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The map label for this gene is shiA [H]

Identifier: 238894513

GI number: 238894513

Start: 2410465

End: 2411937

Strand: Reverse

Name: shiA [H]

Synonym: KP1_2506

Alternate gene names: 238894513

Gene position: 2411937-2410465 (Counterclockwise)

Preceding gene: 238894515

Following gene: 238894506

Centisome position: 45.95

GC content: 60.01

Gene sequence:

>1473_bases
ATGCCCAGTTTGCCAGCCATAAACTTGCCAATTGTAACCTTCAACCCTAAGTTGCTTAACAATTACACAACCTTTTCACA
TCAGGTTGCACCCTGCTCGTACAGAGTGACACCTGACCTATCTACCGTGGCGGGAGAACGTTTCGTAATGAGCAATCCAC
AAGACAACACTGCATCCATTCTGCAGAAAAACAAGAAGGTACTGATCGCGAGCCTGACAGGCAGCGCCATCGAATGGTTC
GATTATTTTCTCTATGGCACCGCCGCCGCGCTGGTGTTCAACAAAATCTTCTTTCCGATGGTCGACCCGGTTATCGGCCT
GATCCTCTCCTGGCTCTCCTTCTCGCTGACGTTTTTTATCCGCCCCATCGGCGGCGTGATTTTCGCCCATATCGGCGATC
GCATCGGCCGCAAGAAGACGCTGGTGCTGACCCTGTCGCTGATGGGGAGCGCCACGGTGGCGATCGGCCTGCTGCCCACC
TACGAGATGGTGGGCCTCTGGGCGCCGGCCCTGCTGATTACTCTGCGCATTATTCAGGGCATGGGTATCGGCGGCGAATG
GGGCGGCGCGCTGCTGCTGGCCTATGAATACGCGCCGGAAAAGCGGAAAGGCTTTTTCGGCAGCATTCCCCAGGCCGGGG
TGACCATCGGCATGTTGATGGCGACATTTATCGTCTCGCTGATGACGCTGTTCGATGAGGCGCAGTTTCTCGCCTGGGGC
TGGCGCATACCGTTCCTGCTCAGCTCCGTCCTCGTTTTTCTCGGCCTGTGGATCCGCAAAGATATCGACGAAACGCCCGC
CTTTAAGCAGGTGAAAAAATCCGGCCAGGTGGCGAAGGCCCCGCTGCGCGATACGCTCAAGCACCACTGGCGGGAAGTGC
TGATCGCCGCCGGCCTGAAAGTGGTGGAGACCGCCCCCTTCTATATCTTCTCCACCTTTGTAGTCAGCTACGCCACCACC
ACCCTGAGCTATCAGAAGTCGCAGGCGCTGGAATCCGTGACCCTGGGCGCGCTGGTGGCCACCGTGATGATCCCGCTGAT
GGGGCTGCTGTCAGACAAGGTGGGTCGGCAAAAGATGTACACCCTGAGCGTGGTGCTGCTGGGGCTGTTTATCGTCCCGT
GGTTCCTGCTGCTCGACACCGGCACCGGCTGGGGCATCATGCTGGCGACGATCGTTGCCTTCGGCATCCTGTGGGCGCCG
GTAACCGCGGTGCTAGGCACCCTGTGCTCTGAGATTTTCAGCGCCAATGTGCGCTATACCGGGATCACCCTCGGCTACCA
GCTGGGCGCCGCGCTGGCCGGGGGCACCGCGCCGCTTATCGCCACCGGTCTGCTGGCAAAATATGACGGGGACTGGCGGC
CGGTGGCCGTTTATCTGGGCGTTACGGTGGCGATTTCGCTGCTGGCGATATTCTGCGCCAGCCGGATGAAGTCCGCGCTG
AGCACGGCCCCCTCCCGGGCGGAAAGCGCCTGA

Upstream 100 bases:

>100_bases
TTGCACCTGAACAACTCACTATGAAAATAACAAAAAACAGCAAAATCAGGTGGAAAATAAAAAATAGCGTCGCGGTTATA
CCAGTTCTAAGCGCGCCATA

Downstream 100 bases:

>100_bases
CCGCAGCCCGCCAGGGCTACTACGGCGCCGACTATCCCGTCCGGCGGCGCTGCGCTTGCGCGGGCCTGGGGGGAGATCGC
GCCGCGGGGGATACCGCTTA

Product: shikimate and dehydroshikimate transport protein

Products: Proton [Cytoplasm]; shikimate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MPSLPAINLPIVTFNPKLLNNYTTFSHQVAPCSYRVTPDLSTVAGERFVMSNPQDNTASILQKNKKVLIASLTGSAIEWF
DYFLYGTAAALVFNKIFFPMVDPVIGLILSWLSFSLTFFIRPIGGVIFAHIGDRIGRKKTLVLTLSLMGSATVAIGLLPT
YEMVGLWAPALLITLRIIQGMGIGGEWGGALLLAYEYAPEKRKGFFGSIPQAGVTIGMLMATFIVSLMTLFDEAQFLAWG
WRIPFLLSSVLVFLGLWIRKDIDETPAFKQVKKSGQVAKAPLRDTLKHHWREVLIAAGLKVVETAPFYIFSTFVVSYATT
TLSYQKSQALESVTLGALVATVMIPLMGLLSDKVGRQKMYTLSVVLLGLFIVPWFLLLDTGTGWGIMLATIVAFGILWAP
VTAVLGTLCSEIFSANVRYTGITLGYQLGAALAGGTAPLIATGLLAKYDGDWRPVAVYLGVTVAISLLAIFCASRMKSAL
STAPSRAESA

Sequences:

>Translated_490_residues
MPSLPAINLPIVTFNPKLLNNYTTFSHQVAPCSYRVTPDLSTVAGERFVMSNPQDNTASILQKNKKVLIASLTGSAIEWF
DYFLYGTAAALVFNKIFFPMVDPVIGLILSWLSFSLTFFIRPIGGVIFAHIGDRIGRKKTLVLTLSLMGSATVAIGLLPT
YEMVGLWAPALLITLRIIQGMGIGGEWGGALLLAYEYAPEKRKGFFGSIPQAGVTIGMLMATFIVSLMTLFDEAQFLAWG
WRIPFLLSSVLVFLGLWIRKDIDETPAFKQVKKSGQVAKAPLRDTLKHHWREVLIAAGLKVVETAPFYIFSTFVVSYATT
TLSYQKSQALESVTLGALVATVMIPLMGLLSDKVGRQKMYTLSVVLLGLFIVPWFLLLDTGTGWGIMLATIVAFGILWAP
VTAVLGTLCSEIFSANVRYTGITLGYQLGAALAGGTAPLIATGLLAKYDGDWRPVAVYLGVTVAISLLAIFCASRMKSAL
STAPSRAESA
>Mature_489_residues
PSLPAINLPIVTFNPKLLNNYTTFSHQVAPCSYRVTPDLSTVAGERFVMSNPQDNTASILQKNKKVLIASLTGSAIEWFD
YFLYGTAAALVFNKIFFPMVDPVIGLILSWLSFSLTFFIRPIGGVIFAHIGDRIGRKKTLVLTLSLMGSATVAIGLLPTY
EMVGLWAPALLITLRIIQGMGIGGEWGGALLLAYEYAPEKRKGFFGSIPQAGVTIGMLMATFIVSLMTLFDEAQFLAWGW
RIPFLLSSVLVFLGLWIRKDIDETPAFKQVKKSGQVAKAPLRDTLKHHWREVLIAAGLKVVETAPFYIFSTFVVSYATTT
LSYQKSQALESVTLGALVATVMIPLMGLLSDKVGRQKMYTLSVVLLGLFIVPWFLLLDTGTGWGIMLATIVAFGILWAPV
TAVLGTLCSEIFSANVRYTGITLGYQLGAALAGGTAPLIATGLLAKYDGDWRPVAVYLGVTVAISLLAIFCASRMKSALS
TAPSRAESA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788292, Length=414, Percent_Identity=38.1642512077295, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1790550, Length=417, Percent_Identity=33.0935251798561, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1789941, Length=436, Percent_Identity=37.6146788990826, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1788942, Length=400, Percent_Identity=32.25, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082231, Length=392, Percent_Identity=23.9795918367347, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082404, Length=420, Percent_Identity=24.047619047619, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 53078; Mature: 52946

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00024 HEMOPEXIN ; PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLPAINLPIVTFNPKLLNNYTTFSHQVAPCSYRVTPDLSTVAGERFVMSNPQDNTASI
CCCCCCCCCEEEEECHHHHCCCCCCCCCCCCCEEEECCCHHHHCCCCEEECCCCCHHHHH
LQKNKKVLIASLTGSAIEWFDYFLYGTAAALVFNKIFFPMVDPVIGLILSWLSFSLTFFI
HHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPIGGVIFAHIGDRIGRKKTLVLTLSLMGSATVAIGLLPTYEMVGLWAPALLITLRIIQG
HHHHHHHHHHHHHHCCCCEEEEEEEEHHCCHHHEEECCCHHHHHHHHHHHHHHHHHHHHC
MGIGGEWGGALLLAYEYAPEKRKGFFGSIPQAGVTIGMLMATFIVSLMTLFDEAQFLAWG
CCCCCCCCCEEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WRIPFLLSSVLVFLGLWIRKDIDETPAFKQVKKSGQVAKAPLRDTLKHHWREVLIAAGLK
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHCCH
VVETAPFYIFSTFVVSYATTTLSYQKSQALESVTLGALVATVMIPLMGLLSDKVGRQKMY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
TLSVVLLGLFIVPWFLLLDTGTGWGIMLATIVAFGILWAPVTAVLGTLCSEIFSANVRYT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GITLGYQLGAALAGGTAPLIATGLLAKYDGDWRPVAVYLGVTVAISLLAIFCASRMKSAL
EEEEHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
STAPSRAESA
HCCCCCCCCC
>Mature Secondary Structure 
PSLPAINLPIVTFNPKLLNNYTTFSHQVAPCSYRVTPDLSTVAGERFVMSNPQDNTASI
CCCCCCCCEEEEECHHHHCCCCCCCCCCCCCEEEECCCHHHHCCCCEEECCCCCHHHHH
LQKNKKVLIASLTGSAIEWFDYFLYGTAAALVFNKIFFPMVDPVIGLILSWLSFSLTFFI
HHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPIGGVIFAHIGDRIGRKKTLVLTLSLMGSATVAIGLLPTYEMVGLWAPALLITLRIIQG
HHHHHHHHHHHHHHCCCCEEEEEEEEHHCCHHHEEECCCHHHHHHHHHHHHHHHHHHHHC
MGIGGEWGGALLLAYEYAPEKRKGFFGSIPQAGVTIGMLMATFIVSLMTLFDEAQFLAWG
CCCCCCCCCEEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WRIPFLLSSVLVFLGLWIRKDIDETPAFKQVKKSGQVAKAPLRDTLKHHWREVLIAAGLK
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHCCH
VVETAPFYIFSTFVVSYATTTLSYQKSQALESVTLGALVATVMIPLMGLLSDKVGRQKMY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
TLSVVLLGLFIVPWFLLLDTGTGWGIMLATIVAFGILWAPVTAVLGTLCSEIFSANVRYT
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GITLGYQLGAALAGGTAPLIATGLLAKYDGDWRPVAVYLGVTVAISLLAIFCASRMKSAL
EEEEHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
STAPSRAESA
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; shikimate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + shikimate [Periplasm] = Proton [Cytoplasm] + shikimate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9524262; 9097040; 9278503 [H]