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The map label for this gene is yegM [H]

Identifier: 238895646

GI number: 238895646

Start: 3561013

End: 3562251

Strand: Direct

Name: yegM [H]

Synonym: KP1_3742

Alternate gene names: 238895646

Gene position: 3561013-3562251 (Clockwise)

Preceding gene: 238895644

Following gene: 238895647

Centisome position: 67.85

GC content: 65.46

Gene sequence:

>1239_bases
ATGAAAGGCAGTAACATACGTCGTTGGGGCGCCGCGCTGGCGGTAGTGATTATCGCCGGGGCCGCCTACTGGTTCTGGCA
CGATCGCGGGACGAGCGGCAGCGGGGCTCCCGCCGCCGGGCAGGGCCCGCAGGGGCCGGGCGGCGCACGCCATGGCCGCT
TTGGCGCCGCGCTGGCGCCGGTGCAGGCGGCCACCGCCACCGAAGAAGCGGTCCCGCGCTATCTCACCGGGCTGGGTACG
GTGACGGCGGCCAATACCGTCACCGTCCGCAGCCGGGTCGACGGCCAACTGCTGAGCCTTCACTTCCAGGAGGGTCAGCA
GGTCAAAGCCGGCGACCTGCTGGCGCAGATCGACCCCAGCCAGTTTAAAGTCGCCCTCGCCCAGGCGCAGGGTCAGCTGG
CGAAAGATCAGGCCACCCTCGCCAACGCCCGCCGCGATCTCGCTCGTTACCAGCAGCTGGTGAAGACCAACCTCGTCTCC
CGCCAGGAGCTCGACACTCAGCAGTCGCTGGTGGTGGAATCCGCCGGCACGGTGAAAGCTGATGAAGCGGCCGTCGCCAG
CGCCCAGCTGCAGCTCGACTGGACCCGCATTACCGCGCCAATTGACGGCCGCGTCGGCTTAAAGCAGGTCGATATCGGCA
ACCAGATCTCCAGCGGGGATACCACCGGGATCGTGGTCCTTACCCAGACGCACCCGATCGACGTGGTCTTTACCCTGCCG
GAAAGCAGCATCGCCACGGTGGTGCAGGCGCAGAAAGCGGGCAAAACGCTCAGCGTCGAAGCCTGGGATCGCACCAATAA
GCAGAAAGTCAGCGTCGGCGAGCTGCTGAGCCTCGATAACCAGATCGATGCGACCACCGGGACCATCAAGCTGAAGGCGC
GCTTTAGCAATCTGGACGACGCGCTGTTCCCCAATCAGTTCGTTAACGCCCGCCTGCTGGTGGACACCCAGCAGAACGCG
GTGGTGATCCCTGCCGCCGCGCTGCAGATGGGCAACGAAGGACATTTCGTATGGGTGCTGAACGATGAGAATAAGGTCAG
CAAACACAGCGTGACGCCCGGCATCCAGGACAGCCAGAAAGTAGTCATCAGCGCCGGGCTTTCCGCCGGAGATCGCGTGG
TCACCGACGGGATTGACCGCCTGACCGAGGGAGCGAAGGTAGAAGTTGTCACCGCCAGCAGCGGCGAGCAGGCGCAGCCC
GCCCCGCGCCAGAGCGGTAAACACGGAGCGCGTTCCTGA

Upstream 100 bases:

>100_bases
TTTCTCAACCTTCTTTTCATAATTCCTCCATTTTTACGGCCCCTTCCCTCACTAAACTAGTATCATTCAGCGAAACGCTT
CAGGATGAGACCGTAAACTA

Downstream 100 bases:

>100_bases
TGCAGGTGTTACCTCCAGGCCGCACCGGCGGCCCGTCCCGGCTGTTTATTATGCGTCCGGTGGCCACCACTCTGCTGATG
GTGGCTATCCTGCTGGCCGG

Product: multidrug efflux system subunit MdtA

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKGSNIRRWGAALAVVIIAGAAYWFWHDRGTSGSGAPAAGQGPQGPGGARHGRFGAALAPVQAATATEEAVPRYLTGLGT
VTAANTVTVRSRVDGQLLSLHFQEGQQVKAGDLLAQIDPSQFKVALAQAQGQLAKDQATLANARRDLARYQQLVKTNLVS
RQELDTQQSLVVESAGTVKADEAAVASAQLQLDWTRITAPIDGRVGLKQVDIGNQISSGDTTGIVVLTQTHPIDVVFTLP
ESSIATVVQAQKAGKTLSVEAWDRTNKQKVSVGELLSLDNQIDATTGTIKLKARFSNLDDALFPNQFVNARLLVDTQQNA
VVIPAAALQMGNEGHFVWVLNDENKVSKHSVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVTASSGEQAQP
APRQSGKHGARS

Sequences:

>Translated_412_residues
MKGSNIRRWGAALAVVIIAGAAYWFWHDRGTSGSGAPAAGQGPQGPGGARHGRFGAALAPVQAATATEEAVPRYLTGLGT
VTAANTVTVRSRVDGQLLSLHFQEGQQVKAGDLLAQIDPSQFKVALAQAQGQLAKDQATLANARRDLARYQQLVKTNLVS
RQELDTQQSLVVESAGTVKADEAAVASAQLQLDWTRITAPIDGRVGLKQVDIGNQISSGDTTGIVVLTQTHPIDVVFTLP
ESSIATVVQAQKAGKTLSVEAWDRTNKQKVSVGELLSLDNQIDATTGTIKLKARFSNLDDALFPNQFVNARLLVDTQQNA
VVIPAAALQMGNEGHFVWVLNDENKVSKHSVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVTASSGEQAQP
APRQSGKHGARS
>Mature_412_residues
MKGSNIRRWGAALAVVIIAGAAYWFWHDRGTSGSGAPAAGQGPQGPGGARHGRFGAALAPVQAATATEEAVPRYLTGLGT
VTAANTVTVRSRVDGQLLSLHFQEGQQVKAGDLLAQIDPSQFKVALAQAQGQLAKDQATLANARRDLARYQQLVKTNLVS
RQELDTQQSLVVESAGTVKADEAAVASAQLQLDWTRITAPIDGRVGLKQVDIGNQISSGDTTGIVVLTQTHPIDVVFTLP
ESSIATVVQAQKAGKTLSVEAWDRTNKQKVSVGELLSLDNQIDATTGTIKLKARFSNLDDALFPNQFVNARLLVDTQQNA
VVIPAAALQMGNEGHFVWVLNDENKVSKHSVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVTASSGEQAQP
APRQSGKHGARS

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=415, Percent_Identity=79.5180722891566, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1789665, Length=327, Percent_Identity=32.1100917431193, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789929, Length=315, Percent_Identity=29.8412698412698, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786668, Length=334, Percent_Identity=33.2335329341317, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87081951, Length=174, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081796, Length=324, Percent_Identity=28.0864197530864, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43408; Mature: 43408

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSNIRRWGAALAVVIIAGAAYWFWHDRGTSGSGAPAAGQGPQGPGGARHGRFGAALAP
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
VQAATATEEAVPRYLTGLGTVTAANTVTVRSRVDGQLLSLHFQEGQQVKAGDLLAQIDPS
HHHHHCCHHHHHHHHHHCCCEEECCEEEEECCCCCEEEEEEECCCCEECCCCEEEEECHH
QFKVALAQAQGQLAKDQATLANARRDLARYQQLVKTNLVSRQELDTQQSLVVESAGTVKA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCC
DEAAVASAQLQLDWTRITAPIDGRVGLKQVDIGNQISSGDTTGIVVLTQTHPIDVVFTLP
CCHHEEEEEEEEEEEEEEECCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCEEEEEECC
ESSIATVVQAQKAGKTLSVEAWDRTNKQKVSVGELLSLDNQIDATTGTIKLKARFSNLDD
CCHHHHHHHHHHCCCEEEEEECCCCCCCEECHHHHHHCCCCCCCCCCEEEEEEECCCCCC
ALFPNQFVNARLLVDTQQNAVVIPAAALQMGNEGHFVWVLNDENKVSKHSVTPGIQDSQK
CCCCCHHCCEEEEEECCCCEEEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCE
VVISAGLSAGDRVVTDGIDRLTEGAKVEVVTASSGEQAQPAPRQSGKHGARS
EEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKGSNIRRWGAALAVVIIAGAAYWFWHDRGTSGSGAPAAGQGPQGPGGARHGRFGAALAP
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
VQAATATEEAVPRYLTGLGTVTAANTVTVRSRVDGQLLSLHFQEGQQVKAGDLLAQIDPS
HHHHHCCHHHHHHHHHHCCCEEECCEEEEECCCCCEEEEEEECCCCEECCCCEEEEECHH
QFKVALAQAQGQLAKDQATLANARRDLARYQQLVKTNLVSRQELDTQQSLVVESAGTVKA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCC
DEAAVASAQLQLDWTRITAPIDGRVGLKQVDIGNQISSGDTTGIVVLTQTHPIDVVFTLP
CCHHEEEEEEEEEEEEEEECCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCEEEEEECC
ESSIATVVQAQKAGKTLSVEAWDRTNKQKVSVGELLSLDNQIDATTGTIKLKARFSNLDD
CCHHHHHHHHHHCCCEEEEEECCCCCCCEECHHHHHHCCCCCCCCCCEEEEEEECCCCCC
ALFPNQFVNARLLVDTQQNAVVIPAAALQMGNEGHFVWVLNDENKVSKHSVTPGIQDSQK
CCCCCHHCCEEEEEECCCCEEEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCE
VVISAGLSAGDRVVTDGIDRLTEGAKVEVVTASSGEQAQPAPRQSGKHGARS
EEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA