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The map label for this gene is guaD [H]

Identifier: 238894826

GI number: 238894826

Start: 2707353

End: 2708663

Strand: Direct

Name: guaD [H]

Synonym: KP1_2840

Alternate gene names: 238894826

Gene position: 2707353-2708663 (Clockwise)

Preceding gene: 238894825

Following gene: 238894828

Centisome position: 51.58

GC content: 61.78

Gene sequence:

>1311_bases
ATGATGGATTACCAGACCGCGGTGCGCGGTGCATTTTTTGATATCGCCGGCGTGGCAGAGACCCCGGATGAGGTGGCCGC
CCAGGCCCGCTATCTCGATGATGGCCTGTTGTTCCTGCAGGAGGGGAAAATTATCGCCCTGCTGCCATGGCATGAGGGGG
AAACCTTTCTGCATCCCCTGAAGGGCTATGTCGATCTGAGGGGTAAGCTGCTGCTGCCGGGGTTCGTTGATGCCCACGTT
CACTATCCGCAGACCGAGATGATCGGCGCCTTTGGCGAACAGCTGCTGGAGTGGCTCACCACCTACACCTTCCCGGTGGA
GAGCCAGTTTGCCGATGCGGAGTATGCCCAGGAGATAGCGCAGTTTTTTGTAAATCAATTGATAAGCCATGGCACCACCA
CCGCGCTGGTGTTTTGTACCCTGCATCCGGCCTCGGTGGAGGCGTTATTCAGCGAAGCGCTGCGTCTGAATATGCGGCTA
ATCGCCGGGAAAGTGATGATGGATCGCCATGTGCCCGACTACCTGTGCGAAACCGCCGGGGAGAGCTACGAGCAGACCCG
GGCGTTGATCCGCCGCTGGCATCAGCGCGGCAGGCTGGGCTATGCCATCACCCCGCGCTTTGCCCCCACCTCGACCCCGG
GGTTGCTGGAGGCGGTGCAGCGCCTGCGGGCCGAGTTTCCCGACACCTGGCTGCAGACGCATCTCAGTGAAAACCGGGAG
GAGATCGCCTGGGTTAAACAGCTGTGGCCTGAGCATGCGCGCTATCTGGATGTCTATCATCACTATCAGCTCACCGGCGA
ACGCAGCGTCTTCGCTCACGGGATCCATCTCGATGATGCCGAGTGGCAGTGCCTGCATGACACCGGGTCCGCAGTCGCCT
TCTGCCCGACGTCGAATCTGTTTCTCGGCAGCGGGCTGTTCCGCCTGCCCGCCTGCTGGCAGCACCAGGTGCGGATGGGC
ATCGGCAGCGACGTCGGAGCCGGGACCACCTTCAGCATGCTGCGGACGCTGGGCGAGGCCTACAAGGTAGGACAACTGCA
GAGCTATCGCCTGCGCGCCAGCGAGGCCTTCTATCACGCCACCCTTGGCGGGGCGCGCGCCCTGCGGCTGGAGGAGAAAA
TTGGCAATTTCCAGCCGGGCAAAGAGGCGGATTTTGTGGTGATTGACCCGGCGGTCACCCCGCTGCAGCGCCTGCGCACA
GGCCGCTGCCATGACATTTATGAGCAGCTGTTCGTGCTGATGACCCTGGGTGATGAACGCAATATCAGCGAGACGTGGGT
GAACGGCGAGCGGGTGTGGTGTCAGGATTGA

Upstream 100 bases:

>100_bases
CTTCCCCTTCTGCCGCGGCGTCTGGCCGCGGCAGGCTGCAAACTGGCACCAATCTTGCTGTTTATCACTATTCCCTGAGC
GTTGAGAGAAGGCAGGTTCG

Downstream 100 bases:

>100_bases
CCCCATCAGCCAGTCCCACTTCCTGAAAAGAACGAGAAAACGCACCATACCTTGTTTGCCACCTTAGCGCAGGCTAACCC
ACTACAGGCGGGGGCTTATT

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MMDYQTAVRGAFFDIAGVAETPDEVAAQARYLDDGLLFLQEGKIIALLPWHEGETFLHPLKGYVDLRGKLLLPGFVDAHV
HYPQTEMIGAFGEQLLEWLTTYTFPVESQFADAEYAQEIAQFFVNQLISHGTTTALVFCTLHPASVEALFSEALRLNMRL
IAGKVMMDRHVPDYLCETAGESYEQTRALIRRWHQRGRLGYAITPRFAPTSTPGLLEAVQRLRAEFPDTWLQTHLSENRE
EIAWVKQLWPEHARYLDVYHHYQLTGERSVFAHGIHLDDAEWQCLHDTGSAVAFCPTSNLFLGSGLFRLPACWQHQVRMG
IGSDVGAGTTFSMLRTLGEAYKVGQLQSYRLRASEAFYHATLGGARALRLEEKIGNFQPGKEADFVVIDPAVTPLQRLRT
GRCHDIYEQLFVLMTLGDERNISETWVNGERVWCQD

Sequences:

>Translated_436_residues
MMDYQTAVRGAFFDIAGVAETPDEVAAQARYLDDGLLFLQEGKIIALLPWHEGETFLHPLKGYVDLRGKLLLPGFVDAHV
HYPQTEMIGAFGEQLLEWLTTYTFPVESQFADAEYAQEIAQFFVNQLISHGTTTALVFCTLHPASVEALFSEALRLNMRL
IAGKVMMDRHVPDYLCETAGESYEQTRALIRRWHQRGRLGYAITPRFAPTSTPGLLEAVQRLRAEFPDTWLQTHLSENRE
EIAWVKQLWPEHARYLDVYHHYQLTGERSVFAHGIHLDDAEWQCLHDTGSAVAFCPTSNLFLGSGLFRLPACWQHQVRMG
IGSDVGAGTTFSMLRTLGEAYKVGQLQSYRLRASEAFYHATLGGARALRLEEKIGNFQPGKEADFVVIDPAVTPLQRLRT
GRCHDIYEQLFVLMTLGDERNISETWVNGERVWCQD
>Mature_436_residues
MMDYQTAVRGAFFDIAGVAETPDEVAAQARYLDDGLLFLQEGKIIALLPWHEGETFLHPLKGYVDLRGKLLLPGFVDAHV
HYPQTEMIGAFGEQLLEWLTTYTFPVESQFADAEYAQEIAQFFVNQLISHGTTTALVFCTLHPASVEALFSEALRLNMRL
IAGKVMMDRHVPDYLCETAGESYEQTRALIRRWHQRGRLGYAITPRFAPTSTPGLLEAVQRLRAEFPDTWLQTHLSENRE
EIAWVKQLWPEHARYLDVYHHYQLTGERSVFAHGIHLDDAEWQCLHDTGSAVAFCPTSNLFLGSGLFRLPACWQHQVRMG
IGSDVGAGTTFSMLRTLGEAYKVGQLQSYRLRASEAFYHATLGGARALRLEEKIGNFQPGKEADFVVIDPAVTPLQRLRT
GRCHDIYEQLFVLMTLGDERNISETWVNGERVWCQD

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=378, Percent_Identity=35.4497354497354, Blast_Score=232, Evalue=6e-61,
Organism=Escherichia coli, GI1789249, Length=427, Percent_Identity=58.07962529274, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6319963, Length=469, Percent_Identity=31.1300639658849, Blast_Score=225, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24643849, Length=389, Percent_Identity=35.73264781491, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 49441; Mature: 49441

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDYQTAVRGAFFDIAGVAETPDEVAAQARYLDDGLLFLQEGKIIALLPWHEGETFLHPL
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHH
KGYVDLRGKLLLPGFVDAHVHYPQTEMIGAFGEQLLEWLTTYTFPVESQFADAEYAQEIA
HHHHCCCCCEECCCEEECCEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
QFFVNQLISHGTTTALVFCTLHPASVEALFSEALRLNMRLIAGKVMMDRHVPDYLCETAG
HHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ESYEQTRALIRRWHQRGRLGYAITPRFAPTSTPGLLEAVQRLRAEFPDTWLQTHLSENRE
CCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHH
EIAWVKQLWPEHARYLDVYHHYQLTGERSVFAHGIHLDDAEWQCLHDTGSAVAFCPTSNL
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECEEECCCCCEEEECCCCEEEECCCCCC
FLGSGLFRLPACWQHQVRMGIGSDVGAGTTFSMLRTLGEAYKVGQLQSYRLRASEAFYHA
CCCCCHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TLGGARALRLEEKIGNFQPGKEADFVVIDPAVTPLQRLRTGRCHDIYEQLFVLMTLGDER
HCCCHHHEEEHHHHCCCCCCCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCC
NISETWVNGERVWCQD
CCHHHCCCCCEEEECC
>Mature Secondary Structure
MMDYQTAVRGAFFDIAGVAETPDEVAAQARYLDDGLLFLQEGKIIALLPWHEGETFLHPL
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHH
KGYVDLRGKLLLPGFVDAHVHYPQTEMIGAFGEQLLEWLTTYTFPVESQFADAEYAQEIA
HHHHCCCCCEECCCEEECCEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
QFFVNQLISHGTTTALVFCTLHPASVEALFSEALRLNMRLIAGKVMMDRHVPDYLCETAG
HHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ESYEQTRALIRRWHQRGRLGYAITPRFAPTSTPGLLEAVQRLRAEFPDTWLQTHLSENRE
CCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHH
EIAWVKQLWPEHARYLDVYHHYQLTGERSVFAHGIHLDDAEWQCLHDTGSAVAFCPTSNL
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECEEECCCCCEEEECCCCEEEECCCCCC
FLGSGLFRLPACWQHQVRMGIGSDVGAGTTFSMLRTLGEAYKVGQLQSYRLRASEAFYHA
CCCCCHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TLGGARALRLEEKIGNFQPGKEADFVVIDPAVTPLQRLRTGRCHDIYEQLFVLMTLGDER
HCCCHHHEEEHHHHCCCCCCCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCC
NISETWVNGERVWCQD
CCHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]