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The map label for this gene is wzc [H]

Identifier: 238895629

GI number: 238895629

Start: 3538377

End: 3540530

Strand: Reverse

Name: wzc [H]

Synonym: KP1_3718

Alternate gene names: 238895629

Gene position: 3540530-3538377 (Counterclockwise)

Preceding gene: 238895630

Following gene: 238895628

Centisome position: 67.46

GC content: 35.98

Gene sequence:

>2154_bases
ATGACTGATAAACTTAATTCAATGTCTACAGGAAGCCAAGAAAGTGACGGGATCGATCTAGGTCGTTTAATTGGTGAAGT
TATTGATCATAAAGGATTGATAATTTCTGTAACTTTCTTTTTTATGGGGCTAGGTTTTTTATATGCATTTTTAGCTCCAC
CCGTATATGAAGCAGATTCATTAGTGCAGGTTGAACAAAATGCAGGAAATAATTTTTTATCGAGCCTTTCTGACGTTCTT
CCAACAACACCGCCTCAATCAGCAGCTGAAATTGAACTAATTAAATCTAGGATGGTGCTTGGTAAAACTATCAATGATTT
AAATCTGAGCGTAGTAATTGAAGAGAAAACTACGCCTATTATAGGTCAGTTTTTAAAGAAAATACGTGGTGATGACGGCA
GTAAAATAAATGTAAAATATTTTAATGTCCCTCATGATGCGTTAGACACGAAGTTTACAATCAAAATAACTGGTAAAGAC
AGCTATACCATTAATCTTGATGATGCCGGCGAATTGAAAGGTCAAGTTAATGAGCCCGTATCGAAAAATGGATTCGAAAT
ATTGCTGACGCAAATTGAGTCTCCGCCAGGTACTGAATTTAGTATAAAACGCAAAGATACTCTTCAAGTACTCAGTGATC
TTAATGACGCATTCACTGTCGCAGATACTGGAAAAGATACAGGTGTATTGTCGCTATCATTAACAGGAAATGATCCTGAA
AAAATAAAGACGATACTTCAAAGTATTACTGATAATTATTTGTTACAGAATATTGAGAGAAAATCGGAAGAGGCAGCAAA
AAGTTTAAACTTTTTGGATCGAAAAATCCCTGATGTAAAAAATGAGCTTAATGCTGCAGAAAATAAGCTAAATTATTACA
GACAGCAAAATAGTTCTGTTGATTTAACTATGGAGGCAAAATCTCTTCTGGATACAATGGTTCAATTAGATGCGCAGATT
AATCAACTAACATTTTCTGAGGCCGAAGTATCCAAACTATATACAAAAGAGCATCCAACATATAGAGCTCTTTTAGAAAA
AAGAAAAACTCTGGAAGAAGAAAAAAATAATCTTAAGAAAAAGATTAATAATCTTCCAGAAACACAACAAGAAGTATTAC
GTTTAACTCGTGATGTCCAGGTTGGGCAAGATGTCTATTTACAACTATTAAACAAAGAACAAGAATTGAGCATTACTAAA
GCAAGTACAGTGGGTAATGTTCGAATAATTGATAATGCCGTAACACAGCCCGATCCAATCAAACCTAAAAAGCTGCTTGT
AATAGTCGTTCTAACGGTGTTTGGAACAATGCTGTCCTTGATGTATGTCATAGTTAAGGTTGCGTTCCATAAAGGTGTTC
AAAGTGCCGAACAACTTGAAGAAAATGGTTTGAATGTGTACGCGAGTATCCCTTTATCTGACTGGCAGTTGAAAAATGTA
AACAACAGCAGGAAAAAGGATAAGAAAAAATTTGATGTATTAATTAAGGAGAATGGTGCAGATTTAGCTATTGAAGCTAT
TAGAGGGTTACGGACGCGTTTATATTTCGCAATGTTAGAAGCGAAAAATAATATTTTAATGATATCAGGTCCAAGTCCTG
AAATAGGCAAAACCTTCGTCAGTACTAACCTTGCAGGGGTAGTTGCTCAGGCAGGACAAAAAGTTTTATTAATTGATGCA
GATATGCGACGAGGATATATGCATCACTACTTTGGCGGTTTGCCCAACAATGGCTTGTCAGAGATACTCACAGGTAGGGT
AGATTACGAGAAGGCTGTTGTTCATACTGATATAGCTGGCTTAGATTACATTGGTCGTGGTGAAATACCACCAAATCCAG
CGGAGCTATTAATGGGGAGTCGCATTGAAAAGTTCCTTGAGTGGGCAAGTGGAAAGTATGATCTTGTATTAGTAGACACT
CCGCCAATTTTAGCAGTGACCGATGCTGCAATAATTGGTCGCCATGTAGGAACCACATTATTAGTTGCTCGCTTTGAAAA
AAACACTGTCAAAGAAATCGATGTTGCTAAAAATAGATTGGAACATAGCGGTGTTATAGTTAAAGGCGTAATATTAAATG
CTGTGACCAGAAAAGCTAGTAATAAATATGGTGAATATGCGTATTATGAATACGAGTATAAATCGAAAGAATAG

Upstream 100 bases:

>100_bases
TATATGAAAAGTAAAGAAGCGTTCGAATCTGTATATAAACTTCTCGACGAATCAGCTCAAAAATGGGCAGACGTCTTAAT
TAAATAGTGCAGGGTATCAG

Downstream 100 bases:

>100_bases
ATAAGCTAAATTAATTTCCCGGGTTTAATACAAACCCGGGTAAATTTAATTTACTTAAGGACTGGGTGTGAATAAAAGAA
TACTAAGCATGCTATTATCA

Product: inner membrane tyrosine autokinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MTDKLNSMSTGSQESDGIDLGRLIGEVIDHKGLIISVTFFFMGLGFLYAFLAPPVYEADSLVQVEQNAGNNFLSSLSDVL
PTTPPQSAAEIELIKSRMVLGKTINDLNLSVVIEEKTTPIIGQFLKKIRGDDGSKINVKYFNVPHDALDTKFTIKITGKD
SYTINLDDAGELKGQVNEPVSKNGFEILLTQIESPPGTEFSIKRKDTLQVLSDLNDAFTVADTGKDTGVLSLSLTGNDPE
KIKTILQSITDNYLLQNIERKSEEAAKSLNFLDRKIPDVKNELNAAENKLNYYRQQNSSVDLTMEAKSLLDTMVQLDAQI
NQLTFSEAEVSKLYTKEHPTYRALLEKRKTLEEEKNNLKKKINNLPETQQEVLRLTRDVQVGQDVYLQLLNKEQELSITK
ASTVGNVRIIDNAVTQPDPIKPKKLLVIVVLTVFGTMLSLMYVIVKVAFHKGVQSAEQLEENGLNVYASIPLSDWQLKNV
NNSRKKDKKKFDVLIKENGADLAIEAIRGLRTRLYFAMLEAKNNILMISGPSPEIGKTFVSTNLAGVVAQAGQKVLLIDA
DMRRGYMHHYFGGLPNNGLSEILTGRVDYEKAVVHTDIAGLDYIGRGEIPPNPAELLMGSRIEKFLEWASGKYDLVLVDT
PPILAVTDAAIIGRHVGTTLLVARFEKNTVKEIDVAKNRLEHSGVIVKGVILNAVTRKASNKYGEYAYYEYEYKSKE

Sequences:

>Translated_717_residues
MTDKLNSMSTGSQESDGIDLGRLIGEVIDHKGLIISVTFFFMGLGFLYAFLAPPVYEADSLVQVEQNAGNNFLSSLSDVL
PTTPPQSAAEIELIKSRMVLGKTINDLNLSVVIEEKTTPIIGQFLKKIRGDDGSKINVKYFNVPHDALDTKFTIKITGKD
SYTINLDDAGELKGQVNEPVSKNGFEILLTQIESPPGTEFSIKRKDTLQVLSDLNDAFTVADTGKDTGVLSLSLTGNDPE
KIKTILQSITDNYLLQNIERKSEEAAKSLNFLDRKIPDVKNELNAAENKLNYYRQQNSSVDLTMEAKSLLDTMVQLDAQI
NQLTFSEAEVSKLYTKEHPTYRALLEKRKTLEEEKNNLKKKINNLPETQQEVLRLTRDVQVGQDVYLQLLNKEQELSITK
ASTVGNVRIIDNAVTQPDPIKPKKLLVIVVLTVFGTMLSLMYVIVKVAFHKGVQSAEQLEENGLNVYASIPLSDWQLKNV
NNSRKKDKKKFDVLIKENGADLAIEAIRGLRTRLYFAMLEAKNNILMISGPSPEIGKTFVSTNLAGVVAQAGQKVLLIDA
DMRRGYMHHYFGGLPNNGLSEILTGRVDYEKAVVHTDIAGLDYIGRGEIPPNPAELLMGSRIEKFLEWASGKYDLVLVDT
PPILAVTDAAIIGRHVGTTLLVARFEKNTVKEIDVAKNRLEHSGVIVKGVILNAVTRKASNKYGEYAYYEYEYKSKE
>Mature_716_residues
TDKLNSMSTGSQESDGIDLGRLIGEVIDHKGLIISVTFFFMGLGFLYAFLAPPVYEADSLVQVEQNAGNNFLSSLSDVLP
TTPPQSAAEIELIKSRMVLGKTINDLNLSVVIEEKTTPIIGQFLKKIRGDDGSKINVKYFNVPHDALDTKFTIKITGKDS
YTINLDDAGELKGQVNEPVSKNGFEILLTQIESPPGTEFSIKRKDTLQVLSDLNDAFTVADTGKDTGVLSLSLTGNDPEK
IKTILQSITDNYLLQNIERKSEEAAKSLNFLDRKIPDVKNELNAAENKLNYYRQQNSSVDLTMEAKSLLDTMVQLDAQIN
QLTFSEAEVSKLYTKEHPTYRALLEKRKTLEEEKNNLKKKINNLPETQQEVLRLTRDVQVGQDVYLQLLNKEQELSITKA
STVGNVRIIDNAVTQPDPIKPKKLLVIVVLTVFGTMLSLMYVIVKVAFHKGVQSAEQLEENGLNVYASIPLSDWQLKNVN
NSRKKDKKKFDVLIKENGADLAIEAIRGLRTRLYFAMLEAKNNILMISGPSPEIGKTFVSTNLAGVVAQAGQKVLLIDAD
MRRGYMHHYFGGLPNNGLSEILTGRVDYEKAVVHTDIAGLDYIGRGEIPPNPAELLMGSRIEKFLEWASGKYDLVLVDTP
PILAVTDAAIIGRHVGTTLLVARFEKNTVKEIDVAKNRLEHSGVIVKGVILNAVTRKASNKYGEYAYYEYEYKSKE

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=720, Percent_Identity=51.1111111111111, Blast_Score=751, Evalue=0.0,
Organism=Escherichia coli, GI1787216, Length=709, Percent_Identity=48.5190409026798, Blast_Score=712, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 79709; Mature: 79578

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKLNSMSTGSQESDGIDLGRLIGEVIDHKGLIISVTFFFMGLGFLYAFLAPPVYEADS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCC
LVQVEQNAGNNFLSSLSDVLPTTPPQSAAEIELIKSRMVLGKTINDLNLSVVIEEKTTPI
CEEEHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHH
IGQFLKKIRGDDGSKINVKYFNVPHDALDTKFTIKITGKDSYTINLDDAGELKGQVNEPV
HHHHHHHHCCCCCCEEEEEEEECCCHHHCCEEEEEEECCCEEEEECCCCHHCCCCCCCCC
SKNGFEILLTQIESPPGTEFSIKRKDTLQVLSDLNDAFTVADTGKDTGVLSLSLTGNDPE
CCCCCEEEEEECCCCCCCCEEECHHHHHHHHHCCCCCEEEECCCCCCEEEEEEECCCCHH
KIKTILQSITDNYLLQNIERKSEEAAKSLNFLDRKIPDVKNELNAAENKLNYYRQQNSSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
DLTMEAKSLLDTMVQLDAQINQLTFSEAEVSKLYTKEHPTYRALLEKRKTLEEEKNNLKK
EEEEHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KINNLPETQQEVLRLTRDVQVGQDVYLQLLNKEQELSITKASTVGNVRIIDNAVTQPDPI
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCEEEECCCCCCEEEEECCCCCCCCC
KPKKLLVIVVLTVFGTMLSLMYVIVKVAFHKGVQSAEQLEENGLNVYASIPLSDWQLKNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEEECCCCCCEECCC
NNSRKKDKKKFDVLIKENGADLAIEAIRGLRTRLYFAMLEAKNNILMISGPSPEIGKTFV
CCHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
STNLAGVVAQAGQKVLLIDADMRRGYMHHYFGGLPNNGLSEILTGRVDYEKAVVHTDIAG
HHHHHHHHHHCCCEEEEEECHHHHCHHHHHCCCCCCCCHHHHHCCCCCHHHHHHEECCCC
LDYIGRGEIPPNPAELLMGSRIEKFLEWASGKYDLVLVDTPPILAVTDAAIIGRHVGTTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHH
LVARFEKNTVKEIDVAKNRLEHSGVIVKGVILNAVTRKASNKYGEYAYYEYEYKSKE
HEEHHCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCCCEEEEEEEECCCC
>Mature Secondary Structure 
TDKLNSMSTGSQESDGIDLGRLIGEVIDHKGLIISVTFFFMGLGFLYAFLAPPVYEADS
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCC
LVQVEQNAGNNFLSSLSDVLPTTPPQSAAEIELIKSRMVLGKTINDLNLSVVIEEKTTPI
CEEEHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHH
IGQFLKKIRGDDGSKINVKYFNVPHDALDTKFTIKITGKDSYTINLDDAGELKGQVNEPV
HHHHHHHHCCCCCCEEEEEEEECCCHHHCCEEEEEEECCCEEEEECCCCHHCCCCCCCCC
SKNGFEILLTQIESPPGTEFSIKRKDTLQVLSDLNDAFTVADTGKDTGVLSLSLTGNDPE
CCCCCEEEEEECCCCCCCCEEECHHHHHHHHHCCCCCEEEECCCCCCEEEEEEECCCCHH
KIKTILQSITDNYLLQNIERKSEEAAKSLNFLDRKIPDVKNELNAAENKLNYYRQQNSSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
DLTMEAKSLLDTMVQLDAQINQLTFSEAEVSKLYTKEHPTYRALLEKRKTLEEEKNNLKK
EEEEHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KINNLPETQQEVLRLTRDVQVGQDVYLQLLNKEQELSITKASTVGNVRIIDNAVTQPDPI
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCEEEECCCCCCEEEEECCCCCCCCC
KPKKLLVIVVLTVFGTMLSLMYVIVKVAFHKGVQSAEQLEENGLNVYASIPLSDWQLKNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEEECCCCCCEECCC
NNSRKKDKKKFDVLIKENGADLAIEAIRGLRTRLYFAMLEAKNNILMISGPSPEIGKTFV
CCHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
STNLAGVVAQAGQKVLLIDADMRRGYMHHYFGGLPNNGLSEILTGRVDYEKAVVHTDIAG
HHHHHHHHHHCCCEEEEEECHHHHCHHHHHCCCCCCCCHHHHHCCCCCHHHHHHEECCCC
LDYIGRGEIPPNPAELLMGSRIEKFLEWASGKYDLVLVDTPPILAVTDAAIIGRHVGTTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHH
LVARFEKNTVKEIDVAKNRLEHSGVIVKGVILNAVTRKASNKYGEYAYYEYEYKSKE
HEEHHCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]