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The map label for this gene is ada [H]

Identifier: 238895760

GI number: 238895760

Start: 3696474

End: 3697538

Strand: Reverse

Name: ada [H]

Synonym: KP1_3867

Alternate gene names: 238895760

Gene position: 3697538-3696474 (Counterclockwise)

Preceding gene: 238895761

Following gene: 238895759

Centisome position: 70.45

GC content: 66.67

Gene sequence:

>1065_bases
ATGAAACCGATAGTTGCCGATACCGATGATCGCCGCTGGCAGGCGGTCTGCGAACGTGATACCCGGGCCGATGGTCAGTT
CGTCTTTGCGGTACTGACCACCGGCATCTGCTGTCGTCCCTCCTGCCGCTCGCGGCGCGCGCGGCGGGAAAACGTACGCT
TTTTTGCCGACGTCGCCGCCGCCGTGGCGGCGGGATTCCGCCCCTGCAAACGCTGCCAACCGGATAAAGACTACCCGCAG
CAGCAAAGGGTCGACAAAGTGGCGCAGGCCTGTCGGCTGCTGGAGCAGGACGCGCCCCTGACCCTCGATGCGCTGGCAGG
CCAGCTGGCGATGAGCCCGTTTCATTTCCACCGTTTATTTAAATCCGTCACCGGCATGACCCCTAAAGCCTGGCAACAAG
CGTGGCGGGCGCAGCGCCTGCGGGAAGCGCTGGAGCAGGGGATACCGGTGACCCGCGCCGCGCTGGCGGCTGGTTTTCCC
GACAGCAGCAGCTATTATCGCCAGGCCGACGCAGCGTTAGGGATGACCGCCAGCCAGTTTCGCCGCGGCGGCGCCGCCAC
CGTGGTAACCTGGACCACGGGCGACTGCGCGCTGGGTCGTTGCCTGGTGGCGCAGAGCGAGCGCGGCGTCTGCGCGGTGC
TGCCGGGTGATAACGATGCGGCATTGATCGACGACCTGCGCCGGCGCTTTCCCAATGCCGAGCTGCGTGAAGGCGACCCC
GATTTTTGTCAGCAGATGGCCGAGATTTTCGCCCACCTCGACGACAGCCGGCGGCCGGTATCGCTGCCGCTGGATCTGCA
GGGCACCGCGTTTCAGCTGCAGGTCTGGCAGGCGCTGCGGCAGATCCCGGCGGGTGAGACCCGCAGCTACCGCCAGGTGG
CAGAGCATATTGGCCAGCCGCGGGCGGTTAGAGCCGTGGCCGGCGCCTGCGCGGCGAATTCGCTGGCGGTGATTGTTCCC
TGCCACCGGGTGGTGCGTGAAGATGGCGCCCTGTCCGGTTATCGCTGGGGAACGGCGCGAAAAGCGCAGCTGCTGGCGCG
CGAGGCCCAACATGAGGAGGAGTAA

Upstream 100 bases:

>100_bases
ACTTTCCTTGTCGGCGAGAAAAATTAAAAAGCAAGATTGCGGGTTTTTTACTGCGGGCTTTACCACAGACTGAGGGTACA
CTTACAGCTGGAGACCCGTC

Downstream 100 bases:

>100_bases
TGCTCGATCTGTTTAGCGATACCCCACCGTGGCAGGAGCCGCTGGCCCCCGGCGCGGTGGTGCTGCGGCGATTTGCCCGC
GAACGCGCCCCGGCGCTGCT

Product: O6-methylguanine-DNA methyltransferase/DNA-binding transcriptional dual regulator

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKPIVADTDDRRWQAVCERDTRADGQFVFAVLTTGICCRPSCRSRRARRENVRFFADVAAAVAAGFRPCKRCQPDKDYPQ
QQRVDKVAQACRLLEQDAPLTLDALAGQLAMSPFHFHRLFKSVTGMTPKAWQQAWRAQRLREALEQGIPVTRAALAAGFP
DSSSYYRQADAALGMTASQFRRGGAATVVTWTTGDCALGRCLVAQSERGVCAVLPGDNDAALIDDLRRRFPNAELREGDP
DFCQQMAEIFAHLDDSRRPVSLPLDLQGTAFQLQVWQALRQIPAGETRSYRQVAEHIGQPRAVRAVAGACAANSLAVIVP
CHRVVREDGALSGYRWGTARKAQLLAREAQHEEE

Sequences:

>Translated_354_residues
MKPIVADTDDRRWQAVCERDTRADGQFVFAVLTTGICCRPSCRSRRARRENVRFFADVAAAVAAGFRPCKRCQPDKDYPQ
QQRVDKVAQACRLLEQDAPLTLDALAGQLAMSPFHFHRLFKSVTGMTPKAWQQAWRAQRLREALEQGIPVTRAALAAGFP
DSSSYYRQADAALGMTASQFRRGGAATVVTWTTGDCALGRCLVAQSERGVCAVLPGDNDAALIDDLRRRFPNAELREGDP
DFCQQMAEIFAHLDDSRRPVSLPLDLQGTAFQLQVWQALRQIPAGETRSYRQVAEHIGQPRAVRAVAGACAANSLAVIVP
CHRVVREDGALSGYRWGTARKAQLLAREAQHEEE
>Mature_354_residues
MKPIVADTDDRRWQAVCERDTRADGQFVFAVLTTGICCRPSCRSRRARRENVRFFADVAAAVAAGFRPCKRCQPDKDYPQ
QQRVDKVAQACRLLEQDAPLTLDALAGQLAMSPFHFHRLFKSVTGMTPKAWQQAWRAQRLREALEQGIPVTRAALAAGFP
DSSSYYRQADAALGMTASQFRRGGAATVVTWTTGDCALGRCLVAQSERGVCAVLPGDNDAALIDDLRRRFPNAELREGDP
DFCQQMAEIFAHLDDSRRPVSLPLDLQGTAFQLQVWQALRQIPAGETRSYRQVAEHIGQPRAVRAVAGACAANSLAVIVP
CHRVVREDGALSGYRWGTARKAQLLAREAQHEEE

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=166, Percent_Identity=30.7228915662651, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788542, Length=353, Percent_Identity=65.1558073654391, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1787596, Length=89, Percent_Identity=44.9438202247191, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI115533070, Length=128, Percent_Identity=44.53125, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI115533068, Length=127, Percent_Identity=44.0944881889764, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320001, Length=92, Percent_Identity=41.304347826087, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137554, Length=140, Percent_Identity=42.1428571428571, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 39178; Mature: 39178

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIVADTDDRRWQAVCERDTRADGQFVFAVLTTGICCRPSCRSRRARRENVRFFADVAA
CCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
AVAAGFRPCKRCQPDKDYPQQQRVDKVAQACRLLEQDAPLTLDALAGQLAMSPFHFHRLF
HHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCHHHHHHHH
KSVTGMTPKAWQQAWRAQRLREALEQGIPVTRAALAAGFPDSSSYYRQADAALGMTASQF
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHH
RRGGAATVVTWTTGDCALGRCLVAQSERGVCAVLPGDNDAALIDDLRRRFPNAELREGDP
HCCCCEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCH
DFCQQMAEIFAHLDDSRRPVSLPLDLQGTAFQLQVWQALRQIPAGETRSYRQVAEHIGQP
HHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
RAVRAVAGACAANSLAVIVPCHRVVREDGALSGYRWGTARKAQLLAREAQHEEE
HHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKPIVADTDDRRWQAVCERDTRADGQFVFAVLTTGICCRPSCRSRRARRENVRFFADVAA
CCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
AVAAGFRPCKRCQPDKDYPQQQRVDKVAQACRLLEQDAPLTLDALAGQLAMSPFHFHRLF
HHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCHHHHHHHH
KSVTGMTPKAWQQAWRAQRLREALEQGIPVTRAALAAGFPDSSSYYRQADAALGMTASQF
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHH
RRGGAATVVTWTTGDCALGRCLVAQSERGVCAVLPGDNDAALIDDLRRRFPNAELREGDP
HCCCCEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCH
DFCQQMAEIFAHLDDSRRPVSLPLDLQGTAFQLQVWQALRQIPAGETRSYRQVAEHIGQP
HHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
RAVRAVAGACAANSLAVIVPCHRVVREDGALSGYRWGTARKAQLLAREAQHEEE
HHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]