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The map label for this gene is yeaP [H]

Identifier: 238894223

GI number: 238894223

Start: 2118023

End: 2119036

Strand: Reverse

Name: yeaP [H]

Synonym: KP1_2191

Alternate gene names: 238894223

Gene position: 2119036-2118023 (Counterclockwise)

Preceding gene: 238894225

Following gene: 238894222

Centisome position: 40.37

GC content: 58.78

Gene sequence:

>1014_bases
ATGTCAGATTTTATTCTTGCCCGGGTGTCGCAAACCCTCGCTGCGGAACAGTCCCTGGAAACCCTGGTGCGCCAGCTGCT
GGAGATGCTGGAGGCGGTGACGCGAATGGAGTCCACCTACCTCACCCGCATTGATACCAACGCCCAGCGGCAGCAGATCA
TGTTCGCCCACAACAGCAGCGAAATGCAGATCCCGGAAGGATTTTCCGTCCCCTGGGATGAATCCCTGTGCAAACGCGCC
CTTGAGGATCAGTGTACGTTTAGCAATGACGTTGCCAACCGCTGGCACTCCTGCATCGCCGCCCAGGAGCTGGGAATCGC
TACTTTTTTAAGCATTCCCGTCCGCCTGGCCGACGGCTCTCTGTTCGGCACCCTCTGCGCCACCAGCCGGCAACAACAGC
CTTATAACCTCGAAGGCGAACAGGTCATGGGCCTGTTTGCGAAGCTCATTTCCCACTACGTGGAAAAAGACACCCTGGTG
CAACAGCTGCAGGCGGCAAACGTCGCGCTGGAGCTGCACTCGTCTACCGATGAGCTCACCCAGCTTCCCAATCGCCGCGC
GCTGTTTAAGCAGCTGGCGTTACGCTTTGCCTCCGCCCGTGCCCAGCAGCAGCAGGTCTCGCTTATTTTTATCGATCTCG
ATGGTTTCAAAGCCATTAACGATCGGTTCGGCCATCCGTGCGGCGACAGCTTTCTGGTGCAGGTCGGCAAACGACTCACC
GCTGTCGCGCGCCGGGAAGATATCGTTGGCCGCCTTGGCGGCGATGAGTTTTTGATCGTCGGTAGCGCCCAGCAGCCTGC
CGCACAGCAGGCGTATGTCACGTCCCTGCGTCAGGCTCTGTGCGGCGTCTACTTCCTCGGCGAACAGCGTATCGACTATG
AGGGCGCCAGCTTCGGGGTGGTCACCTGCGATCCGCAGAGTATCGATGTTGAAGCGGCCTTACGCGCTGCCGATGAGGCG
ATGTACCAGGATAAGAAGTCCCGCCGCCAGGAGAATTTCATTCATATTGACTAA

Upstream 100 bases:

>100_bases
ATGTGATAAATTTAAAAATATCACTGTTTATTTGACGCTGATGTCCGTTTGCAGCCCAATATGCTGGGGTGACGTTTGGC
GTGCTGGAGCTGTATTATTC

Downstream 100 bases:

>100_bases
AGTACCGCGATATCCAGTATCATGCAGGGCATCATTCGTGGGCACAGGGACACAATCATGAAATTGGGTATTCTTTTCCC
GGTGGCGATCTTTATCATCG

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSSEMQIPEGFSVPWDESLCKRA
LEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGSLFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLV
QQLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAALRAADEA
MYQDKKSRRQENFIHID

Sequences:

>Translated_337_residues
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSSEMQIPEGFSVPWDESLCKRA
LEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGSLFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLV
QQLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAALRAADEA
MYQDKKSRRQENFIHID
>Mature_336_residues
SDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSSEMQIPEGFSVPWDESLCKRAL
EDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGSLFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQ
QLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLTA
VARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAALRAADEAM
YQDKKSRRQENFIHID

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=334, Percent_Identity=53.8922155688623, Blast_Score=373, Evalue=1e-105,
Organism=Escherichia coli, GI1788381, Length=160, Percent_Identity=33.125, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786584, Length=163, Percent_Identity=32.5153374233129, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787541, Length=160, Percent_Identity=31.875, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082007, Length=188, Percent_Identity=32.4468085106383, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787802, Length=167, Percent_Identity=27.5449101796407, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787262, Length=160, Percent_Identity=28.125, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87081881, Length=220, Percent_Identity=27.7272727272727, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788956, Length=172, Percent_Identity=31.3953488372093, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI145693134, Length=84, Percent_Identity=42.8571428571429, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 37648; Mature: 37517

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHEEEEEECCC
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHH
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
HCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHH
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
SDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHEEEEEECCC
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHH
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
HCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHH
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]