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The map label for this gene is iroD [H]

Identifier: 238895534

GI number: 238895534

Start: 3441637

End: 3442866

Strand: Direct

Name: iroD [H]

Synonym: KP1_3613

Alternate gene names: 238895534

Gene position: 3441637-3442866 (Clockwise)

Preceding gene: 238895533

Following gene: 238895537

Centisome position: 65.57

GC content: 57.64

Gene sequence:

>1230_bases
ATGCTGAACATGCAACAACATCCCTCAGCTATCGCCAGGTTGCGTAGCCAACTGGCAGCAGGCCACATTGCTAACGTTTC
TGACTTCTGGCGCGACGCTGAATCGCTGAATGGACCGCTGGTGATGCCGGTCGAAGGGGCGGAAGACGAGCGTGAAGTGA
CCTTTCTGTGGCGTGCCTGGCACTCTCTGCAGGGCGTATATCTGCGTCTGAATCGGGTAACGGATAAAGAGCACGTAGCA
AAAGGCATGATGACCCCCCTTCCCGGGACGGATATCTGGACACTAACGCTGCGTTTACCCGCAAGTTACTGCGGCTCCTA
TTCGCTGGTAGAAATCCCCCTCGGCACTCCGGCCAAGATGATTGCACAGGCCGGAGGCCGCTTTGCCGCTCTCCCCGGGC
ACGCCGATCCGCTAAACAAAACGCCAAGAATTAGCGTTCGGGGAAGCTCACAGGAATCGGTGCTGACGCTCGATAAAGCC
CCCGCCCAGCCCGAATGGAGCGGCGGCTCACCCACAGGGCAATTGCTTACCTCCTCGCGCATAATCGCCGGGCAATCGCG
CCGGGTTCAGCTTTATATGCCGGACGTTGATGTTTTGCAGCCCCTGGGCCTAGTGGTGCTGCCCGATGGTGAAACGTGGT
TCGATCATCTAGGAGTATGCGCGGCAATTGACGCTGCTATAAACAACGGACGCATCGTTCCCGTAGCTATAATGGGCATC
GACAACATCGATGAACACGAGCGCAATGCGATACTTGGCGGGCGCAGCGAACTGATAACGGATATTGCCAGGCATCTACT
GCCGACTATTCGTGCCGAACAACCGCAGCGGCAGTGGGCAGACCGTTCTCGCACAGTGTTGGCCGGGCAGAGCCTCGGCG
GAGTCAGCGCGCTAATAGCCGCTCGTCACGCACCAGAAACGTTCGGCCTGGCGCTCAGCCACTCCCCTTCAATGTGGTGG
ACACCGGAAGGCGCCTGCCGGCCAAGCTTATTCAGAGAAACCGATACGTCATGGGTGAGCGAGCATCTGCTTTCTGCCCC
ACCGCAGAATGTTCGTATCCGCCTATGCGTGGGATCACTGGAAGGTTCGACAGTACTGCACGTTCAGCAGCTTCATCAGC
GTCTGCTGAATGCTGGCGTCGATAGCCATTACGCAATTTACACCGGTGGTCACGATTACGCATGGTGGCGCGGCGCATTG
ATTGACGGGCTTGGTTTACTAAAAGGTTGA

Upstream 100 bases:

>100_bases
GTGCACATTAAACATTAAAAAAACACGCTCTGAAACGGCTGCTCCGGGAACAGCCGCTTTAGCTATTTATACTGTTCTCC
TTAATTTTCAAAGAGAGTGA

Downstream 100 bases:

>100_bases
CTTGACCCGAGAATACTTTCAGACATCTGTGTAGATATGGCTCATGGCATAAGGCTATTGTAAGTGTAGAATGACCGCTA
TATGTAAGCATTAGACGAGA

Product: ferric enterochelin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAWHSLQGVYLRLNRVTDKEHVA
KGMMTPLPGTDIWTLTLRLPASYCGSYSLVEIPLGTPAKMIAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKA
PAQPEWSGGSPTGQLLTSSRIIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAIMGI
DNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIAARHAPETFGLALSHSPSMWW
TPEGACRPSLFRETDTSWVSEHLLSAPPQNVRIRLCVGSLEGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGAL
IDGLGLLKG

Sequences:

>Translated_409_residues
MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAWHSLQGVYLRLNRVTDKEHVA
KGMMTPLPGTDIWTLTLRLPASYCGSYSLVEIPLGTPAKMIAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKA
PAQPEWSGGSPTGQLLTSSRIIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAIMGI
DNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIAARHAPETFGLALSHSPSMWW
TPEGACRPSLFRETDTSWVSEHLLSAPPQNVRIRLCVGSLEGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGAL
IDGLGLLKG
>Mature_409_residues
MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAWHSLQGVYLRLNRVTDKEHVA
KGMMTPLPGTDIWTLTLRLPASYCGSYSLVEIPLGTPAKMIAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKA
PAQPEWSGGSPTGQLLTSSRIIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAIMGI
DNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIAARHAPETFGLALSHSPSMWW
TPEGACRPSLFRETDTSWVSEHLLSAPPQNVRIRLCVGSLEGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGAL
IDGLGLLKG

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=370, Percent_Identity=30, Blast_Score=128, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 44585; Mature: 44585

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAW
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
HSLQGVYLRLNRVTDKEHVAKGMMTPLPGTDIWTLTLRLPASYCGSYSLVEIPLGTPAKM
HHHCEEEEEEECCCCHHHHHHCCCCCCCCCCEEEEEEECCHHHCCCCEEEEECCCCHHHH
IAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKAPAQPEWSGGSPTGQLLTSSR
HHHCCCCEEECCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCE
IIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAIMGI
EEECCCCEEEEECCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEECC
DNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIA
CCCCHHHCCEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHH
ARHAPETFGLALSHSPSMWWTPEGACRPSLFRETDTSWVSEHLLSAPPQNVRIRLCVGSL
HHCCCHHHCEEEECCCCEEECCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEEEEECC
EGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGALIDGLGLLKG
CCCEEHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAW
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
HSLQGVYLRLNRVTDKEHVAKGMMTPLPGTDIWTLTLRLPASYCGSYSLVEIPLGTPAKM
HHHCEEEEEEECCCCHHHHHHCCCCCCCCCCEEEEEEECCHHHCCCCEEEEECCCCHHHH
IAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKAPAQPEWSGGSPTGQLLTSSR
HHHCCCCEEECCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCE
IIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAIMGI
EEECCCCEEEEECCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEECC
DNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIA
CCCCHHHCCEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHH
ARHAPETFGLALSHSPSMWWTPEGACRPSLFRETDTSWVSEHLLSAPPQNVRIRLCVGSL
HHCCCHHHCEEEECCCCEEECCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEEEEECC
EGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGALIDGLGLLKG
CCCEEHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]