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The map label for this gene is fruA [H]

Identifier: 238895724

GI number: 238895724

Start: 3655850

End: 3657544

Strand: Reverse

Name: fruA [H]

Synonym: KP1_3827

Alternate gene names: 238895724

Gene position: 3657544-3655850 (Counterclockwise)

Preceding gene: 238895725

Following gene: 238895721

Centisome position: 69.69

GC content: 62.36

Gene sequence:

>1695_bases
ATGAAAACGCTGCTGATTATTGATGCCGGACTCGGACAGGCGCGCGCCTACATGGCGAAAACCCTGCTGGGTGCCGCGGC
GCCGAAAGCGCACCTTGAGCTGATTGATAACCCGAATGACGCCGAACTGGCCATCGTGCTGGGAACCGCGCTGCCGGCCG
ATAGCGCGCTGAATGGTAAAAACGTTTACCTGGGCGATATTAACCGTGCTGTCGCCCATCCGGAGCTGTTCCTGGGAGAA
GCGAAAGACCACGCTAAGCCCTACGTTGCGCCAGCGGCGGTAGCCGTTCCGGCCGCCGCTCAGGGGCAGAAACGCATTGT
CGCGGTCACCGCCTGTCCGACCGGCGTCGCCCACACCTTTATGGCGGCAGAAGCCATCGAAACCGAAGCCAAAAAACGCG
GCTGGTGGGTGAAGGTGGAGACCCGCGGCTCCGTTGGGGCGGGCAATGCCATCACCCCGGAAGAGGTGGCCGAGGCGGAT
CTGGTGATCGTCGCTGCCGATATCGAGGTGGACCTGGCGAAATTCGCCGGCAAGCCGATGTACCGCACCACCACCGGTCT
GGCGCTGAAGAAAACCGCCCAGGAGCTGGATAAAGCGGTGGCGGAAGCCAAACCGTACCAGCCATCCGGCAAACCTCAGG
CGGCTGCTGAAGGGAAAAAAGAGTCGGCTGGCGCCTATCGCCACCTGCTGACCGGCGTCTCCTATATGCTGCCGATGGTA
GTGGCCGGGGGCCTGTGTATCGCGCTCTCCTTTGCCTTCGGGATCAAAGCGTTTGAAGTGAAAGACACCCTGGCGGCGGC
GCTGATGCAGATCGGCGGCGGCTCGGCCTTCGCGCTGATGGTGCCGGTACTGGCAGGCTTTATCGCCTTCTCCATTGCCG
ACCGTCCGGGTCTGACCCCGGGCCTTATCGGCGGTATGCTGGCGGTTAGCGGCGGCTCCGGCTTTATCGGCGGGATCATT
GCTGGTTTCCTTGCCGGTTATGTGGCGAAAGCCATCAGCACGAAGCTGAAACTGCCGCAGAGTATGGAAGCCCTGAAGCC
AATCCTGATCATTCCGCTGGTCTCCAGTCTGATCGTGGGTTTGGCAATGATCTATCTGATCGGTAAACCGGTAGCCGGTA
TCCTCGCCTGGCTGACCCACTGGCTGCAAACCATGGGCACCGCCAACGCGGTTCTGCTGGGCGCGATCCTCGGCGCGATG
ATGTGTACCGATATGGGCGGGCCGGTAAACAAAGCGGCCTATGCCTTTGGCGTTGGCCTGCTGAGTACCCAGACCTATGC
GCCGATGGCGGCGATCATGGCGGCCGGTATGGTGCCACCGCTGGCGATGGGTATCGCGACGCTGGTAGCGCGCAATAAGT
TCGACAAAGGGCAGCGGGAAGGGGGCAAAGCCGCGCTGGTTCTTGGCCTGTGCTTTATCTCGGAAGGGGCGATTCCTTTT
GCCGCCCGTGACCCGATGCGCGTTCTGCCGTGCTGTATCGTCGGCGGCGCGGTAACCGGCGCTATCTCCATGGCGGTCGG
CGCGAAACTGATGGCGCCGCACGGCGGGCTGTTTGTTCTGCTGATCCCGGGGGCAATTACGCCGGTGCTGGGCTACCTGC
TGGCGATTGTTGCCGGAACGCTGGTGGCGGGCCTTGCCTACGCGGTGCTGAAACGCCCTGAGGCGCAAACAGCGGAAGTT
GAAAAAGCGGCATAA

Upstream 100 bases:

>100_bases
GTCAGCCAGAGCAATGTAGGAATTACCGACCGTACCCAGTTGGCCGCGATGATGGCGCGCGTCGACTTACAACCCTTTAA
TTGACAGCAGGAGAGGCATA

Downstream 100 bases:

>100_bases
TCCTACCGCAATAAAAAAGGGCCGACTGTTCGGCCCTTTTTTGTCTCTATTTACGCCACTTCGGCAATCTGCTGCGCCCG
CAGCCAGGCAATCTCTTCCG

Product: PTS system fructose-specific transporter subunits IIBC

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MKTLLIIDAGLGQARAYMAKTLLGAAAPKAHLELIDNPNDAELAIVLGTALPADSALNGKNVYLGDINRAVAHPELFLGE
AKDHAKPYVAPAAVAVPAAAQGQKRIVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEAD
LVIVAADIEVDLAKFAGKPMYRTTTGLALKKTAQELDKAVAEAKPYQPSGKPQAAAEGKKESAGAYRHLLTGVSYMLPMV
VAGGLCIALSFAFGIKAFEVKDTLAAALMQIGGGSAFALMVPVLAGFIAFSIADRPGLTPGLIGGMLAVSGGSGFIGGII
AGFLAGYVAKAISTKLKLPQSMEALKPILIIPLVSSLIVGLAMIYLIGKPVAGILAWLTHWLQTMGTANAVLLGAILGAM
MCTDMGGPVNKAAYAFGVGLLSTQTYAPMAAIMAAGMVPPLAMGIATLVARNKFDKGQREGGKAALVLGLCFISEGAIPF
AARDPMRVLPCCIVGGAVTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGTLVAGLAYAVLKRPEAQTAEV
EKAA

Sequences:

>Translated_564_residues
MKTLLIIDAGLGQARAYMAKTLLGAAAPKAHLELIDNPNDAELAIVLGTALPADSALNGKNVYLGDINRAVAHPELFLGE
AKDHAKPYVAPAAVAVPAAAQGQKRIVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEAD
LVIVAADIEVDLAKFAGKPMYRTTTGLALKKTAQELDKAVAEAKPYQPSGKPQAAAEGKKESAGAYRHLLTGVSYMLPMV
VAGGLCIALSFAFGIKAFEVKDTLAAALMQIGGGSAFALMVPVLAGFIAFSIADRPGLTPGLIGGMLAVSGGSGFIGGII
AGFLAGYVAKAISTKLKLPQSMEALKPILIIPLVSSLIVGLAMIYLIGKPVAGILAWLTHWLQTMGTANAVLLGAILGAM
MCTDMGGPVNKAAYAFGVGLLSTQTYAPMAAIMAAGMVPPLAMGIATLVARNKFDKGQREGGKAALVLGLCFISEGAIPF
AARDPMRVLPCCIVGGAVTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGTLVAGLAYAVLKRPEAQTAEV
EKAA
>Mature_564_residues
MKTLLIIDAGLGQARAYMAKTLLGAAAPKAHLELIDNPNDAELAIVLGTALPADSALNGKNVYLGDINRAVAHPELFLGE
AKDHAKPYVAPAAVAVPAAAQGQKRIVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEAD
LVIVAADIEVDLAKFAGKPMYRTTTGLALKKTAQELDKAVAEAKPYQPSGKPQAAAEGKKESAGAYRHLLTGVSYMLPMV
VAGGLCIALSFAFGIKAFEVKDTLAAALMQIGGGSAFALMVPVLAGFIAFSIADRPGLTPGLIGGMLAVSGGSGFIGGII
AGFLAGYVAKAISTKLKLPQSMEALKPILIIPLVSSLIVGLAMIYLIGKPVAGILAWLTHWLQTMGTANAVLLGAILGAM
MCTDMGGPVNKAAYAFGVGLLSTQTYAPMAAIMAAGMVPPLAMGIATLVARNKFDKGQREGGKAALVLGLCFISEGAIPF
AARDPMRVLPCCIVGGAVTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGTLVAGLAYAVLKRPEAQTAEV
EKAA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=565, Percent_Identity=88.6725663716814, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1786951, Length=428, Percent_Identity=36.214953271028, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082348, Length=488, Percent_Identity=32.9918032786885, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI1790386, Length=299, Percent_Identity=44.4816053511706, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1788729, Length=340, Percent_Identity=28.8235294117647, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1790387, Length=88, Percent_Identity=54.5454545454545, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788730, Length=103, Percent_Identity=39.8058252427184, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790390, Length=65, Percent_Identity=44.6153846153846, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 57550; Mature: 57550

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLIIDAGLGQARAYMAKTLLGAAAPKAHLELIDNPNDAELAIVLGTALPADSALNGK
CCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHEEECCCCCCEEEEEEECCCCCCCCCCCC
NVYLGDINRAVAHPELFLGEAKDHAKPYVAPAAVAVPAAAQGQKRIVAVTACPTGVAHTF
EEEEECCHHHHCCCHHHCCCCHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCHHHHHH
MAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADLVIVAADIEVDLAKFAGKPM
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCEEEEEECCCCHHHHHCCCCC
YRTTTGLALKKTAQELDKAVAEAKPYQPSGKPQAAAEGKKESAGAYRHLLTGVSYMLPMV
EECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
VAGGLCIALSFAFGIKAFEVKDTLAAALMQIGGGSAFALMVPVLAGFIAFSIADRPGLTP
HHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
GLIGGMLAVSGGSGFIGGIIAGFLAGYVAKAISTKLKLPQSMEALKPILIIPLVSSLIVG
HHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAMIYLIGKPVAGILAWLTHWLQTMGTANAVLLGAILGAMMCTDMGGPVNKAAYAFGVGL
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LSTQTYAPMAAIMAAGMVPPLAMGIATLVARNKFDKGQREGGKAALVLGLCFISEGAIPF
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCC
AARDPMRVLPCCIVGGAVTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHH
LVAGLAYAVLKRPEAQTAEVEKAA
HHHHHHHHHHCCCCCHHCHHCCCC
>Mature Secondary Structure
MKTLLIIDAGLGQARAYMAKTLLGAAAPKAHLELIDNPNDAELAIVLGTALPADSALNGK
CCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHEEECCCCCCEEEEEEECCCCCCCCCCCC
NVYLGDINRAVAHPELFLGEAKDHAKPYVAPAAVAVPAAAQGQKRIVAVTACPTGVAHTF
EEEEECCHHHHCCCHHHCCCCHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCHHHHHH
MAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADLVIVAADIEVDLAKFAGKPM
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCEEEEEECCCCHHHHHCCCCC
YRTTTGLALKKTAQELDKAVAEAKPYQPSGKPQAAAEGKKESAGAYRHLLTGVSYMLPMV
EECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
VAGGLCIALSFAFGIKAFEVKDTLAAALMQIGGGSAFALMVPVLAGFIAFSIADRPGLTP
HHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
GLIGGMLAVSGGSGFIGGIIAGFLAGYVAKAISTKLKLPQSMEALKPILIIPLVSSLIVG
HHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAMIYLIGKPVAGILAWLTHWLQTMGTANAVLLGAILGAMMCTDMGGPVNKAAYAFGVGL
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LSTQTYAPMAAIMAAGMVPPLAMGIATLVARNKFDKGQREGGKAALVLGLCFISEGAIPF
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCC
AARDPMRVLPCCIVGGAVTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHH
LVAGLAYAVLKRPEAQTAEVEKAA
HHHHHHHHHHCCCCCHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]