Click here to switch to the map view.

The map label for this gene is pdxK [H]

Identifier: 238895891

GI number: 238895891

Start: 3838853

End: 3839719

Strand: Reverse

Name: pdxK [H]

Synonym: KP1_4014

Alternate gene names: 238895891

Gene position: 3839719-3838853 (Counterclockwise)

Preceding gene: 238895894

Following gene: 238895890

Centisome position: 73.16

GC content: 62.63

Gene sequence:

>867_bases
ATGGGCCAGCAGGATGATATACAATCAGTGCTCTTTCACGACAAAAGCCGGGCGTCGGAAGTGGATATCGTCGCCGTGCA
GTCGCAGGTAGTCTATGGCAGCGTCGGCAACAGCATCGCGGTTCCGGCGATTAAACAGCATGGTCTGCGCGTGCTGGCGG
TGCCGACGGTGCTGTTCAGTAATACGCCCCATTATGAGACGTTCTATGGCGGCATTATTCCGGAAGAGTGGTTTGTCGGG
TATCTGCAGGCGCTGGAGGAGCGCGACGCGCTGCGCGAACTGCGTGCGGTCACCACCGGCTATATGGGCAGCGCAGTGCA
AATCGAACGCCTGGCGCAGTGGCTGACGCGCGTACGGGCCCGCCATCCCGGGTTGTGCATTCTCGTGGATCCGGTCATCG
GCGATGTCGACAGCGGCATCTATGTCAAGGCTGAGATCCCGGACGCCTATCGTCAGCACCTGCTGCCGCTGGCGCAAGGG
ATCACCCCCAATCTGTTCGAACTGGAGACGCTGAGCGGCCAGCGCTGTCGCGATCGGCAGGAGGCGGTCGCCGCGGCGCG
AAGCCTGCTGTCGGACACCCTCAAATGGGTGGTGATCACCAGCGCGCCGGGAGAGGCCGATTCGAGGATCAATGTGCTGG
TGGTGACGGCCGATGCAGTGGAAGTGGTGGTTCACCCGCGGGTGGAGACAGACTTAAAAGGAACCGGCGATCTGTTCTGC
GCGGAGCTGGTGAGCGGGTTGCTTTCCGGCCTGGCGCTGGGGGCAGCGACGCAGGCTGCTGCCCAGCGCGTGCTGGAGGT
GATGAACTGGACTGCCGCCCAGGGGTGTGACGAATTGATCCTACCGCCGCTGGAGCAAAGCAGATGA

Upstream 100 bases:

>100_bases
GGTTTTTCCGGCTAACATTATTGACCTATGACAAAATGGAATTTAGCATAGGACGAATCATAATCAGTGCGTGACCCGCT
GTCCAGCGGGGGGAGAAAAG

Downstream 100 bases:

>100_bases
AAAGCTATCGGTTAGTGATCCGCCAGCAGGGACGCATTGTTGGTCATTTTGATACGACAGGTGAGGCGGCGCTGGAGGAT
GCCTGCGTGGCGCGGTCGCT

Product: pyridoxal kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MGQQDDIQSVLFHDKSRASEVDIVAVQSQVVYGSVGNSIAVPAIKQHGLRVLAVPTVLFSNTPHYETFYGGIIPEEWFVG
YLQALEERDALRELRAVTTGYMGSAVQIERLAQWLTRVRARHPGLCILVDPVIGDVDSGIYVKAEIPDAYRQHLLPLAQG
ITPNLFELETLSGQRCRDRQEAVAAARSLLSDTLKWVVITSAPGEADSRINVLVVTADAVEVVVHPRVETDLKGTGDLFC
AELVSGLLSGLALGAATQAAAQRVLEVMNWTAAQGCDELILPPLEQSR

Sequences:

>Translated_288_residues
MGQQDDIQSVLFHDKSRASEVDIVAVQSQVVYGSVGNSIAVPAIKQHGLRVLAVPTVLFSNTPHYETFYGGIIPEEWFVG
YLQALEERDALRELRAVTTGYMGSAVQIERLAQWLTRVRARHPGLCILVDPVIGDVDSGIYVKAEIPDAYRQHLLPLAQG
ITPNLFELETLSGQRCRDRQEAVAAARSLLSDTLKWVVITSAPGEADSRINVLVVTADAVEVVVHPRVETDLKGTGDLFC
AELVSGLLSGLALGAATQAAAQRVLEVMNWTAAQGCDELILPPLEQSR
>Mature_287_residues
GQQDDIQSVLFHDKSRASEVDIVAVQSQVVYGSVGNSIAVPAIKQHGLRVLAVPTVLFSNTPHYETFYGGIIPEEWFVGY
LQALEERDALRELRAVTTGYMGSAVQIERLAQWLTRVRARHPGLCILVDPVIGDVDSGIYVKAEIPDAYRQHLLPLAQGI
TPNLFELETLSGQRCRDRQEAVAAARSLLSDTLKWVVITSAPGEADSRINVLVVTADAVEVVVHPRVETDLKGTGDLFCA
ELVSGLLSGLALGAATQAAAQRVLEVMNWTAAQGCDELILPPLEQSR

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=241, Percent_Identity=29.4605809128631, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788758, Length=279, Percent_Identity=70.9677419354839, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787924, Length=263, Percent_Identity=33.0798479087452, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17507759, Length=266, Percent_Identity=29.3233082706767, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17507757, Length=276, Percent_Identity=28.2608695652174, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320806, Length=256, Percent_Identity=27.34375, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324354, Length=239, Percent_Identity=27.1966527196653, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45553007, Length=223, Percent_Identity=31.390134529148, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 31277; Mature: 31146

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQQDDIQSVLFHDKSRASEVDIVAVQSQVVYGSVGNSIAVPAIKQHGLRVLAVPTVLFS
CCCHHHHHHHHHCCCCCCCCEEEEEEECEEEEECCCCCEECCHHHHCCCEEEEEHHHHHC
NTPHYETFYGGIIPEEWFVGYLQALEERDALRELRAVTTGYMGSAVQIERLAQWLTRVRA
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RHPGLCILVDPVIGDVDSGIYVKAEIPDAYRQHLLPLAQGITPNLFELETLSGQRCRDRQ
CCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
EAVAAARSLLSDTLKWVVITSAPGEADSRINVLVVTADAVEVVVHPRVETDLKGTGDLFC
HHHHHHHHHHHHCEEEEEEECCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHH
AELVSGLLSGLALGAATQAAAQRVLEVMNWTAAQGCDELILPPLEQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC
>Mature Secondary Structure 
GQQDDIQSVLFHDKSRASEVDIVAVQSQVVYGSVGNSIAVPAIKQHGLRVLAVPTVLFS
CCHHHHHHHHHCCCCCCCCEEEEEEECEEEEECCCCCEECCHHHHCCCEEEEEHHHHHC
NTPHYETFYGGIIPEEWFVGYLQALEERDALRELRAVTTGYMGSAVQIERLAQWLTRVRA
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RHPGLCILVDPVIGDVDSGIYVKAEIPDAYRQHLLPLAQGITPNLFELETLSGQRCRDRQ
CCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
EAVAAARSLLSDTLKWVVITSAPGEADSRINVLVVTADAVEVVVHPRVETDLKGTGDLFC
HHHHHHHHHHHHCEEEEEEECCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHH
AELVSGLLSGLALGAATQAAAQRVLEVMNWTAAQGCDELILPPLEQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA