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The map label for this gene is sfcA [H]

Identifier: 238894890

GI number: 238894890

Start: 2774289

End: 2775986

Strand: Direct

Name: sfcA [H]

Synonym: KP1_2910

Alternate gene names: 238894890

Gene position: 2774289-2775986 (Clockwise)

Preceding gene: 238894889

Following gene: 238894891

Centisome position: 52.86

GC content: 58.13

Gene sequence:

>1698_bases
ATGCAATTTACCCATAAGAAAAACCGTTCCCTGTACATCCCCTACGCGGGTCCCGTTCTGCTTGAATTCCCCCTGCTCAA
CAAGGGAAGCGCCTTCAGTATGGAAGAGCGCAGCAATTTCAACCTGCTCGGCCTGCTGCCGGAAGTGGTTGAAACTATCG
AAGAGCAAGCGGAACGCGCCTGGATCCAGTATCAGGGATTCAAAACTGAAATCGACAAACATATTTATCTGCGTAACATC
CAGGACACCAACGAAACCCTGTTTTATCGCCTGATCGGCAACCACCTTGAAGAGATGATGCCGGTTATCTATACCCCGAC
GGTAGGCGCGGCCTGCGAACGGTTCTCCGAGATCTATCGTCGCGCCCGCGGCGTCTTTATCTCCTACCAGAATCGCCATA
ACCTTGACGACATCCTGCAAAACGTCCCGAACCACAACGTGAAAGTGATTGTGGTCACCGATGGCGAGCGCATTCTCGGC
CTCGGCGACCAGGGGATCGGCGGAATGGGGATCCCGATCGGTAAACTGTCGCTGTATACCACCTGCGGCGGCATCAGCCC
GGCTTACACCCTGCCTATCGTGCTGGACGTCGGAACAAACAATCAGCAGCTGCTCGACGATCCGCTGTATATGGGCTGGC
GCCATCCACGCATTACCGACGACGAGTACTATCAGTTCGTTGACGACGTGATCCAGGCGATTAAGGCCCGTTGGCCGGAC
GTGCTGCTGCAGTTTGAAGATTTTGCGCAAAAGAACGCCATGCCGCTGCTCAACCGCTACCGCAATGAAATCTGCTCGTT
TAACGACGATATTCAGGGCACCGCGGCGGTGACCGTCGGGACGCTGATCGCCGCCAGCCGCGGCGCCGGTAGCCAGCTGA
GCGAGCAAAAAATCGTCTTTCTCGGCGCGGGTTCGGCCGGCTGCGGTATCGCTGAACAGATTATCGCCCAGATCGTCCGC
GAAGGACTCAGTGAAGAAGAGGCCCGCCAGCGCGTGTTTATGGTTGACCGCTTCGGCCTGTTAACCGATGGCATGCCTAA
TCTGCTACCGTTCCAGAACAAGCTGGTGCAAAAGCGTGAGCAGCTGCAGAGCTGGGATACCACCAGCGAGGCGCTGTCCC
TGCTGGACGTAGTGCGCAACGTGAAGCCGAACATCCTGATCGGCGTCTCGGGTCAGCCGGGACTGTTCACGGAAGAGATT
ATCCGCGAGATGCACAAGCACTGCCCGCGGCCGATCGTGATGCCGCTCTCCAACCCAACCTCACGGGTGGAAGCGACGCC
GCAGAATATCCTGAGCTGGACCGACGGCGAGGCGCTGGTCGCCACCGGCAGTCCATTCTCCCCGGTTACCGTGAAAGGCA
AGCAGTATCCCATCGCCCAGTGCAATAACTCCTATATCTTCCCGGGTATTGGACTGGGGGTGATCGCCTCTGGCGCGTCG
CGGGTCACCGACGAGATGCTGATGGCTGCCAGCGAAACCCTGGCGCAGCACTCGCCGCTGGTCAACAACGGCGAAGGTCC
GGTGCTGCCGGAGCTGAAGGATATCCAGACCGTCTCACGGGCAATTGCCTTCGCGGTGGGTAAGGTGGCCCAGGAGCAAG
GCGTGGCGGTGAAAACCTCCGCCGAAGCGCTGCTGCAAGCGATCAGCGATAATTTCTGGTTACCGGAATATCGCAATTAT
CGCCGCACCTCGATTTAA

Upstream 100 bases:

>100_bases
CGCTTGAAGACCTTCTGCTCTATACTCTGCCCGCTGCTTTCCACCCGCCCTTCGCTTATCGCCGCGCCGGGACTGTGGTC
ATGATCAAGGAGTTAGTGCG

Downstream 100 bases:

>100_bases
TCACTGTCACCGGGTCGAAATAGCGGCCCGGTTATTAATAACGTCAGAATAATACCTCCCGCCACAGAAACGTTTTTTCC
GCCTATATACATTCATCGTA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MQFTHKKNRSLYIPYAGPVLLEFPLLNKGSAFSMEERSNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNI
QDTNETLFYRLIGNHLEEMMPVIYTPTVGAACERFSEIYRRARGVFISYQNRHNLDDILQNVPNHNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTTCGGISPAYTLPIVLDVGTNNQQLLDDPLYMGWRHPRITDDEYYQFVDDVIQAIKARWPD
VLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRGAGSQLSEQKIVFLGAGSAGCGIAEQIIAQIVR
EGLSEEEARQRVFMVDRFGLLTDGMPNLLPFQNKLVQKREQLQSWDTTSEALSLLDVVRNVKPNILIGVSGQPGLFTEEI
IREMHKHCPRPIVMPLSNPTSRVEATPQNILSWTDGEALVATGSPFSPVTVKGKQYPIAQCNNSYIFPGIGLGVIASGAS
RVTDEMLMAASETLAQHSPLVNNGEGPVLPELKDIQTVSRAIAFAVGKVAQEQGVAVKTSAEALLQAISDNFWLPEYRNY
RRTSI

Sequences:

>Translated_565_residues
MQFTHKKNRSLYIPYAGPVLLEFPLLNKGSAFSMEERSNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNI
QDTNETLFYRLIGNHLEEMMPVIYTPTVGAACERFSEIYRRARGVFISYQNRHNLDDILQNVPNHNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTTCGGISPAYTLPIVLDVGTNNQQLLDDPLYMGWRHPRITDDEYYQFVDDVIQAIKARWPD
VLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRGAGSQLSEQKIVFLGAGSAGCGIAEQIIAQIVR
EGLSEEEARQRVFMVDRFGLLTDGMPNLLPFQNKLVQKREQLQSWDTTSEALSLLDVVRNVKPNILIGVSGQPGLFTEEI
IREMHKHCPRPIVMPLSNPTSRVEATPQNILSWTDGEALVATGSPFSPVTVKGKQYPIAQCNNSYIFPGIGLGVIASGAS
RVTDEMLMAASETLAQHSPLVNNGEGPVLPELKDIQTVSRAIAFAVGKVAQEQGVAVKTSAEALLQAISDNFWLPEYRNY
RRTSI
>Mature_565_residues
MQFTHKKNRSLYIPYAGPVLLEFPLLNKGSAFSMEERSNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNI
QDTNETLFYRLIGNHLEEMMPVIYTPTVGAACERFSEIYRRARGVFISYQNRHNLDDILQNVPNHNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTTCGGISPAYTLPIVLDVGTNNQQLLDDPLYMGWRHPRITDDEYYQFVDDVIQAIKARWPD
VLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRGAGSQLSEQKIVFLGAGSAGCGIAEQIIAQIVR
EGLSEEEARQRVFMVDRFGLLTDGMPNLLPFQNKLVQKREQLQSWDTTSEALSLLDVVRNVKPNILIGVSGQPGLFTEEI
IREMHKHCPRPIVMPLSNPTSRVEATPQNILSWTDGEALVATGSPFSPVTVKGKQYPIAQCNNSYIFPGIGLGVIASGAS
RVTDEMLMAASETLAQHSPLVNNGEGPVLPELKDIQTVSRAIAFAVGKVAQEQGVAVKTSAEALLQAISDNFWLPEYRNY
RRTSI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=523, Percent_Identity=43.0210325047801, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI62420882, Length=543, Percent_Identity=41.804788213628, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI62420880, Length=543, Percent_Identity=41.804788213628, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI239049447, Length=543, Percent_Identity=41.804788213628, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI4505145, Length=552, Percent_Identity=40.9420289855072, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI270265879, Length=463, Percent_Identity=44.2764578833693, Blast_Score=388, Evalue=1e-107,
Organism=Escherichia coli, GI87081919, Length=565, Percent_Identity=88.4955752212389, Blast_Score=1019, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=543, Percent_Identity=43.8305709023941, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322823, Length=559, Percent_Identity=43.8282647584973, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI281362674, Length=514, Percent_Identity=44.1634241245136, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI281362672, Length=514, Percent_Identity=44.1634241245136, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21356279, Length=514, Percent_Identity=44.1634241245136, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24646386, Length=514, Percent_Identity=43.7743190661479, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24646388, Length=514, Percent_Identity=43.579766536965, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI78707242, Length=517, Percent_Identity=39.2649903288201, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707238, Length=517, Percent_Identity=39.2649903288201, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707240, Length=513, Percent_Identity=39.3762183235867, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363505, Length=535, Percent_Identity=35.3271028037383, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707236, Length=535, Percent_Identity=35.3271028037383, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=36.5422396856582, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363503, Length=538, Percent_Identity=34.9442379182156, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19922384, Length=534, Percent_Identity=30.5243445692884, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62773; Mature: 62773

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFTHKKNRSLYIPYAGPVLLEFPLLNKGSAFSMEERSNFNLLGLLPEVVETIEEQAERA
CCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
WIQYQGFKTEIDKHIYLRNIQDTNETLFYRLIGNHLEEMMPVIYTPTVGAACERFSEIYR
HHHCCCCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
RARGVFISYQNRHNLDDILQNVPNHNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEEECCCCCHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEE
TCGGISPAYTLPIVLDVGTNNQQLLDDPLYMGWRHPRITDDEYYQFVDDVIQAIKARWPD
ECCCCCCCEEEEEEEEECCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHH
VLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRGAGSQLSEQKIVF
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEE
LGAGSAGCGIAEQIIAQIVREGLSEEEARQRVFMVDRFGLLTDGMPNLLPFQNKLVQKRE
EECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QLQSWDTTSEALSLLDVVRNVKPNILIGVSGQPGLFTEEIIREMHKHCPRPIVMPLSNPT
HHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEATPQNILSWTDGEALVATGSPFSPVTVKGKQYPIAQCNNSYIFPGIGLGVIASGAS
HHHHCCHHHHHCCCCCCEEEECCCCCCCEEECCCCCCHHCCCCCEECCCCCHHHHHCCHH
RVTDEMLMAASETLAQHSPLVNNGEGPVLPELKDIQTVSRAIAFAVGKVAQEQGVAVKTS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
AEALLQAISDNFWLPEYRNYRRTSI
HHHHHHHHHCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MQFTHKKNRSLYIPYAGPVLLEFPLLNKGSAFSMEERSNFNLLGLLPEVVETIEEQAERA
CCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
WIQYQGFKTEIDKHIYLRNIQDTNETLFYRLIGNHLEEMMPVIYTPTVGAACERFSEIYR
HHHCCCCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
RARGVFISYQNRHNLDDILQNVPNHNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEEECCCCCHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEE
TCGGISPAYTLPIVLDVGTNNQQLLDDPLYMGWRHPRITDDEYYQFVDDVIQAIKARWPD
ECCCCCCCEEEEEEEEECCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHH
VLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRGAGSQLSEQKIVF
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEE
LGAGSAGCGIAEQIIAQIVREGLSEEEARQRVFMVDRFGLLTDGMPNLLPFQNKLVQKRE
EECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QLQSWDTTSEALSLLDVVRNVKPNILIGVSGQPGLFTEEIIREMHKHCPRPIVMPLSNPT
HHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEATPQNILSWTDGEALVATGSPFSPVTVKGKQYPIAQCNNSYIFPGIGLGVIASGAS
HHHHCCHHHHHCCCCCCEEEECCCCCCCEEECCCCCCHHCCCCCEECCCCCHHHHHCCHH
RVTDEMLMAASETLAQHSPLVNNGEGPVLPELKDIQTVSRAIAFAVGKVAQEQGVAVKTS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
AEALLQAISDNFWLPEYRNYRRTSI
HHHHHHHHHCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA