BacMap

Definition	Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome.
Accession	NC_012731
Length	5,248,520

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The map label for this gene is benD [H]

Identifier: 238894911

GI number: 238894911

Start: 2798501

End: 2799274

Strand: Reverse

Name: benD [H]

Synonym: KP1_2934

Alternate gene names: 238894911

Gene position: 2799274-2798501 (Counterclockwise)

Preceding gene: 238894912

Following gene: 238894909

Centisome position: 53.33

GC content: 64.86

Gene sequence:

>774_bases
ATGCGTTTTACCGATAAAGTCGTCGTCATCACCGGCGCGGCGCAGGGCATTGGCCGCCAGACGGCGGAGCAGGCGGCTGC
AGAAGGCGCGGCTCTGCTGCTCATCGATCGCTCGTCATACGTCCATGAGCTGGCGGCGACGCTGGCGCAATCCGGCTGTC
TGGTGCTGGCGCTGGAGGCGGATCTGGAAGCGTGGGAAAGTACCGAGCAGGCGTTTGCCGCCGGGGTCGCTCATTTTGGC
CGTATCGACGTGCTGATCAACAACGTTGGGGGCACCATCTGGGCGCGCCCCTTTGCCGAATACCAGCCGGAGCAGATTGA
GAAAGAGATCCGCCGCTCGCTGTTCCCCACGCTGTGGGGCTGCCGCGCGGCGCTGCCATGGATGCTGAAGCAGGGCAAAG
GCAGCATCGTCAACATTTCATCGGTGGCGACGGCGGGAGTGAATCGGGTGCCGTACTCGGCGGCGAAAGGCGGCGTTAAC
GCGCTGACCCGGTCGATTGCCATGGAGTACAGCGGCAGCGGTATTAGGATTAACGCCGTGGCCCCGGGCGGGACCGAGGC
GCCGCCGCGCCTGACGCCGCGTAACGAAGAGCAGCCGAGCGAGCAGGAAAAGGCGTGGTATCAGCAGGTCGTCGATCAGA
CGGTGGCGAGCAGTCTGCTGCACCGGTACGGCACGCTGGCGGAACAGGCGAATGCGATCCTGTTTCTCGCCAGCGATGAG
GCCAGCTATATCACCGGCGTGACGCTGCCGGTAGCCGGAGGCGATCTCGGCTAA

Upstream 100 bases:

>100_bases
CGCGGTTGCTATGGCGTTGCGCGACCGCGGGATCACCCCGGCGGGGTTCTGGTATGAGAAATTTATCGCCAGCCAGAGCG
CGGCGGCATAAGGAGACAAA

Downstream 100 bases:

>100_bases
CGGCGGGTGGCGTACCAGCAGAGCAGGGAGCCGAGACATACCATCCCGGCCCCCTGCCAGAAGGACCACGACAGGGTCGC
ACTCAGCAGGATCGCCGCCA

Product: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

Products: NA

Alternate protein names: 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MRFTDKVVVITGAAQGIGRQTAEQAAAEGAALLLIDRSSYVHELAATLAQSGCLVLALEADLEAWESTEQAFAAGVAHFG
RIDVLINNVGGTIWARPFAEYQPEQIEKEIRRSLFPTLWGCRAALPWMLKQGKGSIVNISSVATAGVNRVPYSAAKGGVN
ALTRSIAMEYSGSGIRINAVAPGGTEAPPRLTPRNEEQPSEQEKAWYQQVVDQTVASSLLHRYGTLAEQANAILFLASDE
ASYITGVTLPVAGGDLG

Sequences:

>Translated_257_residues
MRFTDKVVVITGAAQGIGRQTAEQAAAEGAALLLIDRSSYVHELAATLAQSGCLVLALEADLEAWESTEQAFAAGVAHFG
RIDVLINNVGGTIWARPFAEYQPEQIEKEIRRSLFPTLWGCRAALPWMLKQGKGSIVNISSVATAGVNRVPYSAAKGGVN
ALTRSIAMEYSGSGIRINAVAPGGTEAPPRLTPRNEEQPSEQEKAWYQQVVDQTVASSLLHRYGTLAEQANAILFLASDE
ASYITGVTLPVAGGDLG
>Mature_257_residues
MRFTDKVVVITGAAQGIGRQTAEQAAAEGAALLLIDRSSYVHELAATLAQSGCLVLALEADLEAWESTEQAFAAGVAHFG
RIDVLINNVGGTIWARPFAEYQPEQIEKEIRRSLFPTLWGCRAALPWMLKQGKGSIVNISSVATAGVNRVPYSAAKGGVN
ALTRSIAMEYSGSGIRINAVAPGGTEAPPRLTPRNEEQPSEQEKAWYQQVVDQTVASSLLHRYGTLAEQANAILFLASDE
ASYITGVTLPVAGGDLG

Specific function: Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=29.8039215686275, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=29.296875, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI7705925, Length=256, Percent_Identity=30.46875, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=27.906976744186, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=33.0769230769231, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=30.2325581395349, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI66933014, Length=180, Percent_Identity=31.1111111111111, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=29.9492385786802, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=28.6792452830189, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4758504, Length=190, Percent_Identity=30.5263157894737, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4504505, Length=198, Percent_Identity=31.3131313131313, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI142976729, Length=250, Percent_Identity=27.6, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7706318, Length=202, Percent_Identity=31.1881188118812, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI5031737, Length=258, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI210032110, Length=200, Percent_Identity=28, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=25.1908396946565, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI224922801, Length=180, Percent_Identity=32.2222222222222, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=32.03125, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=33.0739299610895, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=29.8039215686275, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=30.7392996108949, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787905, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=29.5719844357977, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=28.740157480315, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=268, Percent_Identity=26.4925373134328, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=25.296442687747, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786812, Length=276, Percent_Identity=29.7101449275362, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789057, Length=274, Percent_Identity=26.6423357664234, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=33.4630350194552, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=32.6771653543307, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=32.2222222222222, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=31.3953488372093, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=30.9701492537313, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=29.5880149812734, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=273, Percent_Identity=30.03663003663, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=30.5660377358491, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=27.4509803921569, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=30.8270676691729, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=29.5880149812734, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=193, Percent_Identity=30.0518134715026, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=193, Percent_Identity=32.6424870466321, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=189, Percent_Identity=31.2169312169312, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=194, Percent_Identity=30.4123711340206, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=259, Percent_Identity=32.046332046332, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=29.0076335877863, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=27.9693486590038, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=27.3408239700375, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=30.1470588235294, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=31.0606060606061, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=195, Percent_Identity=30.2564102564103, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=27.1062271062271, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=243, Percent_Identity=27.1604938271605, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=264, Percent_Identity=31.8181818181818, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322861, Length=201, Percent_Identity=31.8407960199005, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=209, Percent_Identity=29.1866028708134, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571526, Length=262, Percent_Identity=34.3511450381679, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24644339, Length=266, Percent_Identity=34.5864661654135, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=33.969465648855, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=31.4176245210728, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644337, Length=269, Percent_Identity=34.2007434944238, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=28.6852589641434, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355319, Length=264, Percent_Identity=27.6515151515151, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24665243, Length=202, Percent_Identity=34.6534653465347, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221331218, Length=202, Percent_Identity=34.6534653465347, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24665247, Length=203, Percent_Identity=34.4827586206897, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221331216, Length=203, Percent_Identity=34.4827586206897, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737361, Length=198, Percent_Identity=30.8080808080808, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.25 [H]

Molecular weight: Translated: 27297; Mature: 27297

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFTDKVVVITGAAQGIGRQTAEQAAAEGAALLLIDRSSYVHELAATLAQSGCLVLALEA
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEC
DLEAWESTEQAFAAGVAHFGRIDVLINNVGGTIWARPFAEYQPEQIEKEIRRSLFPTLWG
CHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHH
CRAALPWMLKQGKGSIVNISSVATAGVNRVPYSAAKGGVNALTRSIAMEYSGSGIRINAV
HHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHEECCCCEEEEEE
APGGTEAPPRLTPRNEEQPSEQEKAWYQQVVDQTVASSLLHRYGTLAEQANAILFLASDE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
ASYITGVTLPVAGGDLG
CCEEEEEEEEECCCCCC
>Mature Secondary Structure
MRFTDKVVVITGAAQGIGRQTAEQAAAEGAALLLIDRSSYVHELAATLAQSGCLVLALEA
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEC
DLEAWESTEQAFAAGVAHFGRIDVLINNVGGTIWARPFAEYQPEQIEKEIRRSLFPTLWG
CHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHH
CRAALPWMLKQGKGSIVNISSVATAGVNRVPYSAAKGGVNALTRSIAMEYSGSGIRINAV
HHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHEECCCCEEEEEE
APGGTEAPPRLTPRNEEQPSEQEKAWYQQVVDQTVASSLLHRYGTLAEQANAILFLASDE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
ASYITGVTLPVAGGDLG
CCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1740120 [H]