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The map label for this gene is deoR [H]

Identifier: 238893900

GI number: 238893900

Start: 1777992

End: 1778750

Strand: Reverse

Name: deoR [H]

Synonym: KP1_1833

Alternate gene names: 238893900

Gene position: 1778750-1777992 (Counterclockwise)

Preceding gene: 238893901

Following gene: 238893898

Centisome position: 33.89

GC content: 59.95

Gene sequence:

>759_bases
ATGGAAACTCGCCGTGACGAACGTATCAGTCAGCTCATTCAGGCACTTAAACGCAGCGATAAGCTGCATCTGAAAGAAGC
CGCTTCCCTGCTTGGGGTGTCGGAAATGACCATTCGTCGCGACCTCAATGGCCACAGCGGCCCGGTTGTGCTGCTCGGCG
GATACATTGTGCTGGAGCCGCGCAGCGCCACCCATTACCTGCTCAGCGATCAAAAAACCCGGCTGGTCGAGGAAAAACGC
CGTGCCGCTCGCCATGCGGCCGCGCTGCTGGAGGCCCATCAGATGGCCTTCTTCGACTGCGGGACCACCACGCCGTGGAT
TATTGACGCCATTGACGATGCCCTGCCCTTCACCGGCGTCTGCTACTCCCTGAACACCTTTCTGGCCCTGCAGGAAAAAC
CCCAGTGCCGCGCGGTCCTGTGCGGTGGGGAGTTTCATGCCAGCAACGCGATTTTTATGCCGCTGAGCCTTGAGGATACC
CTCAGCCATCTGAGCCCTGATATCGCCTTTTACTCGGCGGCGGGGATCGACTGCGAGCAGGGGGCGACCTGCTATAACCT
GGAAGAGCTGCCGGTTAAGCACTGGGCGATGCGTCACGCGCGCTATCACGTGCTGGTGGTCGACCACAGCAAGTTTGGCA
AAGTGCGTCCGGCGCGCATGGGGGCGTTAGCGAAATTTGACGTGATCGCCAGCGATATCTGCCCGGATGATGAGCTGGTC
GCGCTGGCGAAGGCGCAGCAGATTTCCCTACTGTATTGA

Upstream 100 bases:

>100_bases
CGCCGCCGTCGCTGCGGCCACCGCGTGACTAACCCGCAAGCGACAGGTAAAATCCCGCTAACGCCCTGCCCCCGCAGGGC
GATTTTAGCGCAGAGGGAAT

Downstream 100 bases:

>100_bases
AGCGTCGCTGCCCGCGCCCCGCAGGGCGCGGGCAGGCATCAGGAGAACCAGCTGCCAAACCAGCCGTGCAGTTTCATCAG
CACGAAGTCGATCATCCGGC

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
METRRDERISQLIQALKRSDKLHLKEAASLLGVSEMTIRRDLNGHSGPVVLLGGYIVLEPRSATHYLLSDQKTRLVEEKR
RAARHAAALLEAHQMAFFDCGTTTPWIIDAIDDALPFTGVCYSLNTFLALQEKPQCRAVLCGGEFHASNAIFMPLSLEDT
LSHLSPDIAFYSAAGIDCEQGATCYNLEELPVKHWAMRHARYHVLVVDHSKFGKVRPARMGALAKFDVIASDICPDDELV
ALAKAQQISLLY

Sequences:

>Translated_252_residues
METRRDERISQLIQALKRSDKLHLKEAASLLGVSEMTIRRDLNGHSGPVVLLGGYIVLEPRSATHYLLSDQKTRLVEEKR
RAARHAAALLEAHQMAFFDCGTTTPWIIDAIDDALPFTGVCYSLNTFLALQEKPQCRAVLCGGEFHASNAIFMPLSLEDT
LSHLSPDIAFYSAAGIDCEQGATCYNLEELPVKHWAMRHARYHVLVVDHSKFGKVRPARMGALAKFDVIASDICPDDELV
ALAKAQQISLLY
>Mature_252_residues
METRRDERISQLIQALKRSDKLHLKEAASLLGVSEMTIRRDLNGHSGPVVLLGGYIVLEPRSATHYLLSDQKTRLVEEKR
RAARHAAALLEAHQMAFFDCGTTTPWIIDAIDDALPFTGVCYSLNTFLALQEKPQCRAVLCGGEFHASNAIFMPLSLEDT
LSHLSPDIAFYSAAGIDCEQGATCYNLEELPVKHWAMRHARYHVLVVDHSKFGKVRPARMGALAKFDVIASDICPDDELV
ALAKAQQISLLY

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=252, Percent_Identity=75.3968253968254, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1789829, Length=235, Percent_Identity=28.0851063829787, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789519, Length=244, Percent_Identity=25, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788069, Length=249, Percent_Identity=24.0963855421687, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789059, Length=234, Percent_Identity=26.4957264957265, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790753, Length=240, Percent_Identity=26.25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI226510968, Length=249, Percent_Identity=28.5140562248996, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28003; Mature: 28003

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRRDERISQLIQALKRSDKLHLKEAASLLGVSEMTIRRDLNGHSGPVVLLGGYIVLEP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEECCEEEECC
RSATHYLLSDQKTRLVEEKRRAARHAAALLEAHQMAFFDCGTTTPWIIDAIDDALPFTGV
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCHHHH
CYSLNTFLALQEKPQCRAVLCGGEFHASNAIFMPLSLEDTLSHLSPDIAFYSAAGIDCEQ
HHHHHHEEEECCCCCEEEEEECCEEECCCEEEEEECHHHHHHHCCCCCEEEEECCCCCCC
GATCYNLEELPVKHWAMRHARYHVLVVDHSKFGKVRPARMGALAKFDVIASDICPDDELV
CCCEECHHHCCHHHHHHHHCEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHH
ALAKAQQISLLY
HHHHHCEEEECC
>Mature Secondary Structure
METRRDERISQLIQALKRSDKLHLKEAASLLGVSEMTIRRDLNGHSGPVVLLGGYIVLEP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEECCEEEECC
RSATHYLLSDQKTRLVEEKRRAARHAAALLEAHQMAFFDCGTTTPWIIDAIDDALPFTGV
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCHHHH
CYSLNTFLALQEKPQCRAVLCGGEFHASNAIFMPLSLEDTLSHLSPDIAFYSAAGIDCEQ
HHHHHHEEEECCCCCEEEEEECCEEECCCEEEEEECHHHHHHHCCCCCEEEEECCCCCCC
GATCYNLEELPVKHWAMRHARYHVLVVDHSKFGKVRPARMGALAKFDVIASDICPDDELV
CCCEECHHHCCHHHHHHHHCEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHH
ALAKAQQISLLY
HHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]