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The map label for this gene is poxB [H]

Identifier: 238893932

GI number: 238893932

Start: 1808896

End: 1810614

Strand: Reverse

Name: poxB [H]

Synonym: KP1_1869

Alternate gene names: 238893932

Gene position: 1810614-1808896 (Counterclockwise)

Preceding gene: 238893934

Following gene: 238893931

Centisome position: 34.5

GC content: 60.73

Gene sequence:

>1719_bases
ATGAAGCAGACCGTGGCGGCATACATTGCCAAAACGCTGGAACAGGCCGGCGTGAAACGTATCTGGGGCGTCACCGGAGA
TTCCCTCAATGGATTGAGCGATAGCCTTAACCGCATGGGCACCATCGACTGGATGCCCACCCGGCACGAAGAGGTCGCCG
CTTTCGCCGCTGGCGCGGAAGCGCAGCTGACCGGCGAGCTGGCGGTCTGCGCCGGCTCCTGCGGACCGGGCAACCTGCAT
CTGATTAACGGTTTGTTTGACTGTCATCGCAACCATGTCCCGGTGCTGGCCATCGCCGCCCACATCCCATCCAGCGAAAT
CGGCAGCGGCTATTTTCAGGAAACCCATCCTCAGGAGCTGTTCCGCGAGTGCAGCCATTACTGCGAACTGGTCTCCACGC
CGGAACAGATCCCGCAGGTGCTGGCAGTGGCGATGCGTAAGGCAGTGATTAACCGCGGCGTCTCGGTGGTGGTGCTACCC
GGCGATGTGGCACTGAAGGCCGCCCCGGAAAGCGCCAGCAGCCACTGGTATCATGCGCCGCTGCCGACGGTCACCCCGGC
GGAAGAAGAGCTGCGCAAGCTGGCGCAGCTTATTCGCTACTCCAGCAATATCGCGCTCATGTGCGGCAGCGGTTGCGCCG
GCGCCCACCAGGAACTGGTGGAGTTCGCAGCCAAAATTAAAGCCCCCATCGTCCACGCCCTGCGCGGCAAAGAGCACGTG
GAGTACGACAACCCGTACGATGTGGGCATGACCGGGCTGATTGGCTTCTCCTCTGGCTTCCACACCATGATGAACGCCGA
TACCCTGATCCTGCTGGGCACCCAGTTCCCCTATCGCGCCTTCTACCCAACCGACGCGAAAATTATCCAGATCGACATCA
ACCCCGGCAGCATCGGCGCACACAGTAAGGTCGACATGGCGCTGGTGGGCGATATTAAATCGACGCTGAAGGCGCTGCTG
CCGCTGCTGGAAGAGAAAACCGATCGCCACTTCCTCGATAAGGCGCTGGAGCACTATCGCGACGCGCGAAAAGGGCTCGA
CGATCTGGCTAAACCCAGCGATAAAGCCATTCACCCGCAATATCTGGCGCAGCAGATCAGTCATTTTGCCGATGAAGATG
CCATTTTCACCTGCGATGTCGGTACCCCGACCGTCTGGGCGGCACGCTATCTCAAAATGAATGGTAAACGCCGCCTGCTG
GGCTCGTTCAACCACGGCTCAATGGCCAACGCCATGCCGCAGGCTATCGGCGCCAAGGCCACTGCGCCGGAGCGGCAGGT
AGTGGCCATGTGCGGCGACGGCGGGTTCAGCATGCTGATGGGCGATTTTCTGTCGCTGGCGCAGATGAAGCTGCCGGTGA
AGATTGTCATCTTTAACAACAGCGTGCTGGGCTTCGTGGCGATGGAAATGAAGGCCGGGGGCTATCTCACCGACGGTACG
GAGCTCCACGATACCAACTTCGCCCGCATCGCCGAGGCCTGCGGTATCAAAGGTATACGCGTTGAAAAAGCCTCCGAGGT
GGATGACGCGCTGCAGACCGCCTTCCGCACCGACGGTCCGGTGCTGGTCGACGTCGTCGTCGCCAAAGAGGAACTGGCGA
TCCCGCCGCAGATCAAGCTGGAGCAGGCCAAAGGCTTTAGCCTGTATATGCTGCGGGCGATCATCAGCGGGCGCGGCGAT
GAGGTCATCGAACTGGCGAAAACCAACTGGCTCAGGTAA

Upstream 100 bases:

>100_bases
GGAGAGGAATAAAACCAGCAAAAAATCAGGGGTAATCGGTTACATTGCGGTCAGTTTCATCTAAGCTTGAAGGCGTTATC
AAAAAAAGGAGATGGAGATC

Downstream 100 bases:

>100_bases
AACAGAAGCAATACGTTGAACCAGACCAAGGAAAAGCCGTGATCGATTTACGCAGTGATACCGTTACCCGTCCCGGGCGC
GCCATGCTGGAGGCCATGAT

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MKQTVAAYIAKTLEQAGVKRIWGVTGDSLNGLSDSLNRMGTIDWMPTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLH
LINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSTPEQIPQVLAVAMRKAVINRGVSVVVLP
GDVALKAAPESASSHWYHAPLPTVTPAEEELRKLAQLIRYSSNIALMCGSGCAGAHQELVEFAAKIKAPIVHALRGKEHV
EYDNPYDVGMTGLIGFSSGFHTMMNADTLILLGTQFPYRAFYPTDAKIIQIDINPGSIGAHSKVDMALVGDIKSTLKALL
PLLEEKTDRHFLDKALEHYRDARKGLDDLAKPSDKAIHPQYLAQQISHFADEDAIFTCDVGTPTVWAARYLKMNGKRRLL
GSFNHGSMANAMPQAIGAKATAPERQVVAMCGDGGFSMLMGDFLSLAQMKLPVKIVIFNNSVLGFVAMEMKAGGYLTDGT
ELHDTNFARIAEACGIKGIRVEKASEVDDALQTAFRTDGPVLVDVVVAKEELAIPPQIKLEQAKGFSLYMLRAIISGRGD
EVIELAKTNWLR

Sequences:

>Translated_572_residues
MKQTVAAYIAKTLEQAGVKRIWGVTGDSLNGLSDSLNRMGTIDWMPTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLH
LINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSTPEQIPQVLAVAMRKAVINRGVSVVVLP
GDVALKAAPESASSHWYHAPLPTVTPAEEELRKLAQLIRYSSNIALMCGSGCAGAHQELVEFAAKIKAPIVHALRGKEHV
EYDNPYDVGMTGLIGFSSGFHTMMNADTLILLGTQFPYRAFYPTDAKIIQIDINPGSIGAHSKVDMALVGDIKSTLKALL
PLLEEKTDRHFLDKALEHYRDARKGLDDLAKPSDKAIHPQYLAQQISHFADEDAIFTCDVGTPTVWAARYLKMNGKRRLL
GSFNHGSMANAMPQAIGAKATAPERQVVAMCGDGGFSMLMGDFLSLAQMKLPVKIVIFNNSVLGFVAMEMKAGGYLTDGT
ELHDTNFARIAEACGIKGIRVEKASEVDDALQTAFRTDGPVLVDVVVAKEELAIPPQIKLEQAKGFSLYMLRAIISGRGD
EVIELAKTNWLR
>Mature_572_residues
MKQTVAAYIAKTLEQAGVKRIWGVTGDSLNGLSDSLNRMGTIDWMPTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLH
LINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSTPEQIPQVLAVAMRKAVINRGVSVVVLP
GDVALKAAPESASSHWYHAPLPTVTPAEEELRKLAQLIRYSSNIALMCGSGCAGAHQELVEFAAKIKAPIVHALRGKEHV
EYDNPYDVGMTGLIGFSSGFHTMMNADTLILLGTQFPYRAFYPTDAKIIQIDINPGSIGAHSKVDMALVGDIKSTLKALL
PLLEEKTDRHFLDKALEHYRDARKGLDDLAKPSDKAIHPQYLAQQISHFADEDAIFTCDVGTPTVWAARYLKMNGKRRLL
GSFNHGSMANAMPQAIGAKATAPERQVVAMCGDGGFSMLMGDFLSLAQMKLPVKIVIFNNSVLGFVAMEMKAGGYLTDGT
ELHDTNFARIAEACGIKGIRVEKASEVDDALQTAFRTDGPVLVDVVVAKEELAIPPQIKLEQAKGFSLYMLRAIISGRGD
EVIELAKTNWLR

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=24.910394265233, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1787096, Length=572, Percent_Identity=93.3566433566434, Blast_Score=1094, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=559, Percent_Identity=30.7692307692308, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1790104, Length=547, Percent_Identity=29.2504570383912, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786717, Length=550, Percent_Identity=25.2727272727273, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788716, Length=541, Percent_Identity=23.8447319778189, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=559, Percent_Identity=26.4758497316637, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17531301, Length=559, Percent_Identity=26.4758497316637, Blast_Score=128, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323755, Length=563, Percent_Identity=25.044404973357, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6320816, Length=543, Percent_Identity=23.0202578268877, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922626, Length=550, Percent_Identity=25.0909090909091, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 62000; Mature: 62000

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTVAAYIAKTLEQAGVKRIWGVTGDSLNGLSDSLNRMGTIDWMPTRHEEVAAFAAGAE
CCHHHHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
AQLTGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL
CEECCCEEEEECCCCCCCEEEEHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCCCCHHHH
FRECSHYCELVSTPEQIPQVLAVAMRKAVINRGVSVVVLPGDVALKAAPESASSHWYHAP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCEEECC
LPTVTPAEEELRKLAQLIRYSSNIALMCGSGCAGAHQELVEFAAKIKAPIVHALRGKEHV
CCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
EYDNPYDVGMTGLIGFSSGFHTMMNADTLILLGTQFPYRAFYPTDAKIIQIDINPGSIGA
CCCCCCCCCCCEEEECCCCCHHHHCCCEEEEEECCCCCEEECCCCCEEEEEEECCCCCCC
HSKVDMALVGDIKSTLKALLPLLEEKTDRHFLDKALEHYRDARKGLDDLAKPSDKAIHPQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCHH
YLAQQISHFADEDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQAIGAKA
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCC
TAPERQVVAMCGDGGFSMLMGDFLSLAQMKLPVKIVIFNNSVLGFVAMEMKAGGYLTDGT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCCEECCCC
ELHDTNFARIAEACGIKGIRVEKASEVDDALQTAFRTDGPVLVDVVVAKEELAIPPQIKL
CCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEEEHHHHCCCCCCCH
EQAKGFSLYMLRAIISGRGDEVIELAKTNWLR
HCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKQTVAAYIAKTLEQAGVKRIWGVTGDSLNGLSDSLNRMGTIDWMPTRHEEVAAFAAGAE
CCHHHHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
AQLTGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL
CEECCCEEEEECCCCCCCEEEEHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCCCCHHHH
FRECSHYCELVSTPEQIPQVLAVAMRKAVINRGVSVVVLPGDVALKAAPESASSHWYHAP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCEEECC
LPTVTPAEEELRKLAQLIRYSSNIALMCGSGCAGAHQELVEFAAKIKAPIVHALRGKEHV
CCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
EYDNPYDVGMTGLIGFSSGFHTMMNADTLILLGTQFPYRAFYPTDAKIIQIDINPGSIGA
CCCCCCCCCCCEEEECCCCCHHHHCCCEEEEEECCCCCEEECCCCCEEEEEEECCCCCCC
HSKVDMALVGDIKSTLKALLPLLEEKTDRHFLDKALEHYRDARKGLDDLAKPSDKAIHPQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCHH
YLAQQISHFADEDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQAIGAKA
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCC
TAPERQVVAMCGDGGFSMLMGDFLSLAQMKLPVKIVIFNNSVLGFVAMEMKAGGYLTDGT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCCEECCCC
ELHDTNFARIAEACGIKGIRVEKASEVDDALQTAFRTDGPVLVDVVVAKEELAIPPQIKL
CCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEEEHHHHCCCCCCCH
EQAKGFSLYMLRAIISGRGDEVIELAKTNWLR
HCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]