Click here to switch to the map view.

The map label for this gene is paaH [H]

Identifier: 238894488

GI number: 238894488

Start: 2382135

End: 2383556

Strand: Direct

Name: paaH [H]

Synonym: KP1_2479

Alternate gene names: 238894488

Gene position: 2382135-2383556 (Clockwise)

Preceding gene: 238894487

Following gene: 238894489

Centisome position: 45.39

GC content: 62.52

Gene sequence:

>1422_bases
ATGACGACATCCTTAGTCAACGTGGCGGTGATCGGCAGCGGCACCATGGGGGCCGGCATCGCCGAAGTGGCTGCCGCCGC
CGGGCATCCGGTGCGTATTTTTGATATTAACCCTAAGGCTGTAGACCTGGCGATAGAGGGTATCGCCGGGCGCCTGGCGT
CACGCGTTGCGCGGGGCAAACTGGCGTCAGAGCAGGCCGATGCGCTGCTGGCGCGCCTGCATCCGGCCCACGATTTAGCC
GCACTTGCCGATGCGGATTTAGTGATCGAAGCGGCCTCTGAACGGTTGGAGGTCAAAACGGCGCTGTTCACGCAGCTGGC
GGCGATCTGCGCGCCGTCAACGCTGTTGACCAGTAATACCTCGTCTATTTCGATTACCGCTATCGCCGCCGGGGTCAAAA
ACCCGGAGCGGGTGGCCGGACTGCACTTTTTTAATCCGGCGCCGGTGATGAAGCTGGTCGAGGTGGTGAGTGGTCTTGCG
ACCTCCACAGAAGTGGTGGAGCAGCTGTGCCAGTGCGTAAGCGGCTGGGGGAAACAGCCGGTACGCTGCCGCTCAACGCC
CGGTTTTATCGTTAACCGCGTAGCGCGTCCGTTCTACGCTGAGGCCTGGCGCGCGCTGGAAGAGCAGGTCGCCGCCCCGG
AGGTTATCGATGCCGCTTTGCGTGACGGCGGCGGTTTTCCTATGGGACCGCTGGCGCTGACGGACCTGATTGGCCAGGAC
GTCAACTTCGCCGTGACCTGTTCGGTGTTTAACGCCTTCTGGCAGGACCGCCGCTACCTGCCATCGCTCCTCCAGCAAGA
GCTGGCGCTGGCCGGGCGGCTAGGTAAAAAGAGCGGCCACGGCGTCTATCGCTGGCCCGCTGAGATACTGCCGGACGCGG
CGCTGCCGCCGGTAATGATGGGTGCTGAATCCGTTACCGTCAGAAGTGACAACGTCACTGAATTAGACGATGTCTTGCTG
CTGGAGACTGAAGGCGAGACCGCCCTGGCGCTGAGTATTAAGCATCACCGCCCGGTGGTGGTGTATGACCTGTGCGCCAG
CGATACGGTGGTGCTGGCCGCAGCGGCGACCAACGCGCCTGCGGCCACTGATAAGGCCGTGCATTACTTCCAGCAGCAGG
GCAAGAAAGTGCTGCGTATTGCCGATTATCCCGGCCTGCTGGTGTGGCGCACGGTGGCGATGCTGATTAACGAAGCGCTG
GATGCGGTGCAAAAAGGCGTCGCCAGCCCGCAGGATGTCGATACCGCGATGCGCCTTGGCGTCAACTATCCGCATGGCCC
GCTGGCATGGGGAGAACGCCTTGGCTGGCGGCGGGTGCTGCAACTGCTGGAGAACCTGCAACACCATTATGGCGAGGAGC
GCTATCGCCCCAGTTCCCTGCTGCGCCAGAAGGCGCTGATGGAGAAGCACCATGAGCAATGA

Upstream 100 bases:

>100_bases
GCGCGATTATCAGCGTCTGGCCGGGCGCAGCGATGATTACCGCGAAGGGGTCAGCGCGTTTCTGGCCAAACGGCCACCAC
AGTTCAGCGGGAAATAGATG

Downstream 100 bases:

>100_bases
TCCGTGGCGCAACGCGCGCGTGATGTACGAAAAAGATACCTGCGCCAGAAAGATGGGGATCGAACTTATCGAAATGGACG
ACGGTTTTGCGCAGATGAGT

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTTSLVNVAVIGSGTMGAGIAEVAAAAGHPVRIFDINPKAVDLAIEGIAGRLASRVARGKLASEQADALLARLHPAHDLA
ALADADLVIEAASERLEVKTALFTQLAAICAPSTLLTSNTSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TSTEVVEQLCQCVSGWGKQPVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQD
VNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAEILPDAALPPVMMGAESVTVRSDNVTELDDVLL
LETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNAPAATDKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEAL
DAVQKGVASPQDVDTAMRLGVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ

Sequences:

>Translated_473_residues
MTTSLVNVAVIGSGTMGAGIAEVAAAAGHPVRIFDINPKAVDLAIEGIAGRLASRVARGKLASEQADALLARLHPAHDLA
ALADADLVIEAASERLEVKTALFTQLAAICAPSTLLTSNTSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TSTEVVEQLCQCVSGWGKQPVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQD
VNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAEILPDAALPPVMMGAESVTVRSDNVTELDDVLL
LETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNAPAATDKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEAL
DAVQKGVASPQDVDTAMRLGVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ
>Mature_472_residues
TTSLVNVAVIGSGTMGAGIAEVAAAAGHPVRIFDINPKAVDLAIEGIAGRLASRVARGKLASEQADALLARLHPAHDLAA
LADADLVIEAASERLEVKTALFTQLAAICAPSTLLTSNTSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLAT
STEVVEQLCQCVSGWGKQPVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQDV
NFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAEILPDAALPPVMMGAESVTVRSDNVTELDDVLLL
ETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNAPAATDKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEALD
AVQKGVASPQDVDTAMRLGVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=40.5594405594406, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=38.2838283828383, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=32.2695035460993, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=31.7241379310345, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=31.7241379310345, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI115430219, Length=237, Percent_Identity=27.4261603375527, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1787661, Length=474, Percent_Identity=72.3628691983122, Blast_Score=694, Evalue=0.0,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=37.0229007633588, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=32.9545454545455, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=291, Percent_Identity=40.2061855670103, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=284, Percent_Identity=39.0845070422535, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=38.7543252595156, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=278, Percent_Identity=34.5323741007194, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=278, Percent_Identity=34.5323741007194, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=278, Percent_Identity=34.5323741007194, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=278, Percent_Identity=30.2158273381295, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=440, Percent_Identity=23.6363636363636, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17558304, Length=278, Percent_Identity=32.7338129496403, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI115533614, Length=199, Percent_Identity=27.6381909547739, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193203623, Length=199, Percent_Identity=27.6381909547739, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=32.7464788732394, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=32.7464788732394, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=32.7464788732394, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=31.25, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 50804; Mature: 50673

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01186 EGF_2 ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSLVNVAVIGSGTMGAGIAEVAAAAGHPVRIFDINPKAVDLAIEGIAGRLASRVARGK
CCCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHH
LASEQADALLARLHPAHDLAALADADLVIEAASERLEVKTALFTQLAAICAPSTLLTSNT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCC
SSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLATSTEVVEQLCQCVSGWGKQP
CCEEEEEEECCCCCHHHHHCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
VRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQD
EEECCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHCCC
VNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAEILPDAALPPVMM
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHCCCCCCCCHHC
GAESVTVRSDNVTELDDVLLLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNAP
CCCEEEEECCCCCCCCCEEEEEECCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCCC
AATDKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEALDAVQKGVASPQDVDTAMRLG
CCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
VNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTSLVNVAVIGSGTMGAGIAEVAAAAGHPVRIFDINPKAVDLAIEGIAGRLASRVARGK
CCCEEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHH
LASEQADALLARLHPAHDLAALADADLVIEAASERLEVKTALFTQLAAICAPSTLLTSNT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCC
SSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLATSTEVVEQLCQCVSGWGKQP
CCEEEEEEECCCCCHHHHHCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
VRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQD
EEECCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHCCC
VNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAEILPDAALPPVMM
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHCCCCCCCCHHC
GAESVTVRSDNVTELDDVLLLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNAP
CCCEEEEECCCCCCCCCEEEEEECCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCCC
AATDKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEALDAVQKGVASPQDVDTAMRLG
CCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
VNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]