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The map label for this gene is mhpR [H]

Identifier: 238895172

GI number: 238895172

Start: 3053852

End: 3054715

Strand: Direct

Name: mhpR [H]

Synonym: KP1_3218

Alternate gene names: 238895172

Gene position: 3053852-3054715 (Clockwise)

Preceding gene: 238895163

Following gene: 238895173

Centisome position: 58.19

GC content: 61.46

Gene sequence:

>864_bases
ATGTGCACCAGGTGCACAACACTGTTTTTAAATCATTTTAATGGAGGATTTATGCGTGACGATGAGTCCGCAGCGTACAA
AACGGTGCGCGGATTAAGCCGGGGTTTATTGTTATTAAAATTGTTAAATAAATTCGACGGCGGCGCGACGCCGGGCCTGC
TGGCGGAGTTTAGCGGCCTGCATCGCACCACCGTGCGCCGGCTGCTGGAGACGCTACAGGAGGAGGGTTTTGTCCGCCGC
AGCCGCTCCGATGACAGCTTCCGGTTGACCATTAACGTCCGCCAGCTGAGCGATGGATTTCGTGACGAACATTGGATTTC
TGCCCTCGCCACGCCGCTGCTCGGCGAGCTGCTGCGCGAGGTGCAGTGGCCAACGGACATCACCACCCTCGACGTCGACG
CCATGGTGGTGCGCGAGACTACCCACCGCTTCAGCCGACTGTCGTTTCACCGCGCGATGGTCGGACGGCGGCTGCCGCTG
CTGCTCACCGCCTCCGGACTGACGTGGCTGGCCTTTGCCCCCGACGCGGAACGCGACGCCATCGTCAGCATGCTGGCCGC
CCGTCCGGAAGCTGAGTATCAGCTGGCCCGCGAACCGGAACGGCTGGCGGCGATCCTCGCCCGCACCCGCCAGAACGGCT
ATGGCGAAAACTTCCGCGGCTGGCGGCAGGAGGAGAAAATCGCCTCGATCGCCGTGCCGGTCTGCAGTCAGCAGCGGGTT
ATCGGCTGCCTGAACCTGGTCTATATCGCCAGCGCAATGACCATTGAGCAGGCGGCGCAGAAGCATCTCCCTGCGCTGCA
GAGGGTGGCGAGACAGATAGAAGCCCGCATGGAGGATGAAGAAGTGTGGTACGAAATGCCTTGA

Upstream 100 bases:

>100_bases
TGCCCGGCTGACAGGCAATTTGTTAATCATGTGTAAACGTATTTTTATAATGGGCTGAGTATAGGGCGGGGGTTTTCGGC
TACAATCAAAACATCATCGA

Downstream 100 bases:

>100_bases
TCGCGATGAGGGTAACCGCGATCAACCATTGCGCCCGGCTTCGTTATATAATTTAATACACAACGAATTTTCACGCCATT
CGGGCCACACCATGTCAAAA

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MCTRCTTLFLNHFNGGFMRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGFVRR
SRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPL
LLTASGLTWLAFAPDAERDAIVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRV
IGCLNLVYIASAMTIEQAAQKHLPALQRVARQIEARMEDEEVWYEMP

Sequences:

>Translated_287_residues
MCTRCTTLFLNHFNGGFMRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGFVRR
SRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPL
LLTASGLTWLAFAPDAERDAIVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRV
IGCLNLVYIASAMTIEQAAQKHLPALQRVARQIEARMEDEEVWYEMP
>Mature_287_residues
MCTRCTTLFLNHFNGGFMRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGFVRR
SRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPL
LLTASGLTWLAFAPDAERDAIVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRV
IGCLNLVYIASAMTIEQAAQKHLPALQRVARQIEARMEDEEVWYEMP

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=265, Percent_Identity=77.3584905660377, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1786468, Length=225, Percent_Identity=26.2222222222222, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788131, Length=226, Percent_Identity=28.3185840707965, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 32618; Mature: 32618

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTRCTTLFLNHFNGGFMRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGL
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCH
HRTTVRRLLETLQEEGFVRRSRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLRE
HHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAERDA
HCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCHHHH
IVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRV
HHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
IGCLNLVYIASAMTIEQAAQKHLPALQRVARQIEARMEDEEVWYEMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCC
>Mature Secondary Structure
MCTRCTTLFLNHFNGGFMRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGL
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCH
HRTTVRRLLETLQEEGFVRRSRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLRE
HHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAERDA
HCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCHHHH
IVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRV
HHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
IGCLNLVYIASAMTIEQAAQKHLPALQRVARQIEARMEDEEVWYEMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]