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The map label for this gene is ribA [H]

Identifier: 238894335

GI number: 238894335

Start: 2227029

End: 2227631

Strand: Reverse

Name: ribA [H]

Synonym: KP1_2316

Alternate gene names: 238894335

Gene position: 2227631-2227029 (Counterclockwise)

Preceding gene: 238894341

Following gene: 238894329

Centisome position: 42.44

GC content: 55.06

Gene sequence:

>603_bases
ATGCAGCTTAAACGTGTGGCAGAAGCCAAACTGCCAACCCCCTGGGGCGATTTCCTGATGGTGGGTTTTGAAGAACTGGC
AACCGGACAGGATCATGTCGCGCTGGTGTATGGCGATATATCAGAGCAGTCGCCGGTCCTCGCCCGCGTACATTCAGAGT
GTTTGACGGGCGATGCCCTGTTTAGCCTGCGCTGTGATTGCGGCTTTCAGCTGGAAGCGGCCCTGTCGCATATCGCTGAA
GAAGGTCGGGGGATCCTGCTCTATCACCGCCAGGAAGGACGCAACATTGGTTTATTGAATAAGATCCGCGCCTACGCGCT
GCAGGATCAGGGCTACGACACTGTCGAAGCGAACCATCAGCTTGGCTTCGCCGCCGATGAGCGCGATTTCACCTTGTGCG
CCGACATGTTCAAATTGCTCAACGTTGAGCAGGTGCGGTTATTAACCAATAACCCGAAAAAAGTGGAAATTCTTACCGAA
GCCGGGATCAACATTGTGGAGCGGGTGCCGCTGATCGTCGGGCGTAACCCGAAAAACGCTCACTATCTGGACACCAAAGC
CGCCAAGATGGGCCATCTGCTGAACAGCAAGCCGACGGAATAA

Upstream 100 bases:

>100_bases
CACGGCTAACCGTTCGCGATTAGGAGAACGTCCAGGCGTTGTGGCAAAATAGCGGGAAACAGAAAGCACAGTCAGGTGCT
GACAGAATCTGGAGAATCAC

Downstream 100 bases:

>100_bases
ACCGGTGGAATAACCGAAAAAGGGCCAGCGATGCTGGCCCTTTGTTTCACAGCATATTACGAATAACGTAGTGCAGGATG
CCGTCGTTGCGGTAGTAGGT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISEQSPVLARVHSECLTGDALFSLRCDCGFQLEAALSHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTE
AGINIVERVPLIVGRNPKNAHYLDTKAAKMGHLLNSKPTE

Sequences:

>Translated_200_residues
MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISEQSPVLARVHSECLTGDALFSLRCDCGFQLEAALSHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTE
AGINIVERVPLIVGRNPKNAHYLDTKAAKMGHLLNSKPTE
>Mature_200_residues
MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISEQSPVLARVHSECLTGDALFSLRCDCGFQLEAALSHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTE
AGINIVERVPLIVGRNPKNAHYLDTKAAKMGHLLNSKPTE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=93.3673469387755, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319438, Length=184, Percent_Identity=42.3913043478261, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 22255; Mature: 22255

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISEQSPVLARVHSECLTGDAL
CCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCE
FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCC
LGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPKNA
CCCCCCCCCHHHHHHHHHHHCHHEEEEEECCCCEEEEEECCCCCHHHHCCEEEECCCCCC
HYLDTKAAKMGHLLNSKPTE
EEECHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISEQSPVLARVHSECLTGDAL
CCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCE
FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCC
LGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPKNA
CCCCCCCCCHHHHHHHHHHHCHHEEEEEECCCCEEEEEECCCCCHHHHCCEEEECCCCCC
HYLDTKAAKMGHLLNSKPTE
EEECHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA