Click here to switch to the map view.

The map label for this gene is glpA [H]

Identifier: 238895774

GI number: 238895774

Start: 3717765

End: 3719387

Strand: Direct

Name: glpA [H]

Synonym: KP1_3882

Alternate gene names: 238895774

Gene position: 3717765-3719387 (Clockwise)

Preceding gene: 238895771

Following gene: 238895775

Centisome position: 70.83

GC content: 64.39

Gene sequence:

>1623_bases
ATGACGGGACGTCTTGATAGCGAGGTCATTATCATCGGCGGCGGCGCAACCGGCGCCGGTATCGCCCGCGACTGCGCCCG
GCGCGGATTACGAACGCTGCTCATTGAGCGCCATGATATCGCCACCGGGGCGACCGGCCGGAATCATGGACTGCTGCACA
GCGGCGCCCGCTACGCGGTGACCGACAACGAATCCGCCCGCGAATGCATCAGTGAGAACCGCATCCTGCGCCGCATCGCC
CGCCACTGTATTGAACCGACCAATGGGCTGTTTATCACCCTGCCTGAAGATGACCTGGCATGGCAGCAAACCTTTATCGA
CGCCTGTCAGCAGGCTGGCATAGAGGCCACGCCGCTCTCGCCGCAGGAAGCGCTGCGCCGGGAGCCCGCCGTCAACCCGA
CGCTGCTGGGCGCGGTGCAGGTCCCGGACGGTACCATCGACCCGTTTCGCCTCACCGCGGCCAATATGCTCGACGCCCGC
GAACACGGCGCGCAGATCCTTACCGGCTGCGAAGTAACAGGCCTGCTGCGCCGGGGCGATCGCGTCTGCGGCGTCCAGGT
ATACGACCGCCAACTTCACCAGGCCCGCACTCTGTACGCCGGGATGGTGGTTAACGCCGCCGGGATCTGGGGACAGCGTA
TTGCGGAATATGCCGACCTGCGCATCACCATGTTCCCGGCGAAGGGATCGCTGCTGATCCTCGATCATCGGATTAACAAC
CTGGTGATCAACCGCTGCCGTAAGCCGGCCGACGCCGATATTCTGGTGCCCGGCGATACCATCTCGCTGATCGGCACTAC
CTCAATGCATATTCCTTATGACGAAATTGACGACAACCGGGTAACAGCGGCGGAGGTCGATACCCTGCTGCGCGAAGGGG
AAAAGCTGGCGCCGGTCATGGGCCGCACCCGGATCCTCCGCGCCTACTCCGGCGTCCGCCCGCTGGTGGCCAGCGATAAC
GATCCCAGCGGGCGCGGCGTCAGCCGCGGCATCGTCCTGCTCGACCATGCCCAGCGTGACGGTATGGAAGGCTTCATTAC
TATCACCGGCGGCAAGCTGATGACCTATCGCCTGATGGCCGAGTGGGCCACCGACGCCGTCTGTCGTAAGCTGGGAAACA
CCACCCCCTGTACCACGGCCGAAGCCCCGCTGCCCGGTTCACAGGAGCCAACGGAAAGTACCCTGCAAAAGATTATCTCC
CTCCCCACCCCGCTGCGCGGCTCGGCCGTCTACCGTCACGGCGATCGCACCCCGTCCTGGCTTGGCGACAGCCGCCAGCA
CCGTAGCCTGGTCTGCGAATGTGAAGCCGTCACTGCCGGTGAAGTGAAATACGCGGTGGAAAACCTGGCGGTCAACACCC
TGCTCGACCTGCGCCGCCGCACCCGGATTGGCATGGGGACCTGTCAGGGGGAACTCTGCGCCTGCCGCGCTGCCGGACTG
CTGCAGCGCTTTAACGTCACCACGCCCGCGCAGTCGTTAACCCAGCTCTCGGAATTTCTCAATGAACGCTGGAAGGGCGT
GCAGCCCATCGCCTGGGGCGATGCGCTGCGCGAAAGCGAATTCACCCGCTGGGTCTACCTCGGCCTGTGCGGATTGCCAC
AGGAGCACCGGGATGAAGTTTGA

Upstream 100 bases:

>100_bases
CACATAACACGCTCAAATAACGCGCGAATATGCTCGAAATCAAACAATAACCTTACTAATTGTGGCTAAATGGCGTTAAA
CGAAAGCAGAGGAGCTGAAG

Downstream 100 bases:

>100_bases
TTGCGCGATTATCGGCGGCGGGCTCGCCGGCCTGCTGTGCGGGCTGGCCCTGAATCAGCACGGCCTGCGCAGCGTCATCA
TCAGCCGCGGGCAGAGCGCG

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTGRLDSEVIIIGGGATGAGIARDCARRGLRTLLIERHDIATGATGRNHGLLHSGARYAVTDNESARECISENRILRRIA
RHCIEPTNGLFITLPEDDLAWQQTFIDACQQAGIEATPLSPQEALRREPAVNPTLLGAVQVPDGTIDPFRLTAANMLDAR
EHGAQILTGCEVTGLLRRGDRVCGVQVYDRQLHQARTLYAGMVVNAAGIWGQRIAEYADLRITMFPAKGSLLILDHRINN
LVINRCRKPADADILVPGDTISLIGTTSMHIPYDEIDDNRVTAAEVDTLLREGEKLAPVMGRTRILRAYSGVRPLVASDN
DPSGRGVSRGIVLLDHAQRDGMEGFITITGGKLMTYRLMAEWATDAVCRKLGNTTPCTTAEAPLPGSQEPTESTLQKIIS
LPTPLRGSAVYRHGDRTPSWLGDSRQHRSLVCECEAVTAGEVKYAVENLAVNTLLDLRRRTRIGMGTCQGELCACRAAGL
LQRFNVTTPAQSLTQLSEFLNERWKGVQPIAWGDALRESEFTRWVYLGLCGLPQEHRDEV

Sequences:

>Translated_540_residues
MTGRLDSEVIIIGGGATGAGIARDCARRGLRTLLIERHDIATGATGRNHGLLHSGARYAVTDNESARECISENRILRRIA
RHCIEPTNGLFITLPEDDLAWQQTFIDACQQAGIEATPLSPQEALRREPAVNPTLLGAVQVPDGTIDPFRLTAANMLDAR
EHGAQILTGCEVTGLLRRGDRVCGVQVYDRQLHQARTLYAGMVVNAAGIWGQRIAEYADLRITMFPAKGSLLILDHRINN
LVINRCRKPADADILVPGDTISLIGTTSMHIPYDEIDDNRVTAAEVDTLLREGEKLAPVMGRTRILRAYSGVRPLVASDN
DPSGRGVSRGIVLLDHAQRDGMEGFITITGGKLMTYRLMAEWATDAVCRKLGNTTPCTTAEAPLPGSQEPTESTLQKIIS
LPTPLRGSAVYRHGDRTPSWLGDSRQHRSLVCECEAVTAGEVKYAVENLAVNTLLDLRRRTRIGMGTCQGELCACRAAGL
LQRFNVTTPAQSLTQLSEFLNERWKGVQPIAWGDALRESEFTRWVYLGLCGLPQEHRDEV
>Mature_539_residues
TGRLDSEVIIIGGGATGAGIARDCARRGLRTLLIERHDIATGATGRNHGLLHSGARYAVTDNESARECISENRILRRIAR
HCIEPTNGLFITLPEDDLAWQQTFIDACQQAGIEATPLSPQEALRREPAVNPTLLGAVQVPDGTIDPFRLTAANMLDARE
HGAQILTGCEVTGLLRRGDRVCGVQVYDRQLHQARTLYAGMVVNAAGIWGQRIAEYADLRITMFPAKGSLLILDHRINNL
VINRCRKPADADILVPGDTISLIGTTSMHIPYDEIDDNRVTAAEVDTLLREGEKLAPVMGRTRILRAYSGVRPLVASDND
PSGRGVSRGIVLLDHAQRDGMEGFITITGGKLMTYRLMAEWATDAVCRKLGNTTPCTTAEAPLPGSQEPTESTLQKIISL
PTPLRGSAVYRHGDRTPSWLGDSRQHRSLVCECEAVTAGEVKYAVENLAVNTLLDLRRRTRIGMGTCQGELCACRAAGLL
QRFNVTTPAQSLTQLSEFLNERWKGVQPIAWGDALRESEFTRWVYLGLCGLPQEHRDEV

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=516, Percent_Identity=26.3565891472868, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI285002231, Length=516, Percent_Identity=26.3565891472868, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI197927446, Length=292, Percent_Identity=26.027397260274, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21361378, Length=292, Percent_Identity=26.027397260274, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788574, Length=516, Percent_Identity=81.5891472868217, Blast_Score=874, Evalue=0.0,
Organism=Escherichia coli, GI2367226, Length=459, Percent_Identity=25.0544662309368, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509253, Length=416, Percent_Identity=29.5673076923077, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115534726, Length=429, Percent_Identity=26.5734265734266, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322036, Length=543, Percent_Identity=25.414364640884, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161077125, Length=407, Percent_Identity=29.2383292383292, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653942, Length=407, Percent_Identity=29.2383292383292, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653944, Length=407, Percent_Identity=29.2383292383292, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130025, Length=407, Percent_Identity=29.2383292383292, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130091, Length=239, Percent_Identity=28.4518828451883, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586295, Length=407, Percent_Identity=25.0614250614251, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 59122; Mature: 58991

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRLDSEVIIIGGGATGAGIARDCARRGLRTLLIERHDIATGATGRNHGLLHSGARYAV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEE
TDNESARECISENRILRRIARHCIEPTNGLFITLPEDDLAWQQTFIDACQQAGIEATPLS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCC
PQEALRREPAVNPTLLGAVQVPDGTIDPFRLTAANMLDAREHGAQILTGCEVTGLLRRGD
HHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCC
RVCGVQVYDRQLHQARTLYAGMVVNAAGIWGQRIAEYADLRITMFPAKGSLLILDHRINN
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCEEEEECHHHH
LVINRCRKPADADILVPGDTISLIGTTSMHIPYDEIDDNRVTAAEVDTLLREGEKLAPVM
HHHHHCCCCCCCEEEECCCEEEEEECCEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHH
GRTRILRAYSGVRPLVASDNDPSGRGVSRGIVLLDHAQRDGMEGFITITGGKLMTYRLMA
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEHHHHH
EWATDAVCRKLGNTTPCTTAEAPLPGSQEPTESTLQKIISLPTPLRGSAVYRHGDRTPSW
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
LGDSRQHRSLVCECEAVTAGEVKYAVENLAVNTLLDLRRRTRIGMGTCQGELCACRAAGL
CCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LQRFNVTTPAQSLTQLSEFLNERWKGVQPIAWGDALRESEFTRWVYLGLCGLPQEHRDEV
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHCCCC
>Mature Secondary Structure 
TGRLDSEVIIIGGGATGAGIARDCARRGLRTLLIERHDIATGATGRNHGLLHSGARYAV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEE
TDNESARECISENRILRRIARHCIEPTNGLFITLPEDDLAWQQTFIDACQQAGIEATPLS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCC
PQEALRREPAVNPTLLGAVQVPDGTIDPFRLTAANMLDAREHGAQILTGCEVTGLLRRGD
HHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCC
RVCGVQVYDRQLHQARTLYAGMVVNAAGIWGQRIAEYADLRITMFPAKGSLLILDHRINN
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCEEEEECHHHH
LVINRCRKPADADILVPGDTISLIGTTSMHIPYDEIDDNRVTAAEVDTLLREGEKLAPVM
HHHHHCCCCCCCEEEECCCEEEEEECCEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHH
GRTRILRAYSGVRPLVASDNDPSGRGVSRGIVLLDHAQRDGMEGFITITGGKLMTYRLMA
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEHHHHH
EWATDAVCRKLGNTTPCTTAEAPLPGSQEPTESTLQKIISLPTPLRGSAVYRHGDRTPSW
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
LGDSRQHRSLVCECEAVTAGEVKYAVENLAVNTLLDLRRRTRIGMGTCQGELCACRAAGL
CCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LQRFNVTTPAQSLTQLSEFLNERWKGVQPIAWGDALRESEFTRWVYLGLCGLPQEHRDEV
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]