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The map label for this gene is tcyB [H]

Identifier: 238894801

GI number: 238894801

Start: 2683272

End: 2683937

Strand: Reverse

Name: tcyB [H]

Synonym: KP1_2812

Alternate gene names: 238894801

Gene position: 2683937-2683272 (Counterclockwise)

Preceding gene: 238894802

Following gene: 238894800

Centisome position: 51.14

GC content: 61.71

Gene sequence:

>666_bases
ATGACGGAGCAACTTCATTTCTCTGAGCTCTGGCCGCACTGGCCGGAGCTGCTGGCCGGCCTGTGGGTGACGGTGCAGTT
GACGGTGCTGGCGACGATCGGCGGACTGGCGATCGGCATCCTTGGGGCGGCGATCCGCAGCGGTCGCCCGGGAATGCTCA
GCCGGGTATGGGGCGGATATGTGGAAATCATCCGTAATACGCCGTTTGTGGTGCAGCTCTTTTTTATCGTCTTTGGTTTA
CCGAACCTCGGACTGAAGATGACCGCCGGTGAAGCGGCGCTGCTGGCGATGGTGGTCAACCTCGGCGCCTATAGCACCGA
GATCGTCCGCGCCGGCATCCAGGTGACGCCGAAGGGCCAGTGGGAAGCCGGTCGCGTGCTCGGGCTTAGCCGGACGCAAA
CCTTCGTTCGCGTCGTACTGCCCCCGGCGCTGCAGCGGATTTATCCGGCGCTGGTCAGCCAGTGCATCATTGTGATGCTC
GGCTCGTCAGTGGTGTCGCAGGTCTCCTATGAGGAGCTGACCTTCGCCGCCAACCTGATCCAGTCGCGGACATTTTTGAG
CTTTGAGGTCTATCTGGTAACCACCGGGATCTACTTAGCGTTATCGATAGCGATGCGCCAGCTGCTGATGGCGGCGGGGC
GTAAATGGCTGGGGGTACAGGCCTGA

Upstream 100 bases:

>100_bases
CCTCATCGAGCAGGGCATTAAGGACGGCACCCTCAACGGTCTGTCTGAGAAGTGGCTGAAAGCGCCACTGCCTGCCAGCC
TCGGCGCGTAAGGTCTGGGG

Downstream 100 bases:

>100_bases
TGACCACTTTTACTGACTGGGACATTATCCGCAACCTGCTGCTGGCCGGTCGCTGGACGGTGCTGCTGTCGCTGGTCGCG
TTCACCGGCGGGGCGCTGGT

Product: glutamine ABC transport system permease component

Products: ADP; phosphate; L-glutamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTEQLHFSELWPHWPELLAGLWVTVQLTVLATIGGLAIGILGAAIRSGRPGMLSRVWGGYVEIIRNTPFVVQLFFIVFGL
PNLGLKMTAGEAALLAMVVNLGAYSTEIVRAGIQVTPKGQWEAGRVLGLSRTQTFVRVVLPPALQRIYPALVSQCIIVML
GSSVVSQVSYEELTFAANLIQSRTFLSFEVYLVTTGIYLALSIAMRQLLMAAGRKWLGVQA

Sequences:

>Translated_221_residues
MTEQLHFSELWPHWPELLAGLWVTVQLTVLATIGGLAIGILGAAIRSGRPGMLSRVWGGYVEIIRNTPFVVQLFFIVFGL
PNLGLKMTAGEAALLAMVVNLGAYSTEIVRAGIQVTPKGQWEAGRVLGLSRTQTFVRVVLPPALQRIYPALVSQCIIVML
GSSVVSQVSYEELTFAANLIQSRTFLSFEVYLVTTGIYLALSIAMRQLLMAAGRKWLGVQA
>Mature_220_residues
TEQLHFSELWPHWPELLAGLWVTVQLTVLATIGGLAIGILGAAIRSGRPGMLSRVWGGYVEIIRNTPFVVQLFFIVFGLP
NLGLKMTAGEAALLAMVVNLGAYSTEIVRAGIQVTPKGQWEAGRVLGLSRTQTFVRVVLPPALQRIYPALVSQCIIVMLG
SSVVSQVSYEELTFAANLIQSRTFLSFEVYLVTTGIYLALSIAMRQLLMAAGRKWLGVQA

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787030, Length=214, Percent_Identity=34.5794392523364, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1788226, Length=190, Percent_Identity=34.7368421052632, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787087, Length=211, Percent_Identity=27.0142180094787, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1786873, Length=220, Percent_Identity=27.7272727272727, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787086, Length=213, Percent_Identity=27.6995305164319, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788646, Length=211, Percent_Identity=25.1184834123223, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI48994930, Length=179, Percent_Identity=31.2849162011173, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788645, Length=232, Percent_Identity=28.0172413793103, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786874, Length=211, Percent_Identity=25.5924170616114, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24089; Mature: 23958

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQLHFSELWPHWPELLAGLWVTVQLTVLATIGGLAIGILGAAIRSGRPGMLSRVWGGY
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VEIIRNTPFVVQLFFIVFGLPNLGLKMTAGEAALLAMVVNLGAYSTEIVRAGIQVTPKGQ
HHHHHCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHCCCEECCCCC
WEAGRVLGLSRTQTFVRVVLPPALQRIYPALVSQCIIVMLGSSVVSQVSYEELTFAANLI
CCCCCEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSRTFLSFEVYLVTTGIYLALSIAMRQLLMAAGRKWLGVQA
HHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TEQLHFSELWPHWPELLAGLWVTVQLTVLATIGGLAIGILGAAIRSGRPGMLSRVWGGY
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VEIIRNTPFVVQLFFIVFGLPNLGLKMTAGEAALLAMVVNLGAYSTEIVRAGIQVTPKGQ
HHHHHCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHCCCEECCCCC
WEAGRVLGLSRTQTFVRVVLPPALQRIYPALVSQCIIVMLGSSVVSQVSYEELTFAANLI
CCCCCEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSRTFLSFEVYLVTTGIYLALSIAMRQLLMAAGRKWLGVQA
HHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamine [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamine [Periplasm] + H2O = ADP + phosphate + L-glutamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]