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The map label for this gene is pcaR [H]

Identifier: 238894556

GI number: 238894556

Start: 2452161

End: 2452967

Strand: Reverse

Name: pcaR [H]

Synonym: KP1_2553

Alternate gene names: 238894556

Gene position: 2452967-2452161 (Counterclockwise)

Preceding gene: 238894563

Following gene: 238894553

Centisome position: 46.74

GC content: 64.19

Gene sequence:

>807_bases
ATGGACAAGCATCCAGACGATTTACTGACCGGCGACGGCGATCCGTTTAAAGGCGATCCTAACTTTATGGCCTCCCTGGC
GCGGGGTCTGGAGGTGATTCAGGCGTTCACACCGCAGCGGCCCCTGCTGTCTATCTCACAGATCAGTCAGAAGACCGGCA
TCCCGCGCGCCGCGGTGCGCCGCTGCCTGTATACCCTGAGCAAGCTGGGGTTCGTGTATGCCGAAGACGGTAAGAATTTC
CAGCTGCGGCCGCGGATCCTGGCGCTGGGCCACGCCTGGCTGGCCTCGACGCCGCTGGCGCGTTCGGCGCAGCCGGTGCT
GCGGCATCTGAGCGAAATGCTCAATGAGTCCTGCTCCATCGCGACCCTCGACGGCGACGATATCCTGTATATCGCCCGCG
CCTCCAGCTCGCGGATTATGACCATCGACCTGGATATCGGCAGTCGCCTTCCGGCGTGGGCGACCTCGATGGGCCGGGTG
CTGCTGAGCCATCAGCCGGAGGAGAAGCTCAACGATATGCTGGCCCGGGTGACCATGATCCGCTATACCCCACAGACGGT
GGATTCGGTGGCGAAGCTGCGCGCCGAACTGAAACGGGTGCATCAGCAGGGGTATGCCCTCAACGATCAGGAGCTGGAGA
TGGGGCTGCGCTCCCTCGCGGTCCCGCTGTTTAACGCTCAGGGGCAGGTCCAGGCGGCGCTCAACGTCGGGGTGCATGCG
GGCCAGATGACGGCCCGCGAGATGATCGAGCGCGTGCTGCCGGAGCTGCAAAAAGCCGCCCGCGAGCTGACGCTGCTTCT
GCGCTAA

Upstream 100 bases:

>100_bases
CGATGTCGGTCAAGGGCGATAATCGAAATATGGTGCGATAATCGAACATCGGTTATCTTTAGCGAAAGAATGTGATCGAT
GGCAAATATGGGGAACAGAA

Downstream 100 bases:

>100_bases
CGACTGCGCTTGGCGTGCTGCTCCCAGGTCTCCTGCTTCGCCTGCGCCGATTTACGCAGCGCAACATAGCAGGCGCCGCT
GCCGCCATGATGCGGAAGCG

Product: putative IclR-family transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDKHPDDLLTGDGDPFKGDPNFMASLARGLEVIQAFTPQRPLLSISQISQKTGIPRAAVRRCLYTLSKLGFVYAEDGKNF
QLRPRILALGHAWLASTPLARSAQPVLRHLSEMLNESCSIATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRV
LLSHQPEEKLNDMLARVTMIRYTPQTVDSVAKLRAELKRVHQQGYALNDQELEMGLRSLAVPLFNAQGQVQAALNVGVHA
GQMTAREMIERVLPELQKAARELTLLLR

Sequences:

>Translated_268_residues
MDKHPDDLLTGDGDPFKGDPNFMASLARGLEVIQAFTPQRPLLSISQISQKTGIPRAAVRRCLYTLSKLGFVYAEDGKNF
QLRPRILALGHAWLASTPLARSAQPVLRHLSEMLNESCSIATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRV
LLSHQPEEKLNDMLARVTMIRYTPQTVDSVAKLRAELKRVHQQGYALNDQELEMGLRSLAVPLFNAQGQVQAALNVGVHA
GQMTAREMIERVLPELQKAARELTLLLR
>Mature_268_residues
MDKHPDDLLTGDGDPFKGDPNFMASLARGLEVIQAFTPQRPLLSISQISQKTGIPRAAVRRCLYTLSKLGFVYAEDGKNF
QLRPRILALGHAWLASTPLARSAQPVLRHLSEMLNESCSIATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRV
LLSHQPEEKLNDMLARVTMIRYTPQTVDSVAKLRAELKRVHQQGYALNDQELEMGLRSLAVPLFNAQGQVQAALNVGVHA
GQMTAREMIERVLPELQKAARELTLLLR

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=246, Percent_Identity=30.0813008130081, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786468, Length=217, Percent_Identity=30.8755760368664, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082359, Length=245, Percent_Identity=28.1632653061224, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788581, Length=213, Percent_Identity=26.7605633802817, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786715, Length=243, Percent_Identity=23.0452674897119, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789999, Length=261, Percent_Identity=22.6053639846743, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693096, Length=232, Percent_Identity=28.0172413793103, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29691; Mature: 29691

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKHPDDLLTGDGDPFKGDPNFMASLARGLEVIQAFTPQRPLLSISQISQKTGIPRAAVR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHH
RCLYTLSKLGFVYAEDGKNFQLRPRILALGHAWLASTPLARSAQPVLRHLSEMLNESCSI
HHHHHHHHCCEEEECCCCCEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCE
ATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRVLLSHQPEEKLNDMLARVTMI
EEECCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RYTPQTVDSVAKLRAELKRVHQQGYALNDQELEMGLRSLAVPLFNAQGQVQAALNVGVHA
HCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
GQMTAREMIERVLPELQKAARELTLLLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKHPDDLLTGDGDPFKGDPNFMASLARGLEVIQAFTPQRPLLSISQISQKTGIPRAAVR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHH
RCLYTLSKLGFVYAEDGKNFQLRPRILALGHAWLASTPLARSAQPVLRHLSEMLNESCSI
HHHHHHHHCCEEEECCCCCEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCE
ATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRVLLSHQPEEKLNDMLARVTMI
EEECCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RYTPQTVDSVAKLRAELKRVHQQGYALNDQELEMGLRSLAVPLFNAQGQVQAALNVGVHA
HCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
GQMTAREMIERVLPELQKAARELTLLLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]