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The map label for this gene is alsE [H]

Identifier: 238894781

GI number: 238894781

Start: 2662308

End: 2662988

Strand: Reverse

Name: alsE [H]

Synonym: KP1_2791

Alternate gene names: 238894781

Gene position: 2662988-2662308 (Counterclockwise)

Preceding gene: 238894782

Following gene: 238894780

Centisome position: 50.74

GC content: 46.4

Gene sequence:

>681_bases
ATGAGCGCTAAATTTTCACCGTCACTGATGTGCATGGATTTAACGCAGTTCAAAGAGCAGATCACGGCAATGAATAAAAA
AGCGGATTTTTACCATGTTGATATAATGGATGGCAATTACGTCCGCAATATCACACTGTCTCCCTTTTTTATTGAGAATC
TGAAAAAAATTACTACTGTGCCCATTGATGTTCATCTGATGGTGAATCATCCGGAAGATATCATTCCCATGTGTCTCGAG
GCCGGCGCCGATATCATCAGCTTTCATCCCGAGACGGCGAATAACAAAATATTCCGCCTGCTGAATCAGATCAAGGATGC
GGGCAAAAAGTGCGGGGTGGTGCTGAACCCGGCGACACCGGCAGAAAGCATTGCCGAATATGCGCATCTGCTGGATAAAG
TGACGGTCATGTCGGTTGACCCTGGCTATGCCGGACAAAAGTTTATTCCTGAGTCGCTGAACAAGATTAGAAAGCTCATC
AACATGCGCAAGAATAATGGTTATCGCTATCTGACGGAAATTGATGGCTCTTGCAATGAGAAAACCTTCGGTCAGATTGC
TGAATCCGGGGTAGATGTCTTTATCGTCGGCACATCGGGTCTGTTTTCGCTCCATGAGGATGTCAGCCAGGCGTGGGACA
GAATGATCGAGATCTTCCAACGGGAAACTGTCGCTGCATAA

Upstream 100 bases:

>100_bases
TGGGCTCCACAACCTTTGGAGACGCAGACTTTGGCGTTGTCGGCATCGTGCTGGGTCATATCATCGCAATGTTTAACTAA
CTATTTATCGGAGGTGGTTT

Downstream 100 bases:

>100_bases
CGGGTTATTTCTCTTCGAACCACAGTGTGTATTTGAATAAGCCTTAAAAGATCTGCATCACGCCAGCGATGCTGGTTTGT
TATTTAACGACCACTCTATA

Product: allulose-6-phosphate 3-epimerase

Products: fructose-6-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSAKFSPSLMCMDLTQFKEQITAMNKKADFYHVDIMDGNYVRNITLSPFFIENLKKITTVPIDVHLMVNHPEDIIPMCLE
AGADIISFHPETANNKIFRLLNQIKDAGKKCGVVLNPATPAESIAEYAHLLDKVTVMSVDPGYAGQKFIPESLNKIRKLI
NMRKNNGYRYLTEIDGSCNEKTFGQIAESGVDVFIVGTSGLFSLHEDVSQAWDRMIEIFQRETVAA

Sequences:

>Translated_226_residues
MSAKFSPSLMCMDLTQFKEQITAMNKKADFYHVDIMDGNYVRNITLSPFFIENLKKITTVPIDVHLMVNHPEDIIPMCLE
AGADIISFHPETANNKIFRLLNQIKDAGKKCGVVLNPATPAESIAEYAHLLDKVTVMSVDPGYAGQKFIPESLNKIRKLI
NMRKNNGYRYLTEIDGSCNEKTFGQIAESGVDVFIVGTSGLFSLHEDVSQAWDRMIEIFQRETVAA
>Mature_225_residues
SAKFSPSLMCMDLTQFKEQITAMNKKADFYHVDIMDGNYVRNITLSPFFIENLKKITTVPIDVHLMVNHPEDIIPMCLEA
GADIISFHPETANNKIFRLLNQIKDAGKKCGVVLNPATPAESIAEYAHLLDKVTVMSVDPGYAGQKFIPESLNKIRKLIN
MRKNNGYRYLTEIDGSCNEKTFGQIAESGVDVFIVGTSGLFSLHEDVSQAWDRMIEIFQRETVAA

Specific function: D-ALLOSE METABOLISM. ESSENTIAL FOR THIS PATHWAY. [C]

COG id: COG0036

COG function: function code G; Pentose-5-phosphate-3-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribulose-phosphate 3-epimerase family [H]

Homologues:

Organism=Homo sapiens, GI40385883, Length=199, Percent_Identity=32.1608040201005, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI219879828, Length=199, Percent_Identity=31.1557788944724, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI24307923, Length=155, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790523, Length=212, Percent_Identity=52.8301886792453, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1789788, Length=196, Percent_Identity=39.2857142857143, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1790754, Length=155, Percent_Identity=31.6129032258064, Blast_Score=81, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17552948, Length=199, Percent_Identity=31.1557788944724, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322341, Length=209, Percent_Identity=30.1435406698565, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24586301, Length=202, Percent_Identity=32.1782178217822, Blast_Score=117, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000056
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00834 Ribul_P_3_epim [H]

EC number: 5.1.3.- [C]

Molecular weight: Translated: 25367; Mature: 25235

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01086 RIBUL_P_3_EPIMER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKFSPSLMCMDLTQFKEQITAMNKKADFYHVDIMDGNYVRNITLSPFFIENLKKITTV
CCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHEEC
PIDVHLMVNHPEDIIPMCLEAGADIISFHPETANNKIFRLLNQIKDAGKKCGVVLNPATP
CEEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCCC
AESIAEYAHLLDKVTVMSVDPGYAGQKFIPESLNKIRKLINMRKNNGYRYLTEIDGSCNE
HHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
KTFGQIAESGVDVFIVGTSGLFSLHEDVSQAWDRMIEIFQRETVAA
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAKFSPSLMCMDLTQFKEQITAMNKKADFYHVDIMDGNYVRNITLSPFFIENLKKITTV
CCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHEEC
PIDVHLMVNHPEDIIPMCLEAGADIISFHPETANNKIFRLLNQIKDAGKKCGVVLNPATP
CEEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCCC
AESIAEYAHLLDKVTVMSVDPGYAGQKFIPESLNKIRKLINMRKNNGYRYLTEIDGSCNE
HHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
KTFGQIAESGVDVFIVGTSGLFSLHEDVSQAWDRMIEIFQRETVAA
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-allulose-6-phosphate [C]

Specific reaction: D-allulose-6-phosphate = fructose-6-phosphate [C]

General reaction: Isomerases; Racemases and Epimerases; Acting on Carbohydrates and Derivatives [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 9401019 [H]