGGGAAGGCGTGCCGGAATGGATGCTGAAGATTGCTGAAGAAGA
GCCAGACGCCTGA

Upstream 100 bases:

>100_bases
ACTGAGTAACCGCTATGTGCCGCGCGGCAATCGCCGTAAAGTGCGCGCGCAAATGGCGATTTACGATTATCTCAAATCAC
TCGAACAACCCGACTAACCT

Downstream 100 bases:

>100_bases
TCGTATCTCTGGCAATCAACCGAGCCGGGCGCTTACGCCCGGATTTTTGCTGTTCAGCCGGTCATCTCCTCCGCCAACTG
CGTCAGAGGTACCGGTACCC

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MPINDNTPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLDENSVLSEEAMTRGLNCLSLFAERLQGFS
PSSVCIVGTHTLRQATNAAEFLKRAEKVIPYPIEIISGNEEARLIFMGVEHTQPERGRKLVIDIGGGSTELVIGEDFEPR
LVESRRMGCVSFSQAYFPGGVINKENFQRARLAAVQKLETLAWQFRIQGWTVALGASGTIKAAQEVLVAMGEKDGFITPE
RLEMLVSELLKHKNFDALSLPGLSEDRKAVFAPGLAILCGVFDALAIKELRLSDGALREGVLYEMEGRFRHQDIRSRTAQ
SLANQYNIDREQARRVLETTTQMLEQWQEQNPKLANPHLAALLKWAVMLHEVGLNINHSGMHRHSAYILQNSDLPGFNQE
QQMLMATLVRYHRKAIKLDDLPRFTLFRKKQFLPLIQLLRLGVLLNNQRQATTTPPTLRLQTEAHHWTLTFPHNWFSQNA
LVLLDLEKEQQYWEGVPEWMLKIAEEEPDA

Sequences:

>Translated_510_residues
MPINDNTPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLDENSVLSEEAMTRGLNCLSLFAERLQGFS
PSSVCIVGTHTLRQATNAAEFLKRAEKVIPYPIEIISGNEEARLIFMGVEHTQPERGRKLVIDIGGGSTELVIGEDFEPR
LVESRRMGCVSFSQAYFPGGVINKENFQRARLAAVQKLETLAWQFRIQGWTVALGASGTIKAAQEVLVAMGEKDGFITPE
RLEMLVSELLKHKNFDALSLPGLSEDRKAVFAPGLAILCGVFDALAIKELRLSDGALREGVLYEMEGRFRHQDIRSRTAQ
SLANQYNIDREQARRVLETTTQMLEQWQEQNPKLANPHLAALLKWAVMLHEVGLNINHSGMHRHSAYILQNSDLPGFNQE
QQMLMATLVRYHRKAIKLDDLPRFTLFRKKQFLPLIQLLRLGVLLNNQRQATTTPPTLRLQTEAHHWTLTFPHNWFSQNA
LVLLDLEKEQQYWEGVPEWMLKIAEEEPDA
>Mature_509_residues
PINDNTPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLDENSVLSEEAMTRGLNCLSLFAERLQGFSP
SSVCIVGTHTLRQATNAAEFLKRAEKVIPYPIEIISGNEEARLIFMGVEHTQPERGRKLVIDIGGGSTELVIGEDFEPRL
VESRRMGCVSFSQAYFPGGVINKENFQRARLAAVQKLETLAWQFRIQGWTVALGASGTIKAAQEVLVAMGEKDGFITPER
LEMLVSELLKHKNFDALSLPGLSEDRKAVFAPGLAILCGVFDALAIKELRLSDGALREGVLYEMEGRFRHQDIRSRTAQS
LANQYNIDREQARRVLETTTQMLEQWQEQNPKLANPHLAALLKWAVMLHEVGLNINHSGMHRHSAYILQNSDLPGFNQEQ
QMLMATLVRYHRKAIKLDDLPRFTLFRKKQFLPLIQLLRLGVLLNNQRQATTTPPTLRLQTEAHHWTLTFPHNWFSQNAL
VLLDLEKEQQYWEGVPEWMLKIAEEEPDA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=506, Percent_Identity=86.7588932806324, Blast_Score=896, Evalue=0.0,
Organism=Escherichia coli, GI48994966, Length=495, Percent_Identity=39.5959595959596, Blast_Score=340, Evalue=9e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 57667; Mature: 57536

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPINDNTPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLDENSVLSEE
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AMTRGLNCLSLFAERLQGFSPSSVCIVGTHTLRQATNAAEFLKRAEKVIPYPIEIISGNE
HHHHCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHCCHHHHHHHHHHCCCCCEEEECCCC
EARLIFMGVEHTQPERGRKLVIDIGGGSTELVIGEDFEPRLVESRRMGCVSFSQAYFPGG
CEEEEEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHCCCCEEHHHHHCCCC
VINKENFQRARLAAVQKLETLAWQFRIQGWTVALGASGTIKAAQEVLVAMGEKDGFITPE
CCCHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCHHHHHHHHHHHCCCCCCCCHH
RLEMLVSELLKHKNFDALSLPGLSEDRKAVFAPGLAILCGVFDALAIKELRLSDGALREG
HHHHHHHHHHHHCCCCCEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCHHHCC
VLYEMEGRFRHQDIRSRTAQSLANQYNIDREQARRVLETTTQMLEQWQEQNPKLANPHLA
CEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALLKWAVMLHEVGLNINHSGMHRHSAYILQNSDLPGFNQEQQMLMATLVRYHRKAIKLDD
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
LPRFTLFRKKQFLPLIQLLRLGVLLNNQRQATTTPPTLRLQTEAHHWTLTFPHNWFSQNA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCC
LVLLDLEKEQQYWEGVPEWMLKIAEEEPDA
EEEEEECHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PINDNTPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLDENSVLSEE
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AMTRGLNCLSLFAERLQGFSPSSVCIVGTHTLRQATNAAEFLKRAEKVIPYPIEIISGNE
HHHHCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHCCHHHHHHHHHHCCCCCEEEECCCC
EARLIFMGVEHTQPERGRKLVIDIGGGSTELVIGEDFEPRLVESRRMGCVSFSQAYFPGG
CEEEEEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHCCCCEEHHHHHCCCC
VINKENFQRARLAAVQKLETLAWQFRIQGWTVALGASGTIKAAQEVLVAMGEKDGFITPE
CCCHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCHHHHHHHHHHHCCCCCCCCHH
RLEMLVSELLKHKNFDALSLPGLSEDRKAVFAPGLAILCGVFDALAIKELRLSDGALREG
HHHHHHHHHHHHCCCCCEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCHHHCC
VLYEMEGRFRHQDIRSRTAQSLANQYNIDREQARRVLETTTQMLEQWQEQNPKLANPHLA
CEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALLKWAVMLHEVGLNINHSGMHRHSAYILQNSDLPGFNQEQQMLMATLVRYHRKAIKLDD
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
LPRFTLFRKKQFLPLIQLLRLGVLLNNQRQATTTPPTLRLQTEAHHWTLTFPHNWFSQNA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCC
LVLLDLEKEQQYWEGVPEWMLKIAEEEPDA
EEEEEECHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]