| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is fabG [C]
Identifier: 238893850
GI number: 238893850
Start: 1721127
End: 1721876
Strand: Direct
Name: fabG [C]
Synonym: KP1_1782
Alternate gene names: 238893850
Gene position: 1721127-1721876 (Clockwise)
Preceding gene: 238893849
Following gene: 238893851
Centisome position: 32.79
GC content: 59.73
Gene sequence:
>750_bases ATGTTATTAAAAGATAAAGTCGCCATTATTACTGGCGCGGCCTCCGCACGCGGTTTGGGCTTCGCGACTGCGAAATTATT CGCCGAAAACGGCGCGAAAGTGGTCATTATCGACCTCAATGGCGAAGCCAGTAAAACCGCCGCTGCGGCATTAGGCGAAG GCCATCTCGGCCTGGCGGCCAACGTCGCTGATGAAGTGCAGGTGCAGGCGGCCATCGAACAGATCCTGGCGAAATACGGT CGGGTTGATGTACTGGTCAATAACGCCGGGATTACCCAGCCGCTGAAGCTGATGGATATCAAGCGCGCCAACTATGACGC GGTGCTTGATGTTAGCCTGCGCGGTACGCTGCTGATGTCGCAGGCGGTTATCCCCACCATGCGGGCGCAAAAATCCGGCA GCATCGTCTGCATCTCGTCCGTCTCCGCTCAGCGCGGCGGCGGTATCTTTGGCGGACCGCACTACAGCGCGGCAAAAGCC GGGGTGCTGGGTCTGGCGCGGGCGATGGCGCGCGAGCTTGGCCCGGATAACGTCCGCGTTAACTGCATCACCCCGGGGCT GATTCAGACCGACATTACCGCCGGCAAGCTGACTGATGACATGACGGCCAACATTCTTGCCGGCATTCCGATGAACCGCC TTGGCGACGCGATAGACATCGCCCGCGCCGCGCTGTTCCTCGGCAGCGATCTTTCCTCCTACTCCACCGGCATCACCCTG GACGTCAACGGCGGCATGTTAATTCACTAA
Upstream 100 bases:
>100_bases GCGCCGCCATTGGTTTGGTGGTGATTCTTTTCCTCGATGAACCACAATAACGGAAATATATCCTGTTAATTAATATGACG TAATGTCATGGAGTGAAACT
Downstream 100 bases:
>100_bases GCGAGGCAAACAGATGAAGATGACCGAATCACAAAAAGTCGCCGCGGCGGCGTGGCGTATTCGCCGTTACGCCCTGCAAA TGGGGGAAGTGCAGGGGCAG
Product: putative short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 249; Mature: 249
Protein sequence:
>249_residues MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEGHLGLAANVADEVQVQAAIEQILAKYG RVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMSQAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKA GVLGLARAMARELGPDNVRVNCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL DVNGGMLIH
Sequences:
>Translated_249_residues MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEGHLGLAANVADEVQVQAAIEQILAKYG RVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMSQAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKA GVLGLARAMARELGPDNVRVNCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL DVNGGMLIH >Mature_249_residues MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEGHLGLAANVADEVQVQAAIEQILAKYG RVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMSQAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKA GVLGLARAMARELGPDNVRVNCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL DVNGGMLIH
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=37.1900826446281, Blast_Score=145, Evalue=4e-35, Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=35.6589147286822, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=34.5381526104418, Blast_Score=127, Evalue=1e-29, Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=32.6771653543307, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=31.5555555555556, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=30.5019305019305, Blast_Score=105, Evalue=5e-23, Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=31.3253012048193, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=31.8725099601594, Blast_Score=101, Evalue=5e-22, Organism=Homo sapiens, GI4758504, Length=233, Percent_Identity=34.7639484978541, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=30.8370044052863, Blast_Score=99, Evalue=5e-21, Organism=Homo sapiens, GI4504505, Length=189, Percent_Identity=36.5079365079365, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=34.4086021505376, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=29.3172690763052, Blast_Score=95, Evalue=8e-20, Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=32.994923857868, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI31542939, Length=207, Percent_Identity=32.8502415458937, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI83715985, Length=233, Percent_Identity=33.0472103004292, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=9e-17, Organism=Homo sapiens, GI210032110, Length=225, Percent_Identity=24.4444444444444, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI4503817, Length=186, Percent_Identity=31.7204301075269, Blast_Score=78, Evalue=6e-15, Organism=Homo sapiens, GI302344755, Length=107, Percent_Identity=37.3831775700935, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI4503301, Length=229, Percent_Identity=27.0742358078603, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI7706318, Length=216, Percent_Identity=28.2407407407407, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=31.6939890710383, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI40807363, Length=200, Percent_Identity=30, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI109715829, Length=234, Percent_Identity=24.7863247863248, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI40254986, Length=195, Percent_Identity=31.7948717948718, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI157739938, Length=205, Percent_Identity=25.8536585365854, Blast_Score=64, Evalue=9e-11, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=40.3225806451613, Blast_Score=174, Evalue=7e-45, Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=34.5098039215686, Blast_Score=140, Evalue=6e-35, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=37.007874015748, Blast_Score=136, Evalue=1e-33, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=35.2, Blast_Score=127, Evalue=6e-31, Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=33.7349397590361, Blast_Score=122, Evalue=3e-29, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=35.7723577235772, Blast_Score=115, Evalue=2e-27, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=31.4516129032258, Blast_Score=93, Evalue=1e-20, Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=30.46875, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=31.3725490196078, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=27.6679841897233, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI1787526, Length=254, Percent_Identity=27.9527559055118, Blast_Score=78, Evalue=5e-16, Organism=Escherichia coli, GI1788891, Length=240, Percent_Identity=26.25, Blast_Score=78, Evalue=5e-16, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=28.735632183908, Blast_Score=78, Evalue=7e-16, Organism=Escherichia coli, GI2367365, Length=230, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787820, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=4e-12, Organism=Escherichia coli, GI1787545, Length=260, Percent_Identity=26.1538461538462, Blast_Score=64, Evalue=8e-12, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=38.1526104417671, Blast_Score=151, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=38.8, Blast_Score=150, Evalue=6e-37, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=33.4661354581673, Blast_Score=129, Evalue=1e-30, Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=33.955223880597, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=34.8314606741573, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.0756972111554, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=30.5019305019305, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=32.4528301886792, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=31.5589353612167, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17568967, Length=199, Percent_Identity=31.6582914572864, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=32.5670498084291, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=31.8352059925094, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=28.1954887218045, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=30.0813008130081, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17538182, Length=225, Percent_Identity=32.8888888888889, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=30.9160305343511, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.9160305343511, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17562904, Length=273, Percent_Identity=30.4029304029304, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17561272, Length=192, Percent_Identity=31.7708333333333, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.8850574712644, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=30.3030303030303, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=30.5343511450382, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=30.6513409961686, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=30.7984790874525, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=30.7984790874525, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17567345, Length=193, Percent_Identity=29.0155440414508, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=26.5873015873016, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=27.4111675126904, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI71982365, Length=196, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193203115, Length=203, Percent_Identity=27.0935960591133, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=37.5, Blast_Score=111, Evalue=1e-25, Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=30.3149606299213, Blast_Score=100, Evalue=3e-22, Organism=Saccharomyces cerevisiae, GI6322227, Length=201, Percent_Identity=26.865671641791, Blast_Score=62, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=200, Percent_Identity=27, Blast_Score=62, Evalue=8e-11, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=36.9477911646586, Blast_Score=141, Evalue=3e-34, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=34.6613545816733, Blast_Score=138, Evalue=3e-33, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=35.0597609561753, Blast_Score=129, Evalue=2e-30, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=36.3636363636364, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=36.7588932806324, Blast_Score=124, Evalue=4e-29, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=34.9019607843137, Blast_Score=114, Evalue=5e-26, Organism=Drosophila melanogaster, GI18859837, Length=217, Percent_Identity=36.8663594470046, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=30.0395256916996, Blast_Score=99, Evalue=4e-21, Organism=Drosophila melanogaster, GI24644337, Length=233, Percent_Identity=29.6137339055794, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI17737361, Length=236, Percent_Identity=31.7796610169492, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI24641232, Length=237, Percent_Identity=29.1139240506329, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=29.1866028708134, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21357673, Length=190, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24581726, Length=176, Percent_Identity=26.7045454545455, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI281364892, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24649181, Length=203, Percent_Identity=25.615763546798, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI221510726, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=2e-11, Organism=Drosophila melanogaster, GI21355631, Length=223, Percent_Identity=25.5605381165919, Blast_Score=64, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 25580; Mature: 25580
Theoretical pI: Translated: 8.21; Mature: 8.21
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEGHLGLAA CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCCCCEEE NVADEVQVQAAIEQILAKYGRVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMS CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHEEECCCCCCEEEEEEECCEEEHH QAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKAGVLGLARAMARELGPDNVRV HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE NCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL EEECCCEEEECCCCCCCCCCCHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCHHCCCCEEE DVNGGMLIH EECCCEEEC >Mature Secondary Structure MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEGHLGLAA CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCCCCEEE NVADEVQVQAAIEQILAKYGRVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMS CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHEEECCCCCCEEEEEEECCEEEHH QAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKAGVLGLARAMARELGPDNVRV HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE NCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL EEECCCEEEECCCCCCCCCCCHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCHHCCCCEEE DVNGGMLIH EECCCEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9163424 [H]