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The map label for this gene is aroP [H]

Identifier: 238894454

GI number: 238894454

Start: 2346007

End: 2347386

Strand: Direct

Name: aroP [H]

Synonym: KP1_2444

Alternate gene names: 238894454

Gene position: 2346007-2347386 (Clockwise)

Preceding gene: 238894450

Following gene: 238894455

Centisome position: 44.7

GC content: 60.22

Gene sequence:

>1380_bases
ATGACAACGCAGCAAGAGCATCAGTTAAAACGCGGGTTAAAAAACCGCCACATCCAGTTGATCGCCCTCGGGGGGGCGGT
CGGCACCGGACTGTTTTTAGGTATCGCGCAAACGATCCGTATGGCAGGCCCGTCGGTCCTGCTGGGGTACGCCATCGCCG
GGGTTATCGCTTTCTTTATCATGCGTCAGCTTGGCGAAATGGTGGTAGAGGAGCCGGTGGCGGGGTCGTTCAGCCATTTC
GCCAACCGTTACTGGGGGCCCTTCGCCGGGTTTATGTCCGGCTGGAATTACTGGGTGTTGTACGTGCTGGTAAGCATGGC
GGAGCTGACGGCGGTGGGGATCTATATTCAGTACTGGTGGCCGGAGGTACCCACCTGGCTGTCGGCGGCGATCTTCTTCG
TGGCGATCAACGCCATCAACCTGACGCACGTCAAAGTGTATGGCGAGCTGGAGTTCTGGTTCTCGATTGTCAAAGTGGCC
GCCATCATCAGCATGATCGCCTTTGGCTGCTATCTGTTATTTAGCGGTCACGGCGGCCCGGCGGCGACGGTGGCCAACCT
GTGGCAGGACGGGGGATTTTTCCCTAACGGCATCACGGGCTTGGTGATGGCCATGGCGGTGATCATGTTCTCCTTCGGCG
GGCTTGAGCTGGTGGGGATCACCGCGGCGGAAGCCGACGAACCGCATAAAACCATTCCCAAAGCCACCAACCAGGTGATC
TACCGTATTCTGCTGTTTTACGTGGGGTCGCTGGCGGTCCTGCTGTCACTCTACCCGTGGCGGAACGTCGTGGAAGGGGG
AAGCCCCTTTGTGCTGATCTTTCACGCCATTGACAGCAATATTGTGGCCAACGCCCTCAATCTGGTGGTGCTCACCGCCG
CGCTGTCGGTCTACAACAGCTGCGTCTACTGCAACAGCCGGATGCTGTTCGGCCTGGCTCAGCAGGGCAACGCCCCGCGT
GCGCTGCTGCGGGTGAACCACCGCGGGATCCCATTGACCGCCCTGGCGGTATCCGCCGTCGCCACGGCGCTTTGCGTGGT
GATTAACTATGTGATGCCCGGGAAAGCCTTTGCCCTGCTGATGGCCCTGGTGGTGGCCGCCCTGGTCATCAACTGGGCGA
TGATCTGCATCACTCATCTTAAGTTCCGCCGCGCCATGCAGCGGGCGGGGAAGGTAACGGCTTTCCAGAGTTTCGCCTAT
CCCCTGACAAACTGGCTGTGTCTGCTGTTTCTCGCCGCGATCCTCGGGGTGATGTATCTGATCCCGGACATCCGCATCTC
CGTCTGCCTGATCCCGGTATGGCTGCTGATCCTTGCTGCAGGCTATCTGCTGCGCAGGAAAAGCGCGCCGGCGCCGGTGG
CGGCGCTTGAGGAGCGTTAA

Upstream 100 bases:

>100_bases
TTTCAATTAATTAATTTTTGTCTGACGCTGCAAGGCGCTCCGCTGGCCTGAAAGTTGCTACCGGCGAACGTGACTTTTTA
CAGACAGGGGCAGGTCAGAG

Downstream 100 bases:

>100_bases
TCTGCGACGCCCTGCCTGGCGGCAGGGCGATATTATTGCGCTGAAAATATATAGCGCCAATATATAGGATGGTTTATATA
ATTACGATAAATGATAACTA

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTTQQEHQLKRGLKNRHIQLIALGGAVGTGLFLGIAQTIRMAGPSVLLGYAIAGVIAFFIMRQLGEMVVEEPVAGSFSHF
ANRYWGPFAGFMSGWNYWVLYVLVSMAELTAVGIYIQYWWPEVPTWLSAAIFFVAINAINLTHVKVYGELEFWFSIVKVA
AIISMIAFGCYLLFSGHGGPAATVANLWQDGGFFPNGITGLVMAMAVIMFSFGGLELVGITAAEADEPHKTIPKATNQVI
YRILLFYVGSLAVLLSLYPWRNVVEGGSPFVLIFHAIDSNIVANALNLVVLTAALSVYNSCVYCNSRMLFGLAQQGNAPR
ALLRVNHRGIPLTALAVSAVATALCVVINYVMPGKAFALLMALVVAALVINWAMICITHLKFRRAMQRAGKVTAFQSFAY
PLTNWLCLLFLAAILGVMYLIPDIRISVCLIPVWLLILAAGYLLRRKSAPAPVAALEER

Sequences:

>Translated_459_residues
MTTQQEHQLKRGLKNRHIQLIALGGAVGTGLFLGIAQTIRMAGPSVLLGYAIAGVIAFFIMRQLGEMVVEEPVAGSFSHF
ANRYWGPFAGFMSGWNYWVLYVLVSMAELTAVGIYIQYWWPEVPTWLSAAIFFVAINAINLTHVKVYGELEFWFSIVKVA
AIISMIAFGCYLLFSGHGGPAATVANLWQDGGFFPNGITGLVMAMAVIMFSFGGLELVGITAAEADEPHKTIPKATNQVI
YRILLFYVGSLAVLLSLYPWRNVVEGGSPFVLIFHAIDSNIVANALNLVVLTAALSVYNSCVYCNSRMLFGLAQQGNAPR
ALLRVNHRGIPLTALAVSAVATALCVVINYVMPGKAFALLMALVVAALVINWAMICITHLKFRRAMQRAGKVTAFQSFAY
PLTNWLCLLFLAAILGVMYLIPDIRISVCLIPVWLLILAAGYLLRRKSAPAPVAALEER
>Mature_458_residues
TTQQEHQLKRGLKNRHIQLIALGGAVGTGLFLGIAQTIRMAGPSVLLGYAIAGVIAFFIMRQLGEMVVEEPVAGSFSHFA
NRYWGPFAGFMSGWNYWVLYVLVSMAELTAVGIYIQYWWPEVPTWLSAAIFFVAINAINLTHVKVYGELEFWFSIVKVAA
IISMIAFGCYLLFSGHGGPAATVANLWQDGGFFPNGITGLVMAMAVIMFSFGGLELVGITAAEADEPHKTIPKATNQVIY
RILLFYVGSLAVLLSLYPWRNVVEGGSPFVLIFHAIDSNIVANALNLVVLTAALSVYNSCVYCNSRMLFGLAQQGNAPRA
LLRVNHRGIPLTALAVSAVATALCVVINYVMPGKAFALLMALVVAALVINWAMICITHLKFRRAMQRAGKVTAFQSFAYP
LTNWLCLLFLAAILGVMYLIPDIRISVCLIPVWLLILAAGYLLRRKSAPAPVAALEER

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=283, Percent_Identity=24.3816254416961, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=72.1854304635762, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=65.0224215246637, Blast_Score=610, Evalue=1e-176,
Organism=Escherichia coli, GI1786602, Length=447, Percent_Identity=45.413870246085, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI48994972, Length=459, Percent_Identity=40.7407407407407, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=39.0243902439024, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI87081915, Length=467, Percent_Identity=34.475374732334, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87081708, Length=458, Percent_Identity=36.4628820960699, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI1789017, Length=428, Percent_Identity=35.2803738317757, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788480, Length=395, Percent_Identity=35.9493670886076, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081869, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082023, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=374, Percent_Identity=22.4598930481283, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=406, Percent_Identity=35.9605911330049, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6324061, Length=405, Percent_Identity=35.3086419753086, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=443, Percent_Identity=32.9571106094808, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=416, Percent_Identity=33.8942307692308, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324553, Length=396, Percent_Identity=33.8383838383838, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=406, Percent_Identity=31.5270935960591, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=30.0248138957816, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=408, Percent_Identity=33.8235294117647, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=412, Percent_Identity=31.5533980582524, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=432, Percent_Identity=29.6296296296296, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=28.8888888888889, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321629, Length=404, Percent_Identity=29.9504950495049, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=28.3752860411899, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=433, Percent_Identity=29.0993071593533, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=29.3532338308458, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=29.3532338308458, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324981, Length=413, Percent_Identity=29.7820823244552, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320364, Length=484, Percent_Identity=26.4462809917355, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI221512776, Length=422, Percent_Identity=19.4312796208531, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666159, Length=422, Percent_Identity=19.4312796208531, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50071; Mature: 49940

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00024 HEMOPEXIN ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQQEHQLKRGLKNRHIQLIALGGAVGTGLFLGIAQTIRMAGPSVLLGYAIAGVIAFFI
CCCCHHHHHHHCHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
MRQLGEMVVEEPVAGSFSHFANRYWGPFAGFMSGWNYWVLYVLVSMAELTAVGIYIQYWW
HHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEC
PEVPTWLSAAIFFVAINAINLTHVKVYGELEFWFSIVKVAAIISMIAFGCYLLFSGHGGP
CCCHHHHHHHHHHHHHHHEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AATVANLWQDGGFFPNGITGLVMAMAVIMFSFGGLELVGITAAEADEPHKTIPKATNQVI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
YRILLFYVGSLAVLLSLYPWRNVVEGGSPFVLIFHAIDSNIVANALNLVVLTAALSVYNS
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHH
CVYCNSRMLFGLAQQGNAPRALLRVNHRGIPLTALAVSAVATALCVVINYVMPGKAFALL
HHHCCCHHHHHHHCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MALVVAALVINWAMICITHLKFRRAMQRAGKVTAFQSFAYPLTNWLCLLFLAAILGVMYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPDIRISVCLIPVWLLILAAGYLLRRKSAPAPVAALEER
HCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCC
>Mature Secondary Structure 
TTQQEHQLKRGLKNRHIQLIALGGAVGTGLFLGIAQTIRMAGPSVLLGYAIAGVIAFFI
CCCHHHHHHHCHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
MRQLGEMVVEEPVAGSFSHFANRYWGPFAGFMSGWNYWVLYVLVSMAELTAVGIYIQYWW
HHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEC
PEVPTWLSAAIFFVAINAINLTHVKVYGELEFWFSIVKVAAIISMIAFGCYLLFSGHGGP
CCCHHHHHHHHHHHHHHHEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AATVANLWQDGGFFPNGITGLVMAMAVIMFSFGGLELVGITAAEADEPHKTIPKATNQVI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
YRILLFYVGSLAVLLSLYPWRNVVEGGSPFVLIFHAIDSNIVANALNLVVLTAALSVYNS
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHH
CVYCNSRMLFGLAQQGNAPRALLRVNHRGIPLTALAVSAVATALCVVINYVMPGKAFALL
HHHCCCHHHHHHHCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MALVVAALVINWAMICITHLKFRRAMQRAGKVTAFQSFAYPLTNWLCLLFLAAILGVMYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPDIRISVCLIPVWLLILAAGYLLRRKSAPAPVAALEER
HCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]