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The map label for this gene is tpiA2 [H]

Identifier: 238894157

GI number: 238894157

Start: 2058648

End: 2059442

Strand: Reverse

Name: tpiA2 [H]

Synonym: KP1_2114

Alternate gene names: 238894157

Gene position: 2059442-2058648 (Counterclockwise)

Preceding gene: 238894167

Following gene: 238894156

Centisome position: 39.24

GC content: 59.25

Gene sequence:

>795_bases
ATGACCCCGATATGGTTAGGAACCAGCTGGAAAATGAACAAGCCGCTGTCCCAGGCCATGGCCTGGTGCGAAACGCTGGC
AGCGCGGATGCCGGAGGGCTGTCACCCTGCTATTCAGCCCTTCGTCATTCCCCCCTTCACCGCGATCCAACCCGTCAGCC
ATTTTCTGCAAACGCATCAGTTACCGCTTCTGACCGGCGCGCAGAATATGCATGAAGCGGATCAGGGCGCCTGGACCGGG
GAAATCTCGGCGGCCATGTTGGCAGAAACCGGCGCCACACTTGTTGAGCTGGGACATTCAGAACGACGCGCCGCCTTTAA
TGAAAGCGATGCCGCGATTAATCGAAAAGTGCATAGCGCCTTAGGTCATGGCCTGCGCCCGCTGATCTGTATTGGCGATA
GCGCCGAGGAGAAACGCTGGCAGGTGTCGCGTGAAAGCGTGGTGCGGCAGATGAAGATCGCCCTGTATGGCCTGAGCCAC
CAGCAGGCGCTGCGGACCCTGATTGCGTATGAACCGGTGTGGGCCATTGGCGAACATGGTACGCCCGCCTCACCGCAGGA
GGCGGGTGTCATTCATCAGGCGCTACGTCAGGCGCTTTGCGAGCGGTTTGGTCACGAGACGGGAACCCGTATCCCGCTGC
TCTATGGCGGCAGCGTAACGCTGCAAAACGCGGTGGAATTGCTGCGCCAGCAGGAGATCAATGGGTTGTTTATCGGCCGC
GCGGCCTGGGACGCGCAAGGCTATTGCGACATTGTTCAACGCGTTACACAGGAATTTATTTTGCAGGCGCAGTAA

Upstream 100 bases:

>100_bases
ATCTAACATATGTTCATACAGTGATAAAAAGTTCAACCTCAATACAGGGTATGGCCCCGTTTCTGGCAAGTATTTAATTT
TATTAAGAGGAGAAGCAATG

Downstream 100 bases:

>100_bases
TATAAAAGGGACACCAGAGATGGAAATTCCAGGCCATGATTGAACAAGACTCAGATTACGCCCTGCTCACTGAAATTGCG
GTGGCTTATTACGATCAGGA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM 2; Triose-phosphate isomerase 2 [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTPIWLGTSWKMNKPLSQAMAWCETLAARMPEGCHPAIQPFVIPPFTAIQPVSHFLQTHQLPLLTGAQNMHEADQGAWTG
EISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSH
QQALRTLIAYEPVWAIGEHGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR
AAWDAQGYCDIVQRVTQEFILQAQ

Sequences:

>Translated_264_residues
MTPIWLGTSWKMNKPLSQAMAWCETLAARMPEGCHPAIQPFVIPPFTAIQPVSHFLQTHQLPLLTGAQNMHEADQGAWTG
EISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSH
QQALRTLIAYEPVWAIGEHGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR
AAWDAQGYCDIVQRVTQEFILQAQ
>Mature_263_residues
TPIWLGTSWKMNKPLSQAMAWCETLAARMPEGCHPAIQPFVIPPFTAIQPVSHFLQTHQLPLLTGAQNMHEADQGAWTGE
ISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSALGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQ
QALRTLIAYEPVWAIGEHGTPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGRA
AWDAQGYCDIVQRVTQEFILQAQ

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=251, Percent_Identity=35.0597609561753, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI226529917, Length=251, Percent_Identity=35.0597609561753, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1790353, Length=253, Percent_Identity=33.201581027668, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17536593, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320255, Length=251, Percent_Identity=32.6693227091633, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=36.6935483870968, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=36.6935483870968, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=36.6935483870968, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 29099; Mature: 28967

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIWLGTSWKMNKPLSQAMAWCETLAARMPEGCHPAIQPFVIPPFTAIQPVSHFLQTHQ
CCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHCC
LPLLTGAQNMHEADQGAWTGEISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSA
CCHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHCCHHHHHHCCCHHHHHHHHHHHH
LGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQALRTLIAYEPVWAIGEHG
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHEECCCC
TPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCEEEEEE
AAWDAQGYCDIVQRVTQEFILQAQ
CCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPIWLGTSWKMNKPLSQAMAWCETLAARMPEGCHPAIQPFVIPPFTAIQPVSHFLQTHQ
CCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHCC
LPLLTGAQNMHEADQGAWTGEISAAMLAETGATLVELGHSERRAAFNESDAAINRKVHSA
CCHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHCCHHHHHHCCCHHHHHHHHHHHH
LGHGLRPLICIGDSAEEKRWQVSRESVVRQMKIALYGLSHQQALRTLIAYEPVWAIGEHG
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHEECCCC
TPASPQEAGVIHQALRQALCERFGHETGTRIPLLYGGSVTLQNAVELLRQQEINGLFIGR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCEEEEEE
AAWDAQGYCDIVQRVTQEFILQAQ
CCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]