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The map label for this gene is virB3-4 [H]

Identifier: 238895546

GI number: 238895546

Start: 3450241

End: 3452979

Strand: Direct

Name: virB3-4 [H]

Synonym: KP1_3628

Alternate gene names: 238895546

Gene position: 3450241-3452979 (Clockwise)

Preceding gene: 238895545

Following gene: 238895547

Centisome position: 65.74

GC content: 52.9

Gene sequence:

>2739_bases
ATGGCAAAGCTGCTCAAGGCAATGAAACGCCCGGCGGCGCTGTGGGGGGTGCCTATGGTGCCCCTGCTGGCTGTCACGGG
TGTAACCATCATCGTTGCTGTCTGGACTTCCGTCGCACTCCTGTTCTTACTTCCCGTCGAATTTCTGGTGATGAAATCCC
TCACCAGAAATGAACCAATGCGGTTCAATCTGATTGCCGTTTGGCTGAGAGTGAAGGGAAAACCGGTAGCAAACCGTTTA
TTTGGTGCAACAACACTTATGCCCGTTGAGCATGAGGCTGTTGATATCAAGGAGTTTATAGACGCCATGAAACTAAATCA
GTGTGCCACCATCAAGAAGTATATTCCGTACTCATCGCACATTCATCAGCATGTGGTTCGCTCACCTAAAAGCGATCTGT
ACTGCACCTGGGAATTGATGGGAACGCCGTTCGACTGCGAGTCTGACGAATCACTCCAGTTCGGGACGAACCAGTTACAC
GGGCTAATCCACTCATTCGAAGGTATGCCCGTCACTTTCTATATCCATAACGACCGCAATACGTTTACCGACAATCTTCA
TAAAGATTCCGGCAACCCGTATGCCGATGAAGTTAGCCGTCTTTACTACGCTTCTGTCGGGGTGTTCCGGCGTAACCGCC
TGTTCCTGACAGTCTGCTATCGCCCGTTTGTCAGCCTTGAAAAAGCAGAACGCAAACGGATGAAAGACAGCCAGAAACTA
AAGGAACTGGACGGTGCTTTGCTGGAAATGCTGGAAATAAAAAGCACGCTCGATACCGCGCTGTCGCGCTATGGTGCGCG
GCCTCTCGGTACGTTTACCGAAGGAAGCGCGGTGTTTTCGTCGCAACTGGCTTTCTATGAATATCTGCTAACGCATCAGT
GGCGAAAGGTGCGCGTCACCCGCACCCCGGCCTATGACGTGATGGGAGCGGCGGCGTTGTTCTTTTCGGCTGAATCCGGG
CAGATAAACCACGCCAACGGTACGCAATATTTCCGGGGGCTGGAGGTTAAAGAGTTCTCCGAAGAGACCGCCACGGGGAT
GATGGACTCCCTTCTTTACGCCCCCTGCGATTACGTGATTACGCAGTCCTATACCTGCATGTCACGCGAGGAAGCGAAGA
AAGCCATTAAGCGTACCCGTCGCCTTTTGATGAGTGCCGACGACGATGCTGTTTCCCAGCGGCTGGATCTGGATGTGGCG
CTTGACCTGCTGGCATCGGGGAAAATCGCTTACGGAAAGCACCATTTTTCCATCATGGTGTATTCCCCGTCGCTGGAAAG
CCTGGTTGCTGATACTAACGAAATCAGTAACGCGCTGAACAACATCGGGATAACGCCTGTTCCGGCAGAAATATCGCTTT
CAGCGGCGTATATGGCGCAACTGCCAGGCAACTACAACCTGCGGCCACGTAAAGGGGAGCTGAGTAGCCAGAACTTTGTG
GAGCTGGCCGCGCTCCATAATTTCTATCCGGGCAAGCGCGATAAAGCCCCCTGGGGGGATGCGATGGCCTTACTGCGCAC
CCCGTCAGGCGATGGCTACTATATCAACCTGCATAACACACTGGCAGATAAGGACGAATTCAACGAAAAGAACCCGGCCA
GTACCTGCATCCTCGGTACGAACGGTTCGGGTAAAACCATGTTGATGACGTTCTTTGAGATCATGCAGCAGAAATACGGG
CGTGAGGATAGCTTCTCCCCGGATGCCAAAACCAAACGGCTGACAACCGTTTACCTCGATAAAGACCGGGGCGCAGAGAT
GAACATCCGGGCGCTGGGTGGCCGTTACTATCGGGTTATCAGTGGTGAGTCTACAGGGTGGAACCCGTTCTCGTTGCCAG
CAACCAAACGCAATATCAATTTCATCAAGCAACTGATGAAAATCCTTTGTACCCGCAACGGCTCGACGATCTCCCCACGC
GATGAACGCCGTCTGAGTGATGCGGTTAATGCTGTGATGAATGACGAGCCACAATATCGCGTCTACGGCATTACCCGAAT
GCTGGAGAATTTGCCTGAGCCGGCTACGAAAGAAGCCCAGGAAAACGGCCTTAGCATTCGGTTGTCACAGTGGGCGCAGG
GCGGTGAGTTCGGCTGGGTGTTTGATAACGAGTCTGACACGTTCGATATCAGCAACTGCGATAACTTCGGCATCGACGGA
ACGGAGTTCCTGGACGATGCAAGCGTATGTGCGCCAATCTCGTTTTATCTGCTGTACCGCATTACCAGCCTGCTTGACGG
GCGACGCCTGGTCATTTTCATGGATGAATTCTGGAAGTGGTTACGCGACCCGGTGTTTAAGGACTTTGCTTATAACAAGC
TGAAAACCATCCGTAAGCTGAACGGGATGCTGGTCGTCGGTACTCAATCCCCGGCAGAGATCATCAAAGATGATATCGCC
CCGGCAGTGATTGAGCAGTGCGGGACACAGATTCTGGCGGCGAACCCCAACGCCGACCGCGCACACTATGTTGACGGTAT
GAAGTTTGAGCTGGAAGTGTTCGACGTGGTGAAAGGGCTTGACCCGCAATCCCGCCAGTATGTTGTGGTGAAAAATCAGT
TCAAACGCGGCGATACCAAACGTTTTGCCGCTCGTATCACGCTCGACCTGTCGGGTATCGGCAGACACACCAAAGTCATG
AGCGGCGATGCCCCCAACCTCGAAATATTCGAATCGATTTACCGGGAAGGAATGCAGCCTCATGAATGGCTCGATACCTA
CCTGGCTAAAGCGCTCTGA

Upstream 100 bases:

>100_bases
CGAGAGCCTGTCGCAGTGCGGCTACATCATCATTGGCGGCATTTTAATTGGCGGAGGCAGTGAAATCGGCGCTCTGCTGA
TGAGCTAAGAGGCTGAACAT

Downstream 100 bases:

>100_bases
CCCAAAGGAGATATCCGATGAAAACTCGCTTTCGTACTCTTATTCTGGCTTGTTTCATTGCAAGCCCACTGGCTCATGCT
GGTATTCCCGTCGCTGTTGA

Product: type IV secretory pathway VirB3-4 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 912; Mature: 911

Protein sequence:

>912_residues
MAKLLKAMKRPAALWGVPMVPLLAVTGVTIIVAVWTSVALLFLLPVEFLVMKSLTRNEPMRFNLIAVWLRVKGKPVANRL
FGATTLMPVEHEAVDIKEFIDAMKLNQCATIKKYIPYSSHIHQHVVRSPKSDLYCTWELMGTPFDCESDESLQFGTNQLH
GLIHSFEGMPVTFYIHNDRNTFTDNLHKDSGNPYADEVSRLYYASVGVFRRNRLFLTVCYRPFVSLEKAERKRMKDSQKL
KELDGALLEMLEIKSTLDTALSRYGARPLGTFTEGSAVFSSQLAFYEYLLTHQWRKVRVTRTPAYDVMGAAALFFSAESG
QINHANGTQYFRGLEVKEFSEETATGMMDSLLYAPCDYVITQSYTCMSREEAKKAIKRTRRLLMSADDDAVSQRLDLDVA
LDLLASGKIAYGKHHFSIMVYSPSLESLVADTNEISNALNNIGITPVPAEISLSAAYMAQLPGNYNLRPRKGELSSQNFV
ELAALHNFYPGKRDKAPWGDAMALLRTPSGDGYYINLHNTLADKDEFNEKNPASTCILGTNGSGKTMLMTFFEIMQQKYG
REDSFSPDAKTKRLTTVYLDKDRGAEMNIRALGGRYYRVISGESTGWNPFSLPATKRNINFIKQLMKILCTRNGSTISPR
DERRLSDAVNAVMNDEPQYRVYGITRMLENLPEPATKEAQENGLSIRLSQWAQGGEFGWVFDNESDTFDISNCDNFGIDG
TEFLDDASVCAPISFYLLYRITSLLDGRRLVIFMDEFWKWLRDPVFKDFAYNKLKTIRKLNGMLVVGTQSPAEIIKDDIA
PAVIEQCGTQILAANPNADRAHYVDGMKFELEVFDVVKGLDPQSRQYVVVKNQFKRGDTKRFAARITLDLSGIGRHTKVM
SGDAPNLEIFESIYREGMQPHEWLDTYLAKAL

Sequences:

>Translated_912_residues
MAKLLKAMKRPAALWGVPMVPLLAVTGVTIIVAVWTSVALLFLLPVEFLVMKSLTRNEPMRFNLIAVWLRVKGKPVANRL
FGATTLMPVEHEAVDIKEFIDAMKLNQCATIKKYIPYSSHIHQHVVRSPKSDLYCTWELMGTPFDCESDESLQFGTNQLH
GLIHSFEGMPVTFYIHNDRNTFTDNLHKDSGNPYADEVSRLYYASVGVFRRNRLFLTVCYRPFVSLEKAERKRMKDSQKL
KELDGALLEMLEIKSTLDTALSRYGARPLGTFTEGSAVFSSQLAFYEYLLTHQWRKVRVTRTPAYDVMGAAALFFSAESG
QINHANGTQYFRGLEVKEFSEETATGMMDSLLYAPCDYVITQSYTCMSREEAKKAIKRTRRLLMSADDDAVSQRLDLDVA
LDLLASGKIAYGKHHFSIMVYSPSLESLVADTNEISNALNNIGITPVPAEISLSAAYMAQLPGNYNLRPRKGELSSQNFV
ELAALHNFYPGKRDKAPWGDAMALLRTPSGDGYYINLHNTLADKDEFNEKNPASTCILGTNGSGKTMLMTFFEIMQQKYG
REDSFSPDAKTKRLTTVYLDKDRGAEMNIRALGGRYYRVISGESTGWNPFSLPATKRNINFIKQLMKILCTRNGSTISPR
DERRLSDAVNAVMNDEPQYRVYGITRMLENLPEPATKEAQENGLSIRLSQWAQGGEFGWVFDNESDTFDISNCDNFGIDG
TEFLDDASVCAPISFYLLYRITSLLDGRRLVIFMDEFWKWLRDPVFKDFAYNKLKTIRKLNGMLVVGTQSPAEIIKDDIA
PAVIEQCGTQILAANPNADRAHYVDGMKFELEVFDVVKGLDPQSRQYVVVKNQFKRGDTKRFAARITLDLSGIGRHTKVM
SGDAPNLEIFESIYREGMQPHEWLDTYLAKAL
>Mature_911_residues
AKLLKAMKRPAALWGVPMVPLLAVTGVTIIVAVWTSVALLFLLPVEFLVMKSLTRNEPMRFNLIAVWLRVKGKPVANRLF
GATTLMPVEHEAVDIKEFIDAMKLNQCATIKKYIPYSSHIHQHVVRSPKSDLYCTWELMGTPFDCESDESLQFGTNQLHG
LIHSFEGMPVTFYIHNDRNTFTDNLHKDSGNPYADEVSRLYYASVGVFRRNRLFLTVCYRPFVSLEKAERKRMKDSQKLK
ELDGALLEMLEIKSTLDTALSRYGARPLGTFTEGSAVFSSQLAFYEYLLTHQWRKVRVTRTPAYDVMGAAALFFSAESGQ
INHANGTQYFRGLEVKEFSEETATGMMDSLLYAPCDYVITQSYTCMSREEAKKAIKRTRRLLMSADDDAVSQRLDLDVAL
DLLASGKIAYGKHHFSIMVYSPSLESLVADTNEISNALNNIGITPVPAEISLSAAYMAQLPGNYNLRPRKGELSSQNFVE
LAALHNFYPGKRDKAPWGDAMALLRTPSGDGYYINLHNTLADKDEFNEKNPASTCILGTNGSGKTMLMTFFEIMQQKYGR
EDSFSPDAKTKRLTTVYLDKDRGAEMNIRALGGRYYRVISGESTGWNPFSLPATKRNINFIKQLMKILCTRNGSTISPRD
ERRLSDAVNAVMNDEPQYRVYGITRMLENLPEPATKEAQENGLSIRLSQWAQGGEFGWVFDNESDTFDISNCDNFGIDGT
EFLDDASVCAPISFYLLYRITSLLDGRRLVIFMDEFWKWLRDPVFKDFAYNKLKTIRKLNGMLVVGTQSPAEIIKDDIAP
AVIEQCGTQILAANPNADRAHYVDGMKFELEVFDVVKGLDPQSRQYVVVKNQFKRGDTKRFAARITLDLSGIGRHTKVMS
GDAPNLEIFESIYREGMQPHEWLDTYLAKAL

Specific function: The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice [H]

COG id: COG3451

COG function: function code U; Type IV secretory pathway, VirB4 components

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbE/virB4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004346
- InterPro:   IPR018145 [H]

Pfam domain/function: PF03135 CagE_TrbE_VirB [H]

EC number: NA

Molecular weight: Translated: 102966; Mature: 102835

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLKAMKRPAALWGVPMVPLLAVTGVTIIVAVWTSVALLFLLPVEFLVMKSLTRNEPM
CHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RFNLIAVWLRVKGKPVANRLFGATTLMPVEHEAVDIKEFIDAMKLNQCATIKKYIPYSSH
EEEEEEEEEEECCCCHHHHHHCCEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
IHQHVVRSPKSDLYCTWELMGTPFDCESDESLQFGTNQLHGLIHSFEGMPVTFYIHNDRN
HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCC
TFTDNLHKDSGNPYADEVSRLYYASVGVFRRNRLFLTVCYRPFVSLEKAERKRMKDSQKL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHHH
KELDGALLEMLEIKSTLDTALSRYGARPLGTFTEGSAVFSSQLAFYEYLLTHQWRKVRVT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
RTPAYDVMGAAALFFSAESGQINHANGTQYFRGLEVKEFSEETATGMMDSLLYAPCDYVI
ECCCHHHHHHHHHEEECCCCCEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHH
TQSYTCMSREEAKKAIKRTRRLLMSADDDAVSQRLDLDVALDLLASGKIAYGKHHFSIMV
HCCCHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCEEECCEEEEEEE
YSPSLESLVADTNEISNALNNIGITPVPAEISLSAAYMAQLPGNYNLRPRKGELSSQNFV
ECCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
ELAALHNFYPGKRDKAPWGDAMALLRTPSGDGYYINLHNTLADKDEFNEKNPASTCILGT
HHHHHHHCCCCCCCCCCCCHHEEEEECCCCCEEEEEECCCCCCHHHCCCCCCCCEEEEEC
NGSGKTMLMTFFEIMQQKYGREDSFSPDAKTKRLTTVYLDKDRGAEMNIRALGGRYYRVI
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCEEEEEE
SGESTGWNPFSLPATKRNINFIKQLMKILCTRNGSTISPRDERRLSDAVNAVMNDEPQYR
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
VYGITRMLENLPEPATKEAQENGLSIRLSQWAQGGEFGWVFDNESDTFDISNCDNFGIDG
EHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCEEEEECCCCCEEECCCCCCCCCCC
TEFLDDASVCAPISFYLLYRITSLLDGRRLVIFMDEFWKWLRDPVFKDFAYNKLKTIRKL
HHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHH
NGMLVVGTQSPAEIIKDDIAPAVIEQCGTQILAANPNADRAHYVDGMKFELEVFDVVKGL
CCEEEEECCCHHHHHHHHCCHHHHHHCCCEEEEECCCCCCHHCCCCCEEEEEHHHHHHCC
DPQSRQYVVVKNQFKRGDTKRFAARITLDLSGIGRHTKVMSGDAPNLEIFESIYREGMQP
CCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCHHHHHHHHHCCCCH
HEWLDTYLAKAL
HHHHHHHHHHCC
>Mature Secondary Structure 
AKLLKAMKRPAALWGVPMVPLLAVTGVTIIVAVWTSVALLFLLPVEFLVMKSLTRNEPM
HHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RFNLIAVWLRVKGKPVANRLFGATTLMPVEHEAVDIKEFIDAMKLNQCATIKKYIPYSSH
EEEEEEEEEEECCCCHHHHHHCCEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
IHQHVVRSPKSDLYCTWELMGTPFDCESDESLQFGTNQLHGLIHSFEGMPVTFYIHNDRN
HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCC
TFTDNLHKDSGNPYADEVSRLYYASVGVFRRNRLFLTVCYRPFVSLEKAERKRMKDSQKL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHHH
KELDGALLEMLEIKSTLDTALSRYGARPLGTFTEGSAVFSSQLAFYEYLLTHQWRKVRVT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
RTPAYDVMGAAALFFSAESGQINHANGTQYFRGLEVKEFSEETATGMMDSLLYAPCDYVI
ECCCHHHHHHHHHEEECCCCCEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHH
TQSYTCMSREEAKKAIKRTRRLLMSADDDAVSQRLDLDVALDLLASGKIAYGKHHFSIMV
HCCCHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCEEECCEEEEEEE
YSPSLESLVADTNEISNALNNIGITPVPAEISLSAAYMAQLPGNYNLRPRKGELSSQNFV
ECCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
ELAALHNFYPGKRDKAPWGDAMALLRTPSGDGYYINLHNTLADKDEFNEKNPASTCILGT
HHHHHHHCCCCCCCCCCCCHHEEEEECCCCCEEEEEECCCCCCHHHCCCCCCCCEEEEEC
NGSGKTMLMTFFEIMQQKYGREDSFSPDAKTKRLTTVYLDKDRGAEMNIRALGGRYYRVI
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCEEEEEE
SGESTGWNPFSLPATKRNINFIKQLMKILCTRNGSTISPRDERRLSDAVNAVMNDEPQYR
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
VYGITRMLENLPEPATKEAQENGLSIRLSQWAQGGEFGWVFDNESDTFDISNCDNFGIDG
EHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCEEEEECCCCCEEECCCCCCCCCCC
TEFLDDASVCAPISFYLLYRITSLLDGRRLVIFMDEFWKWLRDPVFKDFAYNKLKTIRKL
HHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHH
NGMLVVGTQSPAEIIKDDIAPAVIEQCGTQILAANPNADRAHYVDGMKFELEVFDVVKGL
CCEEEEECCCHHHHHHHHCCHHHHHHCCCEEEEECCCCCCHHCCCCCEEEEEHHHHHHCC
DPQSRQYVVVKNQFKRGDTKRFAARITLDLSGIGRHTKVMSGDAPNLEIFESIYREGMQP
CCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCHHHHHHHHHCCCCH
HEWLDTYLAKAL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10940027 [H]