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The map label for this gene is lpxP [H]

Identifier: 238894217

GI number: 238894217

Start: 2115434

End: 2116366

Strand: Direct

Name: lpxP [H]

Synonym: KP1_2185

Alternate gene names: 238894217

Gene position: 2115434-2116366 (Clockwise)

Preceding gene: 238894215

Following gene: 238894218

Centisome position: 40.31

GC content: 56.59

Gene sequence:

>933_bases
ATGTTTACAGGAAAAATCATGGCCTGCGTATTTAATAAACAACTTTTACACCCGCGTAACTGGCTGACCTGGTTCGGGCT
CGGCATCCTCTGGTTAATCGTGCAACTGCCTTATCCGCTGCTGCATTTTATCGGCACCAGCGCTGGTCGCCTTTCCCGTC
GCTTTCTTAAACGCCGCGAACATATCGCCCGGCGTAATATCGAACTCTGCTTCCCGGACATGTCGCCAGCGGCGCGCGAG
ACGCTGATCGATCAAAACTTTATGTCGCTGGGAATGGGGCTTATCGAAACCGGCATGGCCTGGTTCTGGAGCGACGAGCG
GGTCAAAAAATGGTTTGATGTCGAGGGGTTCGCCAACCTTAATCACGCGCTTAGCGGTGGGAAAGGGGTAATGGTCGTCG
GCGTGCACTTTATGTCGCTGGAGCTGGGCGGGCGCGCGATGGGGCTGTGTCGGCCAATGATGGCCACCTACCGGCCGCAC
AACAGCCCGCTGATGGAGTGGGTGCAAACCCGCGGTCGCCTGCGTTCGAACAAAGCGATGATCGATCGCAACAATCTGAC
CGGTCTGGTGCATGCCTTGAAATCCGGTGAAGCGGTGTGGTTCGCGCCCGATCAGGATTACGGTCCCAAGGGCAGCGTCT
TTGCACCTTTTTTCTCCGTCCCGCAGGCGGCGACCACCAACGGCACCTATGTCCTGTCCCGCTTATCGGGCGCGAAAATG
TTGAGCATCAGCATGGTACGTAAGCTGGATCGCCGGGGCTATAGCCTGCATATCAGCGAGGTGATGAATGACTATCCGGG
TGAGGATAAGCAGATCGCCGCCGGCTATATCAACAAGGTTATTGAGCGCGAGATCCTGCGCGCTCCCGAGCAGTATCTGT
GGGTACACCGTCGTTTTAAAACCCGACCGCTGGGCGAACCTTCCGTCTATTAA

Upstream 100 bases:

>100_bases
CGGAGGGAATTTCAGCGGATTAGTATTGTCGAACTTGCTGTACGTACCGCCTAATGATGATAAATGGATTCTGTTTTCCT
TAAGCGTTACCACATAATTA

Downstream 100 bases:

>100_bases
CCTTCCCGCACAGGCTGCGCTTTCAAAATCCCGACAGTTGGGGTAACGTGAGCCGGATCATGTTTTAGTCGTGCGCGAAG
GAGTGCAGAGTGTTCGCTGA

Product: putative lipid A biosynthesis acyltransferase

Products: KDO2-(palmitoleoyl)-lipid IVA [C]

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MFTGKIMACVFNKQLLHPRNWLTWFGLGILWLIVQLPYPLLHFIGTSAGRLSRRFLKRREHIARRNIELCFPDMSPAARE
TLIDQNFMSLGMGLIETGMAWFWSDERVKKWFDVEGFANLNHALSGGKGVMVVGVHFMSLELGGRAMGLCRPMMATYRPH
NSPLMEWVQTRGRLRSNKAMIDRNNLTGLVHALKSGEAVWFAPDQDYGPKGSVFAPFFSVPQAATTNGTYVLSRLSGAKM
LSISMVRKLDRRGYSLHISEVMNDYPGEDKQIAAGYINKVIEREILRAPEQYLWVHRRFKTRPLGEPSVY

Sequences:

>Translated_310_residues
MFTGKIMACVFNKQLLHPRNWLTWFGLGILWLIVQLPYPLLHFIGTSAGRLSRRFLKRREHIARRNIELCFPDMSPAARE
TLIDQNFMSLGMGLIETGMAWFWSDERVKKWFDVEGFANLNHALSGGKGVMVVGVHFMSLELGGRAMGLCRPMMATYRPH
NSPLMEWVQTRGRLRSNKAMIDRNNLTGLVHALKSGEAVWFAPDQDYGPKGSVFAPFFSVPQAATTNGTYVLSRLSGAKM
LSISMVRKLDRRGYSLHISEVMNDYPGEDKQIAAGYINKVIEREILRAPEQYLWVHRRFKTRPLGEPSVY
>Mature_310_residues
MFTGKIMACVFNKQLLHPRNWLTWFGLGILWLIVQLPYPLLHFIGTSAGRLSRRFLKRREHIARRNIELCFPDMSPAARE
TLIDQNFMSLGMGLIETGMAWFWSDERVKKWFDVEGFANLNHALSGGKGVMVVGVHFMSLELGGRAMGLCRPMMATYRPH
NSPLMEWVQTRGRLRSNKAMIDRNNLTGLVHALKSGEAVWFAPDQDYGPKGSVFAPFFSVPQAATTNGTYVLSRLSGAKM
LSISMVRKLDRRGYSLHISEVMNDYPGEDKQIAAGYINKVIEREILRAPEQYLWVHRRFKTRPLGEPSVY

Specific function: Unknown

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI87082094, Length=302, Percent_Identity=70.8609271523179, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1787292, Length=300, Percent_Identity=52, Blast_Score=351, Evalue=3e-98,
Organism=Escherichia coli, GI1788161, Length=306, Percent_Identity=24.8366013071895, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: NA

Molecular weight: Translated: 35382; Mature: 35382

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGKIMACVFNKQLLHPRNWLTWFGLGILWLIVQLPYPLLHFIGTSAGRLSRRFLKRRE
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHH
HIARRNIELCFPDMSPAARETLIDQNFMSLGMGLIETGMAWFWSDERVKKWFDVEGFANL
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEECHHHHHHHHCCCCHHCH
NHALSGGKGVMVVGVHFMSLELGGRAMGLCRPMMATYRPHNSPLMEWVQTRGRLRSNKAM
HHHHCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCE
IDRNNLTGLVHALKSGEAVWFAPDQDYGPKGSVFAPFFSVPQAATTNGTYVLSRLSGAKM
EECCCHHHHHHHHHCCCEEEECCCCCCCCCCCEECHHHCCCCCCCCCCCEEEEHHCCCHH
LSISMVRKLDRRGYSLHISEVMNDYPGEDKQIAAGYINKVIEREILRAPEQYLWVHRRFK
HHHHHHHHHHHCCCEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
TRPLGEPSVY
CCCCCCCCCC
>Mature Secondary Structure
MFTGKIMACVFNKQLLHPRNWLTWFGLGILWLIVQLPYPLLHFIGTSAGRLSRRFLKRRE
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHH
HIARRNIELCFPDMSPAARETLIDQNFMSLGMGLIETGMAWFWSDERVKKWFDVEGFANL
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEECHHHHHHHHCCCCHHCH
NHALSGGKGVMVVGVHFMSLELGGRAMGLCRPMMATYRPHNSPLMEWVQTRGRLRSNKAM
HHHHCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCE
IDRNNLTGLVHALKSGEAVWFAPDQDYGPKGSVFAPFFSVPQAATTNGTYVLSRLSGAKM
EECCCHHHHHHHHHCCCEEEECCCCCCCCCCCEECHHHCCCCCCCCCCCEEEEHHCCCHH
LSISMVRKLDRRGYSLHISEVMNDYPGEDKQIAAGYINKVIEREILRAPEQYLWVHRRFK
HHHHHHHHHHHCCCEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
TRPLGEPSVY
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; palmitoleoyl-ACP [C]

Specific reaction: KDO2-lipid IVA + palmitoleoyl-ACP = KDO2-(palmitoleoyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]