Click here to switch to the map view.

The map label for this gene is tktB [H]

Identifier: 238895925

GI number: 238895925

Start: 3870235

End: 3872268

Strand: Direct

Name: tktB [H]

Synonym: KP1_4050

Alternate gene names: 238895925

Gene position: 3870235-3872268 (Clockwise)

Preceding gene: 238895924

Following gene: 238895929

Centisome position: 73.74

GC content: 61.55

Gene sequence:

>2034_bases
TTGCCGCCAAACTGTCACTTTAGTCTCACGGAGAAAAATATGTCCCGAAGAGAGCTTGCCAACGCCATCCGCGCCCTGAG
TATGGACGCCGTGCAGAAAGCCAACTCCGGCCATCCCGGTGCGCCGATGGGGATGGCTGATATTGCCGAAGTGCTGTGGA
ACGATTTTCTCAAGCACAATCCGCAGAACCCTGACTGGGTGGACCGCGACCGCTTTATCTTGTCCAACGGCCACGCGTCG
ATGCTGCTCTACAGTCTGCTGCACCTGACCGGCTACGATCTGCCGCTGTCTGAACTGAAGCAGTTCCGTCAGCTGCACTC
TAAAACGCCCGGCCACCCGGAGCATGGCTATCCCCCTGGGGTGGAAACCACCACCGGCCCGCTGGGCCAGGGGCTGGCGA
ACGCCGTTGGGATGGCCATCGCCGAACGGACGCTGGCGGCGCAGTTTAATCGCCCCGGCCATGAGATCATTGACCATCAC
ACCTGGGTGTTCATGGGCGATGGCTGTTTGATGGAGGGGATCTCCCATGAGGCCTGTTCGCTGGCCGGCACGCTCGGACT
GGGCAAGCTGATCGGTTTTTACGATCACAACGGCATCTCCATCGACGGCAAAACCGAAGGCTGGTTTTCCGATGATACGG
CGGAACGCTTCCGCGCCTATCACTGGCACGTCATAGGCGATATCGACGGCCACGATCCGCAGGCTATCAAACAGGCGATA
ACGGAAGCGCAGGCGGTGAAAGATAAACCGTCACTGATTATCTGCCGGACCATCATCGGCTTCGGTTCGCCCAACAAAGC
CGGCTCAGAGGAGTCTCACGGGGCGGCGCTGGGCGAAAAAGAGGTAGCGCTGGCCCGCCAGCAGCTTGGCTGGAAATATC
CTCCGTTCGAGATCCCGAAAGAGATCTACGCGGGCTGGGATGCGCGTCCGCGCGGGGAAAAAGCGGAGCACGCCTGGAAC
GAGAAATTCGCCGCCTACCAGCAGCAGTTCCCGGAGCTGGCCGCTGAGCTGACCCGACGTATGAATGGCGCCCTGCCGGA
AGACTTTGCCGCGATCGCCCGCGACTACGTGGCGAAACTGCAGGCCGAGCCGGCGAAAATCGCCAGCCGCAAGGCTTCGC
AAAACGCGCTGAACGCCTACGGCCCGCACCTCCCGGAACTGCTGGGCGGTTCTGCGGATCTTGCGCCGAGTAACCTGACC
ATCTGGTCTGGATCGACATCGATTAAAGAAGATCCTGCGGGCAATTATATCCACTACGGGGTGCGCGAGTTTGGCATGAC
CGCGGTGGCCAACGGCATTGCCCTGCACGGGGGCTTTATTCCTTATACCTCGACCTTCCTGATGTTTGTGGAGTACGCCC
GCAACGCCGCGCGCATGGCAGCCCTGATGAAGGCCCGGCAGATCATGGTCTATACCCATGACTCGATCGGTCTTGGGGAA
GACGGGCCGACGCACCAGGCGGTGGAACAGCTGGCCAGTCTGCGGCTGACGCCCAACTTCAGCACCTGGCGCCCCTGCGA
CCAGGTGGAGACCGCCGTCGCCTGGCAGGCGGCTATCGCGCGACAGGGCGGGCCGACGGCGCTGATCCTGTCGCGACAAA
ACCTGGCGCAGATGCCGCGTACCCCGGAACAGGTGCAGGATATCGCCCGGGGTGGCTACGTGCTTAAGGATGCCGGCGGC
AAGCCCGACCTGATCCTCATCGCCACCGGCTCGGAAGTGGAGATCACCGTCCTGGCCGCGGAAAAACTGTTGGCCAAAGG
GGTAAATGTGCGGGTCGTCTCGCTCCCTTCCACTGATGTGTTTGACGCCCAGGATGAGGCCTGGCGCGAATCCGTGCTGC
CATCGGACGTCAGCGCCCGGGTGGCGGTCGAAGCCGGGATAGCGGACTACTGGTATAAATATGTCGGCTTAAAAGGCAAG
ATCGTCGGCATGACCGGCTATGGCGAATCCGCCCCGGCAGAGCAGTTGTTCCCGTTCTTTGGCTTTACGGTCGACCATAT
CGTCGCCACCGCCGAACAGGTGCTTAACGGGTGA

Upstream 100 bases:

>100_bases
GAGTTCCGCTGGGAACATAATCAGGATCCGATGGCGGTCGAAAAGCTAGCGGAGGGGATCCGCCTGTTCGCCGTCGATCA
GCGCAAACTGGAAGATCTGC

Downstream 100 bases:

>100_bases
TCCACAGCGTGGGCCAGGCATCTGGCCCCTGCCAGTTGTCGCACGTCGGCTGCTGCGCGTAGCGGGAGAGGCTGAACCGC
TGGCCGTCAAAACGCCAGCG

Product: transketolase

Products: NA

Alternate protein names: TK 2 [H]

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MPPNCHFSLTEKNMSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFILSNGHAS
MLLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYPPGVETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHH
TWVFMGDGCLMEGISHEACSLAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAI
TEAQAVKDKPSLIICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGEKAEHAWN
EKFAAYQQQFPELAAELTRRMNGALPEDFAAIARDYVAKLQAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLT
IWSGSTSIKEDPAGNYIHYGVREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGE
DGPTHQAVEQLASLRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGYVLKDAGG
KPDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGK
IVGMTGYGESAPAEQLFPFFGFTVDHIVATAEQVLNG

Sequences:

>Translated_677_residues
MPPNCHFSLTEKNMSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFILSNGHAS
MLLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYPPGVETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHH
TWVFMGDGCLMEGISHEACSLAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAI
TEAQAVKDKPSLIICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGEKAEHAWN
EKFAAYQQQFPELAAELTRRMNGALPEDFAAIARDYVAKLQAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLT
IWSGSTSIKEDPAGNYIHYGVREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGE
DGPTHQAVEQLASLRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGYVLKDAGG
KPDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGK
IVGMTGYGESAPAEQLFPFFGFTVDHIVATAEQVLNG
>Mature_676_residues
PPNCHFSLTEKNMSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPQNPDWVDRDRFILSNGHASM
LLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYPPGVETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHHT
WVFMGDGCLMEGISHEACSLAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAIT
EAQAVKDKPSLIICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPKEIYAGWDARPRGEKAEHAWNE
KFAAYQQQFPELAAELTRRMNGALPEDFAAIARDYVAKLQAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLTI
WSGSTSIKEDPAGNYIHYGVREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGED
GPTHQAVEQLASLRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPRTPEQVQDIARGGYVLKDAGGK
PDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDVFDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGKI
VGMTGYGESAPAEQLFPFFGFTVDHIVATAEQVLNG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=586, Percent_Identity=27.4744027303754, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4507521, Length=586, Percent_Identity=27.4744027303754, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI133778974, Length=681, Percent_Identity=25.8443465491924, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI225637459, Length=671, Percent_Identity=23.0998509687034, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI225637463, Length=567, Percent_Identity=24.3386243386243, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637461, Length=567, Percent_Identity=24.3386243386243, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=83.5347432024169, Blast_Score=1170, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=77.6096822995462, Blast_Score=1092, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=669, Percent_Identity=24.6636771300448, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=667, Percent_Identity=47.8260869565217, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=45.3055141579732, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=601, Percent_Identity=27.287853577371, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI45550715, Length=601, Percent_Identity=27.287853577371, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24645119, Length=567, Percent_Identity=26.8077601410935, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24666278, Length=289, Percent_Identity=31.1418685121107, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73678; Mature: 73547

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPNCHFSLTEKNMSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHN
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
PQNPDWVDRDRFILSNGHASMLLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYPPG
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
VETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEGISHEACS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCHHHHCCCHHHHH
LAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAI
HHHHHHHHHHHHEECCCCEEECCCCCCCCCCCHHHHHHHEEEEEEECCCCCCHHHHHHHH
TEAQAVKDKPSLIICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPK
HHHHHHCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCH
EIYAGWDARPRGEKAEHAWNEKFAAYQQQFPELAAELTRRMNGALPEDFAAIARDYVAKL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPAGNYIHYG
HCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHH
VREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGE
HHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
DGPTHQAVEQLASLRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPR
CCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCC
TPEQVQDIARGGYVLKDAGGKPDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDV
CHHHHHHHHHCCEEEECCCCCCCEEEEEECCCEEEEEEEHHHHHHCCCCEEEEECCCCCC
FDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPAEQLFPFF
CCCCHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHH
GFTVDHIVATAEQVLNG
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPNCHFSLTEKNMSRRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHN
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
PQNPDWVDRDRFILSNGHASMLLYSLLHLTGYDLPLSELKQFRQLHSKTPGHPEHGYPPG
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
VETTTGPLGQGLANAVGMAIAERTLAAQFNRPGHEIIDHHTWVFMGDGCLMEGISHEACS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCHHHHCCCHHHHH
LAGTLGLGKLIGFYDHNGISIDGKTEGWFSDDTAERFRAYHWHVIGDIDGHDPQAIKQAI
HHHHHHHHHHHHEECCCCEEECCCCCCCCCCCHHHHHHHEEEEEEECCCCCCHHHHHHHH
TEAQAVKDKPSLIICRTIIGFGSPNKAGSEESHGAALGEKEVALARQQLGWKYPPFEIPK
HHHHHHCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCH
EIYAGWDARPRGEKAEHAWNEKFAAYQQQFPELAAELTRRMNGALPEDFAAIARDYVAKL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QAEPAKIASRKASQNALNAYGPHLPELLGGSADLAPSNLTIWSGSTSIKEDPAGNYIHYG
HCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHH
VREFGMTAVANGIALHGGFIPYTSTFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGE
HHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
DGPTHQAVEQLASLRLTPNFSTWRPCDQVETAVAWQAAIARQGGPTALILSRQNLAQMPR
CCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCC
TPEQVQDIARGGYVLKDAGGKPDLILIATGSEVEITVLAAEKLLAKGVNVRVVSLPSTDV
CHHHHHHHHHCCEEEECCCCCCCEEEEEECCCEEEEEEEHHHHHHCCCCEEEEECCCCCC
FDAQDEAWRESVLPSDVSARVAVEAGIADYWYKYVGLKGKIVGMTGYGESAPAEQLFPFF
CCCCHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHH
GFTVDHIVATAEQVLNG
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8396116; 9205837; 9278503 [H]