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The map label for this gene is gcvR [H]

Identifier: 238895939

GI number: 238895939

Start: 3888534

End: 3889166

Strand: Direct

Name: gcvR [H]

Synonym: KP1_4064

Alternate gene names: 238895939

Gene position: 3888534-3889166 (Clockwise)

Preceding gene: 238895932

Following gene: 238895940

Centisome position: 74.09

GC content: 51.03

Gene sequence:

>633_bases
ATGTTGTATGGCGGTTTTTTTTATGCTTTCCTAATGTTACCTCACCTTTTTAAAGGAAGAACAGGTTTGACAGCCTCATT
ACAACACTATCTGGTTATTACCGCCCTGGGGGCTGACCGTCCCGGCATCGTGAATACGATCACTCGCCACGTCAGCAGCT
GCGGTTGTAATATCGAAGACAGCCGGCTGGCCATGCTCGGTGATGAGTTTACGTTTATCATGCTGCTTTCCGGGTCGTGG
AATGCGATTAACCTGATCGAATCAACTCTGCCGCTGAAAGGCGCGGAGCTGGAGCTGTTGATCGTGATGAAACGCACCAC
TGCGCGCCCGCCGCAGGCCATGCCAAACACCGTTTGGGTCCAGGTTGAGGTGCCGGACTCACCGCATATCATCGAGCGCT
TTACTGCCCTGTGCGATACATGGAATATGAATATTGCGGAGCTGGTGTCCCGCACGCAGCCGGGAGACGGCGATTCCGCG
CAGCTTTTTATCCAGATAACTGCCCACAGTCCTGCGACGCAAAATGCAGCAAATATCGAACAAGCGTTCAAAGCCCTATG
TACAGAACTGAACGCACAAGGCAGTATTAACATCGTTAATTATTCACAGCATGATGAACAGGATGGAGTTTAA

Upstream 100 bases:

>100_bases
TTCCCGTGAACATGGGCCATCCTCAGAGCAGAAGTGCGACAAGATTCTCAATGTTACGTTTGGAGCTGTAATAAAAGCAA
GAGACCCGACGCCATCAGGG

Downstream 100 bases:

>100_bases
CCCATGACCCCACTGAAAGCCGGTGATATCGCACCGAAATTTAGCTTACCGGACCAGGACGGCGAGGAAGTAAATTTAAC
CGACTTCCAGGGACAACGTG

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLYGGFFYAFLMLPHLFKGRTGLTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSW
NAINLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSA
QLFIQITAHSPATQNAANIEQAFKALCTELNAQGSINIVNYSQHDEQDGV

Sequences:

>Translated_210_residues
MLYGGFFYAFLMLPHLFKGRTGLTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSW
NAINLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSA
QLFIQITAHSPATQNAANIEQAFKALCTELNAQGSINIVNYSQHDEQDGV
>Mature_210_residues
MLYGGFFYAFLMLPHLFKGRTGLTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSW
NAINLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSA
QLFIQITAHSPATQNAANIEQAFKALCTELNAQGSINIVNYSQHDEQDGV

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=189, Percent_Identity=84.6560846560847, Blast_Score=327, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 23079; Mature: 23079

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYGGFFYAFLMLPHLFKGRTGLTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIED
CCCHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
SRLAMLGDEFTFIMLLSGSWNAINLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWV
CEEEEECCCEEEEEEEECCCCEEEHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCEEEE
QVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIE
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHH
QAFKALCTELNAQGSINIVNYSQHDEQDGV
HHHHHHHHHCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLYGGFFYAFLMLPHLFKGRTGLTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIED
CCCHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
SRLAMLGDEFTFIMLLSGSWNAINLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWV
CEEEEECCCEEEEEEEECCCCEEEHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCEEEE
QVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIE
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHH
QAFKALCTELNAQGSINIVNYSQHDEQDGV
HHHHHHHHHCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]