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The map label for this gene is cobB [H]

Identifier: 238894154

GI number: 238894154

Start: 2056360

End: 2057190

Strand: Direct

Name: cobB [H]

Synonym: KP1_2111

Alternate gene names: 238894154

Gene position: 2056360-2057190 (Clockwise)

Preceding gene: 238894153

Following gene: 238894155

Centisome position: 39.18

GC content: 61.49

Gene sequence:

>831_bases
ATGCAGTCGCGCCGTTTACATCGATTGAGCCGTTTTCGTCGCAATAAACGTCGGTTGCGTGACCGTCTGCGTCAGCGGAT
TTTCTTTAGGGAGGACAGGATGAAGCCTGAAGCGATGGCAAAACCGAGAGTGGTGGTGTTAACCGGCGCGGGCATCTCGG
CAGAGTCGGGGATCAAAACCTTCCGCGCGGCCGATGGCCTGTGGGAAGAGCATCGGGTGGAAGATGTAGCGACGCCGGAA
GGCTTCGCCCGCGATCCGGCGCTGGTGCAGGCGTTCTACAACGCCCGTCGCCGTCAGTTGCAGAGTCCGGAAATCAAGCC
GAACGCGGCGCATCTGGCGCTGGCGCGTCTGGAGGATCTGCTGGGCGACCATTTTCTGCTGGTCACCCAGAATATTGATA
ATCTGCACGAGCGCGCCGGCAACCGCCGGGTGATCCATATGCACGGCGAGCTGCTAAAGGTGCGCTGTTCGTGGAGCGGC
CAGGTGCTGGAGTGGACCGGCGACGTCACCGCCGAGGACAAGTGCCACTGCTGCCAGTTCCCGGCGGCGCTACGTCCGCA
CGTGGTCTGGTTTGGCGAAATGCCGCTGGGGATGGATGAGATCTACAGCGCGCTGGCCGACGCAGATATTTTTATCGCCA
TCGGCACCTCCGGCCATGTCTATCCGGCGGCTGGCTTTGTGCACGAGGCGCGACTGCACGGCGCCCATACCGTTGAACTG
AACCTGGAGCCCAGCCAGGTGGGCAGCGAGTTTGCCGAGAAGCACTACGGGCTGGCAAGCGAAGTGGTACCCGCCTTTAT
CGATAAGCTGCTGCAGGAAAACGCGCTGTAA

Upstream 100 bases:

>100_bases
TCGCCAGGGTTCCGCGCATTGAGCGCGCGCGCCACGGCGATGCCGGGGGAATGCGCGGTGCGGCCTTCCTTCACCTGACC
CATTAATCACAGAGGTAGCT

Downstream 100 bases:

>100_bases
ACTGAAGCAGCCTGCCGGTAGCCAGGGCGCAGCCCACGGCCGCCGGCAGCGCTGCTGACAAGGATGTCACGTCATGACAG
GAGTCAGACCATGCATAATC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQSRRLHRLSRFRRNKRRLRDRLRQRIFFREDRMKPEAMAKPRVVVLTGAGISAESGIKTFRAADGLWEEHRVEDVATPE
GFARDPALVQAFYNARRRQLQSPEIKPNAAHLALARLEDLLGDHFLLVTQNIDNLHERAGNRRVIHMHGELLKVRCSWSG
QVLEWTGDVTAEDKCHCCQFPAALRPHVVWFGEMPLGMDEIYSALADADIFIAIGTSGHVYPAAGFVHEARLHGAHTVEL
NLEPSQVGSEFAEKHYGLASEVVPAFIDKLLQENAL

Sequences:

>Translated_276_residues
MQSRRLHRLSRFRRNKRRLRDRLRQRIFFREDRMKPEAMAKPRVVVLTGAGISAESGIKTFRAADGLWEEHRVEDVATPE
GFARDPALVQAFYNARRRQLQSPEIKPNAAHLALARLEDLLGDHFLLVTQNIDNLHERAGNRRVIHMHGELLKVRCSWSG
QVLEWTGDVTAEDKCHCCQFPAALRPHVVWFGEMPLGMDEIYSALADADIFIAIGTSGHVYPAAGFVHEARLHGAHTVEL
NLEPSQVGSEFAEKHYGLASEVVPAFIDKLLQENAL
>Mature_276_residues
MQSRRLHRLSRFRRNKRRLRDRLRQRIFFREDRMKPEAMAKPRVVVLTGAGISAESGIKTFRAADGLWEEHRVEDVATPE
GFARDPALVQAFYNARRRQLQSPEIKPNAAHLALARLEDLLGDHFLLVTQNIDNLHERAGNRRVIHMHGELLKVRCSWSG
QVLEWTGDVTAEDKCHCCQFPAALRPHVVWFGEMPLGMDEIYSALADADIFIAIGTSGHVYPAAGFVHEARLHGAHTVEL
NLEPSQVGSEFAEKHYGLASEVVPAFIDKLLQENAL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=235, Percent_Identity=38.2978723404255, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI13787215, Length=236, Percent_Identity=37.2881355932203, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI6912664, Length=248, Percent_Identity=36.2903225806452, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI6912662, Length=259, Percent_Identity=30.1158301158301, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI7657575, Length=227, Percent_Identity=28.6343612334802, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI6912660, Length=207, Percent_Identity=30.9178743961353, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI308199517, Length=234, Percent_Identity=87.6068376068376, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17541892, Length=203, Percent_Identity=32.512315270936, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17567771, Length=119, Percent_Identity=34.453781512605, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28571445, Length=128, Percent_Identity=38.28125, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31281; Mature: 31281

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSRRLHRLSRFRRNKRRLRDRLRQRIFFREDRMKPEAMAKPRVVVLTGAGISAESGIKT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCCCHHHHHH
FRAADGLWEEHRVEDVATPEGFARDPALVQAFYNARRRQLQSPEIKPNAAHLALARLEDL
HHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LGDHFLLVTQNIDNLHERAGNRRVIHMHGELLKVRCSWSGQVLEWTGDVTAEDKCHCCQF
HCCEEEEEECCHHHHHHHCCCCEEEEECCEEEEEEECCCCCEEEECCCCCCCCCCHHHCC
PAALRPHVVWFGEMPLGMDEIYSALADADIFIAIGTSGHVYPAAGFVHEARLHGAHTVEL
CCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCEECCHHHHHHHHHCCCEEEEE
NLEPSQVGSEFAEKHYGLASEVVPAFIDKLLQENAL
ECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSRRLHRLSRFRRNKRRLRDRLRQRIFFREDRMKPEAMAKPRVVVLTGAGISAESGIKT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCCCHHHHHH
FRAADGLWEEHRVEDVATPEGFARDPALVQAFYNARRRQLQSPEIKPNAAHLALARLEDL
HHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LGDHFLLVTQNIDNLHERAGNRRVIHMHGELLKVRCSWSGQVLEWTGDVTAEDKCHCCQF
HCCEEEEEECCHHHHHHHCCCCEEEEECCEEEEEEECCCCCEEEECCCCCCCCCCHHHCC
PAALRPHVVWFGEMPLGMDEIYSALADADIFIAIGTSGHVYPAAGFVHEARLHGAHTVEL
CCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCEECCHHHHHHHHHCCCEEEEE
NLEPSQVGSEFAEKHYGLASEVVPAFIDKLLQENAL
ECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]