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The map label for this gene is ydhC [H]

Identifier: 238895042

GI number: 238895042

Start: 2926296

End: 2927567

Strand: Direct

Name: ydhC [H]

Synonym: KP1_3073

Alternate gene names: 238895042

Gene position: 2926296-2927567 (Clockwise)

Preceding gene: 238895040

Following gene: 238895043

Centisome position: 55.75

GC content: 61.32

Gene sequence:

>1272_bases
ATGCATGTGACAAATATTAGCGTTTCACAAGCCACAATGCACTCCCTACACTCTGCGGCATCGTACCTGTACACCAACTA
TGAGAACGTTATGTCACAACCCGGGAAAGGATTTTTAGTCTGGCTGGCCGGCCTGAGCGTGCTGGGCTTTCTGGCCACCG
ATATGTACCTGCCGGCGTTTGCCGCCATGCAGCAGGATCTCAACACCACCGCCGCCTCCATCAGCGCCAGTCTGAGCCTG
TTCCTCGCCGGCTTCGCGCTGGGCCAGCTGTTCTGGGGACCGCTGTCGGACCGCTATGGACGTAAACCGGTACTGCTGAG
CGGCCTGGCGATTTTCGCGGCCGGCTGTCTGGGGATGCTTTGGGTGCACAACGCCACCCTGATGCTGGCGCTGCGCTTTC
TGCAGGCGATTGGCGTCTGTGCCGCGGCCGTTACCTGGCAGGCGATGGTCGCCGATTACTATCCTGCCCAGCGCACGAAC
CGCATCTTCGCCACCATTATGCCGCTGGTAGGACTGTCGCCGGCGCTGGCCCCGCTGCTGGGCAGCTGGCTGCTGGTGCA
CTTCGAGTGGCAAGCCATCTTCGCCACCCTGTTCGCCATCACTCTGCTGCTGATGCTGCCTGCCCTGCGCCTGAAGGCAG
CCGCGAAGTCAGTAGTAGTGACGCAGCAAAAGATCACCTTTCTCGCGCTGCTGCGCTCCCGGGAATACAGCGGCAACGTC
CTGATCTACGCCGCCTGTTCCGCCAGCTTCTTCGCCTGGCTTACCGGTTCACCTTTTATCCTGCATGAAATGGGCTATGG
CCCAACCGCTATCGGCCTGAGCTATATTCCGCAGACCATCGCCTTTCTGGTGGGAGGCTATGGCTGTCGCGCGGTGCTGC
AGAAATGGTCCGGTCAACAGATGCTGCCGTGGCTGCTGGTGATTTTTGCCGTCAGCGTAGCCGCCACCTGGCTGGTGGGC
CTGCAAACCCATGCCTCGCTGGTGGCGTTAATGATCCCGTTCTGCATGATGGCGGTGGTCAACGGCGGGATCTACCCCAT
CGTGGTTGCTCAGGCGCTGAAGCCTTTTCCGCAGGCGACCGGCCGCGCGGCGGCGCTGCAAAATACCCTGCAGCTTGGCC
TGTGCTTCCTGACCAGTCTGCTGGTATCCGCGCTGATCGCCACGCCGCTGCTGACCACCACCAGCGTCATGCTGGTTTCG
ATTGGCTTAGCCGGAATAGGCTATCGCCTGCAGCAGACGCCGGAGCTGACACCCCACTCTTCCCACGCGTAA

Upstream 100 bases:

>100_bases
AAGCTCCTGCGCGGCCGCGCTGAAGCTGCCGTTACGGGCGACGGCATCAACCACTTCCAGAGAGTATTCAGACCACATTT
TCTGCCTGCAAAATTTTTGA

Downstream 100 bases:

>100_bases
TGCCCGTCGCCAGGGCCCGGACCAGTCGTTAGCATGCTAAGAAATTTTTATTGAAAGCCAGTACTTAGCGTCCTATACTG
GATCCGGGTTCACATAAATA

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MHVTNISVSQATMHSLHSAASYLYTNYENVMSQPGKGFLVWLAGLSVLGFLATDMYLPAFAAMQQDLNTTAASISASLSL
FLAGFALGQLFWGPLSDRYGRKPVLLSGLAIFAAGCLGMLWVHNATLMLALRFLQAIGVCAAAVTWQAMVADYYPAQRTN
RIFATIMPLVGLSPALAPLLGSWLLVHFEWQAIFATLFAITLLLMLPALRLKAAAKSVVVTQQKITFLALLRSREYSGNV
LIYAACSASFFAWLTGSPFILHEMGYGPTAIGLSYIPQTIAFLVGGYGCRAVLQKWSGQQMLPWLLVIFAVSVAATWLVG
LQTHASLVALMIPFCMMAVVNGGIYPIVVAQALKPFPQATGRAAALQNTLQLGLCFLTSLLVSALIATPLLTTTSVMLVS
IGLAGIGYRLQQTPELTPHSSHA

Sequences:

>Translated_423_residues
MHVTNISVSQATMHSLHSAASYLYTNYENVMSQPGKGFLVWLAGLSVLGFLATDMYLPAFAAMQQDLNTTAASISASLSL
FLAGFALGQLFWGPLSDRYGRKPVLLSGLAIFAAGCLGMLWVHNATLMLALRFLQAIGVCAAAVTWQAMVADYYPAQRTN
RIFATIMPLVGLSPALAPLLGSWLLVHFEWQAIFATLFAITLLLMLPALRLKAAAKSVVVTQQKITFLALLRSREYSGNV
LIYAACSASFFAWLTGSPFILHEMGYGPTAIGLSYIPQTIAFLVGGYGCRAVLQKWSGQQMLPWLLVIFAVSVAATWLVG
LQTHASLVALMIPFCMMAVVNGGIYPIVVAQALKPFPQATGRAAALQNTLQLGLCFLTSLLVSALIATPLLTTTSVMLVS
IGLAGIGYRLQQTPELTPHSSHA
>Mature_423_residues
MHVTNISVSQATMHSLHSAASYLYTNYENVMSQPGKGFLVWLAGLSVLGFLATDMYLPAFAAMQQDLNTTAASISASLSL
FLAGFALGQLFWGPLSDRYGRKPVLLSGLAIFAAGCLGMLWVHNATLMLALRFLQAIGVCAAAVTWQAMVADYYPAQRTN
RIFATIMPLVGLSPALAPLLGSWLLVHFEWQAIFATLFAITLLLMLPALRLKAAAKSVVVTQQKITFLALLRSREYSGNV
LIYAACSASFFAWLTGSPFILHEMGYGPTAIGLSYIPQTIAFLVGGYGCRAVLQKWSGQQMLPWLLVIFAVSVAATWLVG
LQTHASLVALMIPFCMMAVVNGGIYPIVVAQALKPFPQATGRAAALQNTLQLGLCFLTSLLVSALIATPLLTTTSVMLVS
IGLAGIGYRLQQTPELTPHSSHA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=386, Percent_Identity=74.6113989637306, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1788509, Length=343, Percent_Identity=26.530612244898, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790146, Length=217, Percent_Identity=30.4147465437788, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790794, Length=231, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082312, Length=338, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787065, Length=217, Percent_Identity=26.2672811059908, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45368; Mature: 45368

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]