| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
Click here to switch to the map view.
The map label for this gene is yqjQ [H]
Identifier: 238894062
GI number: 238894062
Start: 1962866
End: 1963654
Strand: Reverse
Name: yqjQ [H]
Synonym: KP1_2010
Alternate gene names: 238894062
Gene position: 1963654-1962866 (Counterclockwise)
Preceding gene: 238894063
Following gene: 238894060
Centisome position: 37.41
GC content: 63.62
Gene sequence:
>789_bases ATGACCCAACCATCGCACACAGCTTTTATCACCGGCGCGTCCTCAGGTATCGGCGCGATCTATGCCGAACGACTCGCCGC CCGCGGCTACAACCTGATCCTCGCCGCCCGTCGTGAAGACCGTCTGCAGGCGCTCGCCGACCAGCTGCAGGCGCGCTACG CCATCCAGGCAAGCATCCTCAAAGCCGATCTTAGCGAAGAGCACGGGATTGCCGCCGTAGAGCAGCGTCTGCAGCAGGAT CCCGCCATCGACCTGTTCATTAACAACGCCGGCACCGCGAAATTGGCGGGTTTTCTCGCCAGTACGCCACGCGAGCACCA GGCGATTCATACGCTCAACACCACCGCGCTGCTGCGTCTGAGCTATGCCGCGCTGGCCGCTTTCACCCCACGACGCCGGG GGACGCTGATCAATATTGCCTCTATCCTCGCGCTGCATACGCTGCCGGGCAGCGCAGTCTACAGTGCCAGCAAAGCCTGG GTGTTGAGCTTCACCCGCGGCCTGCAGGAGGAGTTTGCCGACAGCGGCGTGCGTATTCAGGCGGTATTGCCGGCGGCGAC CGCTACCGATCTGTGGCCGACCTCCGGCGTGGCGCTGGACGCTCTGCCCAGCGGCACGGTAATGACCACCGAGGATCTGG TTGACGCCGCTCTCAGGGGGCTGGAGATGGGGGAACAGGTCACCTTACCACCGGTTCATGACCTGGGACTGTGGGAGACT TTTGAGCAGTCCAGACTGGCGCTGTTTACCAGCGCGCGAACCGGACAGCCTGCGCCGCGGTATCGATAA
Upstream 100 bases:
>100_bases GGCAAAAATGAAAAAGTCCTGGCAAAATGGTTGCATTATTAAACCTAATATCTCATGCTAAATTTGGTTTAATAATGCAA CCTTTTACGAGGCATTTCTC
Downstream 100 bases:
>100_bases GCGGCACCGTGCGGCGGGCGCTACTCCGGTAGCGGAACCGCCGTCAGGGTACAGATCGCCTCGTGCTCGCCGCCGCGGCG ATCGGTAATCACCACCTTAT
Product: putative short-chain dehydrogenase/reductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 262; Mature: 261
Protein sequence:
>262_residues MTQPSHTAFITGASSGIGAIYAERLAARGYNLILAARREDRLQALADQLQARYAIQASILKADLSEEHGIAAVEQRLQQD PAIDLFINNAGTAKLAGFLASTPREHQAIHTLNTTALLRLSYAALAAFTPRRRGTLINIASILALHTLPGSAVYSASKAW VLSFTRGLQEEFADSGVRIQAVLPAATATDLWPTSGVALDALPSGTVMTTEDLVDAALRGLEMGEQVTLPPVHDLGLWET FEQSRLALFTSARTGQPAPRYR
Sequences:
>Translated_262_residues MTQPSHTAFITGASSGIGAIYAERLAARGYNLILAARREDRLQALADQLQARYAIQASILKADLSEEHGIAAVEQRLQQD PAIDLFINNAGTAKLAGFLASTPREHQAIHTLNTTALLRLSYAALAAFTPRRRGTLINIASILALHTLPGSAVYSASKAW VLSFTRGLQEEFADSGVRIQAVLPAATATDLWPTSGVALDALPSGTVMTTEDLVDAALRGLEMGEQVTLPPVHDLGLWET FEQSRLALFTSARTGQPAPRYR >Mature_261_residues TQPSHTAFITGASSGIGAIYAERLAARGYNLILAARREDRLQALADQLQARYAIQASILKADLSEEHGIAAVEQRLQQDP AIDLFINNAGTAKLAGFLASTPREHQAIHTLNTTALLRLSYAALAAFTPRRRGTLINIASILALHTLPGSAVYSASKAWV LSFTRGLQEEFADSGVRIQAVLPAATATDLWPTSGVALDALPSGTVMTTEDLVDAALRGLEMGEQVTLPPVHDLGLWETF EQSRLALFTSARTGQPAPRYR
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG0300
COG function: function code R; Short-chain dehydrogenases of various substrate specificities
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4557649, Length=184, Percent_Identity=32.6086956521739, Blast_Score=105, Evalue=6e-23, Organism=Homo sapiens, GI226371731, Length=193, Percent_Identity=30.5699481865285, Blast_Score=101, Evalue=7e-22, Organism=Homo sapiens, GI7705855, Length=195, Percent_Identity=27.1794871794872, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI40254992, Length=185, Percent_Identity=28.6486486486486, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=27.2251308900524, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=28.4210526315789, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI5031737, Length=190, Percent_Identity=28.4210526315789, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI19923817, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI109715829, Length=192, Percent_Identity=30.2083333333333, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI20149619, Length=188, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=6e-12, Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=31.25, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI87082100, Length=186, Percent_Identity=30.1075268817204, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI87082160, Length=223, Percent_Identity=26.9058295964126, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=29.1208791208791, Blast_Score=78, Evalue=7e-16, Organism=Escherichia coli, GI1790717, Length=184, Percent_Identity=27.1739130434783, Blast_Score=71, Evalue=8e-14, Organism=Escherichia coli, GI1788459, Length=204, Percent_Identity=28.921568627451, Blast_Score=68, Evalue=8e-13, Organism=Escherichia coli, GI1789208, Length=192, Percent_Identity=27.6041666666667, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI71994604, Length=192, Percent_Identity=35.4166666666667, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI71994600, Length=193, Percent_Identity=35.2331606217617, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17557668, Length=195, Percent_Identity=29.7435897435897, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI212646214, Length=197, Percent_Identity=28.9340101522843, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17559552, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17555706, Length=228, Percent_Identity=26.7543859649123, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI25152911, Length=199, Percent_Identity=27.6381909547739, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17560150, Length=200, Percent_Identity=31, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17508895, Length=226, Percent_Identity=26.1061946902655, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17562904, Length=205, Percent_Identity=27.8048780487805, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=30.5699481865285, Blast_Score=84, Evalue=2e-17, Organism=Saccharomyces cerevisiae, GI6319635, Length=187, Percent_Identity=28.3422459893048, Blast_Score=77, Evalue=3e-15, Organism=Saccharomyces cerevisiae, GI6322067, Length=193, Percent_Identity=29.5336787564767, Blast_Score=74, Evalue=2e-14, Organism=Saccharomyces cerevisiae, GI6322861, Length=186, Percent_Identity=26.3440860215054, Blast_Score=68, Evalue=2e-12, Organism=Drosophila melanogaster, GI24584748, Length=185, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=7e-22, Organism=Drosophila melanogaster, GI161076933, Length=185, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=7e-22, Organism=Drosophila melanogaster, GI28571526, Length=196, Percent_Identity=33.1632653061224, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI28574402, Length=194, Percent_Identity=28.3505154639175, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24584744, Length=194, Percent_Identity=28.3505154639175, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24644339, Length=201, Percent_Identity=29.3532338308458, Blast_Score=91, Evalue=7e-19, Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=30.9644670050761, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI24584752, Length=186, Percent_Identity=31.1827956989247, Blast_Score=89, Evalue=4e-18, Organism=Drosophila melanogaster, GI23397609, Length=197, Percent_Identity=30.9644670050761, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI24640442, Length=190, Percent_Identity=27.3684210526316, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI24643142, Length=217, Percent_Identity=29.9539170506912, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24641232, Length=202, Percent_Identity=30.1980198019802, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI24639444, Length=187, Percent_Identity=31.0160427807487, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI24641388, Length=228, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI116007236, Length=243, Percent_Identity=27.9835390946502, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI17737361, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI21358495, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI116007238, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI281364494, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI28571387, Length=246, Percent_Identity=30.0813008130081, Blast_Score=65, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 28114; Mature: 27983
Theoretical pI: Translated: 6.81; Mature: 6.81
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.1 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 0.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTQPSHTAFITGASSGIGAIYAERLAARGYNLILAARREDRLQALADQLQARYAIQASIL CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH KADLSEEHGIAAVEQRLQQDPAIDLFINNAGTAKLAGFLASTPREHQAIHTLNTTALLRL HHHCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH SYAALAAFTPRRRGTLINIASILALHTLPGSAVYSASKAWVLSFTRGLQEEFADSGVRIQ HHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEE AVLPAATATDLWPTSGVALDALPSGTVMTTEDLVDAALRGLEMGEQVTLPPVHDLGLWET EEECCCCCCCCCCCCCEEEECCCCCCEEEHHHHHHHHHHHHCCCCEECCCCCCCCCHHHH FEQSRLALFTSARTGQPAPRYR HHHCCEEEEEECCCCCCCCCCC >Mature Secondary Structure TQPSHTAFITGASSGIGAIYAERLAARGYNLILAARREDRLQALADQLQARYAIQASIL CCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH KADLSEEHGIAAVEQRLQQDPAIDLFINNAGTAKLAGFLASTPREHQAIHTLNTTALLRL HHHCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH SYAALAAFTPRRRGTLINIASILALHTLPGSAVYSASKAWVLSFTRGLQEEFADSGVRIQ HHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEE AVLPAATATDLWPTSGVALDALPSGTVMTTEDLVDAALRGLEMGEQVTLPPVHDLGLWET EEECCCCCCCCCCCCCEEEECCCCCCEEEHHHHHHHHHHHHCCCCEECCCCCCCCCHHHH FEQSRLALFTSARTGQPAPRYR HHHCCEEEEEECCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8969508; 9384377 [H]