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The map label for this gene is ywrD [H]

Identifier: 238894804

GI number: 238894804

Start: 2685966

End: 2687552

Strand: Direct

Name: ywrD [H]

Synonym: KP1_2816

Alternate gene names: 238894804

Gene position: 2685966-2687552 (Clockwise)

Preceding gene: 238894796

Following gene: 238894805

Centisome position: 51.18

GC content: 68.81

Gene sequence:

>1587_bases
ATGCACAGTAGCAACGTTTCGACCCACGGCATGGCGGTGGCCCCCCACCACCTCGCCAGTCAGAGCGCGCTGGCGATCCT
GCGCGAGGGCGGCAGCGCCATTGAAGCGATGGTGGCTGCCGCGGCGGCCATCGCCGTCGTCTATCCCCATATGAATGGCC
TCGGCGGCGATGGCTTCTGGCTGATCGTGCCGCCTGAGGGAGACCCCATCGCCATTGACGCCAGCGGGGCCGCCGGATCG
CTGGCGACCCTCGAGGCCTACGCCGGACAGCGGCATATTCCCCACCGGGGACCGCAGGCCGCGCTGACCGTCGCCGGCAC
CGTCAGCGGCTGGGACGAGGCGCTGCGTATTTCACGGGACTTAACCGGCCGCGCGCTGCCGGTGGCCCGCCTGCTGGCCG
ATGCGATCGGCTATGCCGAAGACGGCATTCCGGTCACTGCCTCGCAGGCCCACGCCACCGCCAGCAAACTGGAAGAGCTG
CGCCATCAGCCGGGCTTCAGCGAAACCTGGCTGGTCGCGGGCGAGGCCCCGCGGCCCGGCAGCCGCTTCCGCCAGCCCGC
CCTCGCCGGTACCCTGCGCATGCTGGCCAGCGACGGTCTCGACAGTTTCTATCGCGGGCCGCTGGCCGAGCGTCTCGCGC
AGGGTATGGCCGCGCTGGGGATGCCGATCACCCTCGGCGACCTGCAGGCCCACCGCGCCCGGCGTCCGGGGCCGCTGACG
CTCCAGCACCAGCAGGGCACGCTGTGGAATCTTGCGCCGCCGACGCAGGGACTGGTGTCGCTGGCGATCCTTGGCATCAC
CGACCGCCTGAACATGGCCGATGCCGACGACGCGCAAACGGTGCACCGTATCGTCGAAGCCACCAAGCGGGCATTTGCCC
TGCGCGATGCGCATATCACCGATCCACGCCATCTGGATGTGGATGTACAGGCGTTGCTCACCCCGGAAGCCCTGCAGCCG
CTGGCCGACAGCATCGACGACGCCAGCGCTTCCCCCTGGGGCCGCGGCAAAGGCCCGGGCGATACCGTCTGGATGGGCGT
CGTGGATGACAGCGGACTGGCAGTGTCATTTATTCAGAGTATCTATCACGAGTTCGGCAGCGGCGTGGTACTCCCGGACA
CCGGGATCGTCTGGCAAAACCGCGGGGCGGCCTTCAGCCTCGACCCGCAGCATCTCCTGGCGCTGGCCCCTGGCAAACAG
CCATTCCACACCCTCAACCCTGCCGCCGCCCGCCTGAACGATGGCCGGGTGATGGTCTATGGCTCGATGGGCGGCGACGG
TCAGCCGCAAACGCAGGCGGCGCTGTTTACCCGCTATATCCTGCAGGGGGTGCCGTTGCAGGAGAGCATCTCCCGTCCGC
GCTGGCTGCTGGGCCGCACCTGGGGCCAGTCCTCCGACTCACTGAAGCTGGAGGGACGCTTTGCCCCCGCCTGTATCGCT
CGCCTGCGCGAGCTGGGGCACGACGTAGAAGTGCTGGCCGATTTCAGCGAAGCGATGGGCCACGCCGGGGCCATTGTCCG
CCATCCCAACGGTCTGCTTGAAGGGGCGACCGATCCTCGCAGCAACGGCGCCGCCGCCGGGTACTAA

Upstream 100 bases:

>100_bases
GGAAAATTCTGGTCATCGTTTTTATCAATGAAACGAAACGTTCAGAGATGGAACAGCTTTTGCAGTGTTCTGCGGGTGAT
TCGTTCAGAAAGGATAATTT

Downstream 100 bases:

>100_bases
GGAGCAGACCATGACCACACAGCCAGACTGGAGCGAGTATCTGACGCAGATGACTCACCTGTTGGATATGGAGCTGGATG
CGCCGCGCCGTAAGGAGCTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGS
LATLEAYAGQRHIPHRGPQAALTVAGTVSGWDEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEEL
RHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
LQHQQGTLWNLAPPTQGLVSLAILGITDRLNMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQALLTPEALQP
LADSIDDASASPWGRGKGPGDTVWMGVVDDSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQ
PFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY

Sequences:

>Translated_528_residues
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGS
LATLEAYAGQRHIPHRGPQAALTVAGTVSGWDEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEEL
RHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
LQHQQGTLWNLAPPTQGLVSLAILGITDRLNMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQALLTPEALQP
LADSIDDASASPWGRGKGPGDTVWMGVVDDSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQ
PFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY
>Mature_528_residues
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGS
LATLEAYAGQRHIPHRGPQAALTVAGTVSGWDEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEEL
RHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
LQHQQGTLWNLAPPTQGLVSLAILGITDRLNMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQALLTPEALQP
LADSIDDASASPWGRGKGPGDTVWMGVVDDSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQ
PFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=557, Percent_Identity=29.443447037702, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI73915090, Length=557, Percent_Identity=29.443447037702, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI73915096, Length=557, Percent_Identity=29.443447037702, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI73915094, Length=557, Percent_Identity=29.443447037702, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI113429324, Length=534, Percent_Identity=29.2134831460674, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI113429326, Length=536, Percent_Identity=28.9179104477612, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI109148539, Length=446, Percent_Identity=28.47533632287, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI153266901, Length=401, Percent_Identity=27.431421446384, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI153266885, Length=401, Percent_Identity=27.431421446384, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI153266907, Length=385, Percent_Identity=27.012987012987, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789856, Length=555, Percent_Identity=30.2702702702703, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17542894, Length=481, Percent_Identity=25.1559251559252, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193208247, Length=481, Percent_Identity=24.5322245322245, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193208245, Length=481, Percent_Identity=24.5322245322245, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI212646519, Length=459, Percent_Identity=25.4901960784314, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72000294, Length=459, Percent_Identity=25.4901960784314, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506189, Length=457, Percent_Identity=26.0393873085339, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45551474, Length=556, Percent_Identity=26.2589928057554, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642670, Length=556, Percent_Identity=26.2589928057554, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642666, Length=556, Percent_Identity=26.2589928057554, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161077880, Length=556, Percent_Identity=26.2589928057554, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161077878, Length=556, Percent_Identity=26.2589928057554, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=26.614481409002, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55611; Mature: 55611

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFW
CCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEE
LIVPPEGDPIAIDASGAAGSLATLEAYAGQRHIPHRGPQAALTVAGTVSGWDEALRISRD
EEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHC
LTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEELRHQPGFSETWLVAGEAPRPG
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
SRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
HHHCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCEEECCHHHHHCCCCCCEE
LQHQQGTLWNLAPPTQGLVSLAILGITDRLNMADADDAQTVHRIVEATKRAFALRDAHIT
EEECCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DPRHLDVDVQALLTPEALQPLADSIDDASASPWGRGKGPGDTVWMGVVDDSGLAVSFIQS
CCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
IYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQPFHTLNPAAARLNDGRVMVY
HHHHHCCCEEECCCCEEECCCCCEEEECHHHHEEECCCCCCCCCCCHHHHEECCCEEEEE
GSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
ECCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCHHHHH
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY
HHHHCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFW
CCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEE
LIVPPEGDPIAIDASGAAGSLATLEAYAGQRHIPHRGPQAALTVAGTVSGWDEALRISRD
EEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHC
LTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEELRHQPGFSETWLVAGEAPRPG
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
SRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
HHHCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCEEECCHHHHHCCCCCCEE
LQHQQGTLWNLAPPTQGLVSLAILGITDRLNMADADDAQTVHRIVEATKRAFALRDAHIT
EEECCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DPRHLDVDVQALLTPEALQPLADSIDDASASPWGRGKGPGDTVWMGVVDDSGLAVSFIQS
CCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
IYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQPFHTLNPAAARLNDGRVMVY
HHHHHCCCEEECCCCEEECCCCCEEEECHHHHEEECCCCCCCCCCCHHHHEECCCEEEEE
GSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
ECCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCHHHHH
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY
HHHHCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]