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The map label for this gene is pdxY [H]

Identifier: 238895017

GI number: 238895017

Start: 2903798

End: 2904658

Strand: Reverse

Name: pdxY [H]

Synonym: KP1_3046

Alternate gene names: 238895017

Gene position: 2904658-2903798 (Counterclockwise)

Preceding gene: 238895018

Following gene: 238895014

Centisome position: 55.34

GC content: 59.58

Gene sequence:

>861_bases
ATGAAGAACATCCTCGCCATTCAGTCTCACGTTGTGTTTGGCCATGCCGGCAACAGTGCCGCCGAATTTCCGATGCGCCG
TCTGGGCGCCAATGTCTGGCCCCTGAATACCGTACAGTTCTCTAACCATACGCAGTACGGCAAATGGACCGGCTGCGTCA
TGCCGCCTTCGCATTTGACGGAGATCGTTCAGGGCATTGCCGATATCGACAAGCTGCAGACCTGCGATGCGGTACTGAGC
GGCTATCTTGGCTCCGCTGAGCAGGGAGAGCATATCCTCGGTATCGTGCGTCAGGTTAAGGCGGCCAATCCGGCGGCGAA
ATATTTTTGCGATCCAGTGATGGGTCACCCGGAGAAGGGCTGCATCGTCGCGCCGGGCGTGGCGGAGTTCCACGTGCGCT
ATGCGCTGCCGGCCAGCGATATTATTGCCCCGAATCTGGTTGAGCTGGAGATCCTGTGCGGTCATCCGGTCGCCAGCGTC
AGCGAGGCAGTGGCCGCCGCGCGGGAGCTGATTGCCCAGGGGCCGGAAGTGGTATTAGTTAAGCATCTTGCCCGTGCGGG
TCTGAGTATGGATCGTTTTGAGATGCTGTTGGTGACGGCCGAAGAAGCCTGGCATATTAGTCGGCCGCTGGTGGATTTCG
GCCTGCGTCAGCCGGTGGGCGTCGGCGATGTGACCAGCGGTCTGCTGTTGGTTAAATTGCTGCAGGGGGCAAGTCTGCGC
GATGCGCTGGAACACGTCACCGCCGCGGTGTACGAGATTATGCTCGCCACCAAAAATATGCAGGAATACGAACTACAGGT
AGTAGCGGCGCAGGATCGCATCGCCGTACCGGAGCACTGCTTCAGCGCCACCCGGCTGTAA

Upstream 100 bases:

>100_bases
CGCGGTAAGAAAAATTACTGCCTGGTCTGCTGGAAATAAAAAAATACTGCCAGGGCGTGGGAAACCACGCCCTTTTTCTT
TTTAGGGTTGTGGTAAGAAA

Downstream 100 bases:

>100_bases
CTCCCAGGGCCTGCCCGACGTTCCGCCGGGCAGGTTCAGGCCTTATTTTAAGCCTTCAGCCGCCAGTGCGGCCGCCACCG
CCGGACGCGCTGCCACCTGC

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIDKLQTCDAVLS
GYLGSAEQGEHILGIVRQVKAANPAAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLVELEILCGHPVASV
SEAVAAARELIAQGPEVVLVKHLARAGLSMDRFEMLLVTAEEAWHISRPLVDFGLRQPVGVGDVTSGLLLVKLLQGASLR
DALEHVTAAVYEIMLATKNMQEYELQVVAAQDRIAVPEHCFSATRL

Sequences:

>Translated_286_residues
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIDKLQTCDAVLS
GYLGSAEQGEHILGIVRQVKAANPAAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLVELEILCGHPVASV
SEAVAAARELIAQGPEVVLVKHLARAGLSMDRFEMLLVTAEEAWHISRPLVDFGLRQPVGVGDVTSGLLLVKLLQGASLR
DALEHVTAAVYEIMLATKNMQEYELQVVAAQDRIAVPEHCFSATRL
>Mature_286_residues
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIDKLQTCDAVLS
GYLGSAEQGEHILGIVRQVKAANPAAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLVELEILCGHPVASV
SEAVAAARELIAQGPEVVLVKHLARAGLSMDRFEMLLVTAEEAWHISRPLVDFGLRQPVGVGDVTSGLLLVKLLQGASLR
DALEHVTAAVYEIMLATKNMQEYELQVVAAQDRIAVPEHCFSATRL

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=180, Percent_Identity=36.1111111111111, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1787924, Length=286, Percent_Identity=90.5594405594406, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788758, Length=263, Percent_Identity=31.1787072243346, Blast_Score=124, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17507759, Length=291, Percent_Identity=27.1477663230241, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17507757, Length=301, Percent_Identity=26.578073089701, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320806, Length=301, Percent_Identity=30.8970099667774, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324354, Length=285, Percent_Identity=29.8245614035088, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45553007, Length=300, Percent_Identity=28, Blast_Score=114, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 30867; Mature: 30867

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLT
CCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCHHHHH
EIVQGIADIDKLQTCDAVLSGYLGSAEQGEHILGIVRQVKAANPAAKYFCDPVMGHPEKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHCCHHCCCCCCC
CIVAPGVAEFHVRYALPASDIIAPNLVELEILCGHPVASVSEAVAAARELIAQGPEVVLV
CEECCCHHHEEEEEECCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
KHLARAGLSMDRFEMLLVTAEEAWHISRPLVDFGLRQPVGVGDVTSGLLLVKLLQGASLR
HHHHHHCCCHHHHHEEEEECHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHH
DALEHVTAAVYEIMLATKNMQEYELQVVAAQDRIAVPEHCFSATRL
HHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLT
CCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCHHHHH
EIVQGIADIDKLQTCDAVLSGYLGSAEQGEHILGIVRQVKAANPAAKYFCDPVMGHPEKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHCCHHCCCCCCC
CIVAPGVAEFHVRYALPASDIIAPNLVELEILCGHPVASVSEAVAAARELIAQGPEVVLV
CEECCCHHHEEEEEECCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
KHLARAGLSMDRFEMLLVTAEEAWHISRPLVDFGLRQPVGVGDVTSGLLLVKLLQGASLR
HHHHHHCCCHHHHHEEEEECHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHH
DALEHVTAAVYEIMLATKNMQEYELQVVAAQDRIAVPEHCFSATRL
HHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]