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The map label for this gene is nupC [H]

Identifier: 238895875

GI number: 238895875

Start: 3820894

End: 3822135

Strand: Direct

Name: nupC [H]

Synonym: KP1_3997

Alternate gene names: 238895875

Gene position: 3820894-3822135 (Clockwise)

Preceding gene: 238895873

Following gene: 238895877

Centisome position: 72.8

GC content: 52.17

Gene sequence:

>1242_bases
GTGCACGGAAATTTAACCTGCCTCATATTTGGAGCAACTATGGACCGCGTCTTGCATTTTGTCCTCGCGATCGTTGTGGT
GGCTATACTGGCCCTGTTGGTCAGCCATGACCGCCAAAAGATCCGTATTCGTTATGTTGTTCAACTGCTTGTCATTGAAG
TCCTGCTGGCCTGGTTCTTCCTCAACTCCGATATTGGTCTGGGTTTTGTGAAAGGATTTTCCGAGATGTTTGAAAAACTC
CTCGGGTTTGCCAACGAAGGGACAAACTTCGTGTTCGGCGGCATGAACGATAAAGGCCTGGCCTTCTTCTTCCTCAAAGT
TTTGTGCCCTATCGTCTTCATTTCGGCTTTGATCGGCATTTTGCAGCATATTCGTATCCTGCCGATTGTCATTCGCGCGA
TCGGTACCGTCCTGTCGAAAGTTAACGGCATGGGCAAGCTGGAGTCCTTCAACGCCGTGAGCTCGTTGATCCTCGGCCAG
TCGGAAAACTTTATCGCGTATAAAGATATTCTCGGCAAAATGTCGCGCAACCGCATGTACACCATGGCGGCGACGGCGAT
GTCCACCGTGTCCATGTCCATCGTAGGCGCTTACATGACCATGCTGCAGCCAAAGTATGTCGTTGCGGCGCTGGTGCTCA
ACATGTTCAGCACCTTTATCGTTCTGTCATTAATTAACCCTTACCGCGTGGAAGAGAGCGAAGAAAATCTGCAGATGTCG
AATCTGCACGAAGGTCAGAGCTTCTTCGAGATGCTGGGCGAGTATATTCTGGCAGGTTTTAAAGTCGCGATTATCGTGGC
GGCGATGTTGATCGGCTTCATCGCGCTGATCTCGGCGCTGAATGCCCTGTTCGCCACCGTGACCGGTTGGTTCGGCTATA
GCATTTCCTTCCAGGGTATCCTCGGCTATATCTTCTACCCGGTCGCCTGGGTGATGGGTGTGCCGGCAAGCGAAGCGCTG
CAGGTGGGCAGTATTATGGCTACCAAACTGGTCTCCAATGAATTCGTCGCCATGATGGATCTGCAGAAAATTGCCTCGAC
GCTCTCCCCGCGCGCGGAAGGCATTATCTCTATCTTCCTGGTCTCCTTCGCCAACTTCTCATCTATCGGTATTATTGCCG
GGGCGATCAAAGGTCTGAACGAAGAACAGGGCAACGTAGTTTCTCGCTTCGGTCTGAAGCTGGTGTACGGCTCCACGCTG
GTTAGCGTGCTGTCCGCCTCGATTGCGGCGCTGGTTCTGTAA

Upstream 100 bases:

>100_bases
TAACAAAAGTGGATGTTGGATCACTATTTTTGCCATTGGTCACAGTTCCTTGCAATAGTGTGCAATTGATCTCGTTTTCT
TTAAAGCCGTTGCATAGAAT

Downstream 100 bases:

>100_bases
CAGACGTCAGTCATCTGAGCCGGGCAATGCCCGGCTTTTTTTTGCCCGTCATTCACCCAGCGGCTGTGGTTTACCGATCA
GATAACCCTGCAGATAATTC

Product: nucleoside permease

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: Nucleoside-transport system protein nupC [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MHGNLTCLIFGATMDRVLHFVLAIVVVAILALLVSHDRQKIRIRYVVQLLVIEVLLAWFFLNSDIGLGFVKGFSEMFEKL
LGFANEGTNFVFGGMNDKGLAFFFLKVLCPIVFISALIGILQHIRILPIVIRAIGTVLSKVNGMGKLESFNAVSSLILGQ
SENFIAYKDILGKMSRNRMYTMAATAMSTVSMSIVGAYMTMLQPKYVVAALVLNMFSTFIVLSLINPYRVEESEENLQMS
NLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALISALNALFATVTGWFGYSISFQGILGYIFYPVAWVMGVPASEAL
QVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISIFLVSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTL
VSVLSASIAALVL

Sequences:

>Translated_413_residues
MHGNLTCLIFGATMDRVLHFVLAIVVVAILALLVSHDRQKIRIRYVVQLLVIEVLLAWFFLNSDIGLGFVKGFSEMFEKL
LGFANEGTNFVFGGMNDKGLAFFFLKVLCPIVFISALIGILQHIRILPIVIRAIGTVLSKVNGMGKLESFNAVSSLILGQ
SENFIAYKDILGKMSRNRMYTMAATAMSTVSMSIVGAYMTMLQPKYVVAALVLNMFSTFIVLSLINPYRVEESEENLQMS
NLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALISALNALFATVTGWFGYSISFQGILGYIFYPVAWVMGVPASEAL
QVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISIFLVSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTL
VSVLSASIAALVL
>Mature_413_residues
MHGNLTCLIFGATMDRVLHFVLAIVVVAILALLVSHDRQKIRIRYVVQLLVIEVLLAWFFLNSDIGLGFVKGFSEMFEKL
LGFANEGTNFVFGGMNDKGLAFFFLKVLCPIVFISALIGILQHIRILPIVIRAIGTVLSKVNGMGKLESFNAVSSLILGQ
SENFIAYKDILGKMSRNRMYTMAATAMSTVSMSIVGAYMTMLQPKYVVAALVLNMFSTFIVLSLINPYRVEESEENLQMS
NLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALISALNALFATVTGWFGYSISFQGILGYIFYPVAWVMGVPASEAL
QVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISIFLVSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTL
VSVLSASIAALVL

Specific function: Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=423, Percent_Identity=26.4775413711584, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI11545853, Length=373, Percent_Identity=23.8605898123324, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI227116277, Length=404, Percent_Identity=23.2673267326733, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788737, Length=400, Percent_Identity=94.25, Blast_Score=758, Evalue=0.0,
Organism=Escherichia coli, GI1788485, Length=412, Percent_Identity=31.7961165048544, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788488, Length=413, Percent_Identity=30.5084745762712, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560276, Length=393, Percent_Identity=24.9363867684478, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71991794, Length=392, Percent_Identity=25, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45552519, Length=391, Percent_Identity=26.5984654731458, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45552517, Length=391, Percent_Identity=26.5984654731458, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI19921868, Length=391, Percent_Identity=26.5984654731458, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI281360430, Length=347, Percent_Identity=24.207492795389, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 44941; Mature: 44941

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGNLTCLIFGATMDRVLHFVLAIVVVAILALLVSHDRQKIRIRYVVQLLVIEVLLAWFF
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LNSDIGLGFVKGFSEMFEKLLGFANEGTNFVFGGMNDKGLAFFFLKVLCPIVFISALIGI
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQHIRILPIVIRAIGTVLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGKMSRNRMY
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHH
TMAATAMSTVSMSIVGAYMTMLQPKYVVAALVLNMFSTFIVLSLINPYRVEESEENLQMS
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHH
NLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALISALNALFATVTGWFGYSISFQGI
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHH
LGYIFYPVAWVMGVPASEALQVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISIFL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHGNLTCLIFGATMDRVLHFVLAIVVVAILALLVSHDRQKIRIRYVVQLLVIEVLLAWFF
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LNSDIGLGFVKGFSEMFEKLLGFANEGTNFVFGGMNDKGLAFFFLKVLCPIVFISALIGI
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQHIRILPIVIRAIGTVLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGKMSRNRMY
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHH
TMAATAMSTVSMSIVGAYMTMLQPKYVVAALVLNMFSTFIVLSLINPYRVEESEENLQMS
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHH
NLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALISALNALFATVTGWFGYSISFQGI
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHH
LGYIFYPVAWVMGVPASEALQVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISIFL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]