Click here to switch to the map view.

The map label for this gene is mhpA [H]

Identifier: 238895171

GI number: 238895171

Start: 3052061

End: 3053725

Strand: Reverse

Name: mhpA [H]

Synonym: KP1_3217

Alternate gene names: 238895171

Gene position: 3053725-3052061 (Counterclockwise)

Preceding gene: 238895176

Following gene: 238895170

Centisome position: 58.18

GC content: 63.78

Gene sequence:

>1665_bases
ATGACAACATCTACACCCGATATTCAACCCGCCGTGCAGCATACCGCTCAGGTCGCCATCGTTGGCGCCGGTCCGGTTGG
TCTGATGATGGCCAACTACCTTGGCCAGATGGGCATCAGCGTGCTGGTGGTGGAAAAGCTCGCCACACTGATCGATTACC
CGCGGGCCATCGGCATTGACGATGAATCCCTGCGGGCGATGCAGGCGGTGGGGCTGGTGAATGACGTGCTGCCGCATACC
ACGCCGTGGCACGCCATGCGTTTTCTCACCCCAAAAGGCCGCTGCTTTGCCGATATCCAGCCGATGACCGATGAGTTTGG
CTGGTCGCGGCGCAACGCCTTCATTCAGCCGCAGGTCGATGCGGTGATGTATCACGGTCTGCAGCGTTTCCCGCAGGTCC
GCTGCCTCTTCTCCCGCGAAGTGGAAGCCTTTAGCCAGACCGGTGACAGTGTCACGTTAAATCTTAAAGGACCGGACGGC
GAACGGGAGACGGTGCGCGCGGACTGGCTGGTGGCCTGCGACGGCGGCGCCAGCTTTATTCGCCGTACGCTGAACATCCC
CTTCGAAGGTAAAACCGCGCCGAATCAGTGGATCGTCATCGATATCGCTAACGACCCGCTGGCCACCCCGCACGTTTACC
TGTGCTGCGACCCGGTGCGACCCTACGTTTCCGCCGCGCTGCCCCACGGCGTGCGCCGCTTTGAATTTATGGTGATGCCC
GGAGAAACCGAAGCCCAGCTCAGCGAGCCGCACAATATGCGCCGTCTGCTGAGCAAAGTGCTGCCGGACCCGGACCGCGT
CGAGCTGATCCGCCAGCGGGTCTATACGCATAACGCCCGCCTTGCCGAGCGCTTTCGCATCGACCGCGTGCTGCTGGCCG
GCGATGCGGCGCACATCATGCCGGTCTGGCAGGGGCAGGGATATAACAGCGGCATGCGCGACGCCTTCAACCTGGCGTGG
AAGCTGGCGCTGGTGGTCAACGGTAAAGCGGGAGAGACGCTGCTCGACAGCTACCAGCAGGAGCGCCGCGACCACGCGAA
AGCGATGATTGATCTGTCGGTCACCGCCGGCTACGTGCTGGCGCCGCCGAAGCGCTGGCAGGGGGCCGTGCGCGACGGTC
TCTCCTGGCTGCTAAATTACCTGCCGCCGGTGAAACGCTACTTCCTCGAGATGCGCTTTAAGCCGATGCCGCAGTACCGC
GAGGGGGCGCTGCTGACCGACGGCGCCGGCAAGACCTCGCCGGTGGGCAAAATGTTTATTCAACCGCAGGTGACGCTGGA
GAGCGGCGAGAGCGTGCTGCTCGACGAGGTTATCGGGGCGAATTTCGCCATTATCGGCTGGGGCTGCAACCCGCAGTGGG
GGCTCGACGCCGGGCAGATCGCCCGCTGGCGCGCGATTGGCGTGCGCTTTATCCAGGTGGTGCCCGAGGTGCAGATCCAT
CGCGAGCAGGATAACGCCCCCGGCACGCTGCGGGTGGGCGATACGCAAAACCGCCTCAAAAGCTGGTTTGCACTGCATAA
CACCGCCATCGCCGTGGTCAGGCCGGACCGCTTTGTCGCCGCTCTCGCCATCCCGCAAACCCTCGGCGCGCAGCTGACCG
CTCTGGCGGAAAAAATGGCCCTCGCAACCGGGGATACCGCCCACGCTGAAGAGAAGGTGGCCTGA

Upstream 100 bases:

>100_bases
AACCCCCGCCCTATACTCAGCCCATTATAAAAATACGTTTACACATGATTAACAAATTGCCTGTCAGCCGGGCAGTTTCC
GAGTCGTGAGGTCGCTGAGA

Downstream 100 bases:

>100_bases
TATGCATGCCTATTTGCACTGTCTCTCCCACACCCCGCTGGTGGGATTCGTAGACCCGGAGCAGGCGGTCCTTGATGAAG
TGAACCGGGTGATTGCCGAC

Product: 3-(3-hydroxyphenyl)propionate hydroxylase

Products: NA

Alternate protein names: 3-HCI hydroxylase; 3-HPP hydroxylase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTTSTPDIQPAVQHTAQVAIVGAGPVGLMMANYLGQMGISVLVVEKLATLIDYPRAIGIDDESLRAMQAVGLVNDVLPHT
TPWHAMRFLTPKGRCFADIQPMTDEFGWSRRNAFIQPQVDAVMYHGLQRFPQVRCLFSREVEAFSQTGDSVTLNLKGPDG
ERETVRADWLVACDGGASFIRRTLNIPFEGKTAPNQWIVIDIANDPLATPHVYLCCDPVRPYVSAALPHGVRRFEFMVMP
GETEAQLSEPHNMRRLLSKVLPDPDRVELIRQRVYTHNARLAERFRIDRVLLAGDAAHIMPVWQGQGYNSGMRDAFNLAW
KLALVVNGKAGETLLDSYQQERRDHAKAMIDLSVTAGYVLAPPKRWQGAVRDGLSWLLNYLPPVKRYFLEMRFKPMPQYR
EGALLTDGAGKTSPVGKMFIQPQVTLESGESVLLDEVIGANFAIIGWGCNPQWGLDAGQIARWRAIGVRFIQVVPEVQIH
REQDNAPGTLRVGDTQNRLKSWFALHNTAIAVVRPDRFVAALAIPQTLGAQLTALAEKMALATGDTAHAEEKVA

Sequences:

>Translated_554_residues
MTTSTPDIQPAVQHTAQVAIVGAGPVGLMMANYLGQMGISVLVVEKLATLIDYPRAIGIDDESLRAMQAVGLVNDVLPHT
TPWHAMRFLTPKGRCFADIQPMTDEFGWSRRNAFIQPQVDAVMYHGLQRFPQVRCLFSREVEAFSQTGDSVTLNLKGPDG
ERETVRADWLVACDGGASFIRRTLNIPFEGKTAPNQWIVIDIANDPLATPHVYLCCDPVRPYVSAALPHGVRRFEFMVMP
GETEAQLSEPHNMRRLLSKVLPDPDRVELIRQRVYTHNARLAERFRIDRVLLAGDAAHIMPVWQGQGYNSGMRDAFNLAW
KLALVVNGKAGETLLDSYQQERRDHAKAMIDLSVTAGYVLAPPKRWQGAVRDGLSWLLNYLPPVKRYFLEMRFKPMPQYR
EGALLTDGAGKTSPVGKMFIQPQVTLESGESVLLDEVIGANFAIIGWGCNPQWGLDAGQIARWRAIGVRFIQVVPEVQIH
REQDNAPGTLRVGDTQNRLKSWFALHNTAIAVVRPDRFVAALAIPQTLGAQLTALAEKMALATGDTAHAEEKVA
>Mature_553_residues
TTSTPDIQPAVQHTAQVAIVGAGPVGLMMANYLGQMGISVLVVEKLATLIDYPRAIGIDDESLRAMQAVGLVNDVLPHTT
PWHAMRFLTPKGRCFADIQPMTDEFGWSRRNAFIQPQVDAVMYHGLQRFPQVRCLFSREVEAFSQTGDSVTLNLKGPDGE
RETVRADWLVACDGGASFIRRTLNIPFEGKTAPNQWIVIDIANDPLATPHVYLCCDPVRPYVSAALPHGVRRFEFMVMPG
ETEAQLSEPHNMRRLLSKVLPDPDRVELIRQRVYTHNARLAERFRIDRVLLAGDAAHIMPVWQGQGYNSGMRDAFNLAWK
LALVVNGKAGETLLDSYQQERRDHAKAMIDLSVTAGYVLAPPKRWQGAVRDGLSWLLNYLPPVKRYFLEMRFKPMPQYRE
GALLTDGAGKTSPVGKMFIQPQVTLESGESVLLDEVIGANFAIIGWGCNPQWGLDAGQIARWRAIGVRFIQVVPEVQIHR
EQDNAPGTLRVGDTQNRLKSWFALHNTAIAVVRPDRFVAALAIPQTLGAQLTALAEKMALATGDTAHAEEKVA

Specific function: Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI) [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pheA/tfdB FAD monooxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786543, Length=554, Percent_Identity=80.14440433213, Blast_Score=937, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 61467; Mature: 61335

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSTPDIQPAVQHTAQVAIVGAGPVGLMMANYLGQMGISVLVVEKLATLIDYPRAIGID
CCCCCCCCCHHHHCCEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCC
DESLRAMQAVGLVNDVLPHTTPWHAMRFLTPKGRCFADIQPMTDEFGWSRRNAFIQPQVD
HHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCEEEECCCCHHHCCCCCCCCCCCCCHH
AVMYHGLQRFPQVRCLFSREVEAFSQTGDSVTLNLKGPDGERETVRADWLVACDGGASFI
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCCHHHH
RRTLNIPFEGKTAPNQWIVIDIANDPLATPHVYLCCDPVRPYVSAALPHGVRRFEFMVMP
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEEEEEEC
GETEAQLSEPHNMRRLLSKVLPDPDRVELIRQRVYTHNARLAERFRIDRVLLAGDAAHIM
CCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCHHEE
PVWQGQGYNSGMRDAFNLAWKLALVVNGKAGETLLDSYQQERRDHAKAMIDLSVTAGYVL
EEECCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEECCEEE
APPKRWQGAVRDGLSWLLNYLPPVKRYFLEMRFKPMPQYREGALLTDGAGKTSPVGKMFI
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCEEEE
QPQVTLESGESVLLDEVIGANFAIIGWGCNPQWGLDAGQIARWRAIGVRFIQVVPEVQIH
CCEEEECCCCEEEHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
REQDNAPGTLRVGDTQNRLKSWFALHNTAIAVVRPDRFVAALAIPQTLGAQLTALAEKMA
ECCCCCCCEEEECCHHHHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
LATGDTAHAEEKVA
HCCCCCCCCHHCCC
>Mature Secondary Structure 
TTSTPDIQPAVQHTAQVAIVGAGPVGLMMANYLGQMGISVLVVEKLATLIDYPRAIGID
CCCCCCCCHHHHCCEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCC
DESLRAMQAVGLVNDVLPHTTPWHAMRFLTPKGRCFADIQPMTDEFGWSRRNAFIQPQVD
HHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCEEEECCCCHHHCCCCCCCCCCCCCHH
AVMYHGLQRFPQVRCLFSREVEAFSQTGDSVTLNLKGPDGERETVRADWLVACDGGASFI
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCCHHHH
RRTLNIPFEGKTAPNQWIVIDIANDPLATPHVYLCCDPVRPYVSAALPHGVRRFEFMVMP
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEEEEEEC
GETEAQLSEPHNMRRLLSKVLPDPDRVELIRQRVYTHNARLAERFRIDRVLLAGDAAHIM
CCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCHHEE
PVWQGQGYNSGMRDAFNLAWKLALVVNGKAGETLLDSYQQERRDHAKAMIDLSVTAGYVL
EEECCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEECCEEE
APPKRWQGAVRDGLSWLLNYLPPVKRYFLEMRFKPMPQYREGALLTDGAGKTSPVGKMFI
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCEEEE
QPQVTLESGESVLLDEVIGANFAIIGWGCNPQWGLDAGQIARWRAIGVRFIQVVPEVQIH
CCEEEECCCCEEEHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
REQDNAPGTLRVGDTQNRLKSWFALHNTAIAVVRPDRFVAALAIPQTLGAQLTALAEKMA
ECCCCCCCEEEECCHHHHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
LATGDTAHAEEKVA
HCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA