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The map label for this gene is dmsA [H]

Identifier: 238893955

GI number: 238893955

Start: 1839503

End: 1841941

Strand: Direct

Name: dmsA [H]

Synonym: KP1_1895

Alternate gene names: 238893955

Gene position: 1839503-1841941 (Clockwise)

Preceding gene: 238893954

Following gene: 238893956

Centisome position: 35.05

GC content: 58.14

Gene sequence:

>2439_bases
ATGAAAATTAAAGCCCCTGATGCTTTACTGGCTGCTGAGGTAAGCCGCCGTGGTCTGATGAAAACCACGGCAATAGGCGG
CCTGGCGCTGGCCAGCAACGCACTAACGTTACCCTTTACCCGACTGTCGCATGCTGCCGATACGCCGGCGCCCGCCAGTG
AGAAGGTGGTCTGGAGCGCCTGCACCGTCAACTGCGGTAGCCGTTGCCCGCTGCGCATGCACGTGGTGGATGGCGCGATT
AAATACGTCGAAACCGATAATACCGGTGACGATAACTATGACGGTTTGCACCAGGTCCGCGCCTGCCTGCGTGGGCGTTC
AATGCGCCGCCGAGTCTATAATCCGGACCGTCTGAAGTACCCGATGAAGCGCGTTGGTAAACGCGGTGAGGGCAAGTTCG
AGCAAATCAGCTGGGAAGAGGCGTTGGATACCATCGCCAGCAATATGCAGCGGCTGATTAAAGAGTACGGCAATGAATCC
ATCTATCTGAACTACGGCACCGGCACGCTCGGCGGGACGCTGACCCGCTCCTGGCCGCCGGGGAAAACGCTGATTGCCCG
TCTGATGAACTGCTGCGGCGGCTATCTCAACCATTATGGCGACTATTCATCAGCGCAGATTGCTGCCGGTCTGAATTACA
CCTACGGCGGCTGGGCGGACGGCAACAGCCCATCGGATATTGAAAACAGTCAGCTGGTGGTGCTGTTCGGCAATAACCCC
GGCGAAACGCGGATGAGCGGCGGCGGGGTGACGTACTACCTTGAACAGGCGCGGCAGAAATCCAATGCCCGGATGATAAT
CATCGATCCGCGCTATACCGACACCGGCGCCGGGCGTGAAGATGAATGGATCCCGATTCGTCCTGGGACCGATGCGGCAC
TGGTTTCGGGCCTCGCGTGGGTGATGATCACCGAGAATCTGGTCGATCAGCCGTTCCTCGATAAATACTGCGTGGGATAC
GACGAGAAGACGCTGCCCGCCGGTGCGCCAGCCAATGGTCATTACAAAGCTTACATTCTTGGCCAGGGCACTGACGGTAT
CGCCAAAACGCCGGAGTGGGCCTCGACGATTACCGGTATTCCGCGCGAACGCATTGTTAAACTGGCGCGCGAAATTGCCA
CCGCCAAACCGGCCTATATTAGCCAGGGCTGGGGTCCGCAGCGTCACGCCAACGGTGAGATCGCCACCCGCGCCATCTCA
ATGCTCGCCATTCTGACGGGTAACGTCGGGATCAACGGCGGCAATAGCGGGGCGCGCGAGGGCTCGTATAGTTTGCCTTT
TGAGCGTATGCCGACGCTGGAGAATCCGGTTGAGACCAGTATCTCGATGTTTATGTGGACCGATGCGATTGAGCGCGGCC
CGGAAATGACCGCTCTGCGCGACGGCGTACGCGGTAAAGATAAGCTCGACGTGCCGATCAAAATGATCTGGAACTATGCG
GGCAACTGTCTGATTAACCAGCATTCTGAGATCAACCGGACCCACGAAATCCTGCAGGACGACAAGAAATGCGAGATGAT
TGTGGTCATTGACTGCCATATGACCTCCTCGGCGAAATACGCTGATATTCTGCTGCCGGACTGTACCGCCTCCGAGCAGA
TGGATTTCGCGCTGGATGCCTCCTGCGGCAACATGTCCTACGTTATCTTTGCCGATCAGGCCATCAAGCCGCGCTTTGAA
TGCAAAACCATCTATGAGATGACCAGCGAACTGGCAAAGCGTCTGGGCGTCGAAGAGCAGTTTACCGAGGGCCGTACCCA
GGAAGGCTGGATGCGCTATCTGTATGAGCAGTCGCGCAAAGCGATTCCCGACCTGCCGGATTTCGACACCTTCCGTCAGC
AGGGCATCTATAAGCAGCGCGATCCGCAAGGTCATCATGTGGCCTACAAAGCCTTCCGTGAGGATCCGCAGGCTAATCCG
CTGACCACGCCTTCGGGCAAGATCGAAATTTACTCGCAGGATCTGGCGAAAATCGCGGCTACCTGGGAGCTGCCGGAAGG
GGATGTTATCGATCCGCTGCCGATCTACACCCCGGGTTTCGAAAACTACAACGATCCGCTGACAGCGAAATACCCGCTAC
AGCTCACCGGCTTCCACTATAAATCTCGCGTCCACTCGACCTACGGCAACGTCGATGTGCTGAAGGCCGCCTGTCGGCAG
GAGATGTGGATTAACCCGATCGACGCCCGCAAGCGCGGCATTGCCAACGGCGATCGTATTCGCATCTTCAACGATCGGGG
TGAAGTGCATATCGAAGCGAAGGTGACGCCGCGCATGATGCCGGGCGTCGTCGCGCTGGGGGAAGGGGCCTGGTACAACC
CGGACGCCTCGCGTGTGGATCAGGCGGGCAGCATCAACGTGCTGACCACCCAGCGTCCGTCGCCGCTGGCGAAGGGAAAC
CCGTCGCATACCAACCTTGTTCAGGTTGAGAAGCTGTAA

Upstream 100 bases:

>100_bases
TGGATTAAACCAGCATAAAAAACCAATAATATCGCAAAGCATTATATATATGTCTATATAACGCTTGTCAGTTTATTGTG
AGCAACCAAAGCGAGTATCC

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACTCAGTATGGATTTTTTATTGATTCCGCCCGTTGCACCGGTTGCAAAACCTGCGAACTGGCCT
GTAAGGACTACAAGAACCTG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 812; Mature: 812

Protein sequence:

>812_residues
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHAADTPAPASEKVVWSACTVNCGSRCPLRMHVVDGAI
KYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNES
IYLNYGTGTLGGTLTRSWPPGKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAWVMITENLVDQPFLDKYCVGY
DEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGIPRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAIS
MLAILTGNVGINGGNSGAREGSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFADQAIKPRFE
CKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRKAIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANP
LTTPSGKIEIYSQDLAKIAATWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVDQAGSINVLTTQRPSPLAKGN
PSHTNLVQVEKL

Sequences:

>Translated_812_residues
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHAADTPAPASEKVVWSACTVNCGSRCPLRMHVVDGAI
KYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNES
IYLNYGTGTLGGTLTRSWPPGKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAWVMITENLVDQPFLDKYCVGY
DEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGIPRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAIS
MLAILTGNVGINGGNSGAREGSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFADQAIKPRFE
CKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRKAIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANP
LTTPSGKIEIYSQDLAKIAATWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVDQAGSINVLTTQRPSPLAKGN
PSHTNLVQVEKL
>Mature_812_residues
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHAADTPAPASEKVVWSACTVNCGSRCPLRMHVVDGAI
KYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNES
IYLNYGTGTLGGTLTRSWPPGKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAWVMITENLVDQPFLDKYCVGY
DEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGIPRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAIS
MLAILTGNVGINGGNSGAREGSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFADQAIKPRFE
CKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRKAIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANP
LTTPSGKIEIYSQDLAKIAATWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVDQAGSINVLTTQRPSPLAKGN
PSHTNLVQVEKL

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=814, Percent_Identity=89.8034398034398, Blast_Score=1534, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=803, Percent_Identity=67.7459526774595, Blast_Score=1151, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=816, Percent_Identity=66.1764705882353, Blast_Score=1144, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=765, Percent_Identity=31.8954248366013, Blast_Score=299, Evalue=5e-82,
Organism=Escherichia coli, GI87081994, Length=856, Percent_Identity=30.7242990654206, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI145693196, Length=752, Percent_Identity=30.8510638297872, Blast_Score=285, Evalue=8e-78,
Organism=Escherichia coli, GI3868721, Length=781, Percent_Identity=24.8399487836108, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI3868720, Length=468, Percent_Identity=26.7094017094017, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788534, Length=842, Percent_Identity=22.6840855106888, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI3868719, Length=462, Percent_Identity=24.8917748917749, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787477, Length=351, Percent_Identity=25.0712250712251, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787741, Length=307, Percent_Identity=24.7557003257329, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89974; Mature: 89974

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHAADTPAPASEKVVWSA
CCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHCCCEECCHHHHHHCCCCCCCCCCCEEEEE
CTVNCGSRCPLRMHVVDGAIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKY
EEECCCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCHHHCC
PMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNESIYLNYGTGTLGGTLTRSWPP
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCC
GKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAW
CCCEECCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
VMITENLVDQPFLDKYCVGYDEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGI
EEEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCC
PRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGARE
CHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHCCC
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDA
CCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEC
SCGNMSYVIFADQAIKPRFECKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHH
AIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQDLAKIAA
CCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHH
TWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EEECCCCCCCCCCCCCCCCCCCCCCCCCEECCEEEECCHHHHHHHHCCCCHHHHHHHHHH
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVD
HHCCCCHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHHHC
QAGSINVLTTQRPSPLAKGNPSHTNLVQVEKL
CCCCEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKIKAPDALLAAEVSRRGLMKTTAIGGLALASNALTLPFTRLSHAADTPAPASEKVVWSA
CCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHCCCEECCHHHHHHCCCCCCCCCCCEEEEE
CTVNCGSRCPLRMHVVDGAIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKY
EEECCCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCHHHCC
PMKRVGKRGEGKFEQISWEEALDTIASNMQRLIKEYGNESIYLNYGTGTLGGTLTRSWPP
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCC
GKTLIARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSQLVVLFGNNP
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
GETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVSGLAW
CCCEECCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
VMITENLVDQPFLDKYCVGYDEKTLPAGAPANGHYKAYILGQGTDGIAKTPEWASTITGI
EEEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCC
PRERIVKLAREIATAKPAYISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGARE
CHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSYSLPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYA
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHCCC
GNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDA
CCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEC
SCGNMSYVIFADQAIKPRFECKTIYEMTSELAKRLGVEEQFTEGRTQEGWMRYLYEQSRK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHH
AIPDLPDFDTFRQQGIYKQRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQDLAKIAA
CCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHH
TWELPEGDVIDPLPIYTPGFENYNDPLTAKYPLQLTGFHYKSRVHSTYGNVDVLKAACRQ
EEECCCCCCCCCCCCCCCCCCCCCCCCCEECCEEEECCHHHHHHHHCCCCHHHHHHHHHH
EMWINPIDARKRGIANGDRIRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYNPDASRVD
HHCCCCHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHHHC
QAGSINVLTTQRPSPLAKGNPSHTNLVQVEKL
CCCCEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]