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The map label for this gene is yeiQ [H]

Identifier: 238895731

GI number: 238895731

Start: 3663622

End: 3665097

Strand: Direct

Name: yeiQ [H]

Synonym: KP1_3834

Alternate gene names: 238895731

Gene position: 3663622-3665097 (Clockwise)

Preceding gene: 238895729

Following gene: 238895732

Centisome position: 69.8

GC content: 62.74

Gene sequence:

>1476_bases
GTGGGAAGAATGACAACAATTGCAACCGCTACGCTACCGAAGAACGTGCAATACCCTCAATACGATCGCAGCCAGCTCCG
CTCGCGTATTGTCCATTTCGGCTTTGGCGCGTTTCACCGCGCGCACCAGGCGCTGCTCACCGATCGCGTGCTGAATAACG
TCGGCGGCGACTGGGGGATCTGTGAAATCAGTCTGTTCAGCGGCGACACGCTGATGAGCCAGCTTCGCGAACAGGACCAT
CTGTTTACCGTGCTGGAAAAAGGCGCCGACGGCAACCAGCCCATTGTGATCGGCGCGGTGCACGAATGTCTGAACGCCAG
GCTCGATTCGCTGGCGGCGATTATCGAAAAATTTTGCGAGCCGCAGGTAGCGATTGTCTCGCTGACCATTACGGAAAAAG
GCTACTGCATCGATCCGGCGACCGGGAAACTGGATCCGACGCATCCGCGCATTATTCACGATCTGGAGAATCCGACGCTG
CCGCAGTCGGCTCCCGGTATTTTAGTTGAAGCGCTGGCCCGCCGCCGGGAACGAGGCCTTCCGCCCTTTACCGTGCTCTC
CTGCGATAATATCCCCGACAACGGTCACGTGGTAAAAAATGCCGTCCTCGGCATGGCGGAAAAACGCAGCCCGGCGCTGG
CGGACTGGATCGCCGACAACGTCAGCTTCCCGGGCACCATGGTGGATCGCATTGTTCCCGCGGCCACAGCGGAGTCGCTG
GCGGAAATCGCCGCCGTGCTGGGGGTCGACGATCCCTGCGCCATCAGTTGCGAACCCTTCATTCAGTGGGTGGTCGAAGA
TCACTTTGTCGCCGGGCGACCCGCCTGGGAGACGGCGGGCGTGCAGATGACCGATGACGTGTTGCCCTGGGAGCAAATGA
AGCTGCGGATGCTCAACGGCAGCCACTCTTTCCTCGCCTGGCTTGGCTATCTGGCAGGGCATGCGCACATTAGCGACTGC
ATGCAGGATGACGTCTTCCGCCGCGCCGCCCGCCAGCTGATGCTTGACGAACAGGCTCCGACGCTGACCATTACCGGCGT
TGATCTGCTGGCCTATGCCGACAGTCTCATCGCCCGCTTCAGCAATCCGGCGCTCAAACACCGCACCTGGCAAATCGCCA
TGGACGGTAGCCAGAAGCTGCCCCAGCGCATGCTCGATGGCATCCGCGTACATCTGGCGCGCGACAGCCGTTGGCCGCTG
CTGGCTCTCGGCGTGGCCGGCTGGATGCGCTACGTCAGCGGCACGGACGACGCCGGTCAGACGATCGACGTGCGCGATCC
GCTGGTCGACAAGATCCGGCAGCGGGTGGCCCAGAGCGATGAGCAGCAGCGCGTCGACGCCCTGCTGGGGCTGGAGGAAA
TATTTGGCCGCGACCTGCCGCACAACGCCCAGTTTGTCGCCGGGATCCGCGCCGCCTGGCAACAGCTGGCGACGCACGGC
GCCCGCGAGGCCGTCGCCCGCGCGCTGAATTCTTAA

Upstream 100 bases:

>100_bases
GATTGATCCAGCTCACAGTCAGCGGATAATTTCGGCTTACCAATTTAACTTCCTGTCATATAACTTTAGACTGGCATTGT
TAATAAGCAGTTAAACAGGT

Downstream 100 bases:

>100_bases
CAATATTTGCGCTTATGCGGACAGAATTCTCTTCTGTCCGCCTCAGGACTTCTCTTTTCCTCCTTTTTTCGTCAGGATAG
GCGTAACTGTTACAACATTA

Product: putative mannitol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MGRMTTIATATLPKNVQYPQYDRSQLRSRIVHFGFGAFHRAHQALLTDRVLNNVGGDWGICEISLFSGDTLMSQLREQDH
LFTVLEKGADGNQPIVIGAVHECLNARLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGKLDPTHPRIIHDLENPTL
PQSAPGILVEALARRRERGLPPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPALADWIADNVSFPGTMVDRIVPAATAESL
AEIAAVLGVDDPCAISCEPFIQWVVEDHFVAGRPAWETAGVQMTDDVLPWEQMKLRMLNGSHSFLAWLGYLAGHAHISDC
MQDDVFRRAARQLMLDEQAPTLTITGVDLLAYADSLIARFSNPALKHRTWQIAMDGSQKLPQRMLDGIRVHLARDSRWPL
LALGVAGWMRYVSGTDDAGQTIDVRDPLVDKIRQRVAQSDEQQRVDALLGLEEIFGRDLPHNAQFVAGIRAAWQQLATHG
AREAVARALNS

Sequences:

>Translated_491_residues
MGRMTTIATATLPKNVQYPQYDRSQLRSRIVHFGFGAFHRAHQALLTDRVLNNVGGDWGICEISLFSGDTLMSQLREQDH
LFTVLEKGADGNQPIVIGAVHECLNARLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGKLDPTHPRIIHDLENPTL
PQSAPGILVEALARRRERGLPPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPALADWIADNVSFPGTMVDRIVPAATAESL
AEIAAVLGVDDPCAISCEPFIQWVVEDHFVAGRPAWETAGVQMTDDVLPWEQMKLRMLNGSHSFLAWLGYLAGHAHISDC
MQDDVFRRAARQLMLDEQAPTLTITGVDLLAYADSLIARFSNPALKHRTWQIAMDGSQKLPQRMLDGIRVHLARDSRWPL
LALGVAGWMRYVSGTDDAGQTIDVRDPLVDKIRQRVAQSDEQQRVDALLGLEEIFGRDLPHNAQFVAGIRAAWQQLATHG
AREAVARALNS
>Mature_490_residues
GRMTTIATATLPKNVQYPQYDRSQLRSRIVHFGFGAFHRAHQALLTDRVLNNVGGDWGICEISLFSGDTLMSQLREQDHL
FTVLEKGADGNQPIVIGAVHECLNARLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGKLDPTHPRIIHDLENPTLP
QSAPGILVEALARRRERGLPPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPALADWIADNVSFPGTMVDRIVPAATAESLA
EIAAVLGVDDPCAISCEPFIQWVVEDHFVAGRPAWETAGVQMTDDVLPWEQMKLRMLNGSHSFLAWLGYLAGHAHISDCM
QDDVFRRAARQLMLDEQAPTLTITGVDLLAYADSLIARFSNPALKHRTWQIAMDGSQKLPQRMLDGIRVHLARDSRWPLL
ALGVAGWMRYVSGTDDAGQTIDVRDPLVDKIRQRVAQSDEQQRVDALLGLEEIFGRDLPHNAQFVAGIRAAWQQLATHGA
REAVARALNS

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=487, Percent_Identity=78.8501026694045, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1790779, Length=486, Percent_Identity=58.2304526748971, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1787823, Length=488, Percent_Identity=55.5327868852459, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI48994885, Length=504, Percent_Identity=23.2142857142857, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790028, Length=270, Percent_Identity=25.9259259259259, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324401, Length=486, Percent_Identity=38.477366255144, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6320765, Length=486, Percent_Identity=38.477366255144, Blast_Score=350, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54093; Mature: 53962

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRMTTIATATLPKNVQYPQYDRSQLRSRIVHFGFGAFHRAHQALLTDRVLNNVGGDWGI
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
CEISLFSGDTLMSQLREQDHLFTVLEKGADGNQPIVIGAVHECLNARLDSLAAIIEKFCE
EEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCC
PQVAIVSLTITEKGYCIDPATGKLDPTHPRIIHDLENPTLPQSAPGILVEALARRRERGL
CCEEEEEEEEECCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
PPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPALADWIADNVSFPGTMVDRIVPAATAESL
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AEIAAVLGVDDPCAISCEPFIQWVVEDHFVAGRPAWETAGVQMTDDVLPWEQMKLRMLNG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHCC
SHSFLAWLGYLAGHAHISDCMQDDVFRRAARQLMLDEQAPTLTITGVDLLAYADSLIARF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHH
SNPALKHRTWQIAMDGSQKLPQRMLDGIRVHLARDSRWPLLALGVAGWMRYVSGTDDAGQ
CCCHHHCEEEEEEECCHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
TIDVRDPLVDKIRQRVAQSDEQQRVDALLGLEEIFGRDLPHNAQFVAGIRAAWQQLATHG
EEECCCHHHHHHHHHHHCCHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AREAVARALNS
HHHHHHHHHCC
>Mature Secondary Structure 
GRMTTIATATLPKNVQYPQYDRSQLRSRIVHFGFGAFHRAHQALLTDRVLNNVGGDWGI
CCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
CEISLFSGDTLMSQLREQDHLFTVLEKGADGNQPIVIGAVHECLNARLDSLAAIIEKFCE
EEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCC
PQVAIVSLTITEKGYCIDPATGKLDPTHPRIIHDLENPTLPQSAPGILVEALARRRERGL
CCEEEEEEEEECCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
PPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPALADWIADNVSFPGTMVDRIVPAATAESL
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AEIAAVLGVDDPCAISCEPFIQWVVEDHFVAGRPAWETAGVQMTDDVLPWEQMKLRMLNG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHCC
SHSFLAWLGYLAGHAHISDCMQDDVFRRAARQLMLDEQAPTLTITGVDLLAYADSLIARF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHH
SNPALKHRTWQIAMDGSQKLPQRMLDGIRVHLARDSRWPLLALGVAGWMRYVSGTDDAGQ
CCCHHHCEEEEEEECCHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
TIDVRDPLVDKIRQRVAQSDEQQRVDALLGLEEIFGRDLPHNAQFVAGIRAAWQQLATHG
EEECCCHHHHHHHHHHHCCHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AREAVARALNS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]