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The map label for this gene is paaE [H]

Identifier: 238894485

GI number: 238894485

Start: 2379506

End: 2380576

Strand: Direct

Name: paaE [H]

Synonym: KP1_2476

Alternate gene names: 238894485

Gene position: 2379506-2380576 (Clockwise)

Preceding gene: 238894484

Following gene: 238894486

Centisome position: 45.34

GC content: 61.9

Gene sequence:

>1071_bases
ATGACGACGTTCCATTCGCTTAAGGTGGCGAGAGTCGAGCCGGAAACCCGCGATGCGGTGACCATCACTTTTGCGATCCC
GCAAGCCCTGCAGGCGGAATACTGTTTTCGCCCGGGCCAGCATCTGACGCTAAAAGCCCGTCTGGGCGGCGAAGAACTGC
GCCGCTGTTACTCCATTTGTCACAGCCGCACGCCAGGCGAAATTAGCGTCGCGGTCAAAGCCATCGACGGCGGACGCTTC
TCGCGCTACGCCCAGCACGATATCCAGCAGGGTATGGAGCTGGAGGTGATGGTGCCGCAGGGGCATTTCGGTTATCAACC
GCAGGCCGAACGGCAGGGAGAATATCTGGCGATTGCCGCCGGCTCCGGGATCACGCCGATGATGGCGATCATTAGCGCGA
CGCTGGCGACCGAGCCGCAAAGCCGCTTTACGCTGATCTACGGCAACCGCAGCAGCCATAGCATGATGTTCCGCCAGGCG
CTGGCCGATTTAAAAGACCGCTATCCGCAGCGCCTGCAGGTGATCCACCTGTTTAGCCAGGAGTCGATGGACAGCGATCT
GCTACAGGGGCGCATTGACGGCGACAAACTGCGCCAGCTCGCTGACCATCTGCTGGATTTCAGCCGTTTCGACGAGGCCT
TTATCTGCGGTCCGGCGGCGATGATGGACGAGGCGGAAGCGACGTTACGTGAACTTGGCGTAGCGGAGAAATCGATTCAT
CTCGAACGCTTTAATACCCCAGGCGGCAATGTGAAGCGCGCTGCCGGCGTGCAGGCGGAAGGGCGCACGGTGACCATCCG
CCAGGACGGGCGCGATCGGCTTATCGCCCTCAGCGCCGAAGACGACAGCATCCTGGATGCCGCATTGCGTCAGGGCGCCG
ATCTGCCGTTCGCCTGTAAGGGCGGGGTATGCGCCACCTGTAAATGTAAAGTGCTGCGCGGCGAAGTGGCGATGGCCGCC
AATTACAGCCTGGAAGCGGATGAGCTGGCGGCAGGCTACGTGCTGAGCTGCCAGTCGCTGCCGACAAGCGGCGACGTGGT
GGTCGACTTTGACGCGCGGGGGATGGCATGA

Upstream 100 bases:

>100_bases
TCGCTGATAAGCGAATTCGGTTCCACGGCCTGCAAAGCGCTCTATCGCTGCGACAGCTGCCGGGAACCTTTTGATTACTT
TAAATGTATTTGAGGTTGCC

Downstream 100 bases:

>100_bases
GTGACCTGCTGATCCACCGTCATGGCCGGGTGCTTCAGTTGACGCTGAACCGCCCGCAAGCCCGCAACGCGCTGAACAAT
GCCTTATTAACCCAGATTGC

Product: putative phenylacetic acid degradation NADH oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTTFHSLKVARVEPETRDAVTITFAIPQALQAEYCFRPGQHLTLKARLGGEELRRCYSICHSRTPGEISVAVKAIDGGRF
SRYAQHDIQQGMELEVMVPQGHFGYQPQAERQGEYLAIAAGSGITPMMAIISATLATEPQSRFTLIYGNRSSHSMMFRQA
LADLKDRYPQRLQVIHLFSQESMDSDLLQGRIDGDKLRQLADHLLDFSRFDEAFICGPAAMMDEAEATLRELGVAEKSIH
LERFNTPGGNVKRAAGVQAEGRTVTIRQDGRDRLIALSAEDDSILDAALRQGADLPFACKGGVCATCKCKVLRGEVAMAA
NYSLEADELAAGYVLSCQSLPTSGDVVVDFDARGMA

Sequences:

>Translated_356_residues
MTTFHSLKVARVEPETRDAVTITFAIPQALQAEYCFRPGQHLTLKARLGGEELRRCYSICHSRTPGEISVAVKAIDGGRF
SRYAQHDIQQGMELEVMVPQGHFGYQPQAERQGEYLAIAAGSGITPMMAIISATLATEPQSRFTLIYGNRSSHSMMFRQA
LADLKDRYPQRLQVIHLFSQESMDSDLLQGRIDGDKLRQLADHLLDFSRFDEAFICGPAAMMDEAEATLRELGVAEKSIH
LERFNTPGGNVKRAAGVQAEGRTVTIRQDGRDRLIALSAEDDSILDAALRQGADLPFACKGGVCATCKCKVLRGEVAMAA
NYSLEADELAAGYVLSCQSLPTSGDVVVDFDARGMA
>Mature_355_residues
TTFHSLKVARVEPETRDAVTITFAIPQALQAEYCFRPGQHLTLKARLGGEELRRCYSICHSRTPGEISVAVKAIDGGRFS
RYAQHDIQQGMELEVMVPQGHFGYQPQAERQGEYLAIAAGSGITPMMAIISATLATEPQSRFTLIYGNRSSHSMMFRQAL
ADLKDRYPQRLQVIHLFSQESMDSDLLQGRIDGDKLRQLADHLLDFSRFDEAFICGPAAMMDEAEATLRELGVAEKSIHL
ERFNTPGGNVKRAAGVQAEGRTVTIRQDGRDRLIALSAEDDSILDAALRQGADLPFACKGGVCATCKCKVLRGEVAMAAN
YSLEADELAAGYVLSCQSLPTSGDVVVDFDARGMA

Specific function: May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1787658, Length=356, Percent_Identity=76.9662921348315, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1787098, Length=345, Percent_Identity=29.5652173913043, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788104, Length=349, Percent_Identity=23.4957020057307, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788903, Length=220, Percent_Identity=24.5454545454545, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563926, Length=211, Percent_Identity=25.1184834123223, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323510, Length=205, Percent_Identity=26.8292682926829, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322146, Length=235, Percent_Identity=22.9787234042553, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR011884
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 38966; Mature: 38835

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFHSLKVARVEPETRDAVTITFAIPQALQAEYCFRPGQHLTLKARLGGEELRRCYSIC
CCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHH
HSRTPGEISVAVKAIDGGRFSRYAQHDIQQGMELEVMVPQGHFGYQPQAERQGEYLAIAA
HCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCCCEEEEEE
GSGITPMMAIISATLATEPQSRFTLIYGNRSSHSMMFRQALADLKDRYPQRLQVIHLFSQ
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHH
ESMDSDLLQGRIDGDKLRQLADHLLDFSRFDEAFICGPAAMMDEAEATLRELGVAEKSIH
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCHHHEEE
LERFNTPGGNVKRAAGVQAEGRTVTIRQDGRDRLIALSAEDDSILDAALRQGADLPFACK
EEEECCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCEEEC
GGVCATCKCKVLRGEVAMAANYSLEADELAAGYVLSCQSLPTSGDVVVDFDARGMA
CCEEEEEEEEEEECCEEEEECCCCCHHHHCCCEEEEECCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
TTFHSLKVARVEPETRDAVTITFAIPQALQAEYCFRPGQHLTLKARLGGEELRRCYSIC
CCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHH
HSRTPGEISVAVKAIDGGRFSRYAQHDIQQGMELEVMVPQGHFGYQPQAERQGEYLAIAA
HCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCCCEEEEEE
GSGITPMMAIISATLATEPQSRFTLIYGNRSSHSMMFRQALADLKDRYPQRLQVIHLFSQ
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHH
ESMDSDLLQGRIDGDKLRQLADHLLDFSRFDEAFICGPAAMMDEAEATLRELGVAEKSIH
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCHHHEEE
LERFNTPGGNVKRAAGVQAEGRTVTIRQDGRDRLIALSAEDDSILDAALRQGADLPFACK
EEEECCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCEEEC
GGVCATCKCKVLRGEVAMAANYSLEADELAAGYVLSCQSLPTSGDVVVDFDARGMA
CCEEEEEEEEEEECCEEEEECCCCCHHHHCCCEEEEECCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]