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The map label for this gene is hemF [H]

Identifier: 238895905

GI number: 238895905

Start: 3850687

End: 3851586

Strand: Direct

Name: hemF [H]

Synonym: KP1_4029

Alternate gene names: 238895905

Gene position: 3850687-3851586 (Clockwise)

Preceding gene: 238895904

Following gene: 238895924

Centisome position: 73.37

GC content: 61.56

Gene sequence:

>900_bases
ATGAAACCCGATGCCGCGCAGGTAAAAACTTTTCTGCTCCAGCTCCAGGACAACCTCTGTCAGCAGCTGAGCGCCGTGGA
TGGCGCGCCGTTTATTGAAGATGCCTGGCAGCGGGAAGGCGGTGGCGGCGGACGCAGCCGGGTGCTGCGCGAAGGCCGGG
TGTTCGAGCAGGCGGGGGTCAACTTTTCCCACGTCCATGGCGACGCCATGCCTGCCTCCGCCACCGCGCACCGCCCGGAG
CTGGCCGGACGCAGTTTTGAAGCCATGGGCGTCTCGCTGGTGGTTCATCCGCTGAACCCCTACGTGCCCACCAGCCATGC
CAACGTGCGGTTCTTTATTGCCGAAAAGCCTGGCGCCGACCCGGTGTGGTGGTTCGGCGGCGGCTTTGATTTAACCCCTT
ACTACGGCTTTGAAGAGGATGCCGTCCACTGGCATCGTACCGCCCGCGATCTGTGTCTGCCGTTCGGCGAGGAAGTCTAT
CCGCGTTATAAAAAATGGTGCGATGATTACTTCTATCTCAAGCACCGCCAGGAGCAGCGCGGCATCGGCGGTCTGTTCTT
TGACGACCTGAACACCCCGGATTTTGACCACTGCTTCGCCTTTATGCAGGCGGTCGGGAACGGCTATGCTGACGCCTATT
TACCTATCGTCGAACGCCGGAAAGCCACGCCGTACAGCGAACGCGAGCGCCACTTTCAACTCTACCGTCGCGGCCGCTAT
GTCGAGTTCAATCTGGTCTGGGACCGCGGCACCCTGTTCGGTCTGCAGACCGGCGGGCGTACGGAGTCGATTCTGATGTC
GATGCCGCCGCTGGTGCGCTGGGAATATGATTATCAGCCCGAGCCCGGCAGCCCCGAGGCGGCGCTGAGCGAGTTTATTC
AGGTGCGCGACTGGCTGTAA

Upstream 100 bases:

>100_bases
CCACCGCCTTCCGGCAGAAAATCGCCACCGCGATTGCCAACGGCATTATCAGCTATTTCCACTGGTTCGATAACCAGAAA
GCCCATTCGAAGAGACGTTA

Downstream 100 bases:

>100_bases
CGGCCGGATGGCGGCTGGCCACCCGGTAGCGGAGTCTCTTCCCTCACACCCACTGGCGCAGGCGATGGTGCAGCGTCATC
GACGGTTTCTCAGCAAACAG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKPDAAQVKTFLLQLQDNLCQQLSAVDGAPFIEDAWQREGGGGGRSRVLREGRVFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPLNPYVPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCLPFGEEVY
PRYKKWCDDYFYLKHRQEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYADAYLPIVERRKATPYSERERHFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPEPGSPEAALSEFIQVRDWL

Sequences:

>Translated_299_residues
MKPDAAQVKTFLLQLQDNLCQQLSAVDGAPFIEDAWQREGGGGGRSRVLREGRVFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPLNPYVPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCLPFGEEVY
PRYKKWCDDYFYLKHRQEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYADAYLPIVERRKATPYSERERHFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPEPGSPEAALSEFIQVRDWL
>Mature_299_residues
MKPDAAQVKTFLLQLQDNLCQQLSAVDGAPFIEDAWQREGGGGGRSRVLREGRVFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPLNPYVPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCLPFGEEVY
PRYKKWCDDYFYLKHRQEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYADAYLPIVERRKATPYSERERHFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPEPGSPEAALSEFIQVRDWL

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=304, Percent_Identity=47.3684210526316, Blast_Score=281, Evalue=7e-76,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=89.9665551839465, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=42.9022082018927, Blast_Score=261, Evalue=7e-71,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=46.5346534653465, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34270; Mature: 34270

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDAAQVKTFLLQLQDNLCQQLSAVDGAPFIEDAWQREGGGGGRSRVLREGRVFEQAGV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHCC
NFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPLNPYVPTSHANVRFFIAEKPGAD
CEEEECCCCCCCCCCCCCCHHCCCCHHHCCEEEEEECCCCCCCCCCCCEEEEEEECCCCC
PVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCLPFGEEVYPRYKKWCDDYFYLKHRQEQR
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GIGGLFFDDLNTPDFDHCFAFMQAVGNGYADAYLPIVERRKATPYSERERHFQLYRRGRY
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCE
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPEPGSPEAALSEFIQVRDWL
EEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPDAAQVKTFLLQLQDNLCQQLSAVDGAPFIEDAWQREGGGGGRSRVLREGRVFEQAGV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHCC
NFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPLNPYVPTSHANVRFFIAEKPGAD
CEEEECCCCCCCCCCCCCCHHCCCCHHHCCEEEEEECCCCCCCCCCCCEEEEEEECCCCC
PVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCLPFGEEVYPRYKKWCDDYFYLKHRQEQR
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GIGGLFFDDLNTPDFDHCFAFMQAVGNGYADAYLPIVERRKATPYSERERHFQLYRRGRY
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCE
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPEPGSPEAALSEFIQVRDWL
EEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA